Problematic Online Video Watching, Boredom Proneness and Loneliness Among First-Year Chinese Undergraduates: A Two-Wave Longitudinal Study by Yan Z, Yang Z, Xu X, Zhou C, Sang Q

“…To test the research hypotheses, cross-lagged panel models were performed using AMOS 24.0.Results: Our results revealed the that (1) Boredom proneness and problematic online video watching were mutually influenced. (2) Loneliness at T1 positively predicted the level of problematic online video watching at T2 but not vice versa. (3) Boredom proneness mediated the link between loneliness and problematic online video watching. (4) Chinese first-year undergraduates’ levels of problematic online video watching and boredom proneness significantly increased during their educational transition period from high school to university.Conclusion: The present study enhances our understanding of the dynamic relationships between problematic online video watching, boredom proneness and loneliness, highlighting the targeted prevention and interventions for first-year undergraduates.Keywords: problematic online video watching, boredom proneness, loneliness, cross-lagged panel model…”
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Study of Association of Vitamin D Receptor Gene Polymorphisms with Diabetic Nephropathy by Bhuiya Esha, Saravanan Yogaprabhu, Janaki Sneha, Karthick Vijayalakshmi, Viswanathan Mohan, Venkatesan Radha, Dhanasekaran Bodhini

“…The functions of vitamin D are mediated through vitamin D receptor (VDR). Three single nucleotide polymorphisms (SNPs) in VDR gene, namely, TaqI (rs731236), ApaI (rs7975232), and BsmI (rs1544410), have been widely studied in association with diabetes and nephropathy. …”
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Antiamnesic and Neurotrophic Effects of Parkia biglobosa (Jacq.) R. Br (Fabaceae) Aqueous Extract on In Vivo and In Vitro Models of Excitotoxicity by Antoine Kavaye Kandeda, Liliane Yimta Foutse, Corneille Tongoue, Jean Philippe Djientcheu, Théophile Dimo

“…These effects seem to be mediated by antioxidant and anti-inflammatory modulations.…”
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Breast Implant Illness May Be Rooted in Mast Cell Activation: A Case-Controlled Retrospective Analysis by Èva S. Nagy, BMedSci(Hons), MBBS, PhD, FRACS, Grad Cert (Breast Surgery), Mark Westaway, MBBS, DCH, Grad Dip Allergy, Suzanne Danieletto, BSc, MBBS (Hons), FRCPA, MIAC, Lawrence B. Afrin, MD

“…Given that neoantigenic/xenobiotic exposures commonly trigger dysfunctional MCs in MCAS to heighten aberrant mediator expression driving inflammatory and other issues, further investigation of whether BII represents an implant-driven escalation of preexisting MCAS and whether an MCAS diagnosis flags risk for BII seems warranted.…”
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Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway by Zishuo Cheng, Shun Huang, Qiya Tang, Danlan Zhang, Lan Huang

“…Experimental data confirmed vitamin A’s effects on mitochondrial dynamics and metabolic reprogramming through the STAT3 pathway.ConclusionThe study demonstrates that vitamin A’s therapeutic effect on periodontitis is mediated through JAK-STAT pathway-guided mitochondrial metabolic reprogramming in macrophages. …”
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A comprehensive review and meta-analysis of the relationships between interleukin-7 levels and COVID-19 severity by Michal MATUSZEWSKI, Michal PRUC, Lukasz SZARPAK, Alla NAVOLOKINA, Katarzyna KIEZUN, Francesco CHIRICO, Gabriella NUCERA, Yuriy STEPANOVSKYY, Murat YILDIRIM, Anna HILFANOVA, Anastasia BONDARENKO

“…Introduction: As the major mechanism for coronavirus disease 2019, cytokine storm-mediated organ harm continues to dominate current understanding. …”
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Study of factors associated with obesity in patients using antipsychotics in schizophrenia by Vishalakshi Patnam, P Ramya Keerthi, P Ravi Kiran, Dinesh Panati

“…It may also encourage research on the causal pathways and mechanisms mediating the relationship. Aims and Objectives: To study the factors associated with obesity in patients with schizophrenia using antipsychotics. …”
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Respiratory drive: a journey from health to disease by Dimitrios Georgopoulos, Maria Bolaki, Vaia Stamatopoulou, Evangelia Akoumianaki

“…During the involuntary act of breathing, chemical feedback, primarily mediated through CO2, is the main determinant of respiratory drive. …”
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Why should we strive to let them thrive? Exploring the links between homecare professionals thriving at work, employee ambidexterity, and innovative behavior by Terje Slåtten, Barbara Rebecca Mutonyi, Gudbrand Lien

“…Results The main results from the empirical study can be summarized as follows: (i) TAW was found to be positively linked to both EA (b = 0.46) and IIB (b = 0.22); (ii) TAW and EA explained about 30% (R2 = 0.29) the variance in IIB; (iii) The relationship between TAW and IIB was found to be mediated by the EA; (iv) TAW was positively linked to each of the two dimensions that constitute EA. …”
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Techno-structural and 3-D geometric morphometric analysis applied for investigating the variability of Holocene unifacial tools in tropical Central Brazil. by Marina González-Varas, Antoine Lourdeau, Letícia Gonçalves, Rafael Lemos de Souza, Diego Teixeira Mendes, Tatyana Beltrão de Oliveira, Gustavo Furlaneto Silva, Hubert Forestier, Rolando Romero, Antonio Pérez-Balarezo

