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9881
Search for electroweak production of a vector-like T quark using fully hadronic final states
Published 2020-01-01“…Upper limits at 95% confidence level are set on the cross sections for T quark-mediated production of tHQq, tZQq, and their sum, where Q is the associated top or bottom heavy quark and q is another associated quark. …”
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9882
MELK prevents radiofrequency ablation-induced immunogenic cell death and antitumor immune response by stabilizing FABP5 in hepatocellular malignancies
Published 2025-01-01“…Mechanically, MELK binds to fatty acid-binding protein 5 (FABP5), and affects its ubiquitination through the K48R pathway to increase its stability, thereby activating protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling axis to weaken the RFA-mediated antitumor effect. In addition, the synthesis of arginylglycylaspartic acid (RGD)-lipid nanoparticles (LNPs) targeting tumor cell-intrinsic MELK enhanced RFA efficacy in HCC. …”
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9883
Radiofrequency ablation combined with immunotherapy to treat hepatocellular carcinoma: a comprehensive review
Published 2025-01-01“…On the one hand, RFA can induce the immunogenic substances including Ficolin-3, IL-1 and heat shock protein and regulate the immune cells by mediating the Th1/Th2 ratio, increasing Th17 cells, etc. …”
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9884
Click chemistry-enabled gold nanorods for sensitive detection and viability evaluation of copper(II)-reducing bacteria
Published 2025-02-01“…Our method, termed AuNRs–bacteria-initiated click chemistry (AuNRs–BICC), detects CuII-reducing bacteria by quantifying AuNRs bound to a biosensing interface via bacteria-mediated CuII reduction to CuI and subsequent click chemistry with biosensing interface of azide modifications. …”
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9885
Inhibitory effects of estetrol on the invasion and migration of immortalized human endometrial stromal cells
Published 2024-02-01“…WASF-1 was found to be a potential mediator based on metastasis PCR array. WASF-1 was upregulated by E2 and downregulated by E4. …”
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9886
Antitumor effects of natural killer cells derived from gene-engineered human-induced pluripotent stem cells on hepatocellular carcinoma
Published 2025-02-01“…The TRAIL and perforin/granzyme B pathways are largely involved in this cytotoxic mechanism, as indicated by the reduction in cytotoxicity induced by TRAIL inhibitory antibodies and concanamycin A, which inhibits perforin/granzyme B-mediated cytotoxicity. Our data suggest that eNK cells, whose functions have been enhanced by genetic engineering, have the potential to improve HCC treatment.…”
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9887
Transformation of NO in Combustion Gases by DC Corona
Published 2025-01-01“…The reactions involving O and OH radicals were more important in positive corona, whereas ozone-mediated oxidation dominated in negative corona. The research results demonstrate that ESP technology with DC corona offers a promising, energy-efficient solution for NO<sub>x</sub> control in small-scale combustion systems.…”
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9888
Mechanisms of Herbal Nephroprotection in diabetes mellitus
Published 2020-01-01“…The pathogenesis of DN is viewed as a continuum going from the original offense, high glucose, through the noxious products it generates (advanced glycation end-products, products of oxidative and nitrosative stress) and the signaling chains consequently brought into action, to the harmful mediators of inflammation, sclerosis, and proliferation that eventually lead to DN, despite the countervailing attempts of the protective mechanisms. …”
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9889
CAFs-released exosomal CREB1 promotes cell progression and immune evasion in thyroid cancer via the positive regulation of CCL20
Published 2025-12-01“…Exosomal CREB1 knockdown receded cell progression and enhanced CD8+ T function by mediating CCL20. CAFs-associated exosomal CREB1 downregulation inhibited tumorigenesis through affecting CCL20.Conclusion CAFs-derived exosomes accelerated the malignant behaviors and immune evasion in TC by carrying CREB1 to up-regulate CCL20.…”
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9890
Polysaccharide Fraction Isolated from <i>Saccharina japonica</i> Exhibits Anti-Cancer Effects Through Immunostimulating Activities
Published 2025-01-01“…</i>) injection of SJP boosted the cytolytic activity mediated by NK cells and CTLs against tumor cells. …”
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9891
Control of BKPyV-DNAemia by a Tailored Viro-Immunologic Approach Does Not Lead to BKPyV-Nephropathy Progression and Development of Donor-Specific Antibodies in Pediatric Kidney Tra...
Published 2024-12-01“…In our cohort, no significant correlation was observed between BKPyV-DNAemia and the development of DSA and antibody-mediated rejection. However, patients who experienced and cleared BKPyV-DNAemia had a worse allograft survival at a median follow-up of 18.9 years (<i>p</i> = 0.048). …”
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9892
VCP downstream metabolite glycerol-3-phosphate (G3P) inhibits CD8+T cells function in the HCC microenvironment
Published 2025-01-01“…These findings highlight a previously unrecognized mechanism involving VCP and G3P in suppressing T-cell-mediated immunity in the TME, positioning VCP as a promising upstream target for enhancing immunotherapy in HCC.…”
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9893
Repeated ionizing radiation exposure induces TRIP13 expression, conferring radioresistance in lung cancer cells
Published 2025-01-01“…This study elucidates a novel mechanism of treatment resistance in NSCLC cells, in which TRIP13 promotes HR mediated DNA repair and resistance to ionizing radiation.…”
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9894
Autophagy activation alleviates annulus fibrosus degeneration via the miR-2355-5p/mTOR pathway
Published 2025-01-01“…Conclusions Autophagy, mediated by the miR-2355-5p/mTOR pathway, plays a protective role in AFCs degeneration. …”
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9895
Novel architecture of ternary ZnO/PMA/AgI heterojunctions towards boosted visible-light photocatalytic destruction of antibiotics
Published 2025-01-01“…This achievement was attributed to the high redox properties of PMA as an effective electron transfer mediator between AgI and ZnO semiconductors. Moreover, the developed heterojunction facilitates the migration and separation of photoproduced charge carriers. …”
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9896
EMC2 suppresses ferroptosis via regulating TFRC in nasopharyngeal carcinoma
Published 2025-02-01“…EMC2 regulated ferroptosis by mediating the level of TFRC. Conclusions: EMC2 suppresses ferroptosis and promotes tumor progression, and the EMC2-TFRC axis is a novel ferroptosis regulatory pathway. …”
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9897
Seaweed (Porphyra) cultivation enhances production of autochthonous refractory dissolved organic matter in coastal ecosystems
Published 2025-02-01“…Redundancy analysis revealed that more microbial modules mediated organic matter transformations during the cultivation period, leading to a 169% higher estuarine addition of microbially-sourced humic-like C3 compared to the non-cultivation period. …”
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9898
Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens
Published 2025-01-01“…The two prime-boosted and the single-dose intranasal BCG groups displayed greater cell-mediated immune responses to PPDs than the two single-dose intranasal HIMB vaccines. …”
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9899
Porcine granulosa cell transcriptomic analyses reveal the differential regulation of lncRNAs and mRNAs in response to all-trans retinoic acid
Published 2025-02-01“…Conclusion These findings expand the lncRNA catalogue and provide a basis for further studies on the mechanism of ATRA-mediated lncRNA regulation of follicular development in pigs.…”
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9900
The Synergistic Effect of TRPV1 on Oxidative Stress-Induced Autophagy and Apoptosis in Microglia
Published 2021-01-01“…However, the experimental results do not fully demonstrate that the TRPV1-mediated antioxidative and antiapoptosis effect is through the affecting autophagy entirely.…”
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