Preliminary investigation on the establishment of a new meibomian gland obstruction model and gene expression by Ming Sun, Huanmin Cheng, Zheng Yang, Jiangqin Tang, Shengshu Sun, Zhanglin Liu, Shaozhen Zhao, Lijie Dong, Yue Huang

“…The tear production of rats was measured by phenol red cotton thread, the tear film breakup time and corneal fluorescein staining scores of rats were detected under cobalt blue light of slit lamp. …”
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Quantitative Physiologic MRI Combined with Feature Engineering for Developing Machine Learning-Based Prediction Models to Distinguish Glioblastomas from Single Brain Metastases by Seyyed Ali Hosseini, Stijn Servaes, Brandon Hall, Sourav Bhaduri, Archith Rajan, Pedro Rosa-Neto, Steven Brem, Laurie A. Loevner, Suyash Mohan, Sanjeev Chawla

“…Median values of mean diffusivity (MD), fractional anisotropy, linear, planar and spheric anisotropic coefficients, and relative cerebral blood volume (rCBV) and maximum rCBV values were measured from CERs and immediate peritumor regions. …”
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Qinggan Yipi capsule ameliorates hepatic fibrosis in rats by down-regulating the TGF-β1/Smad2/3 signaling pathway and improving gut microbiota imbalance by Wenjing Xue, Haiqing Liu, Ziheng Su, Siqi Wang, Junping Cheng, Yunzhi Pan, Lurong Zhang

“…The composition of the gut microbiota was analyzed using 16S rRNA gene sequencing.ResultsHistopathological analysis, serum biochemical tests, and ELISA measurements showed that QgYp effectively decreased the levels of ALT, AST, HA, LN, PCIII, and IV-C while improving collagen deposition and hepatocyte necrosis. …”
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Spatiotemporal distribution patterns of cephalopods and their responses to changes in the marine environment in the coastal waters of Zhejiang, China by Jun Liang, Jun Liang, Yongdong Zhou, Yongdong Zhou, Tian Wu, Feng Chen, Feng Chen, Kaida Xu, Kaida Xu, Guangjie Fang, Yazhou Zhang, Yazhou Zhang

“…Thus, exploring the spatial and seasonal variations in cephalopod distribution and their associations with environmental factors is important for elucidating cephalopod diversity and the distribution of cephalopods under changing environmental conditions and for developing reasonable resource management and conservation measures.MethodsOn the basis of trawl survey data from 123 stations in the coastal waters of Zhejiang, China, in the spring and autumn of 2021, the relationships among the cephalopod species composition and diversity characteristics and the spatial and seasonal changes and environmental factors were investigated via the relative importance index (IRI), the alpha diversity index, and the GAM.ResultsThe results revealed that the cephalopods in the coastal waters of Zhejiang belonged to three orders, six families, and 10 genera and that the dominant species were gradually replaced by species of minor economic importance and endemic small-scale fishery species. …”
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CEERS: Increasing Scatter along the Star-forming Main Sequence Indicates Early Galaxies Form in Bursts by Justin W. Cole, Casey Papovich, Steven L. Finkelstein, Micaela B. Bagley, Mark Dickinson, Kartheik G. Iyer, L. Y. Aaron Yung, Laure Ciesla, Ricardo O. Amorín, Pablo Arrabal Haro, Rachana Bhatawdekar, Antonello Calabrò, Nikko J. Cleri, Alexander de la Vega, Avishai Dekel, Ryan Endsley, Eric Gawiser, Mauro Giavalisco, Nimish P. Hathi, Michaela Hirschmann, Benne W. Holwerda, Jeyhan S. Kartaltepe, Anton M. Koekemoer, Ray A. Lucas, Sara Mascia, Bahram Mobasher, Pablo G. Pérez-González, Giulia Rodighiero, Kaila Ronayne, Sandro Tacchella, Benjamin J. Weiner, Stephen M. Wilkins

“…We consider SFRs averaged from the SFHs over 10 Myr (SFR _10 ) and 100 Myr (SFR _100 ), where the photometry probes SFRs on these timescales, effectively tracing nebular emission lines in the rest-optical (on  ~10 Myr timescales) and the UV/optical continuum (on  ~100 Myr timescales). We measure the slope, normalization and intrinsic scatter of the SFR– M _* relation, taking into account the uncertainty and the covariance of galaxy SFRs and M _* . …”
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Association of blood inflammatory phenotypes and asthma burden in children with moderate-to-severe asthma by Amir Hossein Alizadeh Bahmani, Susanne J.H. Vijverberg, Simone Hashimoto, Christine Wolff, Catarina Almqvist, Lizan D. Bloemsma, Susanne Brandstetter, Paula Corcuera-Elosegui, Mario Gorenjak, Susanne Harner, Anna M. Hedman, Michael Kabesch, Leyre López-Fernández, Aletta D. Kraneveld, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Barbara S. Dierdorp, Tamara Dekker, Nariman K.A. Metwally, Jan Willem Duitman, René Lutter, Paul Brinkman, Mahmoud I. Abdel-Aziz, Anke H. Maitland-van der Zee

