EHMT2‐mediated R‐loop formation promotes the malignant progression of prostate cancer via activating Aurora B by Yuyang Zhang, Mingqin Su, Yiming Chen, Li Cui, Wei Xia, Renfang Xu, Dong Xue, Xiansheng Zhang, Xingliang Feng

“…The proliferation of cells was measured through CCK‐8 tests, clonogenesis and subcutaneous xenografts of human PCa cells in BALB/c nude mice. …”
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Soluble galectin-4 in colorectal cancer is associated with tumor progression, but is not a predictor of the disease outcome by Elena Y. Yakunina, Olga V. Kovaleva, Ruslan A. Zukov, Alexey N. Gratchev, Sergey S. Salamatin, Sofya O. Kochkina, Zaman Z. Mammadli, Nikolay E. Kushlinskii

“…Galectin-4 levels were measured in serum obtained by a standard method before the start of specific treatment, by the enzyme-linked immunosorbent assay (ELISA). …”
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Access to context-specific lexical-semantic information during discourse tasks differentiates speakers with latent aphasia, mild cognitive impairment, and cognitively healthy adult... by Brielle C. Stark, Brielle C. Stark, Sarah Grace Dalton, Alyssa M. Lanzi, Alyssa M. Lanzi

“…PurposeMild language impairments experienced by adults with neurogenic communication disorders are often difficult to detect due to the lack of sensitive traditional performance-based measures. This is problematic since many adults who have mild language deficits experience daily activity and participation limitations that are undetected and not managed. …”
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A Systematic Review and Meta-analysis of Randomized Controlled Trials on Comparing Transabdominal Preperitoneal Versus Lichtenstein Operations for Primary Inguinal Hernia Repair by Muhammad Aslam Javed, Muhammad Arshad Abbas, Mudassar Murtaza, Wasif Majeed Chaudhry, Adnan Faisal, Muhammad Mohsin Gillani

“…In addition to the surgical operation and hospital stay duration, acute post-operative pain, return to work time, hematoma, wound infection, and seroma incidence were also measured. The Randomized controlled trials (RCTs) comparing TAPP and Lichtenstein operations for primary inguinal hernia repair and studies reporting on at least one of the above-mentioned outcomes were included. …”
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Double-Blind Clinical Trial of Arginine Supplementation in the Treatment of Adult Patients with Sickle Cell Anaemia by Renata M. N. Eleutério, Francisco O. Nascimento, Tamara G. Araújo, Marilena F. Castro, Tarcísio P. Almeida Filho, Pedro A. Maia Filho, José Eleutério, Darcielle B. D. Elias, Romélia P. G. Lemes

“…The clinical experiments were performed by a haematologist. The main outcome measures were nitrite and pain. Results. Statistical analysis showed that the levels of NO were increased in the study group, and there was also a reduction in pain frequency using a pain frequency scale by day, week, and month. …”
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Validation of the Polish version of the Functional Oral Intake Scale against flexible endoscopic evaluation of swallowing and the International Dysphagia Diet Standardization Initi... by Magdalena Milewska, Barbara Jamroz, Mariusz Panczyk, Joanna Chmielewska-Walczak, Tomasz Czernicki, Marta Dabrowska-Bender, Marcin Folwarski, Marcin Folwarski, Dorota Szostak-Wegierek

“…The primary outcome measures included the Penetration-Aspiration Scale (PAS) score from FEES, pharyngeal residue quantification, and IDDSI-FDS scores. …”
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Efficacy of Aeromonas hydrophila formalin-killed cells and lipopolysaccharides vaccines in maternal immunity of tilapia broodstock and the offspring resistance by Rahma Mulyani, Sukenda Sukenda, Sri Nuryati

