Clerodendrum volubile Ethanol Leaf Extract: A Potential Antidote to Doxorubicin-Induced Cardiotoxicity in Rats by Olufunke Esan Olorundare, Adejuwon Adewale Adeneye, Akinyele Olubiyi Akinsola, Daniel Ayodele Sanni, Mamoru Koketsu, Hasan Mukhtar

“…Also, CVE profoundly attenuated alterations in the cardiac tissue oxidative stress markers’ activities while improving DOX-associated cardiac histological lesions that were possibly mediated via free radical scavenging and/or antioxidant mechanisms. …”
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Human Platelets Take up Anti-VEGF Agents by B. Sobolewska, B. Fehrenbacher, P. Münzer, H. Kalbacher, S. Geue, Konstantinos Stellos, M. Schaller, F. Ziemssen

“…Nevertheless, whether the different localization and transport of bevacizumab are truly related to specific differences of receptor-mediated endocytosis has to be revealed by further research.…”
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Towards PErsonalised PRognosis for children with traumatic brain injury: the PEPR study protocol by Jaap Oosterlaan, Marsh Königs, Job B M van Woensel, Marc Engelen, Marjan E Steenweg, Petra J W Pouwels, Cece C Kooper, Hilgo Bruining, Arne Popma, Dennis R Buis, Maayke Hunfeld

“…However, outcome varies between patients and is mediated by complex interplay between demographic factors, premorbid functioning and (sub)acute clinical characteristics. …”
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Unveiling antidiabetic and antioxidant activities of biogenically synthesized red fluorescent graphene quantum dots using Bauhinia variegata L. leaves by Pooja Kadyan, Jaya Saini, Parul Singh, Ponnusamy Thillai Arasu, Sudhir Kumar Kataria

“…Present study presents the phyto-mediated synthesis of red fluorescent graphene quantum dots using the leaves of Bauhinia variegata as a sustainable precursor. …”
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Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cel... by Huayu Fan, Hui Zhao, Yan Hou, Danni Meng, Jizong Jiang, Eon-Bee Lee, Yinzheng Fu, Xiangdong Zhang, Rui Chen, Yongtao Wang

“…Abstract Background Interfacial heterogeneity is widely explored to reveal molecular mechanisms of force-mediated pathways due to biased tension. However, the influence of cell density,, curvature, and interfacial heterogeneity on underlying pathways of mechanotransduction is obscure. …”
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The interplay between sex, lifestyle factors and built environment on 20-year cardiovascular disease incidence; the ATTICA study (2002–2022) by Evangelia G. Sigala, Christina Chrysohoou, Fotios Barkas, Evangelos Liberopoulos, Petros P. Sfikakis, Antigoni Faka, Costas Tsioufis, Christos Pitsavos, Demosthenes Panagiotakos

“…Multivariate analyses, including generalized structural equation modeling (GSEM), revealed that the impact of the urban built environment on the long-term (20-year) CVD risk is mediated by lifestyle-related risk factors.ConclusionUrban inhabitants exhibit a higher long-term CVD incidence compared to their rural counterparts, which was partially explained by their lifestyle behaviors. …”
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Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: Potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety... by Mohamed Imath, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Ramalingam Karthik Raja, Gholamreza abdi

“…The aim of present study was examined antibacterial, antioxidant, antibiofilm and cytotoxicity of liver cancerous cells using Fioria vitifolia mediated chitosan nanoparticles (FV-CNPs). Thus, the biosynthesized of CNPs were characterized using UV, XRD, FTIR, FESEM, and EDX to describe their morphology. …”
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Ir-6: A Novel Iridium (III) Organometallic Derivative for Inhibition of Human Platelet Activation by Ren-Shi Shyu, Themmila Khamrang, Joen-Rong Sheu, Chih-Wei Hsia, Marappan Velusamy, Chih-Hsuan Hsia, Duen-Suey Chou, Chao-Chien Chang

“…Neither the adenylate cyclase inhibitor SQ22536 nor the guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one significantly reversed the Ir-6-mediated inhibition of collagen-induced platelet aggregation. …”
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Protocol for a scoping review of the use of information and communication technology platforms for the delivery and utilisation of transgender healthcare by Muhammad Naveed Noor, Isaac Yeboah Addo, Jialiang Cui, Sujith Kumar Prankumar, Horas TH Wong, Christopher Tumwine

“…In this paper, we discuss our protocol for a scoping review of the literature about the delivery and utilisation of digitally mediated health services for transgender populations.Methods and analysis This scoping review of the provision and experience of telemedicine among transgender people will follow the methodological framework developed by Arksey and O’Malley. …”
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Cross-species comparisons between pigs and mice reveal conserved sex-specific intraspinal inflammatory responses after spinal cord injury by Reena Kumari, Gabrielle V. Hammers, Robert H. Hammons, Andrew N. Stewart, Steven M. MacLean, Tracy Niedzielko, Lonnie E. Schneider, Candace L. Floyd, John C. Gensel

“…Intraspinal inflammation mediates SCI pathophysiology. The purpose of this study was to evaluate the effect of sex on inflammation and outcomes in a pig thoracic contusion/compression SCI model. …”
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Comparative lipidome and transcriptome provide novel insights into zero-valent iron nanoparticle-treated Fremyella diplosiphon by Yavuz S. Yalcin, Samson Gichuki, Huan Chen, Anithachristy Sigamani Arumanayagam, Shyama Malika Malwalage, Viji Sitther

