Chidamide Suppresses the Growth of Cholangiocarcinoma by Inhibiting HDAC3 and Promoting FOXO1 Acetylation by Yongpan Li, Jujia Zheng, Qiang Huo, Zhongchao Chen, Jun Chen, Xiangwei Xu

“…Overall, this study reveals that CDM can exhibit antitumor effects against CCA by promoting HDAC3-mediated FOXO1 acetylation, thus identifying a new therapeutic avenue for the treatment of CCA.…”
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Peripheral Contributions to Visceral Hyperalgesia by GF Gebhart

“…Primary hyperalgesia (arising from the site of injury) is generally considered to be due to sensitization of sensory receptors (eg, nociceptors) and perhaps activation of so-called ‘silent nociceptors’ by mediators released, synthesized or attracted to the site of tissue injury. …”
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Yeast silent mating type loci form heterochromatic clusters through silencer protein-dependent long-range interactions. by Adriana Miele, Kerstin Bystricky, Job Dekker

“…We have employed live cell 3-D imaging and chromosome conformation capture (3C) to determine the contribution of nuclear positioning and heterochromatic factors in mediating associations of the silent mating type loci. …”
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The Power of Mimesis and the Mimesis of Power in the Production of Subjectivity by A. S. Kondakova

“…Thus, in Foucauldian thought, violence internalized and instrumentalized by power through its localization in institutions is external to the individual — who appears to be a passive recipient of subjectifying practices; this also reflects the “political capture of the body” by biopower as the infection of the individual by power and self-control, and, consequently, becoming a mediator of power oneself. In contrast, the Girardian perspective—in which mimesis is the primary condition for the formation and operation of society—asserts the supremacy of violence around which institutions form, due to which violence is only partially removed from the individual. …”
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The Interplay of Aging and PANoptosis in Osteoarthritis Pathogenesis: Implications for Novel Therapeutic Strategies by Liu S, Zhang G, Li N, Wang Z, Lu L

“…In OA, dysregulated apoptosis, necroptosis, and pyroptosis, particularly in chondrocytes, exacerbate cartilage damage. Apoptosis, mediated by the JNK pathway, reduces chondrocyte density, while necroptosis and pyroptosis, involving RIPK-1/RIPK-3 and the NLRP3 inflammasome, respectively, amplify inflammation and cartilage destruction. …”
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Whole-Body Physiologically Based Pharmacokinetic Modeling of GalNAc-Conjugated siRNAs by Emilie Langeskov Salim, Kim Kristensen, Erik Sjögren

“…<b>Methods</b>: Model development was performed using published studies in mice leveraging the PK-Sim^® standard implementation for large molecules with added implementations of ASGPR-mediated liver disposition and downstream target effects. …”
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The Pragmatics of Stereotypes in Trevor Noah’s Stand-up Comedy Routines by Idania Rosa Castro Bravo

“…To carry out this study, we used and analyzed a real corpus based on 11 television-mediated stand-up comedy shows. These routines were performed by Noah between 2009 and 2022. …”
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North American avian species that migrate in flocks show greater long-term non-breeding range shift rates by Stephen H. Vickers, Timothy D. Meehan, Nicole L. Michel, Aldina M. A. Franco, James J. Gilroy

“…Therefore, in some cases range-shifts may be limited by the capacity for novel migratory programmes to be transferred between generations, which can be genetically and socially mediated. Methods Here we used 50 years of North American Breeding Bird Survey and Audubon Christmas Bird Count data to test the prediction that breeding and/or non-breeding range-shifts are more prevalent among flocking migrants, which possess a capacity for rapid social transmission of novel migration routes. …”
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A phase 1 clinical trial of SP16, a first-in-class anti-inflammatory LRP1 agonist, in healthy volunteers. by George F Wohlford, Leo F Buckley, Dinesh Kadariya, Taeshik Park, Juan Guido Chiabrando, Salvatore Carbone, Virginia Mihalick, Matthew S Halquist, Adam Pearcy, Dana Austin, Cohava Gelber, Antonio Abbate, Benjamin Van Tassell

“…<h4>Background</h4>Endogenous serine protease inhibitors are associated with anti-inflammatory and pro-survival signaling mediated via Low-density lipoprotein receptor-related protein 1 (LRP1) signaling. …”
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Integral Roles of Specific Proteoglycans in Hair Growth and Hair Loss: Mechanisms behind the Bioactivity of Proteoglycan Replacement Therapy with Nourkrin® with Marilex® in Pattern... by Jan Wadstein, Erling Thom, Aida Gadzhigoroeva

