Maternal obesity increases hypothalamic miR-505-5p expression in mouse offspring leading to altered fatty acid sensing and increased intake of high-fat food. by Laura Dearden, Isadora C Furigo, Lucas C Pantaleão, L W P Wong, Denise S Fernandez-Twinn, Juliana de Almeida-Faria, Katherine A Kentistou, Maria V Carreira, Guillaume Bidault, Antonio Vidal-Puig, Ken K Ong, John R B Perry, Jose Donato, Susan E Ozanne

“…Animal models show that programmed offspring obesity is preceded by hyperphagia, but the mechanisms that mediate these changes are unknown. Using a mouse model of maternal obesity, we observed increased intake of a high-fat diet (HFD) in offspring of obese mothers that precedes the development of obesity. …”
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A peripheral subepithelial network for chemotactile processing in the predatory sea slug Pleurobranchaea californica. by Tigran Norekian, Yichen Liu, Ekaterina D Gribkova, Jilai Cui, Rhanor Gillette

“…Ciliary clusters likely drive the sensory nerve spikes via SeN, mediating appetitive and stimulus place codes to CNS. …”
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Chi-miR-4110 promotes granulosa cell apoptosis by targeting Sma- and Mad-related protein 2 (Smad2) in the caprine ovary. by Xiaopeng An, Yuxuan Song, Jinxing Hou, Yue Zhang, Kaiwen Chen, Haidong Ma, Xinyan Zhao, Guang Li, Kexin Gao, Shan Wang, Binyun Cao, Yueyu Bai

“…Our findings may provide relevant data for the investigation of miRNA-mediated regulation of ovarian functions.…”
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White adipose tissues and skeletal muscles as a target of chrysin during the treatment of obesity in rats by Omar S. Hassan, Magda A. Megahed, Nesma A. Ghazal

“…Also, the effects of chrysin may be mediated through acting as an anti-inflammatory and antioxidative stress agent. …”
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Antibacterial action of penicillin against Mycobacterium avium complex by D. Deshpande, G. Magombedze, S. Srivastava, T. Gumbo

“…However, ODE model parameter estimates vs. exposure were a better fit. The exposure mediating E max was 84.6% (95% CI 76.91–82.98) of time concentration exceeded the minimum inhibitory concentration (MIC). …”
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Endotoxin Triggers Tumor Initiation Events in Nontumorigenic Breast Epithelial Cells and Enhances Invasion-Related Phenotype in Pretumorigenic and Tumorigenic Breast Epithelial Cel... by Farah Yassine, Sabreen F. Fostok, Nataly Naser Al Deen, Rabih S. Talhouk

“…Results showed that short-term ET exposure upregulated matrix metalloproteinase-9 (MMP-9) activity in nontumorigenic mammary epithelial cells of mouse (SCp2) and human origins (HMT-3522 S1; S1) and upregulated inflammatory mediators including nitric oxide (NO) and interleukin 1-β in tumorigenic human breast cells (MDA-MB-231), all in a dose-dependent manner. …”
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Pseudomonas evades immune recognition of flagellin in both mammals and plants. by Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp

“…Interestingly, AprA also prevents flagellin-mediated immune responses (such as growth inhibition and callose deposition) in Arabidopsis thaliana plants. …”
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Evaluation of Retinal Layers and Choroidal Structures Using Optical Coherence Tomography in Alopecia Areata by Burak OREN, Gozde AKSOY AYDEMIR, Serkan DUZAYAK, Hasan KIZILTOPRAK

“…Conclusions: Along with T-lymphocyte-mediated hair follicle damage, choroidal melanocyte damage and inflammation can also be observed in AA patients. …”
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A versatile site-directed gene trap strategy to manipulate gene activity and control gene expression in Caenorhabditis elegans. by Haania Khan, Xinyu Huang, Vishnu Raj, Han Wang

“…We show that, by recombinase-mediated cassette exchange (RMCE) via microinjection or genetic crossing, the cGAL gene trap lines can be further engineered in vivo to easily swap cGAL with other bipartite expression systems' drivers, including QF/QF2, Tet-On/Tet-Off, and LexA, to generate new gene trap lines with different drivers at the same genomic locus. …”
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Salivary stimulatory and anti-inflammatory effects of aqueous Lilium brownii var. viridulum Baker extract for Sjögren’s syndrome: in vitro and in vivo studies by Na-Yeon Ha, Haein Jeong, Mun Seog Chang, Jinsung Kim

