Intermittent fasting boosts antitumor immunity by restricting CD11b+Ly6Clow Ly6Glow cell viability through glucose metabolism in murine breast tumor model by Chenghao Fu, Zhehao Liang, Zemiao Niu, Ning Chen, Yuemin Li, Zhenhua Liang, Yanwei Huo, Hao Xi, Rong Wang, Yonghuan Yan, Xiaoru Gano, Mengtian Wang, Yun Huang, Yan Zhang, Mingming Gao, Pin Lü

“…Interestingly, we observed that Ly6Glow G-MDSC sharply decreased after fasting treatment, and the cell surface markers and protein mass spectrometry data showed potential therapeutic targets. …”
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Effect of Body Weight Supported Treadmill Training on Motor Function of Rats with Spinal Cord Injury Based on AMPK-Autophagy Signaling Pathway by CAI Jili, ZHAI Chenyuan, WANG Zun, WU Qi, FANG Lu, WANG Yu, WANG Tong

“…From the 8th day after modeling, the exercise group received treadmill training with weight reduction of 20%-40% of the body mass, and the treadmill speed was set at 6 m a minute, 20 minutes a time, twice a day for 3 weeks. …”
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Effect of Tiaoxin Recipe on Memory Learning and Synaptic Plasticity in APP/PS1 Double Transgenic Alzheimer's Disease Mice based on αCaMKⅡ-CREB-BDNF Signal Pathway by Xiaowen WANG, Hong QIAN, Chunjuan SHEN, Yanjun LI, Haixin YUAN, Jian WANG

“…According to the conversion standard of equivalent dose between animal and human in pharmacological test, the drug dose was converted according to human equivalent dose (body mass:60 kg) in Donepezil group and Tiaoxin recipe group. …”
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Novel role of FTO in regulation of gut–brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure by Ruonan Chen, Xiaoqin Chai, Yunxiao Zhang, Tianxiu Zhou, Yinyin Xia, Xuejun Jiang, Bo Lv, Jun Zhang, Lixiao Zhou, Xin Tian, Ruonan Wang, Lejiao Mao, Feng Zhao, Hongyang Zhang, Jun Hu, Jingfu Qiu, Zhen Zou, Chengzhi Chen

“…Fat mass and obesity-associated protein (FTO) is the key demethylase that reverses the abnormally altered N6-methyladenosine (m6A) modification in eukaryotic cells under environmental pollutants exposure. …”
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NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner by Tiange Lu, Juan Yang, Yiqing Cai, Mengfei Ding, Zhuoya Yu, Xiaosheng Fang, Xiangxiang Zhou, Xin Wang

“…Chromosome spreads, co-immunoprecipitation (co-IP), mass spectrometry (MS), and chromatin immunoprecipitation (ChIP) assays were conducted to untangle the role and mechanism of NCAPD3 in DLBCL. …”
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Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology wit... by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Ultra-High Performance Liquid Chromatography with Quadrupole Time-of-Flight Mass Spectrometry (UPLC-Q-TOF-MS) was used in conjunction with network pharmacology and molecular docking to identify and predict SHSY’s active chemical components and targets. …”
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Effectiveness of ertugliflozin during Ramadan fasting in patients with type 2 diabetes mellitus: a real-world study (ErtuRamadan study) by Md Faruque Pathan, Nazma Akter, Marufa Mustari, M. Saifuddin, Mirza Sharifuzzaman, Mohammad Motiur Rahman, Mohammed Ripon, S. M. Mohiuddin, A. B. M. Kamrul-Hasan, Mohammad Abdul Hannan, Muhammad Shah Alam, Samira Mahjabeen, Faria Afsana, Muhammed Abu Bakar, Tahniyah Haq, Afsar Ahammed, Samir Kumar Talukder, Sourav Sarkar, Shahjada Selim

“…The primary endpoints were changes in HbA1c levels, body weight, body mass index (BMI), and the incidence of hypoglycemia during Ramadan fasting.ResultsThe mean age of the study participants was 50.37 ± 11.14 (SD) years, with 40.6% male and 58.7% female. …”
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Golgi-restored vesicular replenishment retards bone aging and empowers aging bone regeneration by Peisheng Liu, Hao Guo, Xiaoyao Huang, Anqi Liu, Ting Zhu, Chenxi Zheng, Fei Fu, Kaichao Zhang, Shijie Li, Xinyan Luo, Jiongyi Tian, Yan Jin, Kun Xuan, Bingdong Sui

“…Importantly, in vivo administration of CA-EVs significantly enhanced the bone defect repair rate and improved bone mass in aging mice, suggesting their therapeutic value for treating age-related osteoporosis and promoting bone regeneration. …”
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Wild grasses as the reservoirs of infection of rust species for winter soft wheat in the Northern CaucasusWild grasses as the reservoirs of infection of rust species for winter sof... by E. I. Gultyaeva, L. A. Bespalova, I. B. Ablova, E. L. Shaydayuk, Zh. N. Khudokormova, D. R. Yakovleva, Yu. A. Titova

