Characterization and miRNA Profiling of Extracellular Vesicles from Human Osteoarthritic Subchondral Bone Multipotential Stromal Cells (MSCs) by Clara Sanjurjo-Rodríguez, Rachel E. Crossland, Monica Reis, Hemant Pandit, Xiao-nong Wang, Elena Jones

“…These EVs could therefore mediate the cross-talk between the SB and cartilage in OA potentially modulating chondrocyte viability and endogenous cartilage regeneration.…”
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Mechanism of Cytosolic Phospholipase A2 Activation in Ghrelin Protection of Salivary Gland Acinar Cells against Ethanol Cytotoxicity by Bronislaw L. Slomiany, Amalia Slomiany

“…Ghrelin, a peptide hormone, newly identified in oral mucosal tissues, has emerged recently as an important mediator of the processes of mucosal defense. Here, we report on the mechanism of ghrelin protection against ethanol cytotoxicity in rat sublingual salivary gland cells. …”
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Neurofilament light chain levels in neuronal surface antibody-associated autoimmune encephalitis: a systematic review and meta-analysis by Qi-Lun Lai, Meng-Ting Cai, Er-Chuang Li, Gao-Li Fang, Chun-Hong Shen, Yong-Feng Xu, Song Qiao, Jia-Jia Wang, Qin-Jie Weng, Yin-Xi Zhang

“…Abstract Background Neuronal surface antibody-associated autoimmune encephalitis (NSAE) is a group of neuro-inflammatory disorders that is mediated by autoantibodies against the cell-surface and synaptic antigens. …”
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Integrative analysis of single-cell and transcriptome sequencing with experimental validation reveals PKHD1L1 as a novel biomarker in lung adenocarcinoma by Xiangqian Zhang, Jie Wang, Hanyang Su, Xiaojin Liu

“…Abstract Polycystic kidney and hepatic disease 1-like protein 1 (PKHD1L1) is predicted to encode a large type I transmembrane protein involved in hearing transmission and mediating cellular immunity under physiological conditions. …”
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Nootkatone Derivative Nootkatone-(E)-2-iodobenzoyl hydrazone Promotes Megakaryocytic Differentiation in Erythroleukemia by Targeting JAK2 and Enhancing JAK2/STAT3 and PKCδ/MAPK Cro... by Yang Pan, Feng Xiao, Chaolan Pan, Hui Song, Peng Zhao, Meijun Chen, Liejun Huang, Jue Yang, Xiaojiang Hao

“…In conclusion, N2 shows great promise as a differentiation therapy for erythroleukemia, offering a novel approach by targeting JAK2-mediated signaling pathways to induce megakaryocytic differentiation.…”
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Amino-Functionalized Wood Aerogel for Efficient Removal of Copper Ions from Water by Junwang Meng, Hao Guan, Xinjian Dai, Xiaoqing Wang

“…The amino-functionalized wood aerogel was prepared from natural balsa wood via a delignification treatment, followed by TEMPO-mediated oxidation of the delignified wood and then grafting polyethylenimine (PEI) onto the oxidized cellulose skeleton. …”
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C–C bond coupling with sp3 C–H bond via active intermediates from CO2 hydrogenation by Qianli Ma, Jianian Cheng, Xiaojing Wu, Jin Xie, Ruihui Zhang, Zhihe Mao, Hongfang Yang, Wenjun Fan, Jianrong Zeng, Johannes Hendrik Bitter, Guanna Li, Zelong Li, Can Li

“…Abstract Compared to the sluggish kinetics observed in methanol-mediated side-chain alkylation of methyl groups with sp3 C–H bonds, CO2 hydrogenation emerges as a sustainable alternative strategy, yet it remains a challenge. …”
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Hypoxia Promotes Vascular Smooth Muscle Cell (VSMC) Differentiation of Adipose-Derived Stem Cell (ADSC) by Regulating Mettl3 and Paracrine Factors by Jiaying Lin, Qianqian Zhu, Jialyu Huang, Renfei Cai, Yanping Kuang

“…In addition, our results suggested that hypoxia stress promotes the ADSC differentiate into VMSCs and regulates the secretion of VEGF, HGF, TGF-β, GM-CSF, bFGF, and SDF-1 by mediating Mettl3 gene expression. These observations might contribute to novel progress in understanding the role of epitranscriptomic regulation in the VSMC differentiation of ADSCs and provide a promising perspective for new therapeutic strategies for tissue regeneration.…”
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Pleural Mesothelial Cells-Induced Monocytes to the Pleural Cavity through the Effect of C3 Lytic Products in Tuberculous Pleural Effusion by Lisha Luo, Juntao Feng, Shuanglinzi Deng, Xinyue Hu, Bingrong Zhao, Wei Tang, Xiaozhao Li

“…The recruitment of monocytes into TPE mediated by PMCs could be inhibited by anti-CR1, anti-CR3, and anti-CXCL12 monoclonal antibodies (mAbs). …”
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Sensory Overresponsivity, Loneliness, and Anxiety in Taiwanese Adults with Autism Spectrum Disorder by Ya-Cing Syu, Ling-Yi Lin

“…Participants who experienced sensory avoiding more frequently reported higher anxiety and feelings of loneliness, with loneliness mediating the relationship between sensory avoiding and anxiety. …”
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Stability and transepithelial transport of oligopeptide (KRQKYD) with hepatocyte-protective activity from Jinhua ham in human intestinal Caco-2 monolayer cells by Wen Nie, Feiran Xu, Kai Zhou, Jieying Deng, Ying Wang, Baocai Xu

