Assessing gut barrier integrity and reproductive performance following pre-mating oral administration of solid-lipid-nanoparticles designed for drug delivery by Valentina Lacconi, Valentina Lacconi, Micol Massimiani, Micol Massimiani, Giulia Antonello, Paolo Gasco, Roberta Bernardini, Cristiana Ferrari, Lorenzo Ippoliti, Gina La Sala, Antonio Pietroiusti, Ivana Fenoglio, Chiara Riganti, Luisa Campagnolo

“…Embryonic development was also evaluated and no effects on the number of implantation sites, fetus numbers, incidence of fetal resorptions, and measurements of crown-rump length, as well as fetal and placental weights, were observed in the treated mothers. …”
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Analyzing practice pattern in treating partial-thickness rotator cuff tears: a dual perspective from national database and American Shoulder and Elbow Surgeons PARCIAL research gro... by H. Mike Kim, MD, Emily Leary, PhD, Champ L. Baker, 3rd, MD, Leslie A. Barnes, MD, R. Alexander Creighton, MD, Frances Cuomo, MD, Matthew J. DiPaola, MD, Abdullah Foad, MD, James M. Gregory, MD, Brian F. Grogan, MD, Scott G. Kaar, MD, MBA, Eitan M. Kohan, MD, Sumant G. Krishnan, MD, Eddie Y. Lo, MD, John T. Moor, MD, Michael Nguyen, BS, Monica DiFiori, MD, Gabriel Masters, BA, Te Feng Arthur Chou, MD, Riccardo Raganato, MD, Lucas P. Bowen, BS, Jordan J. Harmon, BS, Tessa C. Griffin, BS, Alec E. Winzenried, MD, Evan M. Polce, BS, Cory J. Call, BS, Benjamin Nwadike, MD, Alvin Ouseph, MS, Monia Nazemi, MS, Kyle McCall, BA

“…The retrospective chart review of the ASES research group revealed that PTRCT repairs constituted 27.8% of all rotator cuff repairs with substantial variability among institutions (8.6%-67.1%), that nonoperative measures were commonly employed, with a mean 12-month duration before surgical repair, and that the most common type of nonoperative treatment was supervised physical therapy combined with corticosteroid injection (37.7%). …”
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The Effects of a Red-Light Controllable Nitric Oxide Donor, NORD-1, on Erectile Dysfunction in Rats with Streptozotocin Induced Diabetes Mellitus by Yuji Hotta, Kyoya Oyama, Takuma Yoshida, Naoya Ieda, Taiki Mori, Yasuhiro Horita, Tomoya Kataoka, Yoko Furukawa-Hibi, Susumu Ohya, Hidehiko Nakagawa, Kazunori Kimura

“…Five weeks after the treatment, we performed a functional study by measuring intracavernous pressure (ICP) under cavernous nerve stimulation before and after NORD-1 treatment with and without light irradiation. …”

Prevalence and factors associated with neonatal sepsis in Mali: a cross-sectional study by Bienvenu Salim Camara, Alexandre Delamou, Haoua Dembele, Hamadoun Sangho, Birama Apho Ly, Sidikiba Sidibé, Alioune Camara, Cheick Sidya Sidibé, Alhassane Diallo, Abdoulaye Touré, Fatoumata Bintou Traoré, Elhadj Marouf Diallo, Fatimata Yaro, Mariam Traoré

“…Data were analyses using bivariate and multivariate logistic regression.Setting This facility-based study was conducted in four health facilities consisting of two hospitals and two reference health centres in Mali.Participants The study participants comprised 795 randomly selected neonates and their indexed mother.Outcome measures The primary outcome of the study was the prevalence of sepsis in the considered health facilities. …”
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Time-varying intensity of ventilatory inefficiency and mortality in patients with acute respiratory distress syndrome by Lianlian Jiang, Hui Chen, Wei Chang, Qin Sun, Xueyan Yuan, Zongsheng Wu, Jianfeng Xie, Ling Liu, Yi Yang

