Construction and characterization of chimeric FcγR T cells for universal T cell therapy by Juanjuan Zhao, Manling Chen, Xudong Li, Zhaoqi Chen, Wei Li, Rongqun Guo, Min Wang, Zhongxing Jiang, Yongping Song, Jianxiang Wang, Delong Liu

“…Conclusion The anti-tumor effects of the CFR T cells in vitro and in xenograft mouse models are mediated by specific MoAbs such as RTX and herceptin. …”
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Depot-specific acetylation profiles of adipose tissues—therapeutic targets for metabolically unhealthy obesity by Haoyue Guo, Zhiyi Zhang, Juntao Yang, Jiangfeng Liu, Hongwei Lin, Ningbei Yin

“…Differential ECM remodeling adaptability between SA and VA was primarily mediated by fibranexin and integrin, with COL6A1, COL6A3, and ITGA5 identified as differentially acetylated proteins overlapping between our dataset and previous studies. …”
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Social learning activities to improve community engagement in waste management program by S. Sunarti, R.S.Y. Zebua, J.H. Tjakraatmadja, A. Ghazali, B. Rahardyan, K. Koeswinarno, S. Suradi, N. Nurhayu, R.H.A. Ansyah

“…Instead, path model analysis indicated the mediating effect  of Practice-based learning for Dialogue-based learning and Affective Factors, with the accuracy model at a moderate level (R2 = 42%; Q2 = 0.2258). …”
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Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients by Ali Fadhel Ahmed, Dzul Azri Mohamed Noor, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Nur Aizati Athirah Daud

“…Common types of SCARs include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). Immune-mediated mechanisms involving human leukocyte antigen (HLA) alleles have been implicated in the pathogenesis of this reaction. …”
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Effects of milk extracellular vesicles from Holstein Friesian and Brown Swiss heat-stressed dairy cows on bovine mammary epithelial cells by S. Castellani, L. Basiricò, A. Maggiolino, C. Lecchi, P. De Palo, U. Bernabucci

“…Focusing on the functioning of the mammary gland, attention has been recently paid to a new method of cell-cell communication mediated by extracellular vesicles, which with their cargo can affect the target cells' phenotypic traits, behavior, and biological functions. …”
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Growth of microbes in competitive lifestyles promotes increased ARGs in soil microbiota: insights based on genetic traits by Zishu Liu, Xiangwu Yao, Chengyi Chen, Yuxiang Zhao, Chifei Dong, Lingtao Sun, Junxian Zhao, Baofeng Zhang, Zhendi Yu, Dongqing Cheng, Lizhong Zhu, Baolan Hu

“…It has chromosomally carried kinds of multidrug resistance genes such as mexAB-oprM and mexCD-oprJ could mediate the intrinsic resistance to OTC. Streptomycetaceae has shown a better adaptive ability than other microbes at the clinical OTC concentrations. …”
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Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis by Meng Wang, Yi Zheng, Qian Hao, Guochao Mao, Zhijun Dai, Zhen Zhai, Shuai Lin, Baobao Liang, Huafeng Kang, Xiaobin Ma

“…The expression of miR-210-3p in BMSC-derived exosomes is markedly elevated in hypoxic conditions. Exosome-mediated transfer of miR-210-3p from hypoxic BMSCs to TNBC targets NFIX and activates Wnt/β-Catenin signaling in TNBC. …”
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Influence of Arbuscular Mycorrhizal Fungi on Nitrogen Dynamics During <i>Cinnamomum camphora</i> Litter Decomposition by Yuehong Gao, Xiaoyu Long, Yiqi Liao, Yonghui Lin, Zaihua He, Qin Kong, Xiangshi Kong, Xingbing He

“…This was likely driven by AMF-mediated phosphorus (P) mineralization. Nutrient acquiring, especially P by phosphatase, were the main factors in predicting litter decomposition and protein degradation. …”
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Blue-LED assisted Photodegradation kinetics of rhodamine-6G dye, enhanced anticancer activity and cleavage of plasmids using Au-ZnO nanocomposite by Pilavadi Thangamuniyandi, Devan Umapathy, Loganathan Nagarajan, Antony Joseph Velanganni Arockiam

