Early Changes in Tumor Perfusion from T1-Weighted Dynamic Contrast-Enhanced MRI following Neural Stem Cell-Mediated Therapy of Recurrent High-Grade Glioma Correlate with Overall Su... by Prativa Sahoo, Paul Frankel, Julie Ressler, Margarita Gutova, Alexander J. Annala, Behnam Badie, Jana Portnow, Karen S. Aboody, Massimo D’Apuzzo, Russell C. Rockne

“…The contrast-enhancing (CE) volume was measured from the last dynamic phase acquired in the DCE sequence. …”
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Application of humanistic care for patients with abdominal aortic aneurysm (人文关怀护理在腹主动脉瘤患者中的应用) by WANG Qianqian (王倩倩), QI Jiaxin (齐加新), JIANG Zhenzhen (蒋真真)

“…The hospitalization satisfaction was evaluated by self-made questionnaire, and emotional state of were measured by Self-rating Anxiety Scale ( SAS ) and Self-rating Depression Scale ( SDS ). …”
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Population Pharmacokinetics of Pegcetacoplan in Patients with Geographic Atrophy or Neovascular Age-related Macular Degeneration by Ryan L. Crass, PharmD, Komal Prem, MD, Francois Gauderault, PhD, Ramiro Ribeiro, MD, PhD, Caroline R. Baumal, MD, Brandon Smith, PhD, Daniel Epling, PhD, Sunny Chapel, PhD

“…Predicted PK parameters and exposure metrics were generated via simulation in serum and vitreous humor. Main Outcome Measures: Pharmacokinetic parameters. Results: Intravitreal pegcetacoplan displayed absorption-limited (i.e., “flip-flop”) kinetics with median empirical Bayes estimated pegcetacoplan absorption and elimination half-lives of 13.1 days and 4.51 days, respectively. …”
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HIV-1 resistance mutations and genetic diversity among children failing antiretroviral treatment in five healthcare facilities in Benin, West Africa. by Edwige Hermione Dagba Gbessin, Edmond Tchiakpe, René Kpemahouton Keke, Nicole Vidal, Michel Kiréopori Gomgnimbou, Haziz Sina, Euloge Senan Adjou, Aldric Afangnihoun, Moussa Bachabi, Akadiri Yessoufou, Abdoul-Salam Ouedraogo, Lamine Baba-Moussa

“…<h4>Methods</h4>A cross-sectional study was carried out from November 20, 2020, to November 30, 2022, in children under 15 years of age who failed ongoing antiretroviral treatment at five facilities care in Benin (VL > 3log10 on two consecutive realizations three months apart). Viral loads were measured using the m2000 RealTime Abbott platform. …”
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Association between daily sitting time and sarcopenia in the US population: a cross-sectional study by Alei Zhang, Yanlei Li, Jinlei Zhou, Yuan Zhang, Shanggao Xie, Haiyu Shao, Tingxiao Zhao, Tao Tang

“…Daily sitting time was assessed through questionnaires, while sarcopenia was measured using body mass index (BMI) adjusted appendicular skeletal muscle mass (ASM). …”
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Effect of Aerobic Exercise on Blood Glucose Among Those with Prediabetes: A Systematic Review and Meta-Analysis by Tianyi Jiang, Zichen Ye, Qu Lu, Peixia Cheng, Qi Gao

“…Five databases, including PubMed, Embase, the Cochrane Library, Web of Science, and CINAHL, were searched up to September 2024 to identify randomized controlled trials measuring the effect of aerobic exercise on blood glucose levels among individuals with prediabetes. …”
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Exploring the Prevalence and Components of Metabolic Syndrome in Sub-Saharan African Type 2 Diabetes Mellitus Patients: A Systematic Review and Meta-Analysis by Nelson Musilanga, Hussein Nasib, Given Jackson, Frank Shayo, Clarkson Nhanga, Saleh Girukwigomba, Ambokile Mwakibolwa, Samson Henry, Keneth Kijusya, Edgar Msonge

“…Therefore, it is essential to promote lifestyle modifications, such as regular exercise and balanced diets, prioritize routine obesity screenings, and implement early interventions and robust public health measures to mitigate the risks associated with central obesity.…”
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Sequence-structure based prediction of pathogenicity for amino acid substitutions in proteins associated with primary immunodeficiencies by Ekaterina S. Porfireva, Anton D. Zadorozhny, Anastasia V. Rudik, Dmitry A. Filimonov, Alexey A. Lagunin, Alexey A. Lagunin

