Mediating Mendelian randomization in the proteome identified potential drug targets for obesity-related allergic asthma by Jiannan Lin, Shuwen Lu, Xiaoyu Zhao

“…Plasma proteins such as TPST1, ROR1, and DAPK1 mediate this relationship, with TPST1 accounting for over 10% of the mediation effect. …”
Get full text

The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota by Jingda Zhang, Lin Hou, Shanxiang Lei, Yan Li, Guogang Xu

“…Of note, paraprevotella_clara served an important mediating role in the type 2 diabetes associated with cigarette smoke. …”
Get full text

AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex by Yui Kanaoka, Takaharu Mori, Wataru Nagaike, Seira Itaya, Yuto Nonaka, Hidetaka Kohga, Takamitsu Haruyama, Yasunori Sugano, Ryoji Miyazaki, Muneyoshi Ichikawa, Takayuki Uchihashi, Tomoya Tsukazaki

Get full text

Estrogen-mediated modulation of sterile inflammatory markers and baroreflex sensitivity in ovariectomized female Wistar rats by Md. Iqbal Alam, Naba Sami, Aftab Alam, Sheema Wazib, Neha Dhyani, Sher Afghan, Mairaj Ahmed Ansari

“…Conclusion: Estrogen mediates cardioprotection by improving baroreflex sensitivity in ovariectomized Wistar rats through modulation of the NO pathway.…”
Get full text

Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization by Xianghui Huang, Jia Xu, Ye Xu, Bingxin Huangfu, Feng Zhang, Yanzhou Hu, Ruxin Gao, Xinxin Ren, Boyang Zhang, Kunlun Huang, Xiaoyun He

“…We found that SFN attenuates the inflammatory injury in a macrophage cell line and the liver of NASH mice, owing to the promotion of M1-type macrophage polarization toward the M2-type and the regulation of inflammatory mediators. Further analysis demonstrated that this SFN-induced macrophage M2-type polarization occurs in a Krüppel-like factor 4 (KLF4)-dependent manner. …”
Get full text

Feasibility of a videoconferencing-based parent-mediated intervention: a mixed-method pilot study by Marie-Maude Geoffray, Marie-Maude Geoffray, Maeva Bourgeois-Mollier, Maud Maleysson-Baste, Natacha Gallifet, Sara Dochez, Sara Dochez, Gaelle Bonis, Agathe Jay, Lucie Jurek, Lucie Jurek

Subjects: Get full text

Insulin Resistance Mediates the Association Between Vitamin D and Non-Alcoholic Fatty Liver Disease by Caiyan Zou, Xuekui Liu, Maosheng He, Yan Sun, Yiquan Sang, Gangshan Peng, Yamei Ma, Houfa Geng, Jun Liang

Subjects: Get full text

The Role of Dectin-1-Mediated M1 Macrophage Polarization in Cerebral Ischemia-Reperfusion Injury by Chen Zongyun, Lin Bixia, Ding Fadian, Hong Xiaoping, Chen Hongbin, Deng Yu, Liu Qicai, Ye Xiaoyi, Zeng Kai

Get full text

Mesenchymal Stromal Cells Mediate Clinically Unpromising but Favourable Immune Responses in Kidney Transplant Patients by Urvashi Kaundal, Raja Ramachandran, Amit Arora, Deepesh B. Kenwar, Ratti Ram Sharma, Ritambhra Nada, Mukut Minz, Vivekanand Jha, Aruna Rakha

Get full text

Exploring the Mediating Role of Student Attitudes in the Relationship between Dysfunctional Teams and Student Team Performance by Amrita Dutt, Vijaishri Tewari, Shashikant Rai, Shardul Shankar

Subjects: Get full text

HPLC-MS/MS-Mediated Analysis of the Pharmacokinetics, Bioavailability, and Tissue Distribution of Schisandrol B in Rats by Dahu Liang, Zijing Wu, Yanhao Liu, Chao Li, Xianghong Li, Bin Yang, Haitang Xie, Hua Sun

