Serum Exosomes miR-122-5P Induces Hepatic and Renal Injury in Septic Rats by Regulating TAK1/SIRT1 Pathway by Wang J, Jiang Y, Yuan Y, Ma X, Li T, Lv Y, Zhang J, Chen L, Zhou J, Meng Y, Zhang B, Dong X, Ma L

“…Recent studies have emphasized the critical role of serum exosomes and their miRNA content in mediating sepsis-induced organ dysfunction. The objective of this study is to elucidate the mechanism underlying the impact of miR-122-5p on sepsis-associated liver and kidney injury using inhibitors for miR-122-5p as well as GW4869, an inhibitor targeting exosome release.Materials and Methods: Exosomes were isolated from serum samples of septic rats, sepsis patients, and control groups, while liver and kidney tissues were collected for subsequent analysis. …”
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Hairy transcriptional repression targets and cofactor recruitment in Drosophila. by Daniella Bianchi-Frias, Amir Orian, Jeffrey J Delrow, Julio Vazquez, Alicia E Rosales-Nieves, Susan M Parkhurst

“…While a major step forward in understanding the molecular mechanism(s) surrounding Hairy-mediated repression was made with the identification of Groucho, Drosophila C-terminal binding protein (dCtBP), and Drosophila silent information regulator 2 (dSir2) as Hairy transcriptional cofactors, the identity of Hairy target genes and the rules governing cofactor recruitment are relatively unknown. …”
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Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…Acute cellular rejection (ACR) was diagnosed based on clinical and histological findings, graft gene expression of pro- and anti-inflammatory mediators assessed by RT-qPCR, serum IL-6 and IL-10 levels by Luminex, and Treg frequency analyzed by flow cytometry (CD4+CD25highFoxP3+).…”
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Acquired sperm hypomethylation by gestational arsenic exposure is re-established in both the paternal and maternal genomes of post-epigenetic reprogramming embryos by Keiko Nohara, Takehiro Suzuki, Kazuyuki Okamura, Tomoko Kawai, Kazuhiko Nakabayashi

“…Furthermore, the results suggest that this re-establishment is achieved in collaboration with other factors that mediate region-specific methylation changes. These results also highlight the possibility that arsenic-induced sperm methylome changes could contribute to the development of disease predisposition in offspring.…”
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The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy by Lin Wang, Qingxia Kong, Xinyi Leng, Howan Leung, Yang Li

“…It not only forms the basis of cell membranes but is also an important bioactive mediator. It can not only act as a second messenger in cells to activate downstream signaling pathways but can also exert biological effects by being secreted outside cells and binding to S1P receptors on the cell membrane. …”
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The MicroRNA-106a/20b Strongly Enhances the Antitumour Immune Responses of Dendritic Cells Pulsed with Glioma Stem Cells by Targeting STAT3 by Hui Zhou, Chengmei Sun, Cong Li, Shiting Hua, Feng Li, Ruichun Li, Dongpeng Cai, Yuxi Zou, Yingqian Cai, Xiaodan Jiang

“…This study indicted that the miR-106a/20b activation could be one of the important molecular mechanisms leading to enhance antitumour immune responses of GSC-mediated DCs, which downregulated the expression of STAT3 to alleviate its the inhibitory effect.…”
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Inequalities in children’s tooth decay requiring dental extraction under general anaesthetic: a longitudinal study using linked electronic health records by Carol Dezateux, Nicola Firman, Vanessa Muirhead

“…Further research is needed to understand factors mediating inequalities in DGA. These findings emphasise the importance of targeting the wider determinants of inequalities in tooth extraction and ensuring equitable access to preventive and restorative dentistry.…”
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PDE4B promotes ferroptosis in nucleus pulposus cells and is involved in intervertebral disc degeneration by Weixing Xu, Rana Dhar, Danyang Zheng, Qi Peng, Yue Li, Sheng Mei, Huifang Tang

“…Our study suggested that aberrant PDE4B activation in NP tissues induces pathological changes in IDD mediated by ferroptosis, and PDE4 inhibitor reveres the process of IDD by suppressing ferroptosis, and has a synergic effect with ferroptosis inhibitor. …”
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Disease-associated genetic variants in the regulatory regions of human genes: mechanisms of action on transcription and genomic resources for dissecting these mechanisms by E. V. Ignatieva, E. A. Matrosova

“…At the same time, attention is concentrated on the transcriptional level of regulation as an initial step in the expression of any gene. A triggering event mediating the effect of a pathogenic genetic variant on the level of gene expression can be, for example, a change in the functional activity of transcription factor binding sites (TFBSs) or DNA methylation change, which, in turn, affects the functional activity of promoters or enhancers. …”
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A Strategy to Revalue a Wood Waste for Simultaneous Cadmium Removal and Wastewater Disinfection by Aleksandra Ivanovska, Sonja Veljović, Biljana Dojčinović, Nenad Tadić, Katarina Mihajlovski, Maja Natić, Mirjana Kostić