“…Antibody level and lysozyme were measured in the broodstock, egg, and offsprings. In the first experiment, the result showed that vaccinated broodstock and their offsprings had delivered a significant antibody level and lysozyme activity compared with the control.  …”
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Work-related burnout and its associated factors among kindergarten teachers: a multi-center cross-sectional study in Ethiopia by Anmut Endalkachew Bezie, Girum Tareke Zewude, Amensisa Hailu Tesfaye, Amensisa Hailu Tesfaye, Asmare Asrat Yirdaw, Alebachew Bitew Abie, Giziew Abere

“…A standardized, self-administered Copenhagen Burnout Inventory was utilized to measure work-related burnout. We used EpiData V4.6 and SPSS V26 for data entry and analysis, respectively. …”
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Comparison of biodegradable and durable polymer drug-eluting stents in acute coronary syndrome: a meta-analysis by Tingting Wei, Can Huang, Yifan Zeng, Haoyong Yuan, Zhongshi Wu, Ting Lu, Yalin Liu

“…Objective To compare the safety and effectiveness between biodegradable polymer drug-eluting stents (BP-DES) and durable polymer drug-eluting stents (DP-DES) in patients with acute coronary syndrome (ACS).Design Meta-analysis of randomised controlled trials (RCTs).Primary and secondary outcome measures Major adverse cardiovascular events (MACEs) were considered the primary endpoint. …”
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Therapy for Dupuytren’s Disease (II): Collagenase Therapy vs. Limited Fasciectomy—A Long-Term Comparative Study by Nikolaus Wachtel, Francesca Romana Dingler, Constanze Kuhlmann, Sinan Mert, Elisabeth Maria Haas-Lützenberger, Verena Alt, Nicholas Moellhoff, Riccardo Giunta, Wolfram Demmer

“…Finger extension (Tubiana stage), strength, sensitivity, the effect of possible risk factors, and patient-reported outcome measures (PROMs) were compared between the two groups. …”
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Smartphone-Based Intervention Targeting Norms and Risk Perception Among University Students with Unhealthy Alcohol Use: Secondary Mediation Analysis of a Randomized Controlled Tria... by Joseph Studer, John A Cunningham, Elodie Schmutz, Jacques Gaume, Angéline Adam, Jean-Bernard Daeppen, Nicolas Bertholet

“…Mediators were perceived drinking norms and perceived risks for health measured at baseline and 3 months. Parallel mediation analyses and moderated mediation analyses were conducted to test whether (1) the intervention effect was indirectly related to lower DV and HDDs at 6 months (adjusting for baseline values) through perceived drinking norms and perceived risks for health at 3 months (adjusting for baseline values) and (2) the indirect effects through perceived drinking norms differed between participants who overestimated or who did not overestimate other people’s drinking at baseline. …”
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Comparative- and Cost-Effectiveness Research Determining the Optimal Intervention for Advancing Transgender Women With HIV to Full Viral Suppression (Text Me, Alexis!): Protocol fo... by Cathy J Reback, Thomas Blue, Ali Jalali, Raphael Landovitz, Michael J Li, Raymond P Mata, Danielle Ryan, Philip J Jeng, Sean M Murphy

“…Using the same time points as the Health Resources and Services Administration demonstration projects, the repeated-measures design will assess participants at baseline, 3, 6, 12, and 18 months post randomization. …”
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Remimazolam Suppresses Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury by Regulating AKT/GSK-3β/NRF2 Pathway by Duan M, Yu N, Liu J, Zhao Y, Zhang J, Song S, Wang S

“…Reactive oxygen species (ROS), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), NRF2, heme oxygenase 1 (HO-1), AKT, P-AKT, GSK-3β, P-GSK-3β protein expression, and nuclear translocation of NRF2 were measured in cell and animal assays.Results: Reduced SY5Y cell viability and increased apoptosis caused by OGD/R injury, elevated neurological deficit scores and cerebral infarct volume induced by brain I/R injury in rats, cerebral cell injury, as well as elevated Bax, Cleaved-Caspase 3, decreased Bcl2, and increased number of TUNEL-positive cells in rat brain tissue were all moderated by remimazolam. …”
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Cardiac manifestations of Fabry disease in G3Stg/GlaKO and GlaKO mouse models-Translation to Fabry disease patients. by Abirami Kugadas, Pietro Artoni, Wanida Ruangsiriluk, Meng Zhao, Natalia Boukharov, Rizwana Islam, Dmitri Volfson, Katayoun Derakhchan