Get full text

From Uncertainty to Anxiety: How Uncertainty Fuels Anxiety in a Process Mediated by Intolerance of Uncertainty by Yuanyuan Gu, Simeng Gu, Yi Lei, Hong Li

Get full text

Nomophobia and University Business Students’ Burnout in Online Learning: Mediating effect of Fear of Missing Out by Gangaram Biswakarma, Basu Dev Lamichhane, Deepika Neupane, Keshav Subedi

“…The study found a significant relationship between Nomophobia, FoMO, and SBO, where Nomophobia affects FoMO and SBO, while FoMO notably impacts SBO's academic efficacy. FoMO partially mediates the Nomophobia-SBO relationship. Gender doesn't moderate the relationship with SBO, indicating no distinction between male and female students. …”
Get full text

The mediating effect of teacher commitment in the relationship between burnout and role performance of early childhood teachers by Sungwon Kim, Jiyoung Lee

“…The purpose of this study is to examine the mediating effect of teacher commitment on the relationship between burnout and role performance of early childhood teachers. …”
Get full text

The impact of physical exercise on primary school teachers’ professional ethics: the mediating role of self-control by Chu Kequn, Yang Xiuqing, Zhang Tinghui

Subjects: Get full text

Presynaptic CRF1 Receptors Mediate the Ethanol Enhancement of GABAergic Transmission in the Mouse Central Amygdala by Zhiguo Nie, Eric P. Zorrilla, Samuel G. Madamba, Kenner C. Rice, Marissa Roberto, George Robert Siggins

“…These data indicate that presynaptic CRF1 receptors play a critical role in permitting or mediating ethanol enhancement of GABAergic synaptic transmission in CeA, via increased vesicular GABA release, and thus may be a rational target for the treatment of alcohol abuse and alcoholism.…”
Get full text

CRISPR/Cas9-mediated genomic insertion of functional genes into Lactiplantibacillus plantarum WCFS1 by Kamilla Wiull, Lisa K. Haugen, Vincent G. H. Eijsink, Geir Mathiesen

“…Our system successfully knock-in four expression cassettes varying in length from ~800–1,300 bp with high efficiency and insert an expression cassette encoding a SARS-CoV-2 antigen receptor-binding domain (RBD) with an anchor mediating surface display, which has not been achieved previously using CRISPR/Cas9. …”
Get full text

Fun at work and knowledge sharing: The mediating role of organizational inclusion and moderating role of authentic leadership by Ishfaq Ahmed

“…Building upon organizational support theory, this study proposes and empirically investigates this relationship through the mediation of organizational inclusion and moderation of authentic leadership. …”
Get full text

Neuropilin1-dependent paracrine signaling of cancer cells mediated by miRNA exosomal cargo by Claudia Palazzo, Roberta Mastrantonio, Noemi Gioelli, Erika Testa, Francesco Recco, Donatella Lucchetti, Giulia Villari, Alessio D’Alessio, Alessandro Sgambato, Flavio Mignone, Guido Serini, Maria Teresa Viscomi, Luca Tamagnone

“…Results In this study, we show that diverse human cancer cells release NRP1 embedded in exosome-like small extracellular vesicles, which mediate a previously unknown NRP1-dependent paracrine signaling mechanism regulating endothelial cell migration. …”
Get full text

The Helplessness Dimension of Pain Catastrophizing Mediates the Relation between PTSD Symptoms and Pain Rehabilitation Measures by Matthew Schumann, Julia Craner, Elizabeth Kacel, Eleshia Morrison, Keith Gascho, Judy Gebhard, Wesley Gilliam

“…The patients completed measures of pain severity, pain interference, pain catastrophizing, depressive symptoms, quality of life (QOL), and PTSD symptoms at pretreatment. Results. Parallel mediation analyses were conducted to evaluate the mediating effect of the Pain Catastrophizing Scale subscales on the relationship between PTSD symptomatology and pain-relevant variables. …”
Get full text