“…Good compliance with pseudo-second kinetic order indicated that cadmium adsorption was mediated by chemical forces. Thermodynamic parameters revealed the spontaneous and exothermic character of cadmium ion adsorption onto mulberry and myrobalan plum. …”
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Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repair by Yinan Xiao, Yu Wu, Qilong Wang, Mo Li, Chaolin Deng, Xiaoyang Gu

“…RNA sequencing and proximity labeling were employed to identify the molecular mechanisms underlying PFKFB3-mediated resistance. The in vivo efficacy of PARPi and PFK158 combination therapy was evaluated in OC xenograft models. …”
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Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

“…However, chronic inflammation can be harmful and significantly contribute to the development and progression of chronic diseases, with macrophage-mediated responses being central to these processes. …”
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Combination Blockade of the IL6R/STAT-3 Axis with TIGIT and Its Impact on the Functional Activity of NK Cells against Prostate Cancer Cells by S. González-Ochoa, M. C. Tellez-Bañuelos, A. S. Méndez-Clemente, A. Bravo-Cuellar, G. Hernández Flores, L. A. Palafox-Mariscal, J. Haramati, E. J. Pedraza-Brindis, K. Sánchez-Reyes, P. C. Ortiz-Lazareno

“…However, additional therapeutic targets such as the IL6R/STAT-3 axis and TIGIT have been proposed, mainly due to their relevance in the development of PCa and regulation of NK cell-mediated cytotoxicity. Here, we evaluate the effect of inhibitors directed against these therapeutic targets primarily via an analysis of NK cell function versus prostate cancer cells. …”
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Kriptokokal meningitis: Aspek klinis dan diagnosis laboratorium by Efrida ., Desi Ekawati

“…Associated factors with virulence of Cryptococcus neoformans is the polysaccharide capsule, melanin production and thermotolerance. Cell-mediated immunity has an important role in host defense against Cryptococcus. …”
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Most diverse, most neglected: weevils (Coleoptera: Curculionoidea) are ubiquitous specialized brood-site pollinators of tropical flora by Haran, Julien, Kergoat, Gael J., de Medeiros, Bruno A. S.

“…Plants engaged in weevil-mediated pollination are generally of typical cantharophilous type exhibiting large, white and fragrant flowers or inflorescences and they also show specific structures to host the larval stages of their specialist pollinators. …”
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Mapping Antimicrobial Resistance in <i>Staphylococcus epidermidis</i> Isolates from Subclinical Mastitis in Danish Dairy Cows by Desiree Corvera Kløve, Mikael Lenz Strube, Peter M. H. Heegaard, Lærke Boye Astrup

“…Results further showed that each herd had one primary sequence type (ST) and resistance profile associated with it, and plasmid-mediated horizontal gene transfer of ARGs was indicated This study underscores the importance of routine resistance surveillance and species-specific diagnoses to improve treatment outcomes and ensure prudent use of antimicrobials.…”
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Inhibition of miR-182-5p Targets FGF9 to Alleviate Osteoarthritis by Yang Sun, Sanmao Su, Mengjun Li, Ang Deng

“…Ki67 expression in cartilage was detected using immunohistochemistry (IHC). TdT-mediated dUTP nick-end labeling (TUNEL) assays were used to calculate the apoptosis rate of cartilage. …”
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Dose-dependent effects of gamma radiation on the early zebrafish development and gene expression. by Selma Hurem, Leonardo Martín Martín, Dag Anders Brede, Eystein Skjerve, Rasoul Nourizadeh-Lillabadi, Ole Christian Lind, Terje Christensen, Vidar Berg, Hans-Christian Teien, Brit Salbu, Deborah Helen Oughton, Peter Aleström, Jan Ludvig Lyche

“…Ingenuity Pathway Analysis identified retinoic acid receptor activation, apoptosis, and glutathione mediated detoxification signaling as the most affected pathways in the lower dose rate (0.54 mGy/h), while eif2 and mTOR, i.e., involved in the modulation of angiogenesis, were most affected in higher dose rates (5.4 and 10.9 mGy/h). …”
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Strategies for genetic manipulation of the halotolerant black yeast Hortaea werneckii: ectopic DNA integration and marker-free CRISPR/Cas9 transformation by Yainitza Hernandez-Rodriguez, A. Makenzie Bullard, Rebecca J. Busch, Aidan Marshall, José M. Vargas-Muñiz

“…Here, we report a new ectopic integration protocol for H. werneckii using polyethylene glycol-CaCl2 mediated protoplast transformation. This approach relies on a drug (hygromycin B) resistance gene to select for successful integration of the genetic construct. …”
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Outcomes of intravitreal dexamethasone implant (Ozurdex®) in patients with post-surgical macular edema – a real-world scenario by Elder Ohara de Oliveira Júnior, Isabel Ahn, Rodrigo Antonio Brant Fernandes, Arthur Gustavo Fernandes

“…Abstract Background Clinically significant macular edema (CME) is the leading cause of visual loss after ophthalmologic surgery due to the release of inflammatory mediators promoted by the procedures. We aimed to evaluate the outcomes of intravitreal Ozurdex® (700 µg dexamethasone) implants as a primary therapeutical option for post-surgical macular edema cases. …”
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