Metabolite profiling in assessing ulcerative colitis activity: A systematic review by Danyang Cui, Xu Han, Jiazhu Jin, Yanhong Wang, Zijia Chen, Yang Gong, Miao Jiang

“…Background: Ulcerative colitis (UC) is an immune-mediated chronic inflammatory condition of the colon, characterized by defects in the intestinal epithelial barrier, dysbiosis of the microbiota, and immune dysregulation. …”
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The influence of e-trust on a job performance model based on employees’ dynamic capabilities during a crisis caused by a Black Swan event by Katarzyna Tworek, Guangyan Luo, Marcin Paska, Anna Sałamacha

“…FINDINGS: It has been proven that the higher the level of e-trust is, the stronger the influence of EDC is on job performance of organizations operating under a crisis caused by a Black Swan event mediated by P-J fit, work motivation, job satisfaction and work engagement. …”
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Corticostriatal maldevelopment in the R6/2 mouse model of juvenile Huntington's disease by Carlos Cepeda, Sandra M. Holley, Joshua Barry, Katerina D. Oikonomou, Vannah-Wila Yazon, Allison Peng, Deneen Argueta, Michael S. Levine

“…This was confirmed by increased occurrence of GABAA receptor-mediated giant depolarizing potentials at P7. At P14, the rheobase of CPNs was significantly reduced, along with increased excitability. …”
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Population genetic analysis of clinical Mycobacterium abscessus complex strains in China by Xiangchen Li, Xiangchen Li, Yelei Zhu, Yewei Lu, Kunyang Wu, Yang Che, Xiaomeng Wang, Weixin Wang, Junli Gao, Junshun Gao, Zhengwei Liu, Zhengwei Liu, Zhuxian Zhou

“…An acquired erm(46) gene, likely obtained via phage-mediated horizontal gene transfer, was detected in one MabA strain.ConclusionThis study provides key genetic insights into the dynamics of MABC in China. …”
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Metabolic reprogramming and macrophage expansion define ACPA-negative rheumatoid arthritis: insights from single-cell RNA sequencing by Yafeng Jiang, Zhaolan Hu, Roujie Huang, Kaying Ho, Pengfei Wang, Jin Kang, Jin Kang

“…CellChat analysis identified CD45 and CCL5 as key pathways facilitating macrophage-monocyte interactions in ACPA− RA, prominently involving iron-mediated metabolite communication. Metabolic flux analysis indicated elevated beta-alanine and glutathione metabolism in ACPA− RA macrophages.ConclusionThese findings underscore that ACPA-negative rheumatoid arthritis is marked by elevated classical monocytes in circulation and metabolic reprogramming of synovial macrophages, particularly in complement cascade and glutathione metabolism pathways. …”
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Phase I study of intratumoral administration of CV8102 in patients with advanced melanoma, squamous cell carcinoma of the skin, squamous cell carcinoma of the head and neck, or ade... by Lucie Heinzerling, Michael Fluck, Caroline Robert, Celeste Lebbe, Erika Richtig, Sven D Koch, Ulrike Gnad-Vogt, Tobias Seibel, Thomas Eigentler, Juan Martin-Liberal, Sebastian Ochsenreither, Peter Mohr, Patrick Terheyden, Carsten Weishaupt, Michael Erdmann, Lukas Koch, Ainara Soria, Igor Samoylenko, Jürgen Krauß, Peter Brossart, Franz Georg Bauernfeind, Marina Gonzalez, Peter Wengenmayer, Ioannis Thomas, Artem Poltoratskiy, Marina Sekacheva, Beate Schmitt-Bormann, Gianluca Quintini, Martin Falk, Paula Codó, Arjun Oberoi, Jana Hess, Yulia Semiletova, Casilda Llacer Perez, Oliver Schönborn-Kellenberger

“…Another patient experienced Grade 3 immune-mediated pneumonitis. No DLTs occurred in the combination therapy dose escalation cohort. …”
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Cancer-associated fibroblasts induce almonertinib resistance in non-small cell lung cancer by Guohao Wei, Yu Nie, Min Sun, Wenzheng Zhou, Huihui Zhao, Fangfang Chen, Chuandong Zhu

“…Methods The anti-cancer effects of almonertinib on NSCLC cells, as well as the reversal of these effects mediated by CAFs, were validated through phenotypic experiments. …”
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Macular edema after retinal vein occlusions. Macular morphometry and chorioretinal hemodynamics by A.A. Fil', E.L. Sorokin, O.V. Kolenko

“…The association between the severity of macular edema and vitreous levels of pro-inflammatory mediators (IL-1β, IL-6, TNF-α, MCP-1, and VEGF) is established. …”
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Impact of Prenatal Stress on Neuroendocrine Programming by Odile Viltart, Christel C. A. Vanbesien-Mailliot