“…Also, the AO-EB dual staining and DCFH-DA analysis of SKBr3 and A549 cells revealed ROS-mediated cell death via apoptosis. Moreover, plasmid cleavage studies against supercoiled pBR322 DNA result in single-stranded linear DNA without traversing the nicked circular form, suggesting the possible DNA targeting activity of Au-ZnO nanozyme. …”
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PINK1 modulates Prdx2 to reduce lipotoxicity‐induced apoptosis and attenuate cardiac dysfunction in heart failure mice with a preserved ejection fraction by Hao Zhang, Tianyu Xu, Xiyuan Mei, Qiming Zhao, Qiling Yang, Xianghui Zeng, Zhuang Ma, Haobin Zhou, Qingchun Zeng, Dingli Xu, Hao Ren

“…The overexpression of PINK1 induced Prdx2 expression and effectively attenuated palmitic acid‐induced apoptosis through the c‐Jun amino‐terminal kinase (JNK) and mitogen‐activated protein kinase (p38) pathways, whereas siRNA‐mediated Prdx2 knockdown abolished the protective effect of PINK1. …”
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Early Electroacupuncture Extends the rtPA Time Window to 6 h in a Male Rat Model of Embolic Stroke via the ERK1/2-MMP9 Pathway by Xin-chang Zhang, Ya-hui Gu, Wen-tao Xu, Yang-yang Song, Ao Zhang, Zhi-hui Zhang, Si-yuan Jiang, Si-qi Chang, Guang-xia Ni

“…This neuroprotective effect may be mediated by the inhibition of the ERK1/2-MMP9 pathway and alleviation of the destruction of the BBB.…”
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tiRNA-Gln-CTG is Involved in the Regulation of Trophoblast Cell Function in Pre-eclampsia and Serves as a Potent Biomarker by Yixiao Wang, Xiaohong Ji, Hengmei Shi, Sicong Liu, Hong Yu

“…Extracellular vesicle (EV) carriers may mediate the level of tiRNA-Gln-CTG in the circulation. …”
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Genetic parameters and genome-wide association studies including the X chromosome for various reproduction and semen quality traits in Nellore cattle by Felipe E. de Carvalho, José Bento S. Ferraz, Victor B. Pedrosa, Elisangela C. Matos, Joanir P. Eler, Marcio R. Silva, José D. Guimarães, Fernando Bussiman, Barbara C. A. Silva, Henrique A. Mulim, Artur Oliveira Rocha, Andre C. Araujo, Hui Wen, Gabriel S. Campos, Luiz F. Brito

“…The main gene ontology terms identified are “Oocyte Meiosis”, “Progesterone Mediated Oocyte Maturation”, “Thermogenesis”, “Sperm Flagellum”, and “Innate Immune Response”. …”
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Barriers to 12-month treatment of common anxiety, mood, and substance use disorders in the World Mental Health (WMH) surveys by Maria Carmen Viana, Alan E. Kazdin, Meredith G. Harris, Dan J. Stein, Daniel V. Vigo, Irving Hwang, Sophie M. Manoukian, Nancy A. Sampson, Jordi Alonso, Laura Helena Andrade, Guilherme Borges, Brendan Bunting, José Miguel Caldas-de-Almeida, Giovanni de Girolamo, Peter de Jonge, Oye Gureje, Josep Maria Haro, Elie G. Karam, Viviane Kovess-Masfety, Jacek Moskalewicz, Fernando Navarro-Mateu, Daisuke Nishi, Marina Piazza, José Posada-Villa, Kate M. Scott, Cristian Vladescu, Bogdan Wojtyniak, Zahari Zarkov, Ronald C. Kessler, Timothy Kessler, World Mental Health Survey collaborators

“…., comparing the n = 2,692 respondents who received treatment with the n = 2,444 who did not) were examined as predictors of barriers, while barriers were examined as mediators of associations between these predictors and treatment. …”
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Deciphering the functional roles of PE18 and PPE26 proteins in modulating Mycobacterium tuberculosis pathogenesis and immune response by Aquib Ehtram, Mohd Shariq, Neha Quadir, Neha Quadir, Salma Jamal, Manjunath Pichipalli, Sheeba Zarin, Sheeba Zarin, Javaid Ahmad Sheikh, Nasreen Z. Ehtesham, Seyed E. Hasnain, Seyed E. Hasnain

