Photobiomodulation in ocular therapy: current status and future perspectives by Hasan Chichan, Iftkhar Hamzah Aldujaly, Konstantinos Michalakis, Levent Kanal

“…This review specifically targets the treatment of retinal diseases including age-related macular degeneration, diabetic macular edema, myopia and acute retinal light injury with photobiomodulation. …”
Get full text

Histological Characterization of the Dicer1 Mutant Zebrafish Retina by Saeed Akhtar, Sarita Rani Patnaik, Rakesh Kotapati Raghupathy, Turki M. Al-Mubrad, John A. Craft, Xinhua Shu

“…DICER1 was recently shown to have another function of silencing the toxicity of Alu RNAs in retinal pigment epithelium (RPE) cells, which are involved in the pathogenesis of age related macular degeneration. In this study, we characterized a Dicer1 mutant fish line, which carries a nonsense mutation (W1457Ter) induced by N-ethyl-N-nitrosourea mutagenesis. …”
Get full text

Pharmacotherapy for AMD: state-of-the-art by I.A. Koroleva, A.A. Gvetadze, T.B. Romanova

“…<p> <i>The article discusses the evolution of the treatment for a socially important disease, age-related macular degeneration (AMD). Data on earlier and recent treatment for “wet” AMD as well as promising trends in the development of novel medications are addressed.…”
Get full text

Sustained Intraocular Pressure Rise after the Treat and Extend Regimen at 3 Years: Aflibercept versus Ranibizumab by Alper Bilgic, Laurent Kodjikian, Jay Chhablani, Anand Sudhalkar, Megha Trivedi, Viraj Vasavada, Vaishali Vasavada, Shail Vasavada, Samaresh Srivastava, Deepak Bhojwani, Aditya Sudhalkar

“…Patients. 789 patients (1021 eyes; 602 males) enrolled in T&E using aflibercept/ranibizumab for diabetic macular edema (DME), wet age-related macular degeneration (AMD), or macular edema in retinal vein occlusion (RVO). …”
Get full text

Management of Uveitis-Related Choroidal Neovascularization: From the Pathogenesis to the Therapy by Enzo D’Ambrosio, Paolo Tortorella, Ludovico Iannetti

“…Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization. …”
Get full text

Examining the Choroid in Ocular Inflammation: A Focus on Enhanced Depth Imaging by Abeir Baltmr, Sue Lightman, Oren Tomkins-Netzer

“…The choroid is the vascular layer that supplies the outer retina and is involved in the pathogenesis of several ocular conditions including choroidal tumors, age related macular degeneration, central serous chorioretinopathy, diabetic retinopathy, and uveitis. …”
Get full text

Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization by Rodolfo Mastropasqua, Luca Di Antonio, Silvio Di Staso, Luca Agnifili, Angela Di Gregorio, Marco Ciancaglini, Leonardo Mastropasqua

“…Patients were affected with myopic CNV (2 eyes), age-related macular degeneration related (2), branch retinal vein occlusion (BRVO) (2), and branch retinal artery occlusion (BRAO) (1). …”
Get full text

Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

“…Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. …”
Get full text

Comparison of different decellularization methods for human anterior lens capsules by Jianfeng Yu, Pengfei Li, Kai Fan, Jiawei Luo, Huaijin Guan

“…Abstract Background Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. …”
Get full text

Alzheimer’s Disease as a Result of Stimulus Reduction in a GABA-A-Deficient Brain: A Neurocomputational Model by Mariana Antonia Aguiar-Furucho, Francisco Javier Ropero Peláez

“…Several research studies point to the fact that sensory and cognitive reductions like cataracts, deafness, macular degeneration, or even lack of activity after job retirement, precede the onset of Alzheimer’s disease. …”
Get full text

The endocannabinoid system and ophthalmic pathologies: a review of molecular mechanisms and its implications for clinical practice by Tomasz Charytoniuk, Stanisław Półjanowski, Mateusz Michalak, Karolina Kaźmierczak, Bartłomiej Kałużny