“…Methods Blood inflammatory parameters (eosinophil and neutrophil counts and inflammatory mediators using multiplex immunoassay technology) were measured in children (6–17 years) with moderate-to-severe asthma from the SysPharmPediA cohort across four European countries. …”
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Impact of warning pictorials and size on perceived effectiveness of cigar warning labels in a nationally representative between-subjects experiment by James F Thrasher, Tara L Queen, Jennifer Cornacchione Ross, Sarah D Kowitt, Leah M Ranney, Adam O Goldstein, Chineme Enyioha, Desmond Jenson, Paschal Sheeran, Sonia A Clark, Kristen L Jarman, Michelle Z Yang

“…Reactance to the labels was also measured. Data were analysed with mixed-effects models.Results Pictorial+text cigarillo HWLs were deemed more effective than text-only HWLs in PWE (b=0.34, SE=0.08, p<0.001), self-reported learning (b=0.20, SE=0.08, p=0.01), thinking about risks (b=0.18, SE=0.08, p=0.03) and new knowledge (b=0.34, SE=0.12, p<0.01). …”
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Pre-eclampsia as a predictor of early-onset cardiovascular impairment among young women (PREECARDIA study): protocol for a prospective cohort study by Albertino Damasceno, Amabelia Rodrigues, Nuno Lunet, Ruben Turé, Eunice Barai, Almame Cissé, Gabriel Sanca, Tida Iafa, Waldir Jalo, Bubacar Embalo, Marcos Dju, Vasco Iala

“…At each follow-up assessment, the women will have their blood pressure measured with a digital sphygmomanometer and a 24-hour ambulatory blood pressure monitor. …”
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Intranigral Administration of β-Sitosterol-β-D-Glucoside Elicits Neurotoxic A1 Astrocyte Reactivity and Chronic Neuroinflammation in the Rat Substantia Nigra by Claudia Luna-Herrera, Irma A. Martínez-Dávila, Luis O. Soto-Rojas, Yazmin M. Flores-Martinez, Manuel A. Fernandez-Parrilla, Jose Ayala-Davila, Bertha A. León-Chavez, Guadalupe Soto-Rodriguez, Victor M. Blanco-Alvarez, Francisco E. Lopez-Salas, Maria E. Gutierrez-Castillo, Bismark Gatica-Garcia, America Padilla-Viveros, Cecilia Bañuelos, David Reyes-Corona, Armando J. Espadas-Alvarez, Linda Garcés-Ramírez, Oriana Hidalgo-Alegria, Fidel De La Cruz-lópez, Daniel Martinez-Fong

“…We injected 6 μg BSSG/1 μL DMSO or vehicle into the left substantia nigra and immunostained with antibodies against tyrosine hydroxylase (TH) together with markers of microglia (OX42), astrocytes (GFAP, S100β, C3), and leukocytes (CD45). We also measured nitric oxide (NO), lipid peroxidation (LPX), and proinflammatory cytokines (TNF-α, IL-1β, IL-6). …”
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Clinical implementation of next-generation sequencing testing and genomically-matched therapy: a real-world data in a tertiary hospital by Jin Won Kim, Hee Young Na, Sejoon Lee, Ji-Won Kim, Koung Jin Suh, Se Hyun Kim, Yu Jung Kim, Keun-Wook Lee, Jong Seok Lee, Jaihwan Kim, Jin-Hyeok Hwang, Kihwan Hwang, Chae-Yong Kim, Yong Beom Kim, Soomin Ahn, Kyu Sang Lee, Hyojin Kim, Hye Seung Lee, So Yeon Park, Gheeyoung Choe, Jee Hyun Kim, Jin-Haeng Chung

“…Of 32 patients with measurable lesions who received NGS-based therapy, 12 (37.5%) achieved a partial response, and 11 (34.4%) achieved stable disease. …”
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Impact of Extended Membrane Rupture on Neonatal Inflammatory Responses and Composite Neonatal Outcomes in Early-Preterm Neonates—A Prospective Study by Maura-Adelina Hincu, Liliana Gheorghe, Luminita Paduraru, Daniela-Cristina Dimitriu, Anamaria Harabor, Ingrid-Andrada Vasilache, Iustina Solomon-Condriuc, Alexandru Carauleanu, Ioana Sadiye Scripcariu, Dragos Nemescu

“…This prospective study aimed to measure neonates’ inflammatory markers in the first 72 h of life based on ROM duration. …”
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Understanding social behaviours across neurodiverse young people: roles of social cognition and self-regulation by Iciar Iturmendi-Sabater, Evdokia Anagnostou, Marc A. Fournier, Jennifer Crosbie, Russell Schachar, Robert Nicolson, Stelios Georgiadis, Elizabeth Kelley, Jessica Jones, Jessica Brian, Hsiang-Yuan Lin, Meng-Chuan Lai