“…Among factors susceptible of contributing to such a deleterious programming, nutrients and hormones, especially steroid hormones, are considered as powerful mediators of the fetal organization since they readily cross the placental barrier. …”
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The effect of environmental awareness as a moderation on determinants of green product purchase intention by A.S. Rama, . Yasri, P. Susanto

“…Fourth, attitudes toward green brands mediate green brand positioning and knowledge on green product purchase intention by 0.218 and 0.057, respectively. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…This in vitro study demonstrates a novel odontogenic mechanism mediated by ectopic expression of the transcription factor Atoh1 in human DPSCs. …”
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Effect of Propolis on PPP2R1A and Apoptosis in Cancer Cells by Burak Durmaz, Latife Merve Oktay Çelebi, Ayşe Çekin, Ayshan Ahadova, Nur Selvi Günel, Hatice Kalkan Yıldırım, Ali Mert Özgönül, Eser Yıldırım Sözmen

“…Recently, it has been shown that protein phosphatase 2A (PP2A) dysfunction was common in many cancer types and was mediated by various inactivation mechanisms. Although many research studies observed antitumor effect of propolis extracts in various types of cancer, the mechanism of effect are still obscure. …”
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Changes in Aqueous Humor Cytokine Profile Following Intravitreal Brolucizumab Injection by Ruamviboonsuk V, Kongwattananon W, Chuaypen N

“…The results suggested that type IV cell-mediated hypersensitivity could play a role in IOI following intravitreal brolucizumab injection.Keywords: anti-VEGF, intravitreal injection, inflammation, hypersensitivity, intravitreal injection…”
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HLA-DMB correlates with antitumor immunity and an improved prognosis in endometrial carcinoma tumors by Xiaoyu Xi, Xiaona Zhang, Jianxin Tang, Xiumei Fan, Jiexian Du

“…Mechanistically, HLA-DMB primarily participates in CD22-mediated regulation of B cell receptors (BCR), leading to BCR antigen activation and the production of second messengers. …”
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CRISPR/Cas12a-based method coupled with isothermal amplification to identify Alternaria spp. isolated from wheat grain samples by Aisha Shaizadinova, Aisha Shaizadinova, Meruyert Amanzholova, Meruyert Amanzholova, Irina Rukavitsina, Sailau Abeldenov, Anuar Rysbekovich Zhumakayev

“…Isothermal amplification methods, including nucleic acid sequence-based amplification (NASBA), loop-mediated isothermal amplification (LAMP), and recombinase polymerase amplification (RPA), enable nucleic acid amplification at constant temperatures, making them ideal for point-of-care diagnostics without the need for thermal cycling equipment. …”
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Environmental microbial communications in gram-positive and gram-negative bacteria by P. Srikanth, D. Sivakumar, J. Nouri

“…The scope of quorum sensing extends to inter-nation communication, mediate through numerous newly diagnosed extra-cell signal molecules known as autoinducers. …”
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The relationship between vision status and its influencing factors among primary and secondary school students: The masking effect of physical activity level and the moderating eff... by Jiyan Xu, Yanjun Li, Siyuan Ma, Shimeng Dai, Weiwei Xu, Mengjiao Sang, Kaijie Feng

“…The physical activity level played a significant masking effect between lifestyle behaviors and vision status (a*b = 0.002, c’=-0.044), and academic stress played a moderating role in the process of lifestyle behaviors affecting physical activity level and vision status. A moderated mediator model was constructed and fitted well (RMSEA = 0.028, CFI = 0.953, NFI = 0.934). …”
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Role of Vigilin and RACK1 in dengue virus-Aedes aegypti-Wolbachia interactions by Guijie Wang, Mazhar Hussain, Zhi Qi, Sassan Asgari

“…Vigilin is, therefore, a multifunctional protein reported to be associated with RNA transport and metabolism, sterol metabolism, chromosome segregation, carcinogenesis, and heterochromatin-mediated gene silencing. The receptor for activated C kinase 1 (RACK1) is another highly conserved protein involved in many cellular pathways. …”
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Rutas literarias: (inter)espacio didáctico para leer, caminar y hablar el libro / Reading itinerary: (inter)didactic space to read, walk and talk the book by Miguel Sánchez García, Juana Rosa Suárez-Robaina

“…The relationship already established between reader and text is now joined by the experience with whom the work mediates on the route: an expert voice that encourages interaction in the recognized and vivified space of the story. …”
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Murine DX5+NKT Cells Display Their Cytotoxic and Proapoptotic Potentials against Colitis-Inducing CD4+CD62Lhigh T Cells through Fas Ligand by Jens M. Werner, Michael Damian, Stefan A. Farkas, Hans J. Schlitt, Edward K. Geissler, Matthias Hornung

“…Furthermore, DX5+NKT cells likely mediate their cytotoxic and proapoptotic potentials via FasL, confirming recent reports about iNKT cells. …”
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