“…The best SSPR models demonstrated high accuracy, with an average ROC AUC of 0.831 ± 0.037, a Balanced accuracy of (0.763 ± 0.034), MCC (0.457 ± 0.06), and F-measure (0.623 ± 0.07) across all genes, outperforming the most popular bioinformatics tools.ConclusionsThe best created SSPR models for the prediction of pathogenicity of amino acid substitutions related with PIDs have been implemented in a freely available web application SAV-Pred (Single Amino acid Variants Predictor, http://www.way2drug.com/SAV-Pred/), which may be a useful tool for medical geneticists and clinicians. …”
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Incidence of acute lower respiratory tract disease hospitalisations, including pneumonia, among adults in Bristol, UK, 2019, estimated using both a prospective and retrospective me... by Jo Southern, Adam Finn, Catherine Hyams, James Campling, Bradford D Gessner, Elizabeth Begier, Maria Garcia Gonzalez, Sharon Gray, Jennifer Oliver

“…Retrospective review: 7727 adult admissions.Primary and secondary outcome measures The incidence of aLRTD and its subsets in the adult population of Southmead Hospital, Bristol UK.Results Based on ICD-10 code analysis, annual incidences per 100 000 population were: aLRTD, 1901; pneumonia, 591; LRTI, 739; heart failure, 402. aLRTD incidence was highest among those ≥65 years: 65–74 (3684 per 100 000 adults), 75–84 (6962 per 100 000 adults) and ≥85 (11 430 per 100 000 adults). …”
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Kajian Perencanaan Strategis Sistem Informasi pada Bisnis Ritel Berbasis Metodologi Ward & Peppard : Studi Kasus PT. Gramedia Asri Media by Christina Deni Rumiarti, Bagas Ryant Setiawan, I Dewa Made Pranata Wiana

“…This situation encourages the need of measurable planning to achieve the company's vision and mission. …”
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Clinical outcome analysis for surgical fixation versus conservative treatment on rib fractures: a systematic evaluation and meta-analysis by Penglong Zhao, Qiyue Ge, Haotian Zheng, Jing Luo, Xiaobin Song, Liwen Hu

“…The Cochrane Collaboration Risk of Bias 2 (RoB 2) and the Newcastle–Ottawa Scale (NOS) tool were employed to assess methodological quality, and relative risks (RR) with 95% confidence intervals (CI) were calculated to evaluate the outcome measures. The primary outcome was all-cause mortality, while the secondary outcomes included hospital length of stay (HLOS), ICU length of stay (ILOS), duration of mechanical ventilation (DMV), and the incidence of pneumonia. …”
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Carbapenem-resistant Enterobacterales (CRE) colonisation as a predictor for subsequent CRE infection: A retrospective surveillance study by Courtney M. Tubb, Marco Tubb, Jonathan Hooijer, Rispah Chomba, Jeremy Nel

“…Given the association between CRE colonisation and subsequent infection, urgent measures are required to reduce CRE colonisation rates. …”
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Network meta-analysis of cadmium toxicity against Chlorella vulgaris and the role of growth stimulants and macronutrients by M. Iqhrammullah, S. Saudah, M. Monalisa, F. Fahrurrozi, S.A. Akbar, S.S. Lubis

“…The collected data were then subjected to Bayesian frequentist network meta-analysis, utilizing standardized mean difference and a 95 percent confidence interval as measures of effect size. Additionally, a linear regression analysis was performed to examine the dose-dependent impact of cadmium toxicity.FINDINGS: Dose-dependent toxic effects of cadmium on Chlorella vulgaris were evident (R-square of more than 0.90), particularly at a concentration of 1 part per million, deemed as the maximum tolerable threshold. …”
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Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study by Daniel Kpodji Awaitey, Elliot Elikplim Akorsu, Emmanuel Allote Allotey, David Annor Kwasie, Precious Kwablah Kwadzokpui, Philip Apraku Tawiah, Stephen Adomako Amankwah, Albert Abaka-Yawson

“…The high incidence of hemoglobin AS implies the possibility of having an increased population of individuals with sickle cell disease in future if measures are not put in place to improve screening, counseling, and education of the public about the health threat SCD poses.…”
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Knowledge, attitude and practice regarding screening and managing diabetic microvascular complications among general practitioners of community health centres: a cross-sectional st... by Hua Yang, Jian Gao, Ying Yu, Cuiling Huang, Chengdian Lan, Zhangyan Chen