“…This study aims to investigate the relationship between 28-day mortality in ARDS patients and their longitudinal exposure to ventilatory inefficiency, as reflected by serial measurements of PaCO2 and VR. Methods We conducted a secondary analysis of four randomized controlled trials (FACTT, ALTA, EDEN, and SAILS) from the ARDS Network. …”
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Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs by Thiago Fellipe Ortiz de Camargo, Thiago Fellipe Ortiz de Camargo, Guilherme Alberto Sousa Ribeiro, Guilherme Alberto Sousa Ribeiro, Maria Carolina Bueno da Silva, Luan Oliveira da Silva, Pedro Paulo Teixeira e Silva Torres, Denise do Socorro Rodrigues da Silva, Mayler Olombrada Nunes de Santos, William Salibe Filho, Marcela Emer Egypto Rosa, Magdala de Araujo Novaes, Thiago Augusto Massarutto, Osvaldo Landi Junior, Elaine Yanata, Marcio Rodrigues da Cunha Reis, Gilberto Szarf, Pedro Vieira Santana Netto, Joselisa Peres Queiroz de Paiva

“…The algorithm's performance was measured using accuracy, sensitivity, and specificity. …”
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Protocolized approach saves the limb in peripheral arterial injury: A decade experience by Pratyusha Priyadarshini, Supreet Kaur, Komal Gupta, Abhinav Kumar, Junaid Alam, Dinesh Bagaria, Narender Choudhary, Amit Gupta, Sushma Sagar, Biplab Mishra, Subodh Kumar

“…Injury prevention, robust prehospital care, and rapid referral to specialized trauma center are few efficient measures, which can decrease the morbidity associated with vascular injury.…”
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Intramedullary Fixation for Metacarpal Fractures: A Multi-Institutional Prospective Outcomes Study by Michael B. Gehring, MD, Brandon Wolfe, BA, Riley Kahan, BS, Stephanie D. Malliaris, MD, Kia M. Washington, MD, Matthew D. Folchert, MD, Kyros Ipaktchi, MD, Mark A. Greyson, MD, Alexander Lauder, MD, Matthew L. Iorio, MD

“…Grip strength, goniometric motion measurements, and complications were also obtained. Results: One-hundred-one fractures were treated in 82 patients with an average age of 33 years and mean follow-up of 69 days. …”
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Associations of blood-based biomarkers of neurodegenerative diseases with mortality, cardio- and cerebrovascular events in persons with chronic coronary syndrome by Valerie Lohner, Laura Perna, Ben Schöttker, Robert Perneczky, Hermann Brenner, Ute Mons

“…Methods: We used data from a cohort of persons with CCS for whom major adverse events were recorded over a follow-up of 20 years. We measured biomarkers of neurodegenerative diseases in baseline blood samples, using the Single-Molecule Array Technology on a HD-1 Analyzer. …”
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Distinct sex differences in ethanol consumption and operant self-administration in C57BL/6J mice with uniform regulation by glutamate AMPAR activity by Sara Faccidomo, Sara Faccidomo, Vallari R. Eastman, Taruni S. Santanam, Katarina S. Swaim, Seth M. Taylor, Clyde W. Hodge, Clyde W. Hodge

“…Motivation to consume EtOH was measured using operant self-administration procedures. …”
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Pharmacological management of gambling disorder: A systematic review and network meta-analysis by Konstantinos Ioannidis, Cinzia Del Giovane, Charidimos Tzagarakis, Jeremy E. Solly, Samuel J. Westwood, Valeria Parlatini, Henrietta Bowden-Jones, Jon E. Grant, Samuele Cortese, Samuel R. Chamberlain