“…Pretreatment with an energy inhibitor (sodium azide), a competitive peptide transporter inhibitor (Gly-Pro) and a transcytosis inhibitor wortmannin did not decrease the level of transepithelial KRQKYD transport, indicating that the transport mechanism of KRQKYD was not associated with energy dependent, vector mediated and endocytosis. The tight junction disruptor cytochalasin D signif icantly increased the level of transepithelial KRQKYD transport (P＜0.05), suggesting that intact KRQKYD was absorbed by paracellular transport.…”
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Biallelic SLC13A1 loss-of-function variants result in impaired sulfate transport and skeletal phenotypes, including short stature, scoliosis, and skeletal dysplasia by Christina G. Tise, Katie Ashton, Lachlan de Hayr, Kun-Di Lee, Omkar L. Patkar, Emma Krzesinski, Jennifer A. Bassetti, Erin M. Carter, Cathleen Raggio, Andreas Zankl, Anas M. Khanshour, Kristhen N. Atala, Jonathan J. Rios, Carol A. Wise, Ying Zhu, Futao Zhang, Tony Roscioli, Michael Buckley, Robert J. Harvey, Paul A. Dawson

“…SLC13A1 is a sodium-sulfate cotransporter primarily expressed in the kidney, where it mediates sulfate reabsorption and maintenance of circulating sulfate levels. …”
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Feedback regulation in multistage cell lineages by Wing-Cheong Lo, Ching-Shan Chou, Kimberly K. Gokoffski, Frederic Y.-M. Wan, Arthur D. Lander, Anne L. Calof, Qing Nie

“…Together, the existence of multiple cellstages within a lineage and complex feedback regulation are thought to conferupon a tissue the ability to autoregulate development and regeneration,in terms of both cell number (total tissue volume) and cell identity(the proportions of different cell types, especially TD cells, within the tissue).In this paper, we model neurogenesis in the olfactory epithelium (OE) of the mouse,a system in which the lineage stages and mediators of feedback regulation that governthe generation of terminally differentiated olfactory receptor neurons (ORNs) have beenthe subject of much experimental work. …”
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The roles of ICT and governance quality in the finance-growth nexus of developing countries: a dynamic GMM approach by Ummar Faruk Saeed, Rabiatu Kamil, Ishmael Wiredu

“…(2) How does ICT access mediate the financial development and economic growth nexus? …”
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Genes Involved in the Transcriptional Regulation of Pluripotency Are Expressed in Malignant Tumors of the Uterine Cervix and Can Induce Tumorigenic Capacity in a Nontumorigenic Cel... by Graciela Ruiz, Heriberto A. Valencia-González, Delia Pérez-Montiel, Felipe Muñoz, Rodolfo Ocadiz-Delgado, Jorge Fernández-Retana, Carlos Pérez-Plasencia, Osbaldo Reséndis-Antonio, Patricio Gariglio, Alejandro García-Carrancá

“…Importantly, we observed that lentiviral-mediated transduction of these factors confers, to a nontumorigenic immortalized human cell line, properties of cancer stem cells as the ability to form tumors in a mouse model. …”
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A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization—explanation of its folded conformation by Rodolfo Moreno-Fuquen, Juan F. Avellaneda-Tamayo, Kevin Arango-Daraviña, Javier Ellena, Alan R. Kennedy

“…Additionally, supramolecular interactions in the crystal are mediated by hydrogen bonds and dispersion forces, forming dimers and layered structures. …”
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Flammulina velutipes polysaccharide-iron(III) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters by Chenying Shi, Chen Cheng, Xiaotong Lin, Yanfang Qian, Yufeng Du, Guitang Chen

“…These results showed that in vitro, the uptake of FVP1-Fe(III) was mediated by sodium-dependent glucose transporter-1 (SGLT1) and facilitated glucose transporter-2 (GLUT2) and GLUT2 played a dominant function. …”
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Novel derivative of nicotinic acid ameliorates doxorubicin-induced cardiac injury via regulation of redox homeostasis by Yana V. Loboda, Mikhail V. Korokin, Alexey V. Kuznetsov, Tatiana N. Malorodova, Anton P. Danilenko, Anna A. Peresypkina, Oleg S. Gudyrev, Ol’ga A. Kop’eva, Tatyana G. Pokrovskaya, Liliya V. Korokina, Valeriya N. Khruslova, Valeriya A. Nazarenko, Tatyana V. Avtina, Alexey V. Deikin, Aleksandr A. Dolzhikov, Tatiana V. Puzanova, Lyudmila M. Danilenko

“…A significant role in potassium 5-hydroxynicotinate-mediated cardioprotection is, apparently, related to the reduction of oxidative stress and down-regulation of the level of intracellular calcium.…”
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Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases by Ali Mahdavi Fard, Jeffrey Desilets, Sangita Patel

“…The general activation of the T-cell-mediated immune response and proinflammatory cytokines such as IFNγ may underlie the role of the COVID vaccines in reactivation of herpetic stromal keratitis and the clinical findings in our reported cases.…”
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The Relationship of immunoglobulin-e and tumor necrosis factor in patients with allergic rhinitis in Babylon province by Bushra Jihad Sabbar, Zenaa Abbass Ali, Tariq Hussein Mgheer

“…It is caused by immunoglobulin E (IgE)-mediated reactions to inhaled allergens, smoking and alcohol use, gender, age, overweight, adoption of pets, race, educational achievement, and family history can represent a risk factor for allergic rhinitis (AR). …”
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