“…Mechanistic insights into endosome-phagosome maturation and actin cytoskeleton dynamics were obtained through fluorescence microscopy.ResultsOur biochemical analyses confirmed interactions between PE18/PPE26, PE18/PPE27, PE19/PPE25, and EspG5/PPE, highlighting their involvement in ESX-5-mediated secretion. Cell fractionation studies revealed that PE/PPE proteins predominantly localize to the cell wall, with PE18 also secreted extracellularly. …”
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Aerobic exercise alleviates statin-induced PCSK9 upregulation by increasing epoxyeicosatrienoic acid levels through the FoxO3a–Sirt6 axis by Jiahui Hu, Hao Lei, Jingyuan Chen, Leiling Liu, Yajun Gui, Kaijun Sun, Danyan Xu

“…Further, EETs significantly suppressed PCSK9 expression, subsequently reducing the LDL-C levels (all p < 0.05); this effect was mediated via the activation of the forkhead box O3a–silent mating type information regulation 2 homolog 6 (FoxO3a–Sirt6) axis, with no impact on the sterol regulatory element binding protein 2 and 3-hydroxy-3-methylglutaryl-CoA reductase (SREBP2-HMGCR) pathway. …”
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Development and validation of genome-informed and multigene-based qPCR and LAMP assays for accurate detection of Dickeya solani: a critical quarantine pathogen threatening the pota... by Shefali Dobhal, Gem Santillana, Michael J. Stulberg, Dario Arizala, Anne M. Alvarez, Mohammad Arif

“…Our study employed a whole-genome comparative approach, identifying unique target gene loci (LysR and TetR family of transcriptional regulators gene regions) and designing loop-mediated isothermal amplification (LAMP) and a multi-gene-based multiplex TaqMan qPCR assays for specific detection and differentiation of D. solani. …”
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RETRACTED ARTICLE: Bone mesenchymal stem cell-derived exosomal microRNA-7-5p inhibits progression of acute myeloid leukemia by targeting OSBPL11 by Duanfeng Jiang, Xin Wu, Xiaoying Sun, Wei Tan, Xin Dai, Youbang Xie, Ashuai Du, Qiangqiang Zhao

“…The purpose of this study was to investigate the effects of exosomes derived from bone marrow mesenchymal stem cells (BMSCs) on the regulation of AML and the underlying mechanisms mediated by microRNA (miRNA). Methods Dysregulated miR-7-5p in AML patients was identified using qRT-PCR and its clinical significance was explored. …”
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GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway by Chao Tang, Lin Li, Chongying Zhu, Qiang Xu, Zihao An, Shouying Xu, Chao Lin

“…By RNA-sequencing and experiments in vitro using multiple ovarian cancer cell models as well as in vivo using subcutaneous xenografts assay and in situ transplantation ovarian cancer model in nude mice, we further demonstrated that RAB8A positively mediated OC progression through activating HH signaling pathway by disassociating the protein–protein complex formation of GLI and SuFu (Suppressor of Fused), which reciprocally enhanced GPR137 activity, forming a regulation loop between HH signaling and GPR137. …”
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Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat by Shellye González-González, Mariana Gutiérrez-Pérez, Mara A. Guzmán-Ruiz, Estefania Espitia-Bautista, Rosa María Pavón, Karla P. Estrada-Rodríguez, Alejandro Díaz-Infante R., Cecilia G. Guadarrama Gándara, Carolina Escobar, Natalí N. Guerrero-Vargas

“…During adolescence, this process occurs within the NAc, where immune-mediated remodeling directly impacts social play behavior.MethodsThis study investigated the effects of maternal exposure to DLAN or a light-dark cycle (LD) before (5 weeks) and during the gestational period (21–23 days) on the metabolism and behavior of offspring in adolescence and adulthood. …”
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