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10081
RETRACTED: The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model
Published 2022-04-01“…Our results also indicate that bradykinin, an inflammatory mediator, and TRPV1, an ion channel linked to nociceptive signaling, are host factors involved in the coughing mechanism.…”
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10082
Systemic immune response at gastroesophageal reflux disease
Published 2015-10-01“…At erosive and/or ulcerative esophagitis in comparison to NERD and Barret's esophagus production of proinflammatory cytokines IL-8, the IFN-γ and TNF-α prevails, that indicates development of Th1-mediated immune response. At Barret's esophagus expression of anti-inflammatory cytokines IL-4 and IL-10 is increased, that indicates on development of Th2-immune response.…”
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10083
Chromosome‐scale genome assembly of Poa trivialis and population genomics reveal widespread gene flow in a cool‐season grass seed production system
Published 2024-03-01“…The genetic resources and insights into P. trivialis provided by this study will improve weed management strategies and enable the development of molecular detection tests for contaminated seed lots to limit seed‐mediated gene flow. These resources should also be beneficial for turfgrass breeders seeking to improve desirable traits of commercial P. trivialis varieties and help to guide breeding efforts in other crops to enhance the resiliency of agricultural ecosystems under climate change. …”
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10084
Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior
Published 2018-01-01“…Three moleculargenetic chains describing connections between polymorphic and neuronal apoptosis genes mediated by differentially expressed genes were reconstructed. …”
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10085
Deciphering the generation of heterogeneity in esophageal squamous cell carcinoma metastasis via single-cell multiomics analysis
Published 2025-02-01“…Abstract Background Chromatin accessibility plays a crucial role in mediating transcriptional dysregulation and heterogeneity in Esophageal Squamous Cell Carcinoma (ESCC). …”
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10086
The temporal relationship between mitochondrial quality and renal tissue recovery following ischemia-reperfusion injury
Published 2025-01-01“…Renal injury, physiological function, mitochondrial assessment, and cellular mediators were analyzed. Results: Prolonging ischemia duration reduces bioenergetic function while disrupting the balance of mitochondrial fusion, fission, and mitophagy at the gene expression level while maintaining intact mitochondrial copy number. …”
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10087
Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells
Published 2020-06-01“…In addition, the combined effects of PPIs with anticancer drugs, as well as the mechanism of PPI-mediated anti-proliferative activity were evaluated. …”
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10088
Functional and Structural Investigation of Myenteric Neurons in the Human Colon
Published 2025-01-01“…Background and Aims: The enteric nervous system independently controls gastrointestinal function including motility, which is primarily mediated by the myenteric plexus, therefore also playing a crucial role in functional intestinal disorders. …”
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10089
Metamorphosis of the Identity of the Human Сompleted: from Digital Donor to Digital Centaur
Published 2025-01-01“…Smartphones, computers, the Internet of Things, and AI assistants, which form an integral technosystem that mediates the everyday life of man, are complex cultural tools that become his complements and extensions – part of the personality. …”
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10090
Development of the algal pigment-based salinity transfer function for lakes on the Tibetan Plateau and evaluation of the quantitative reconstruction
Published 2025-01-01“…Comparison with other paleoclimatic and meteorological records revealed that the lake salinity was mainly influenced by climate-mediated changes in regional precipitation and effective moisture. …”
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10091
Association between cytokines and progression-free survival in ovarian cancer following CRS/HIPEC treatment
Published 2025-01-01“…This study investigated the relationship between serum cytokines, particularly monocyte chemoattractant protein-1 (MCP-1), a key inflammatory mediator, and recurrence risk in EOC patients undergoing CRS/HIPEC. …”
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10092
Association of Major Histocompatibility Complex Polymorphism With Acute Phase Response in Broiler Chicken
Published 2024-11-01“…The antibody response to the Newcastle disease vaccine (NDV) was also measured to assess humoral mediated immunity. Lastly, the correlation between immune responses and MHC alleles was investigated to identify the most effective alleles in a stress‐related situation. …”
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10093
Manifestation of agronomically valuable traits in the progeny of a sorghum mutant carrying the genetic construct for RNA silencing of the γ-kafirin gene
Published 2024-03-01“…Using Agrobacterium-mediated genetic transformation of immature embryos of the grain sorghum cv. …”
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10094
PPAR-α Agonist Fenofibrate Decreased Serum Irisin Levels in Type 2 Diabetes Patients with Hypertriglyceridemia
Published 2015-01-01“…The physiologic effects of irisin are partially mediated through peroxisome proliferator-activated receptor-α (PPAR-α). …”
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10095
Polymorphism in the TRP8 gene in Kyrgyz population: putative association with highland adaptation
Published 2015-12-01“…The human TRPM8 gene encodes a receptor mediating cold sensitivity, and this fact points to its putative role in cold adaptation. …”
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10096
Adapting to change: exploring the distribution dynamics of the alien and potentially invasive aphid species Cinara curvipes (Hemiptera: Aphididae) in the context of global warming
Published 2025-12-01“…Unique survival mechanisms, including the production of numerous winged morphs under overcrowded conditions, enable rapid dispersal facilitated by human-mediated transport, notably through the “Christmas trees” trade. …”
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10097
Characterization of the Phosphotransferase from <i>Bacillus subtilis</i> 1101 That Is Responsible for the Biotransformation of Zearalenone
Published 2025-01-01“…Furthermore, adding 1 mmol/L Fe<sup>2+</sup> or Fe<sup>3+</sup> to the reaction system increased the efficiency of ZPH1101 in converting ZEA by 100% relative to the system containing solely 1 mmol/L ATP and 1 mmol/L Mg<sup>2+</sup>, suggesting that low concentrations of Fe<sup>2+</sup> or Fe<sup>3+</sup> can improve the ZPH1101-mediated transformation of ZEA. This study contributes to the enzymatic removal of ZEA and broadens the spectrum of strain and enzyme options available to researchers for ZEA detoxification efforts.…”
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10098
Studying the Humoral Response against SARS-CoV-2 in Cuban COVID-19 Recovered Patients
Published 2024-01-01“…Additionally, a simple and rapid ELISA based on antibody-mediated blockage of the binding RBD-ACE2 was implemented for detecting, as a surrogate of conventional test, the levels of anti-RBD inhibitory antibodies in convalescent sera. …”
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10099
Knockdown of zebrafish tmem242 enhances the production of ROS that signals to increase f9a expression resulting in DIC-like condition
Published 2025-01-01“…Inhibition of ATP synthase with oligomycin elevated ROS and f9a transcripts, while ROS inhibition reduced f9a expression, suggesting ROS-mediated regulation. Further analysis revealed increased sirt6 and nrf2 transcripts after tmem242 knockdown, with their knockdown reducing f9a levels. …”
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10100
Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads
Published 2025-01-01“…Ultrasound and microbubble mediated blood brain barrier opening is a non-invasive and effective technique for drug delivery to targeted brain region. …”
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