“…Furthermore, various research indicated the involvement of ECS in the molecular basis of various pathologies, mostly glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD). Therefore, the researchers believe that this biological system, its receptors, pathways, and ligands might be considered as an auxiliary compound to reduce the number of patients suffering from ophthalmic diseases. …”
Get full text

Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians by Pearse A. Keane, Srinivas R. Sadda

“…Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. …”
Get full text

"Energetics of the outer retina II: Calculation of a spatio-temporal energy budget in retinal pigment epithelium and photoreceptor cells based on quantification of cellular process... by Christina Kiel, Stella Prins, Alexander J E Foss, Philip J Luthert

“…Impaired energy metabolism combined with high demands are expected to cause energy insufficiencies that make the OR susceptible to complex blinding diseases such as age-related macular degeneration (AMD). Here, anatomical, physiological and quantitative molecular data were used to calculate the ATP expenditure of the main energy-consuming processes in three cell types of the OR for the night and two different periods during the day. …”
Get full text

Posterior Chamber Hemorrhage during Fluorescein Angiography by Manuel A. P. Vilela

“…A 76-year-old male was referred for angiographic control of age-related macular degeneration. He was pseudophakic OU, BCVA 20/40 OU. …”
Get full text

Anti-Vascular Endothelial Growth Factors as a Potential Risk for Implant Failure: A Clinical Report by Elham Emami, Pierre de Grandmont, Mélanie Menassa, Nicholas Audy, Robert Durand

“…This clinical report presents a rare case of implant failure in a patient who received intravitreal injections of a vascular endothelial growth factor (VEGF) inhibitor for the treatment of age-related macular degeneration. Following CARE guidelines, the report presents a case rehabilitated with a mandibular 2-implant overdenture using the immediate-loading protocol and standard procedures. …”
Get full text

Fundus Autofluorescence and Clinical Applications by Cameron Pole, Hossein Ameri

“…Emerging clinical evidence has demonstrated the usefulness of FAF in diagnosis and management of an increasing number of chorioretinal conditions, such as age-related macular degeneration, central serous chorioretinopathy, retinal drug toxicities, and inherited retinal degenerations such as retinitis pigmentosa and Stargardt disease. …”
Get full text

Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage. by Nehal Nailesh Mehta, Ines D Nagel, Akshay Agnihotri, Anna Heinke, Lingyun Cheng, Dirk-Uwe Bartsch, William R Freeman, Maria-Laura Gomez

“…<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.…”
Get full text

Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases by Maria H. Madeira, Raquel Boia, Paulo F. Santos, António F. Ambrósio, Ana R. Santiago

“…This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.…”
Get full text

Solitary vitreous cysts: a series of case reports by A.B. Galimova, I.V. Baranchikova, G.I. Garipova, I.R. Karachurina, R.Yu. Ziyazetdinova

“…In one case, bilateral vitreous cysts were identified in conjunction with agerelated macular degeneration. To the best of our knowledge, this represents the inaugural description of this association. …”
Get full text

Pooled Multicenter Safety Analysis of Lupin’s Intravitreal Biosimilar Ranibizumab (Ranieyes) in Chorioretinal Vascular Diseases by Debdulal Chakraborty, Tushar Kanti Sinha, Sourav Sinha, Aniruddha Maiti, Angshuman Mukherjee, Krishnendu Nandi, Sudipta Das, Saptorshi Majumdar, Dinesh Rungta, Ranabir Bhattacharya

“…Abstract Introduction This study aims to evaluate the ocular and systemic safety profiles of intravitreal biosimilar ranibizumab Ranieyes (Lupin Pharmaceuticals, Mumbai, India) in real-world clinical settings across multiple chorioretinal vascular diseases, including neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) in adults. …”
Get full text