In vitro high-content screening reveals miR-429 as a protective molecule in photoreceptor degeneration by Georgios Petrogiannakis, Irene Guadagnino, Santiago Negueruela, Martina Di Guida, Elena Marrocco, Mariateresa Pizzo, Annalaura Torella, Mariateresa Zanobio, Marianthi Karali, Diego Luis Medina, Sabrina Carrella, Sandro Banfi

“…Adeno-associated viral vector-mediated subretinal delivery of miR-429 in the RhoP23H/+ IRD mouse model preserved electrophysiological responses and was associated with reduced inflammatory processes in the retina. …”
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Proteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection by Dan Ma, Qian-Yu Zhang, Heng-Mo Rong, Kan Zhai, Zhao-Hui Tong

“…Exosomes are nanoscale small extracellular vesicles abundant with protein cargo and can mediate immune response during infectious disease. …”
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Clinical Outcomes and Donor-specific Antibody Rebound 5 y After Kidney Transplant Enabled by Imlifidase Desensitization by Ian S. Jaffe, BS, Anna Runström, MSc, Vasishta S. Tatapudi, MD, Elaina P. Weldon, MSN, ACNP-BC, Cecilia L. Deterville, MS, Rebecca A. Dieter, PharmD, Robert A. Montgomery, MD, DPhil, Bonnie E. Lonze, MD, PhD, Massimo Mangiola, PhD

“…Three participants had antibody-mediated rejection (AMR), which occurred in the first 30 d in all cases and was successfully treated. …”
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Osteosíntesis de radio y ulna con placa bloqueada en oso hormiguero gigante (Myrmecophaga tridactyla) by Sarah Manuela Stuart Gomez, Kelvin Pinto Acero, Gaston Roberto Gómez Castro

“…La resolución se aborda mediate osteosíntesis de ambas estructuras óseas con un sistema de doble placa bloqueada de titanio bajo plan anestésico de ketamina 4mg/Kg, dexmedetomidina 0.025 mg/kg y midazolam 0.1 mg/Kg; el mantenimiento se realizó con isoflurano a razón de 3% como inicio de la anestesia y 1.5% de mantenimiento. …”
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The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients by Basma A. Yasseen, Aya A. Elkhodiry, Hajar El-sayed, Mona Zidan, Azza G. Kamel, Mohamed A. Badawy, Marwa S. Hamza, Riem M. El-Messiery, Mohamed El Ansary, Engy A. Abdel-Rahman, Engy A. Abdel-Rahman, Sameh S. Ali

“…It is generally assumed that organ damage causes toxic acidosis, but since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes, we asked if metabolic acidosis mediated by the glycolytic neutrophils is associated with lung damage and impaired oxygen delivery in critically ill patients.MethodsBased on prospective mortality outcome, critically ill COVID-19 patients were divided into ICU- survivors and ICU-non-survivors. …”
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Shock Breakouts from Compact Circumstellar Medium Surrounding Core-collapse Supernova Progenitors May Contribute Significantly to the Observed ≳10 TeV Neutrino Background by Eli Waxman, Tal Wasserman, Eran O. Ofek, Avishay Gal-Yam

“…A quantitative theory describing the evolution of the electromagnetic spectrum during a breakout, as the radiation-mediated shock is transformed into a collisionless one, is required to enable (i) using data from upcoming surveys that will systematically detect large numbers of young,  <1 day old SNe to determine the preexplosion mass-loss history of the SN progenitor population, and (ii) a quantitative determination of the neutrino luminosity and spectrum.…”
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Immune regulation is more effective in the U937 inflammation model with mesenchymal stem cell extracellular vesicles stimulated by pro-inflammatory cytokines by Canan Öztürk, Zehra S. Halbutoğullari

“…It is thought that the mediators (cytokines, growth factors, etc.) secreted by stem cells change under inflammatory conditions, and the therapeutic activity of MSCs increases. …”
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Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson’s Patients by Maria L. Bringas Vega, Shengnan Liu, Min Zhang, Ivonne Pedroso Ibañez, Lilia M. Morales Chacon, Lidice Galan Garcia, Vanessa Perez Bocourt, Marjan Jahanshahi, Pedro A. Valdes-Sosa

“…From our results rHuEPO seems to mediate an effect on N1 sources in lingual gyri but not on behavioural performance. …”
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Ghrelin Increases Beta-Catenin Level through Protein Kinase A Activation and Regulates OPG Expression in Rat Primary Osteoblasts by Emanuela Mrak, Lavinia Casati, Francesca Pagani, Alessandro Rubinacci, Guido Zarattini, Valeria Sibilia

“…Since canonical Wnt/β-catenin pathway is critically associated with bone homeostasis, we investigated its involvement in mediating ghrelin effects in osteoblasts and in osteoblast-osteoclast cross talk. …”
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Pseudomonas cold shock proteins suppress bacterial effector translocation in Nicotiana benthamiana by Shen Cong, Jun-Zhou Li, Mei-Ran Zhang, Mei-Ran Zhang, Hai-Lei Wei, Wei Zhang

