Within-host bayesian joint modeling of longitudinal and time-to-event data of Leishmania infection. by Felix M Pabon-Rodriguez, Grant D Brown, Breanna M Scorza, Christine A Petersen

“…In addition to measuring antibody levels produced by the immune system, we adapt data from CD4+ and CD8+ T cell proliferation, and expression of interleukin 10, interferon-gamma, and programmed cell death 1 as inflammatory or regulatory factors mediating the disease process. The model is developed using data collected from a cohort of dogs naturally exposed to Leishmania infantum. …”
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General Approach to Identifying Potential Targets for Cancer Imaging by Integrated Bioinformatics Analysis of Publicly Available Genomic Profiles by Yongliang Yang, S. James Adelstein, Amin I. Kassis

“…Previously, we published a literature mining of potential targets for our in-house enzyme-mediated cancer imaging and therapy technology. Here we present a simple and integrated bioinformatics analysis approach that assembles a public cancer microarray database with a pathway knowledge base for ascertaining and prioritizing upregulated genes encoding cell surface- or membrane-bound proteins, which could serve imaging targets. …”
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Over-the-counter carrageenan-based sprays may interfere with PCR testing of nasopharyngeal swabs to detect SARS-CoV-2. by Taylor Corocher, Kira Edwards, Yvonne Hersusianto, Donald Campbell, Hui Yin Lim, Paul Monagle, Prahlad Ho

“…A direct comparison of carrageenan- and heparin-mediated PCR interference demonstrated that carrageenan PCR interference occurs to a lesser degree, but is not reversible by the addition of heparinase I. …”
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Role of astrocytes and microglia in hepatic encephalopathy associated with advanced chronic liver disease: lessons from animal studies by Wouter Claeys, Anja Geerts, Lien Van Hoecke, Christophe Van Steenkiste, Roosmarijn E. Vandenbroucke

“…Key circulating neurotoxins are ammonia and inflammatory mediators. In the brain, pathophysiology is less well understood, but is thought to be driven by glial cell dysfunction. …”
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Spreading the load: mobile information and communications technologies and their effect on information overload by D.K. Allan, M. Shoard

“…</b> A conceptual model of the interactions and relationships among the key elements that drive and mediate the information flows and information behaviour within a complex organizational environment was developed. …”
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Contract Conditions and BIM Use Effectiveness to Improve Project Performance by Francisco Villena Manzanares, Tatiana García-Segura, Eugenio Pellicer

“…Using the partial least squares structural equation modeling (PLS-SEM) method, 92 answers were analyzed, finding contractual conditions to be mediating. These results show that appropriate conditions set in a contract with regard to handling BIM technology have a positive impact on the performance and outcomes of a project. …”
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ParSite is a multicolor DNA labeling system that allows for simultaneous imaging of triple genomic loci in living cells. by Xiaohui He, Yadong Sun, Hanhui Ma

“…A pair of genomic loci labeled by ParSite could be colocalized with p53-binding protein 1 (53BP1) in response to CRISPR/Cas9-mediated double-strand breaks (DSBs). The ParSite permits tracking promoter and terminator dynamics of the APP gene, which spans 290 kilobases in length. …”
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The relationship between parental emotional abuse and interpersonal competence and digital game addiction: A path analysis by İbrahim Taş

“…Interpersonal competence mediates the relationship between maternal emotional abuse and digital game addiction. …”
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The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis. by Ziyu Wan, Tao Ma

“…This correlation is mediated by both tau and amyloid pathology, suggesting a higher hierarchical role in determining AD pathological effects than other biomarkers. …”
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腺病毒介导HSV-TK/GCV系统治疗口腔鳞癌机制的研究 by 王安训, 黄洪章

“…【方法】HSV-TK/GCV 系统治疗口腔鳞癌细胞(Tca 8113 细胞株)后分别应用3 H-TdR 掺入法、流式细胞仪 (FCM)、TUNEL(TdT-mediated dUTP Nick End Labeling)法和透射电镜等方法进行检测。【结果】HSV-TK/GCV 系统治疗 后:3H-TdR 掺入法显示掺入率下降, GCV 为5 ×10 -4 mol/ L 时掺入率随感染复数(MOI)的上升而显著下降(P <0.001);与 对照组比较, FCM 显示S 期比率显著升高(P <0.001), G2 +M 期比率下降为0(P <0.001), G1/ G0 期的改变不明显(P >0.05);透射电镜及TUNEL 法检测均未见凋亡细胞。…”
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The causal effect of Internet use on rural middle-aged and older adults’ depression: A propensity score matching analysis by Junqi Ma