“…AQP-5 and M3 muscarinic acetylcholine receptor (M3R) expression and inflammatory mediator levels were determined using western blotting and enzyme-linked immunosorbent assay. …”
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Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. by Elliott D SoRelle, Lauren E Haynes, Katherine A Willard, Beth Chang, James Ch'ng, Heather Christofk, Micah A Luftig

“…Distinct subpopulations of lytic cells further displayed variable profiles for transcripts known to escape virus-mediated host shutoff. These data reveal previously unknown and promiscuous outcomes of lytic reactivation with broad implications for viral replication and EBV-associated oncogenesis.…”
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Indigenous Environmental Activism and Media Depiction by Raphaela G O Pavlakos

“…I argue that anything human-mediated holds bias, including photographs. Because of this, I propose reading the performance of Indigenous-led environmental activism through media representation, specifically photographs used in media coverage of Indigenous environmental activism. …”
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Defensive healthcare practice: systematic review of qualitative evidence by James Thomas, Melissa Harden, Theo Lorenc, Claire Khouja, Helen Fulbright

“…The qualitative evidence calls into question the view of defensive practice as a key mediator linking litigation risk to inappropriate treatment and excess costs.…”
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Effects of Salmonella Typhimurium infection on intestinal flora and intestinal tissue arachidonic acid metabolism in Wenchang chickens by Shenghong Chen, Yaochen Xie, Dingqian Guo, Tiansen Li, Zhen Tan, Xuhua Ran, Xiaobo Wen

“…Typhimurium activates the ARA cyclooxygenase metabolic pathway, which in turn mediates the development of intestinal inflammation in Wenchang chickens. …”
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Administration of Melatonin in Diabetic Retinopathy Is Effective and Improves the Efficacy of Mesenchymal Stem Cell Treatment by Samraa H. Abdel-Kawi, Khalid S. Hashem

“…Our results showed that administration of melatonin and/or stem cell restored the retinal oxidative/antioxidant redox and reduced retinal inflammatory mediators. Coadministration of melatonin and stem cells enhanced the number of transplanted stem cells in the retinal tissue and significantly reduced retinal BDEF, VEGF, APOA1, and RBP4 levels as compared to melatonin and/or stem alone. …”
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Present(ed) bodies, absent agency: “patients’ perspectives” at the Museum Vrolik of the body and medicine by Azia Lafleur

“…Their presence/absence is investigated by using embodied inquiry to attend to the affective encounter between the audience and the bodily remains on display, as felt through the embodied experiencing of visiting the exhibit and mediated by the cultural, physical and institutional context and curation of the Vrolik itself. …”
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Mechanisms for dysregulation of excitatory-inhibitory balance underlying allodynia in dorsal horn neural subcircuits. by Alexander G Ginsberg, Scott F Lempka, Bo Duan, Victoria Booth, Jennifer Crodelle

“…These circuits are hypothesized to be part of the neural pathways that mediate two different types of allodynia: static and dynamic. …”
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Theoretical Accounts of Gulf War Syndrome: From Environmental Toxins to Psychoneuroimmunology and Neurodegeneration by Eamonn Ferguson, Helen J. Cassaday

“…Such associative mechanisms could be mediated through the hypothalamus and limbic system via vagal nerve innervation and would provide an explanation for the persistence of a set of symptoms (e.g., fever) that should normally be short lived and self-limiting. …”
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The First Record of an Aggressive Form of Ocular Tumour Enhanced by Marek’s Disease Virus Infection in Layer Flock in Al-Najaf, Iraq by Aoula Al-Zebeeby, Ali Hadi Abbas, Haider Abas Alsaegh, Furkan Sabbar Alaraji

“…To our knowledge, this is the first record of an aggressive MD virus infection-mediated ocular tumour in a layer flock in Al-Najaf province, Iraq.…”
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Increasing Cattle Herd Size or Density in C₃ Grass–Legume Meadows Reduces Dietary Quality by John Derek Scasta, Fernando Forster Furquim

“…Structural equation modeling (SEM) that mediated time (i.e., Day of Year) rendered all animal number or density variables as significant predictors for CP and DOM (negative estimates) and for DOM:CP (positive estimate), indicating that congregating animals in larger groups and/or greater densities, even in meadows with high-quality forage species, may reduce post-ingestive diet quality estimates by −1.2% and −2.0 for CP and DOM for every +100 animals or for every +10 animals per hectare. …”
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