“…Significant reduction in Global longitudinal strain (GLS) measuring local myofiber contractility of the LV was also detected at 13-months. …”
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Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus (LEGEND-T2DM): a protocol for a series of multinational, real-world compar... by Rohan Khera, Yuan Lu, Harlan M Krumholz, Martijn J Schuemie, Ruijun Chen, George Hripcsak, Marc A Suchard, Patrick B Ryan, Anna Ostropolets

“…The study will pursue data-driven, large-scale propensity adjustment for measured confounding, a large set of negative control outcome experiments to address unmeasured and systematic bias.Ethics and dissemination The study ensures data safety through a federated analytic approach and follows research best practices, including prespecification and full disclosure of results. …”
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The Model of Disengagement of Talent with Meta-synthesis Method by Ali Asghar Mobasheri, Ali Nasr Isfahani, Hadi Teimouri

“…By identifying these antecedents, the study provides a valuable foundation for planning and implementing necessary measures to prevent and manage talent disengagement. …”
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New job, new habits? A multilevel interrupted time series analysis of changes in diet, physical activity and sleep among young adults starting work for the first time by Alena F. Oxenham, Tanya Braune, Esther van Sluijs, Hannah Fairbrother, Adam Martin, Eleanor M. Winpenny

“…Results Sleep duration was stable over the years before and after starting work, but starting work was associated with an immediate reduction in sleep duration (β $$\:=\:$$ -9.74 [95% CI:-17.32 to -2.17 min/night). Physical activity, measured in Metabolic Equivalent Tasks (METs), increased immediately after starting work (β = 113.3, [95% CI: 80.49 to 146.11] MET-min/day), but subsequently decreased over time after starting work (β= -26.7, [95% CI: -40.75 to -12.66] MET-min/day/year). …”
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Dairy intake and cognitive function in older adults in three cohorts: a mendelian randomization study by Natalia Ortega, Nick J. Mueller, Abbas Dehghan, Tosca O. E. de Crom, Armin von Gunten, Martin Preisig, Pedro Marques-Vidal, Marco Vinceti, Trudy Voortman, Nicolas Rodondi, Patricia O. Chocano-Bedoya

“…Methods We included 43,836 individuals over 55 years old with genotyping, dietary data, and cognitive function measurements from three population-based studies: CoLaus|PsyCoLaus (Switzerland), the Rotterdam Study (the Netherlands) and the Canadian Longitudinal Study on Aging (CLSA - Canada). …”
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Short-term Effects of Sling Exercise Combined with Massage on the Treatment of Neck Type Cervical Spondylopathy by LI Jianfei, ZHAO Hong, CHEN Qian, LI Li, ZHANG Deqi

“…Before and after treatment, the McGill Pain Questionnaire (MPQ) and the Neck Disability Index (NDI) were used to evaluate the cervical function and quality of life of patients, and the median frequency (MF) of the upper trapezius muscle was measured by electromyography biofeedback instrument.ResultsBefore treatment, the MPQ scores, NDI scores and MF value of the three groups were not statistically different (<italic>P</italic>&gt;0.05). …”
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Safety profile of sacituzumab govitecan in patients with breast cancer: A systematic review and meta-analysis by Maria Inez Dacoregio, Isabella Michelon, Caio Ernesto do Rego Castro, Francisco Cezar Aquino de Moraes, Guilherme Rossato de Almeida, Lis Victória Ravani, Maysa Vilbert, Ricardo Lima Barros Costa

“…We highlight the need for protocols establishing prophylactic measures and strategies to mitigate SG-related toxicity.…”
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