“…Furthermore, we demonstrated that the suppression of effector translocation mediated by CSPs was less pronounced compared to that triggered by FliC. …”
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Transcriptomic data reveals MYC as an upstream regulator in laying hen follicular recruitment by Ashley E Kramer, Kathryn M Ellwood, Nicole Guarino, Cong-Jun Li, Aditya Dutta

“…This study investigates the genetic drivers mediating the transition of pre-recruitment follicles to the pre-ovulatory phase, a crucial stage before ovulation. …”
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Stem Cells from Human Exfoliated Deciduous Teeth Attenuate Trigeminal Neuralgia in Rats by Xiaofeng Bai, Xuedi Zhang, Chun Wang, Yao Liu, Xuemei Liu, Yu Fan, Xia Zhang

“…Owing to their neuroprotective and immunomodulatory effects, these neural crest cells have potential roles in mediating chronic pain. In this study, we established a rat model of chronic constriction injury of the infraorbital nerve (CCI-ION) to evaluate the analgesic effect of SHED in neuropathic pain. …”
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Emergence in Elderly Patient Undergoing General Anesthesia with Xenon by Maria Sanfilippo, Ahmed Abdelgawwad Wefki Abdelgawwad Shousha, Antonella Paparazzo

“…Xenon is a noble gas with anesthetic properties mediated by antagonism of N-methyl-D-aspartate receptors. …”
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Beyond age: Decoding the investment DNA of generations Z and Y in Indonesia by Debbi Chyntia Ovami, Henny Zurika Lubis, Esa Setiana, Ita Mustika, Sari Wulandari

“…In addition, fintech proficiency mediates the effects of financial literacy, risk perception, family background, and income on investment decisions (p &lt; 0.05). …”
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Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial CellsSummary by Kodisundaram Paulrasu, Ravindran Caspa Gokulan, Wael El-Rifai, Zhibin Chen, Jianwen Que, Timothy C. Wang, Olivier G. Boutaud, Karoline Briegel, Sergey I. Dikalov, Monica T. Garcia-Buitrago, Alexander I. Zaika

“…Dysregulation of proteostasis induces ferroptotic cell death and is mediated by modification of cellular proteins with reactive isoLGs that can be prevented by isoLG scavengers. …”
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AKR1D1*36 C>T (rs1872930) allelic variant is associated with variability of the CYP2C9 genotype predicted pharmacokinetics of ibuprofen enantiomers – a pilot study in healthy volun... by Kapedanovska Nestorovska Aleksandra, Jakjovski Krume, Naumovska Zorica, Sterjev Zoran, Geskovska Nadica Matevska, Mladenovska Kristina, Suturkova Ljubica, Dimovski Aleksandar

“…The role of AKR1D1*36C>T (rs 1872930) allelic variant in interindividual variability of CYP450 mediated drug metabolism was recently elucidated. A total of 27 healthy male subjects, volunteers in IBP single-dose two-way cross-over bioequivalence studies were genotyped for CYP2C9*2, CYP2C9*3 and AKR1D1*36 polymorphisms. …”
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A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer by Prarthana Chatterjee, Satarupa Banerjee

“…Intriguingly, FOXM1 overexpression was found to be highest in Triple-negative breast cancer (TNBC), the most aggressive BC with the worst prognosis. However, FOXM1-mediated TNBC pathogenesis is not completely elucidated. …”
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Progress of CCL20-CCR6 in the airways: a promising new therapeutic target by Ya -Jing Li, Wan-Li Geng, Chen-Chen Li, Jia-Hao Wu, Fei Gao, Yong Wang

“…Within the respiratory system, CCL20-CCR6 demonstrates heightened expression in conditions such as allergic asthma, chronic airway inflammation, non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), and other respiratory diseases, which is conducive to the inflammatory mediators recruitment and tumor microenvironment remodeling. …”
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Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice by Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida

“…Nearly 40% of Cys644 is normally polysulfidated, which is a preferential target for GSSG-mediated S-glutathionylation. Cys644 S-glutathionylation is resistant to Drp1 depolysulfidation-dependent mitochondrial hyperfission and myocardial dysfunction caused by hypoxic stress. …”
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Enhanced Oxidative Phosphorylation Driven by TACO1 Mitochondrial Translocation Promotes Stemness and Cisplatin Resistance in Bladder Cancer by Minhua Deng, Zhaohui Zhou, Jiawei Chen, Xiangdong Li, Zefu Liu, Jingwei Ye, Wensu Wei, Ning Wang, Yulu Peng, Xin Luo, Lijuan Jiang, Fangjian Zhou, Xianchong Zheng, Zhuowei Liu

“…Intriguingly, the mitochondrial translocation of TACO1 is mediated by the heat shock protein 90 β (HSP90β), a process that requires circFOXK2 as a scaffold for the TACO1‐HSP90β interaction. …”
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