Supplementation of dairy cows with bovine somatotropin or omega-3 rich fish oil affects the endometrial expression of peroxisome proliferator-activated receptors by Leslie A. MacLaren, Todd R. Bilby, Frank Michel, Aydin Guzeloglu, Charles R. Staples, William W. Thatcher

“…Treatment with bST is associated with increased PPARδ mRNA abundance in pregnant but not cyclic cows, suggesting that the effect may be mediated by the embryo. Increased abundances of PPARα mRNA are observed in response to bST during pregnancy in lactating cows but not in non-lactating cows, highlighting the importance of lactation status in determining bST response. …”
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Knockdown of Adra2a Increases Secretion of Growth Factors and Wound Healing Ability in Diabetic Adipose-Derived Stem Cells by Xiangyuan Zhao, Yong Zhang, Xinzhen Zuo, Shubai Wang, Xiao Dong

“…Clonidine was used to active Adra2a, and lentivirus-mediated RNAi was used to knockdown Adra2a. The secretion and expression of growth factors were detected by enzyme-linked immunosorbent assay (ELISA) and real-time RT-qPCR, respectively. …”
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Activating Transcription Factor 5 Promotes Tumorigenic Capability in Cervical Cancer Through the Wnt/β-Catenin Signaling Pathway by Shi F, Wei Y, Huang Y, Yao D

“…Knockdown ATF5 expression in cervical cancer cell lines was constructed using lentivirus-mediated shRNA to explore the role of ATF5 in cervical cancer through cell viability, transwell, and wound healing experiments. …”
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Тransplastomic tobacco plants producing the hydrophilic domain of the sheep pox virus coat protein L1R by D. K. Beisenov, G. E. Stanbekova, B. K. Iskakov

“…Spectinomycin-resistant tobacco lines were obtained by biolistic gun-mediated genetic transformation. PCR analysis in the presence of gene-specific primers confirmed integration of the transgene into the plant genome. …”
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Центральные и гормональные механизмы адаптации к десинхронизационному стрессу by Парвин Асад кызы Зульфугарова, Ариф Алиовсад оглы Мехтиев

“…В первой серии исследований изучалось влияние десинхронизации на уровень белка 2, опосредующего активность коллапсина (collapsin-response mediator protein 2 (CRMP2)) в гипоталамусе и эпифизе, методом твердофазного непрямого иммуноферментного анализа (НИФА). …”
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Muon (g − 2) and thermal WIMP DM in U 1 L μ − L τ $$ \textrm{U}{(1)}_{L_{\mu }-{L}_{\tau }} $$ models by Seungwon Baek, Jongkuk Kim, P. Ko

“…This setup relies on DM particles annihilating into SM particles through a Z′-mediated s-channel. In this work, we show that this tight relationship between M Z ′ $$ {M}_{Z^{\prime }} $$ and M DM can be evaded or nullified both for scalar and spin-1/2 DM by considering the contributions from the dark Higgs boson (H 1). …”
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Multisectoral actions in primary health care: A realist synthesis of scoping review. by Resham B Khatri, Daniel Erku, Aklilu Endalamaw, Eskinder Wolka, Frehiwot Nigatu, Anteneh Zewdie, Yibeltal Assefa

“…However, there is limited understanding and interpretation of how MSAs on health articulate and mediate health outcomes. This realist review explored how MSAs influence on implementing PHC towards universal health coverage (UHC) in the context of multilevel health systems.…”
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Blood Management and Risk Assessment for Transfusion in Pediatric Spinal Deformity Surgery by Pedro Fernandes, Joaquim Soares do Brito, Isabel Flores, Jacinto Monteiro

“…A linear regression model to estimate hematic losses revealed that only body weight and transfusion showed predictive power, resulting in a low predictive model (R2 = 0.156; F(3,167) = 15.483, p<0.001). A mediated model to explain blood loss was built based on a set of variables influencing transfusion which is, in turn, related to blood loss. …”
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Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…A deficiency of available energy for brain cells under neurodegenerative diseases is either developed due to age-dependent underexpression of genes that encode glycolytic enzymes or induced due to the uncoupling of oxidation and phosphorylation that could be mediated by inflammatory cytokines. Since the activity of many enzymes is under the control of adenosine triphosphate (ATP) or cofactors, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), energy deficiency can cause metabolic changes in brain tissue. …”
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Work-related smartphone use during off-job hours and work-life conflict: A scoping review. by Holly Blake, Juliet Hassard, Jasmeet Singh, Kevin Teoh

“…This relationship was mediated by psychological detachment from work, and communication about family demands with one's supervisor. …”
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Listeria monocytogenes use multiple mechanisms to disseminate from the intestinal lamina propria to the mesenteric lymph nodes by Joshua S. Nowacki, Grant S. Jones, Sarah E. F. D'Orazio