“…However, the factors influencing their morphological and structural variability remain largely unexplored, obscuring our understanding of their ergonomics and their role as mediators between humans and tropical environments. …”
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Antibiofilm and Anti-Quorum Sensing Potential of Safely-Synthesized Hydrated Zirconium Oxide-Coated Alginate Beads against Some Pathogenic Bacteria by Alfred Ngenge Tamfu, Yasemin Ispirli Dogaç, Ozgur Ceylan, Andreea Botezatu Dediu, Selahattin Bozkurt, Rodica Mihaela Dinica

“…At MIC and sub-MIC concentrations, the synthesized beads inhibited the production of violacein in C. violaceum CV12472 and C. violaceum CV026, indicating that they can reduce QS-mediated virulence factors in bacteria. Antimicrobial activity was evaluated against Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Candida albicans, and Candida tropicalis, and MIC values ranged from 1.25 mg/mL to 10 mg/mL. …”
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Myocardin-Related Transcription Factor A (MRTF-A) Regulates the Balance between Adipogenesis and Osteogenesis of Human Adipose Stem Cells by Laura Hyväri, Sari Vanhatupa, Heidi T. Halonen, Minna Kääriäinen, Susanna Miettinen

“…Our results strongly indicate that MRTF-A is an important regulator of the balance between osteogenesis and adipogenesis of hASCs through its role in mediating the cytoskeletal dynamics. These results provide MRTF-A as a new interesting target for guiding the stem cell differentiation in tissue engineering applications for regenerative medicine.…”
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Parenting after a history of childhood maltreatment: A scoping review and map of evidence in the perinatal period. by Catherine Chamberlain, Graham Gee, Stephen Harfield, Sandra Campbell, Sue Brennan, Yvonne Clark, Fiona Mensah, Kerry Arabena, Helen Herrman, Stephanie Brown, ‘Healing the Past by Nurturing the Future’ group

“…Observational studies illustrate sociodemographic and mental health protective and risk factors that mediate/moderate intergenerational pathways to parental and child wellbeing. …”
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Combination of Fractional Exhaled Nitric Oxide (FeNO) Level and Asthma Control Test (ACT) in Detecting GINA-Defined Asthma Control in Treated Asthmatic Patients in Vietnam by Vinh Nguyen Nhu, Pham Le An, Niels H. Chavannes

“…FeNO has been used as a marker for Th2-mediated airway inflammation in asthma. There is evidence which recommends the use of this biomarker in asthma management. …”
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Impact of loneliness on suicidal ideation during the COVID-19 pandemic: findings from a cross-sectional online survey in Japan by Takahiro Tabuchi, Ryo Okubo, Hirokazu Tachikawa, Midori Matsushima, Haruhiko Midorikawa, Miyuki Aiba

“…Additionally, the results showed that those who were lonely, and continued to feel lonely during the pandemic, had the highest PRs of suicidal ideation.Conclusion Loneliness had both direct and indirect effects on suicidal ideation mediated through depression. Those who felt lonelier during the pandemic had the highest risk of suicidal ideation. …”
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Sources and Effects of Fluids in Continental Retrograde Shear Zones: Insights from the Kuckaus Mylonite Zone, Namibia by C. A. Stenvall, A. Fagereng, J. F. A. Diener, C. Harris, P. E. Janney

“…Exhumed continental retrograde faults, nonetheless, show evidence for the operation of fluid-mediated weakening mechanisms during deformation at midcrustal conditions. …”
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MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi. by Sajith Raghunandanan, Kai Zhang, Yan Zhang, Raj Priya, Ching Wooen Sze, Yongliang Lou, Michael J Lynch, Brian R Crane, Mark H Kaplan, Chunhao Li, X Frank Yang

“…These findings reveal that MCP5, regulated by both the Rrp1 and Rrp2 pathways, is critical for establishing infection in mammalian hosts by evading NK cell-mediated host innate immunity and is important for the transmission of spirochetes from ticks to mammalian hosts. …”
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Care, conflict, and coexistence: Human–wildlife relations in community forests by Madison Stevens, Shalini Rawat, Terre Satterfield

“…We report on qualitative and quantitative analyses to consider community forest users' perceptions of living with wildlife—mediated by cultural norms, livelihood demands, and everyday encounters—and investigate beliefs about (1) lethal control as a response to conflict and (2) responsibilities for managing and protecting wildlife. …”
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Investigation of Scutellaria Barbata’s immunological mechanism against thyroid cancer using network pharmacology and experimental validation by Gen Ouyang, Yuangui Zhu, Zhehao Ouyang

“…KEGG enrichment analysis suggested that the anticancer effect of SBH might be mediated through signaling pathways such as AGE-RAGE and PI3K-Akt. …”
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To study the role of tofacitinib and betamethasone pulse in the treatment of vitiligo at a tertiary care centre: an observational comparative study by Rashmi Singh, Surabhi Shandilya, Kamalpreet Kaur Bhaikhel, Gopi Krishna Maddali

“…Tofacitinib is also known to inhibit IFN-γ mediated inflammation, which is an important step in the development of vitiligo lesions. …”
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