“…We used standardized mean differences (SMD) using Hedges' g to measure the efficacy outcomes, and for the effect for tolerability we used dropout rate due to medication side effects, expressed as odds ratio (OR). …”
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Effects of Eleclazine (GS6615) on the proarrhythmic electrophysiological changes induced by myocardial stretch by Francisco J. Chorro, Francisco J. Chorro, Francisco J. Chorro, Luis Such-Miquel, Luis Such-Miquel, Samuel Cuñat, Oscar Arias-Mutis, Oscar Arias-Mutis, Patricia Genovés, Patricia Genovés, Manuel Zarzoso, Manuel Zarzoso, Antonio Alberola, Antonio Alberola, Luis Such-Belenguer, Luis Such-Belenguer, Irene Del Canto, Irene Del Canto

“…Programmed stimulation and high-resolution mapping techniques were applied using multiple epicardial electrodes.ResultsAt baseline, both the ventricular refractory period measured at a fixed cycle length (250 m) and its surrogate obtained during ventricular fibrillation (VF) decreased significantly during stretch (baseline 128 ± 15 vs. stretch 110 ± 14 m; n = 15; p < 0.001, and baseline 52 ± 13 vs. stretch 44 ± 9 m; n = 11; p < 0.05), while the VF dominant frequency (DF) increased significantly (DF baseline 13 ± 3 vs. stretch 17 ± 5Hz; n = 11; p < 0.01). …”
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Association between maternal infertility treatment and child neurodevelopment: findings from the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study in Miyagi a... by Mami Ishikuro, Shinichi Kuriyama, Shigeo Kure, Junichi Sugawara, Taku Obara, Nobuo Yaegashi, Tatsui Otsuka, Aoi Noda, Keiko Murakami, Fumihiko Ueno, Fumiko Matsuzaki, Tomomi Onuma, Zen Watanabe, Naomi Shiga, Noriyuki Iwama, Hamada Hirotaka, Masahito Tachibana, Hiroaki Tomita, Masatoshi Saito

“…Pregnant women were recruited in obstetric clinics or hospitals and their children were followed up by the questionnaire.Outcome measures The children’s neurodevelopmental outcomes were assessed at 2 and 3.5 years of age using the Ages and Stages Questionnaire, third edition (ASQ-3), which consists of questions on five developmental domains. …”
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Fetal Hemoglobin as a Predictive Biomarker for Retinopathy of Prematurity: A Prospective Multicenter Cohort Study in Portugal by Mariza Fevereiro-Martins, Laura Aguiar, Ângela Inácio, Carlos Cardoso, Ana Carolina Santos, Carlos Marques-Neves, Hercília Guimarães, Rui Pinto, Manuel Bicho

“…Clinical data were collected during hospitalization, and HbF fractions were measured from blood samples in the first four weeks of life using standardized methods. …”
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Real-world treatment patterns and clinical characteristics in patients with moderate-to-severe systemic lupus erythematosus: an analysis of the SLE Prospective Observational Cohort... by Raj Tummala, Richard A Furie, Laurent Arnaud, Eric F Morand, Martin Aringer, Stephanie Chen, Barnabas Desta, Alberta Hoi, Bo Ding, Christine Peschken, Jonatan Hedberg, Tina Grünfeld Eén, Alessandro Sorrentino, Danuta Kielar

“…Disease activity (SLE Disease Activity Index 2000 (SLEDAI-2K)), average oral glucocorticoid dose and use of other treatments—specifically antimalarials, biologics and immunosuppressants—were measured over time. Subgroup analyses were stratified by baseline interferon gene signature (IFNGS) status and disease activity (SLEDAI-2K) status.Results Patient demographics and baseline characteristics were similar among subgroups; the majority of patients were on antimalarials (n=670; 81.1%), followed by glucocorticoids (n=537; 65.0%), immunosuppressants (n=453; 54.8%) and biologics (n=175; 21.2%). …”
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Construct validity and responsiveness of ASAS Health Index assessed in two longitudinal studies of tumour necrosis factor alpha inhibitor initiation and dose reduction in patients... by Merete Lund Hetland, Inge Juul Sørensen, Mikkel Østergaard, Mikael Boesen, Susanne Juhl Pedersen, Sara Nysom Christiansen, Ole Rintek Madsen, Mette Klarlund, Marie Wetterslev, Mate Lorincz, Mads Bakkegaard, Anne Duer, Kasper Kjærulf Gosvig