“…Conclusion The paper confirms that Internet use significantly reduces depression, with social interaction and social support playing a mediating role. The results of the study show that strengthening rural Internet infrastructure can promote healthy aging in rural areas.…”
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Universal parent-focused child sexual abuse prevention: A quasi-experimental protocol. by Ella Abourjaily, Kate Guastaferro, Kassidy McElwee, Christian M Connell

“…We will use data collected from the baseline to measure potential mediators of CSA-related awareness and intention to use protective and preventive behaviors. …”
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Regulation of the IgE response by T follicular regulatory cells by Alexander L. Dent

“…Allergen-specific IgE is a major mediator of allergic responses and contributes greatly to allergic disease in the human population. …”
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Dual RNA-seq reveals transcriptome changes during Fusarium virguliforme-Trichoderma afroharzianum interactions. by Mirian F Pimentel, Leonardo F Rocha, Arjun Subedi, Jason P Bond, Ahmad M Fakhoury

“…Several differentially expressed genes-encoding secreted proteins, including CAZymes and CBM1-domain-containing proteins, were up-regulated in Th19A and Th4 upon interaction with the pathogen, even before physical contact, demonstrating possible volatile-mediated recognition of both isolates by F. virguliforme. …”
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Combined Online-Discussion as a Tool for Formation of Future Engineers’ Reflexion under Conditions of Education Digitalization. by S. A. Mikheev

“…The four-stage technology of pedagogical application of combined OD combining online-discussions with face-to-face reflexive classes is described, taking into account the mediated nature of learning in the digital environment and psychological features of future engineers related to the specifics of technical thinking. …”
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Regulation of meristem and hormone function revealed through analysis of directly-regulated SHOOT MERISTEMLESS target genes by Tamara Lechon, Nicholas A. Kent, James A. H. Murray, Simon Scofield

“…Finally, we use a subset of these target genes to perform Bayesian network analysis to infer gene regulatory associations and to construct a refined GRN for STM-mediated control of meristem function.…”
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An analysis of causal relationships among the factors affecting the academic performance of students at the Alborz University of Medical Sciences by Leili Salehi, Mandana Shirazi, Maryam Safarnavadeh, Zohreh Mahmoodi

“…The present study aimed at evaluating the mediating role of self-efficacy in the relationship between stress and effort–reward imbalance (E.R.I) and the students’ academic performance (AP) at the Alborz University of Medical Sciences. …”
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Real-life effectiveness and safety of baricitinib in 17 Japanese patients with alopecia areata: a 60-week single center study by Akihiko Uchiyama, Takeshi Araki, Keiji Kosaka, Sei-Ichiro Motegi

“…Alopecia areata (AA) is a chronic immune-mediated skin disorder characterized by non-scarring hair loss. …”
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RNA editing regulates host immune response and T cell homeostasis in SARS-CoV-2 infection. by Molly Huang, Adam Mark, Jessica Pham, Karina Vera, Amanda M Saravia-Butler, Afshin Beheshti, Qingfei Jiang, Kathleen M Fisch

“…Adenosine to inosine (A-to-I) RNA editing by ADAR1 has been implicated in maintaining self-tolerance, preventing autoimmunity, and mediating antiviral immunity. Foreign viral double-stranded RNA triggers rapid interferon response and activates ADAR1 in the host immune system. …”
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Analysis of engineered T7 bacteriophages containing genetic sequences encoding antimicrobial peptides by Tobias Ludwig, Daniela Volke, Andor Krizsan

“…The integration of DNA sequences derived from CRAMP and melittin into the phage genome resulted in the created T7Select-(M)CRAMP and T7Select-(M)melittin phages, which showed a lysis behavior like the phage without insert and partially inhibited the growth of potentially phage-resistant E. coli strains after the phage-mediated lysis.…”
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