“…Objective To evaluate the knowledge, attitude and practice (KAP) regarding screening and managing diabetic microvascular complications, encompassing diabetic retinopathy (DR), diabetic kidney disease (DKD) and diabetic neuropathy (DN), among general practitioners (GPs).Design Cross-sectional study.Setting The online questionnaire survey was conducted between April and July 2023.Participants GPs from community health centres (CHCs) in all 16 districts of Shanghai were recruited.Primary and secondary outcome measures The data of sociodemographic characteristics, KAP scales, training experience and screening instruments for community screening and managing diabetic microvascular complications were collected. …”
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Assessment of choroidal vessels in healthy eyes using 3-dimensional vascular maps and a semi-automated deep learning approach by Nicola Valsecchi, Elham Sadeghi, Elli Davis, Mohammed Nasar Ibrahim, Nasiq Hasan, Sandeep Chandra Bollepalli, Sumit Randhir Singh, Luigi Fontana, Jose Alain Sahel, Kiran Kumar Vupparaboina, Jay Chhablani

“…The three vessels for each sector were measured, to obtain the mean choroidal vessel diameter (MChVD). …”
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Comparison of Effect Sevoflurane-Based Anesthesia and Propofol-Based Anesthesia on the Early Postoperative Renal Function of Living Kidney Transplant Donors: A Randomized Controlle... by Cai J, Kang F, Han M, Huang X, Yan W, Wan F, Li J

“…Kidney injury marker-1 (KIM-1), interleukin-18 (IL-18) and tissue inhibitor of metalloproteinase-2 (TIMP-2) were measured by enzyme-linked immunosorbent assay. Record the cystatin C, glomerular filtration rate, urine output during perioperative period.Results: There were both increases in biomarkers of kidney injury before and 1, 2 and 6 days after the anaesthetic surgery in donors, However, no statistical differences in KIM-1 (P (0.42 pg/mL (95% CI 0.21 to 0.63 pg/mL)) vs S (0.26 pg/mL (95% CI 0.02 to 0.49 pg/mL)), − 0.16 pg/mL (95% CI − 0.48 to 0.16 pg/mL)), IL-18 (P (178.54 pg/mL (95% CI 110.15 to 24693 pg/mL)) vs S (175.86 pg/mL (95% CI 100.35 to 251.38 pg/mL)), − 2.68 pg/mL (95% CI − 105.61 to 100.25 pg/mL)), and TIMP-2 (P (12.88 ng/mL (95% CI 8.69 to 17.07 ng/mL)) vs S (14.85 ng/mL (95% CI 10.23 to 19.46 ng/mL)), 1.97 ng/mL (95% CI − 4.30 to 8.23 ng/mL)) concentration changes between the two types of anaesthesia.Conclusion: There was no difference between sevoflurane and propofol anaesthesia on postoperative changes in biomarkers of renal injury in living kidney transplant donors.Keywords: general anesthetics, sevoflurane, propofol, renal transplantation…”
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Unanchored simulated treatment comparison on survival outcomes using parametric and Royston-Parmar models with application to lenvatinib plus pembrolizumab in renal cell carcinoma by Christopher G. Fawsitt, Janice Pan, Philip Orishaba, Christopher H. Jackson, Howard Thom

“…Treatment effects were measured using difference in restricted mean survival time (RMST), over shortest follow-up of input trials, and hazard ratios at 6, 12, 18, and 24 months. …”
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Pairing regression and configurational analysis in health services research: modelling outcomes in an observational cohort using a split-sample design by Jason J Sico, Laura J Myers, Dawn M Bravata, Ying Zhang, Anthony J Perkins, Edward J Miech, Joanne Daggy

“…Background Configurational methods are increasingly being used in health services research.Objectives To use configurational analysis and logistic regression within a single data set to compare results from the two methods.Design Secondary analysis of an observational cohort; a split-sample design involved randomly dividing patients into training and validation samples.Participants and setting Patients who had a transient ischaemic attack (TIA) in US Department of Veterans Affairs hospitals.Measures The patient outcome was the combined endpoint of all-cause mortality or recurrent ischaemic stroke within 1 year post-TIA. …”
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Comparative Results of “Epi-Off” Conventional versus “Epi-Off” Accelerated Cross-Linking Procedure at 5-year Follow-Up by Cristina Ariadna Nicula, Dorin Nicula, Anca Maria Rednik, Adriana Elena Bulboacă

“…Main outcomes comprised refraction, keratometry measurements, uncorrected (UCVA) and best-corrected visual acuity (BCVA), and topographical indices. …”
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