“…Background The Assessment of SpondyloArthritis international Society Health Index (ASAS HI) is a novel questionnaire of global functioning for patients with axial spondyloarthritis (SpA).Objective The objective was to assess the construct validity, discriminatory ability and responsiveness of ASAS HI in relation to patient-reported outcome measures (PROMs), MRI and radiography.Methods Data from two longitudinal studies with tumour necrosis factor inhibitor (TNFi) initiation (novel MRI And biomarkers in Golimumab-treated patients with axial spondyloarthritis (MANGO): n=45) respectively tapering (Dose adjustment of Biological treatment in patients with SpA (DOBIS): n=106) were used. …”
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Evaluation of naturally occurring IgG anti-Vi antibody titers as predictors and correlates of typhoid fever in Dhaka, Bangladesh by Farhana Khanam, Natasha Y. Rickett, Faisal Ahmmed, Md Taufiqul Islam, Cecilia Kathure Mbae, Justin Im, Asma Binte Aziz, Beatrice Ongadi, Fahima Chowdhury, Ashraful Islam Khan, Afroza Akter, Md Golam Firoj, Sadia Isfat Ara Rahman, Kassa Haile, Se Eun Park, Martin Bundi Mwebia, Moses Mwangi, Benjamin Ngugi, Meseret Gebre Behute, Kelvin Kering, Suneth Agampodi, Suman Kanungo, Xinxue Liu, Andrew J. Pollard, K. Zaman, Deok Ryun Kim, Samuel Kariuki, Firdausi Qadri, John D. Clemens

“…Plasma IgG anti-Vi antibodies were measured using a standard enzyme-linked immunosorbent assay in random serosurveys of a population that had not previously received typhoid vaccination. …”
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Clinicopathological Significance of FOXO4 Expression and Correlation with Prx1 in Head and Neck Squamous Cell Carcinoma by Yunping Lu, Yajun Shen, Lingyu Li, Min Zhang, Min Wang, Lihua Ge, Jing Yang, Xiaofei Tang

“…FOXO4 protein expression was observed via immunohistochemistry (IHC) and the binding of Prx1 to FOXO4 measured by Duolink analysis in a 4-nitro-quinoline-1-oxide- (4NQO-) induced tongue carcinogenesis model in Prx1+/+ and Prx1+/− mice. …”
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A Randomized Trial of Insulin Glargine plus Oral Hypoglycemic Agents versus Continuous Subcutaneous Insulin Infusion to Treat Newly Diagnosed Type 2 Diabetes by Shuo Lin, Mu Chen, Wanling Chen, Keyi Lin, Panwei Mu, Bilian Zhu, Wen Xu, Manman Wang, Jianping Weng, Longyi Zeng

“…Newly diagnosed hospitalized patients with type 2 diabetes and fasting plasma glucose (FPG) ≥11.1 mmol/L or glycated hemoglobin (HbA1c) ≥9% (75 mmol/mol) were randomized to CSII or insulin glargine in combination with metformin and gliclazide. The primary outcome measure was the mean amplitude of glycemic excursions (MAGE), and secondary endpoints included time to reach glycemic control target (FPG < 7 mmol/L and 2-hour postprandial plasma glucose < 10 mmol/L), markers of β-cell function, and hypoglycemia. …”
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Inflammatory markers link triglyceride-glucose index and obesity indicators with adverse cardiovascular events in patients with hypertension: insights from three cohorts by Yanqiu Huang, Yi Zhou, Yadan Xu, Xiaoyu Wang, Ziyi Zhou, Kang Wu, Qiqi Meng, Liao Wang, Yang Yang, Hong Gao, Juan Ji, Xu Jiang, Yang Yang, Lipeng Hao, Hui Wang

“…Mediation analysis explored the mediating role of inflammatory markers in the above relationships. Results Five measures of insulin resistance were linked to CVD and related death in a U-shaped pattern, with the highest group having different risk increases. …”
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