“…Only in some years with favorable weather conditions its mass development is noted on susceptible cultivars. …”
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The Impact of Ageing on Diaphragm Function and Maximal Inspiratory Pressure: A Cross-Sectional Ultrasound Study by Toru Yamada, Taro Minami, Takahiro Shinohara, Shuji Ouchi, Suguru Mabuchi, Shunpei Yoshino, Ken Emoto, Kazuharu Nakagawa, Kanako Yoshimi, Mitsuko Saito, Ayane Horike, Kenji Toyoshima, Yoshiaki Tamura, Atsushi Araki, Ryoichi Hanazawa, Akihiro Hirakawa, Takeshi Ishida, Takuma Kimura, Haruka Tohara, Masayoshi Hashimoto

“…Multivariate linear regression analysis adjusted for sex, height, body mass index, and underlying diseases showed positive associations between age and diaphragm thickness (<i>p</i> = 0.001), but not with TF or DE. …”
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Associations between social networks, messaging apps, addictive behaviors, and sleep problems in adolescents: the EHDLA study by María Navalón-González, José Adrián Montenegro-Espinosa, Héctor Gutiérrez-Espinoza, Jorge Olivares-Arancibia, Rodrigo Yañéz-Sepúlveda, Daniel Duclos-Bastías, Daniel Duclos-Bastías, Miriam Garrido-Miguel, Miriam Garrido-Miguel, Miriam Garrido-Miguel, Arthur Eumann Mesas, José Francisco López-Gil, Estela Jiménez-López, Estela Jiménez-López

“…These analyses were adjusted for age, sex, body mass index, socioeconomic level, physical activity, sedentary behavior, and adherence to the Mediterranean diet.ResultsHigher SN use was related to greater presence of sleep-related problems [prevalence ratio (PR) = 1.04; 95% confidence interval (CI) 1.01–1.07; p = 0.015]. …”
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A comparative analysis of autograft choices of anterior cruciate ligament reconstruction and their effects on muscle strength and joint biomechanics by Wiem Issaoui, Wiem Issaoui, Ismail Dergaa, Ismail Dergaa, Ismail Dergaa, Hatem Ghouili, Abdelfatteh El Omri, Noomen Guelmami, Philippe Chomier, Mourad Ghrairi, Helmi Ben Saad, Helmi Ben Saad, Helmi Ben Saad, Wassim Moalla, Wassim Moalla

“…In this study, the effects of four autografts are investigated: Iliotibial band (ITB), combined ITB and hamstring tendon (ITB + HT), hamstring tendon (HT) and bone-tendon-bone (BTB) on quadriceps and hamstring peak torque (QPT and HPT) recovery and hamstring to quadriceps ratio (H:Q) to assess knee stability and function.MethodsForty-two active males (mean ± standard deviation of age: 31.5 ± 6.1 years, height: 177 ± 6 cm, weight: 76 ± 11 kg, body mass index: 24.5 ± 2.2 kg/m²) with primary ACL ruptures were allocated to the four graft groups (ITB: n = 16, ITB + HT: n = 12, HT: n = 7, BTB: n = 7) and underwent a standardized rehabilitation protocol. …”
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Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis by Sandra M Herrmann, Riley Fadden, Ryan J Sullivan, Kerry L Reynolds, Harish Seethapathy, Meghan E Sise, Shruti Gupta, Alexandra-Chloe Villani, Qiyu Wang, Daiana Moreno, Destiny Harden, R Neal Smith, Ivy A Rosales, Robert B Colvin, Sarah Chute, Lynn D Cornell, Nancy J Yang, Sara Barmettler, Sophia Wells, Jocelyn Farmer

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Gut bacteria Prevotellaceae related lithocholic acid metabolism promotes colonic inflammation by Liping Chen, Zhenghao Ye, Junhua Li, Lijia Wang, Yu Chen, Meiping Yu, Jian Han, Jiangeng Huang, Dongyan Li, Yongling Lv, Kai Xiong, De’an Tian, Jiazhi Liao, Ursula Seidler, Fang Xiao

“…Methods Bile acids in fecal samples from patients with IBD and DSS-induced colitis mice, with and without antibiotic treatment, were analyzed using ultraperformance liquid chromatography-mass spectrometry (UPLC-MS). The composition of the microbiota in fecal samples from IBD patients and DSS-colitis mice was characterized via Illumina MiSeq sequencing of the bacterial 16S rRNA gene V3-V4 region. …”
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Lentivirus‐mediated gene therapy for Fabry disease: 5‐year End‐of‐Study results from the Canadian FACTs trial by Aneal Khan, Dwayne L. Barber, William M. McKillop, C. Anthony Rupar, Christiane Auray‐Blais, Graeme Fraser, Daniel H. Fowler, Alexandra Berger, Ronan Foley, Armand Keating, Michael L. West, Jeffrey A. Medin