“…Social behaviours and dysregulation were measured by the caregiver-reported Adaptive Behavior Assessment System Social domain and Child Behavior Checklist Dysregulation Profile, respectively. …”
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Shatavari supplementation during eight weeks of resistance training increases training load, enhances skeletal muscle contractility and alters the skeletal muscle proteome in older... by Elsa Greed, Elsa Greed, Jack Pritchard, Lauren Struszczak, Esra Bozbaş, Georgia Ek, Jordan Acheson, Jordan Acheson, Ben Winney, Aaliyah Qadir, Karl Ka-Lam Wong, Joanna Bowtell, Mary O’Leary

“…Pre and post training, measures of leg strength, neuromuscular function and vastus lateralis (VL) biopsies were obtained. …”
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A preliminary study on the reference intervals of vitamin K in some areas of Beijing with normal physical examination population by Lin Chen, Meiqi Chen, Shi Cheng, Jiaxin Fei, Dan Xu, Xueyun Hou, Nannan Li, Yuliang Yuan, Guijian Liu, Cheng An

“…Serum VK1, MK4, and MK7 were firstly measured by high-performance liquid chromatography and mass spectrometry in 434 subjects. …”
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Multienvironment Evaluation of Tannin-Free Photoperiod-Insensitive Sorghum (Sorghum bicolor (L) Moench) for Yield and Resistance to Grain Mold in Senegal by Cyril Diatta, Mame P. Sarr, Thierry Klanvi Tovignan, Ousmane Aidara, Daniel Kwadjo Dzidzienyo, Elisabeth Diatta-Holgate, Jacques Martin Faye, Eric Yirenkyi Danquah, Samuel Kwame Offei, Ndiaga Cisse

“…The results of this study showed strong genetic variability among studied genotypes for all measured traits. The highly significant G × E interaction effects for grain yield and panicle grain mold rating score (PGMR) indicated that both traits are influenced by genetics and to some extent by environment. …”
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Rapid antigen testing by community health workers for detection of SARS-CoV-2 in Dhaka, Bangladesh: a cross-sectional study by Mahbubur Rahman, Ayesha Sania, Seonjoo Lee, Tahmina Shirin, A S M Alamgir, Yael K Rayport, Ahmed Nawsher Alam, Joanna Andrecka, Eric Brum, Fergus Chadwick, Tasnuva Chowdhury, Zakiul Hasan, Davina L Hill, Farzana Khan, Mikolaj Kundegorski, Motahara Tasneem, Katie Hampson

“…Household testing by community health workers in low-resource settings is an inexpensive approach that can increase testing capacity, accessibility and the effectiveness of control measures through immediately actionable results.…”
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Effects of myo-inositol supplementation in the diet on myo-inositol concentrations in the intestine, blood, eggs, and excreta of laying hens by Vera Sommerfeld, Anna Hanauska, Korinna Huber, Jörn Bennewitz, Amélia Camarinha-Silva, Martina Feger, Michael Föller, Michael Oster, Siriluck Ponsuksili, Sonja Schmucker, Jana Seifert, Volker Stefanski, Klaus Wimmers, Markus Rodehutscord

“…Regression analysis indicated that, on average, 84% of supplemented MI was retained in the body or metabolized and excreted in a different form. Based on the measured MI concentrations in the blood and eggs, dietary MI was not completely absorbed in the small intestine and, to a different extent, in the two laying hen strains. …”
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Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure by Jing Ye, Zhen Wang, Di Ye, Yuan Wang, Menglong Wang, Qingwei Ji, Ying Huang, Ling Liu, Ying Shi, Lei Shi, Tao Zeng, Yao Xu, Jianfang Liu, Huimin Jiang, Yingzhong Lin, Jun Wan

“…The plasma concentrations of IL-11 were measured in 240 patients with chronic HF (CHF) and 80 control subjects without signs of significant heart disease. …”
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Feasibility study of a randomised controlled trial of preoperative and postoperative nutritional supplementation in major lung surgery by Amelia Swift, Sebastian T Lugg, Babu Naidu, Nikolaos Efstathiou, Amy Kerr, Hazem Fallouh, Maninder Kalkat, Richard Steyn, Salma Kadiri, Ehab Bishay, Krishna Kholia, Venessa Rogers

“…The two groups were well balanced and tools used to measure outcomes were robust. Compliance with nutritional drinks was 97% preoperatively and 89% postoperatively; 89% of the questionnaires at 3 months were returned fully completed. …”
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Indications for an antidepressive effect of thymosin alpha-1 in a small open-label proof of concept study in common variable immune deficiency patients with depression by Daniël G. Aynekulu Mersha, Sarah E. Fromme, Frank van Boven, Gara Arteaga-Henríquez, Annemarie Wijkhuijs, Marianne van der Ent, Raf Berghmans, Bernard T. Baune, Hemmo A. Drexhage, Virgil Dalm

“…At the start, at 8 weeks and 8 weeks after the last injection, the HDRS was recorded and blood samples drawn for measuring naïve and memory T cells, Th17 and Treg cells, hsCRP, IL-6 and IL-7. …”
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