“…This emerging insight has led to the recognition of “dysregulated proteoglycan metabolism” as a plausible causal or mediating pathology in hair growth disorders in both men and women. …”
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Epidemiological profile of animal bite victims attending anti-rabies clinic in a tertiary care hospital in eastern Rajasthan: An observational study by Ankit Raj, Shalini Singh, Dharmesh Sharma, Rajeev Yadav

“…The National Action Plan for Dog-Mediated Rabies Elimination emphasizes the importance of formulating state and district-level action plans tailored to local circumstances and evidence. …”
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The parent-doctor-child triangle: a structural equation modeling-based study in pediatric outpatient clinics in Indonesia by Areta Idarto, Ferdi Antonio

“…Overall parental satisfaction significantly influenced behavioral intention and mediated its relationship with Child ZAP. The mother’s and the child’s age served as moderating factors. …”
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Identifying Ocean Submesoscale Activity From Vertical Density Profiles Using Machine Learning by Leyu Yao, John R. Taylor, Dani C. Jones, Scott D. Bachman

“…Abstract Submesoscale eddies are important features in the upper ocean where they mediate air‐sea exchanges, convey heat and tracer fluxes into ocean interior, and enhance biological production. …”
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Mobility, ICT, and health: a built environment investigation of older Chinese migrants’ social isolation and loneliness by Amber DeJohn, Bochu Liu, Xinlin Ma, Michael J. Widener, Zhilin Liu

“…Older adults reported adopting information and communication technology (ICT) during pandemic lockdowns. ICT-mediated socializing may have different impacts on loneliness than in-person equivalents. …”
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Detection of OqxAB Efflux Pumps, a Multidrug-Resistant Agent in Bacterial Infection in Patients Referring to Teaching Hospitals in Ahvaz, Southwest of Iran by Mojtaba Moosavian, Mahtab Khoshkholgh Sima, Nazanin Ahmad Khosravi, Effat Abbasi Montazeri

“…Bacterial infections due to multidrug resistance (MDR) may be mediated by the overexpression of efflux pumps. In this study, we investigated the prevalence of oqxA and oqxB genes as two encoding agents of efflux pumps and the determination of antibiotic resistance rate in clinical isolates of Enterobacteriaceae. …”
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Neuronal Plasticity Associated with Burn Injury and Its Relevance for Perception and Management of Pain in Burn Patients by Terence J Coderre, Manon Choinière

“…The physiological responses to burn injury involve many different mediators and mechanisms, all of which contribute to pain perception and development of neuronal plasticity underlying short and long term changes in pain sensitivity. …”
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Effects of lysine and methionine on mRNA expression of candidate transcription factors by primary bovine mammary epithelial cells. by Boning Li, Ashlin M Edick, Madison K Fox, John Doelman, Sergio A Burgos, John P Cant

“…Eight transcription factors were selected as candidate mediators of EAA effects on mammary cell function via the amino acid response (ATF4, ATF6), mitogen-activated protein kinase (JUN, FOS, EGR1), and mechanistic target of rapamycin complex 1 (MYC, HIF1A, SREBF1). …”
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Investigating the Prognostic and Oncogenic Roles of Membrane-Associated Ring-CH-Type Finger 9 in Colorectal Cancer by Jiayan Zhang, Qinghan Jiao, Zhigang Chen

“…In vitro experiments involved siRNA-mediated MARCHF9 knockdown in COAD cell lines (SW480 and LoVo). …”
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Exclusive displaced hadronic signatures in the LHC forward region by Xabier Cid Vidal, Yuhsin Tsai, Jose Zurita

“…We also apply this projected bound to two scenarios with Higgs portal couplings, where the scalar mediator S either couples to a) the SM quarks only, or b) to both quarks and leptons in the minimal flavor violation paradigm. …”
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Legitimizing Factors of the American Hegemony: The Changing Role of Coalitions and Partnerships by A. N. Bogdanov

“…For this purpose, the U.S. relied on traditional alliances and intergovernmental organizations as mediators in relations between Washington and the less powerful countries in order to ensure the legitimacy of the American engagement. …”
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