“…Globotriaosylceramide (Gb3) and lyso‐Gb3 levels in urine and plasma were assessed by mass spectrometry. qPCR assays measured vector copy number in PB leucocytes. …”
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Rare Occasions: Tidal Disruption Events Rarely Power the AGNs Observed in Dwarf Galaxies by Joanne Tan, Guang Yang, Jonelle L. Walsh, W. N. Brandt, Bin Luo, Franz E. Bauer, Chien-Ting Chen, Mouyuan Sun, Yongquan Xue

“…Based on the spectral energy distribution modeling with x-cigale , we select AGNs hosted by dwarf galaxies (stellar mass below 10 ^10 M _⊙ ). We focus on X-ray sources with full-band detections, leading to a sample of 78 AGNs (0.122 ≤ z ≤ 3.515). …”
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Prevalence and factors associated with severe fatigue 2 years into the COVID-19 pandemic: a cross-sectional population-based study in Geneva, Switzerland by Silvia Stringhini, Idris Guessous, C Martinez, A Flahault, S Hurst, N Vuilleumier, L Kaiser, K M Posfay-Barbe, O Zimmermann, S Stringhini, A Uppal, P Schaller, J Berthelot, D Pittet, H Baysson, Hélène Baysson, S Yerly, E Lorthe, Mayssam Nehme, Nick Pullen, María-Eugenia Zaballa, A Bal, Clément Romain Hugo Graindorge, Stephanie Schrempft, I Arm-Vernez, A S Azman, D Bachmann, J-F Balavoine, R P Barbe, A R Bouhet, G Bryand-Rumley, F Chappuis, P Collombet, S Coudurier-Boeuf, D S Courvoisier, C de Mestral, P D’ippolito, R Dubos, R Dumont, N El Merjani, N Francioli, C Graindorge, I Guessous, S Harnal, G Kathari, O Kherad, J Lamour, P Lescuyer, A G L’Huillier, A J Loizeau, S Mechoullam, L Metral-Boffod, M Nehme, N Noël, F Pennacchio, J Perez-Saez, G Poulain, C Pugin, N Pullen, V Richard, D Rochat, S Rouzinov, K Samir, H S Ramirez, E Satin, S Schrempft, C Semaani, S Testini, D Urrutia-Rivas, C Verolet, P Vetter, J Villers, G Violot, A Wisniak, M-E Zaballa

“…We assessed prevalence ratios of severe fatigue considering sociodemographic factors, health and behavioural characteristics (body mass index, depression, recent diagnosis of chronic disease or allergy, acute health event, smoking status, physical activity and sleep quality) and recent self-reported COVID-19 infections.Results A total of 4040 individuals participated (participation rate 59%, 58% were women, mean age 53.2 (SD=14.1 years)). …”
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Indoor, outdoor, and personal exposure to PM2.5 and associated health risk in community-dwelling elderly residents in Fuzhou city, 2021: a cross-sectional study by Shuling KANG, Xin LIN, Kan LIN, Baoying LIU, Chuancheng WU, Jianjun XIANG, Jingwen CHEN, Quan ZHOU

“…PM2.5 concentration was measured with the weighing method; polycyclic aromatic hydrocarbons (PAHs) and metal elemental components in collected PM2.5 were determined by ultra-high performance liquid chromatography and inductively coupled plasma mass spectrometry. The health risk associated with PAHs and metals in PM2.5 was assessed by using the health risk assessment model recommended by the United States Environmental Protection Agency. …”
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The First Large Identification of 3ANX and NX Producing Isolates of <i>Fusarium graminearum</i> in Manitoba, Western Canada by Maria Antonia Henriquez, Srinivas Sura, Sean Walkowiak, David Kaminski, Anne Kirk, Mark W. Sumarah, Parthasarathy Santhanam, Nina Kepeshchuk, Jules Carlson, E. RoTimi Ojo, Pam de Rocquigny, Holly Derksen

“…Mycotoxins were quantified in these samples using mass spectrometry. Using the same rice culture, genomic DNA was isolated, and the <i>Tri1</i> coding sequence along with its flanking regions (upstream and downstream of the <i>Tri1</i> gene) was amplified and sequenced. …”
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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…The genetic regulation of lipid species and their impact on cardiometabolic risk during early life remain unexplored. Methods: Using mass spectrometry-based lipidomics, we measured 227 plasma lipid species in 1149 children and adolescents (44.8% boys) with a median age of 11.2 years. …”
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