“…We show here that CCR2−/− mice had a significant reduction in Ly6Chi monocytes in the MLN but no change in bacterial burden following foodborne infection; thus, dissemination of L. monocytogenes associated with monocytes is not required for colonization of the MLN. To block CCR7-mediated trafficking of dendritic cells from the lamina propria, we treated mice with anti-VEGFR3 antibody (clone AFL4) prior to and during infection but did not see a change in dendritic numbers in the MLN as had been previously reported with other anti-VEGFR3-specific antibodies. …”
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Target Proteins in Human Autoimmunity: Cytochromes P450 and Udp-Glycoronosyltransferases by Petra Obermayer-Straub, Christian Peer Strassburg, Michael Peter Manns

“…In a small minority of patients, certain drugs are known to induce immune-mediated, idiosyncratic drug reactions, also known as ’drug-induced hepatitis’. …”
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Characterization and ameliorative effects of Chenopodium murale hydroethanolic extract against diethylnitrosamine-induced hepato-renal damage and malfunction by Howida S. Abou- Seif, Osama M. Ahmed, Samah A. El-Newary, Marwa E. Shabana, Mahitab I. EL-Kassaby, Ghada M. Elqattan, Hussein G. Sawie

“…C. murale reflecting its ameliorative potential which diminished obviously the DEN-induced elevated hepato-renal levels of IL-1β and TNF-α (immuno- inflammatory indicators), also down regulated Bcl-2, NF-κB, and Nrf-2 (inflammatory mediators). Conclusion These findings proved that C. murale might protect and ameliorate DEN-induced hepato-renal damage through activation of antioxidant and anti-inflammatory systems.…”
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A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…GO enrichment and KEGG pathway analyses suggested that RNF187 may play a role in the pathogenesis of cancer through processes such as "bounding membrane of organelle," "macroautophagy," "proton-transporting V-type ATPase complex," "autophagy," "Ubiquitin mediated proteolysis," "Ferroptosis," "Phagosome," and etc. …”
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Effect of Rho-Kinase and Autophagy on Remote Ischemic Conditioning-Induced Cardioprotection in Rat Myocardial Ischemia/Reperfusion Injury Model by Jie Gao, Feng Min, Shasha Wang, Heng Lv, Huan Liang, Ben Cai, Xianjie Jia, Qin Gao, Ying Yu

“…This study investigated the mechanism of Rho-kinase-mediated autophagy in RIC. Methods. Sixty male Sprague–Dawley rats were randomly divided into six groups: sham, I/R, RIC, I/R+fasudil, RIC+wortmannin, and RIC+fasudil+wortmannin. …”
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miR-208a-3p discriminates osteoporosis, predicts fracture, and regulates osteoclast activation through targeting STC1 by Hongbing Qian, Fei Jia, Huiling Qin

“…Conclusion Serum miR-208a-3p served as a diagnostic biomarker for OP and a risk factor for fracture in post-menopausal women. miR-208a-3p regulated macrophage inflammation and further mediated osteoclast activation via targeting STC1.…”
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CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies by Lena Gockeln, Florian Wirsdörfer, Verena Jendrossek

“…Thus, while targeting CD73 may enhance the efficacy of radio-immunotherapies in cancer treatment by mitigating tumor immune escape and improving immune-mediated tumor killing, it also raises concerns about increased immune-related adverse events (irAEs) in the normal tissue. …”
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Foreign Policy Image of the Eurasian Economic Union in the Mass Media of the United Kingdom by Olga Yu. Vikhrova, Iaroslava S. Gorlova

“…In a mediatized world, the images of regional unions can sometimes become more important than their territorial and raw material resources. …”
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Physiological Alterations due to Hepatotoxicity and the Protective Role of Cleome viscosa Linn Seed Extract in Experimental Animals by Addai-Mensah Donkor, Martin Ntiamoah Donkor, Benjamin Ahenkorah, Kwadwo Asante Asare-Konadu, Emmanuel Asiedu, Richard Mosobil

“…For that reason, in the future, oral intake of C. viscosa seed extract as an adjunct natural therapy may be worthwhile to protect against liver failure-mediated inhibitory effects on reproductive function.…”
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Effect of Mitochondrial Tu Translation Elongation Factor on Water-holding Capacity of Qinchuan Cattle Meat during Postmortem Aging by SI Jianfang, ZHANG Jing, GAO Shuang, MA Jiarong, CAO Songmin, LI Yalei, LUO Ruiming

“…Through proteomics, 23 differential proteins related to TUFM were identified, and Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that the differential proteins could mediate cellular autophagy by participating in energy metabolism through a variety of pathways. …”
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