“…Abstract Understanding the intricate interplay between nanoparticle-mediated cyanobacterial interactions is pivotal in elucidating their impact on the transcriptome and lipidome. …”
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Biomarkers of racism-based stress injury: A feasibility and correlation study by Rachel Wangari Kimani, Jonathan N. Tobin, Steven W. Cole, Ann Campbell, Erich D. Jarvis

“… Abstract Background: Persistent discrimination and identity threats contribute to adverse health outcomes in minoritized groups, mediated by both structural racism and physiological stress responses. …”
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Early health technology assessment of tongue swab for non-sputum based pulmonary tuberculosis diagnosis in ThailandResearch in context by Langming Mou, Teerawat Wiwatpanit, Apiwat Piriyapol, Puwadol Chawengkul, Janjira Thaipadungpanit, Puttarin Kulchaitanaroaj, Yot Teerawattananon, Yi Wang

“…An early health economic model evaluated the cost-effectiveness of two innovative strategies: tongue swab with Loop-Mediated Isothermal Amplification (LAMP) and tongue swab with real-time polymerase chain reaction (RTPCR). …”
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An Intranasal Vaccination with a Recombinant Outer Membrane Protein H against Haemorrhagic Septicemia in Swamp Buffaloes by Anucha Muenthaisong, Boondarika Nambooppha, Amarin Rittipornlertrak, Pallop Tankaew, Thanya Varinrak, Korkiat Muangthai, Kheemchompu Atthikanyaphak, Takuo Sawada, Nattawooti Sthitmatee

“…In conclusion, the rOmpH-based intranasal vaccine could elicit protective ability and induce antibody- and cell-mediated immune response against virulent P. multocida strain among swamp buffaloes.…”
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Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma by Junchen Liu, Junchen Liu, Kun Dai, Kun Dai, Muhammad Auwal Saliu, Muhammad Auwal Saliu, Mansur Dabai Salisu, Mansur Dabai Salisu, Jiangyu Gan, Lukman Olalekan Afolabi, Dehong Yan, Guizhong Zhang, Maoxuan Liu, Maoxuan Liu, Xiaochun Wan, Xiaochun Wan

“…VPA treatment enhanced the susceptibility of glioblastoma cells to NKG2D CAR-T mediated cytotoxicity in both 2D monolayer and 3D tumor spheroid models in vitro. …”
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RAB3GAP2 dysregulation in adult T-cell leukemia/lymphoma (ATLL) compared to acute lymphoblastic leukemia (ALL): a molecular perspective by Samira Pourrezaei, Arash Letafati, Ghazale Molaverdi, Mehdi Norouzi, Sayed-Hamidreza Mozhgani

“…These proteins play a pivotal role in both translation and immune activation, suggesting a potential correlation between the observed disparities and the virus-mediated progression of cancer. However, it is worth noting that the expression differences in FANCM, EIF4H, SMC6, and WDR7 between ATLL and ALL were minimal. …”
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Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro by Omar S. Qureshi, Emma J. Sutton, Rosemary F. Bithell, Shauna M. West, Rona M. Cutler, Gillian McCluskey, Graham Craggs, Asher Maroof, Nicholas M. Barnes, David P. Humphreys, Stephen Rapecki, Bryan J. Smith, Anthony Shock

“…Rozanolixizumab was also able to mediate antibody bipolar bridging (ABB), a phenomenon that led to a reduction of labeled FcγRI from the surface of human macrophages in an FcRn-dependent manner. …”
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Reconstruction and computational analysis of the microRNA regulation gene network in wheat drought response mechanisms by M. A. Kleshchev, A. V. Maltseva, E. A. Antropova, P. S. Demenkov, T. V. Ivanisenko, Y. L. Orlov, H. Chao, M. Chen, N. A. Kolchanov, V. A. Ivanisenko

“…Wheat adaptation to water deficit is ensured by complex molecular genetic mechanisms, including the coordinated work of multiple genes regulated by transcription factors and signaling non-coding RNAs, particularly microRNAs (miRNAs). miRNA-mediated regulation of gene expression is considered one of the main mechanisms of plant resistance to abiotic stresses. …”
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Unveiling the link between NADPH oxidase 2 activation and mitochondrial superoxide formation in leukemic cell killing induced by arsenic trioxide by Andrea Spina, Andrea Guidarelli, Gloria Buffi, Mara Fiorani, Orazio Cantoni

“….-) formation induced by clinically relevant concentrations of arsenic trioxide (ATO; As2O3) in acute promyelocytic leukemia (APL) cells.Carefully controlled inhibitor studies and small interfering RNA mediated downregulation of p47phox (a component of the NOX 2 complex) expression demonstrated that, in an APL cell line, ATO promotes upstream NOX 2 activation critically connected with the formation of mitoO2.- and with the ensuing mitochondrial permeability transition (MPT)-dependent apoptosis.Instead, acute myeloid leukemia (AML) cell lines respond to ATO with low NOX 2 activation, resulting in a state that is non-permissive for mitoO2.- formation. …”
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CSF3 promotes colorectal cancer progression by activating p65/NF-κB signaling pathway and inducing an immunosuppressive microenvironment by Junfeng Xu, Na Li, Hui Xie, Changwei Duan, Xingchen Liao, Ruoran Li, Heng Zhang, Yuanming Pan, Xianzong Ma, Shuwen Du, Jianqiu Sheng, Xin Wang, Lang Yang, Peng Jin

“…Mechanistically, CSF3 was found to mediate CRC development by activating the NF-κB signaling pathway, as evidenced by the decreased phosphorylation of p65 and reduced IκBα ubiquitination in CSF3-silenced cells. …”
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