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161
Topical Nonsteroidal Anti-Inflammatory Drugs for Macular Edema
Published 2013-01-01“…Hence, new therapeutic effects can be achieved, such as reduction of exudation secondary to age-related macular degeneration or diabetic maculopathy. We provide an updated review on the clinical use of NSAIDs for retinal diseases, with a focus on the potential future applications.…”
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162
Development of Anti-VEGF Therapies for Intraocular Use: A Guide for Clinicians
Published 2012-01-01“…Around this time, it also became clear that increased intraocular VEGF production was not limited to ischemic retinal diseases but was also a feature of choroidal vascular diseases such as neovascular age-related macular degeneration (AMD). Thus, a new therapeutic era emerged, utilizing VEGF blockade for the management of chorioretinal diseases characterized by vascular hyperpermeability and/or neovascularization. …”
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163
Significance of Hyperreflective Foci as an Optical Coherence Tomography Biomarker in Retinal Diseases: Characterization and Clinical Implications
Published 2021-01-01“…Despite this, HRF can be considered OCT biomarkers for disease progression, treatment response, and prognosis in several retinal diseases, including diabetic macular edema, age-related macular degeneration (AMD), retinal vascular occlusions, and inherited retinal dystrophies. …”
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164
"Energetics of the outer retina II: Calculation of a spatio-temporal energy budget in retinal pigment epithelium and photoreceptor cells based on quantification of cellular process...
Published 2025-01-01“…Impaired energy metabolism combined with high demands are expected to cause energy insufficiencies that make the OR susceptible to complex blinding diseases such as age-related macular degeneration (AMD). Here, anatomical, physiological and quantitative molecular data were used to calculate the ATP expenditure of the main energy-consuming processes in three cell types of the OR for the night and two different periods during the day. …”
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165
Posterior Chamber Hemorrhage during Fluorescein Angiography
Published 2015-01-01“…A 76-year-old male was referred for angiographic control of age-related macular degeneration. He was pseudophakic OU, BCVA 20/40 OU. …”
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166
Anti-Vascular Endothelial Growth Factors as a Potential Risk for Implant Failure: A Clinical Report
Published 2020-01-01“…This clinical report presents a rare case of implant failure in a patient who received intravitreal injections of a vascular endothelial growth factor (VEGF) inhibitor for the treatment of age-related macular degeneration. Following CARE guidelines, the report presents a case rehabilitated with a mandibular 2-implant overdenture using the immediate-loading protocol and standard procedures. …”
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167
Fundus Autofluorescence and Clinical Applications
Published 2021-07-01“…Emerging clinical evidence has demonstrated the usefulness of FAF in diagnosis and management of an increasing number of chorioretinal conditions, such as age-related macular degeneration, central serous chorioretinopathy, retinal drug toxicities, and inherited retinal degenerations such as retinitis pigmentosa and Stargardt disease. …”
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168
The rate of eye comorbidities in patients with cataracts (results of a population study)
Published 2023-08-01“…Among them, age-related macular degeneration (AMD) ranked first (13.46%). Glaucomatous optic neuropathy (GON)/glaucoma) and myopic macular degeneration/myopia were also common (6.77% and 4.93%, respectively). …”
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169
Dry eye disease treatment improves subjective quality-of-life responses in patients with AMD, independent of disease stage.
Published 2025-01-01“…<h4>Purpose</h4>To determine the impact of severity of age-related macular degeneration (AMD) on subjective treatment response in patients treated for dry eye disease.…”
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170
Switching to faricimab from the current anti-VEGF therapy: evidence-based expert recommendations
Published 2025-01-01“…Dual inhibition of the angiopoietin (Ang)/Tie and vascular endothelial growth factor (VEGF) signalling pathways in patients with retinal diseases, such as neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DME), may induce greater vascular stability and contribute to increased treatment efficacy and durability compared with treatments that only target the VEGF pathway. …”
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171
Contribution of Microglia-Mediated Neuroinflammation to Retinal Degenerative Diseases
Published 2015-01-01“…This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.…”
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172
Lutein, Zeaxanthin, and meso-Zeaxanthin in the Clinical Management of Eye Disease
Published 2015-01-01“…Observational studies have reported that increased dietary intake and higher serum levels of lutein and zeaxanthin are associated with lower risk of age-related macular degeneration (AMD), especially late AMD. Randomized, placebo-controlled clinical trials have demonstrated that xanthophyll supplementation increases macular pigment levels, improves visual function, and decreases the risk of progression to late AMD, especially neovascular AMD. …”
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173
Automatic Detection of Hard Exudate in Color Retinal Fundus Image and Diabetic Maculopathy Grading
Published 2025-01-01“…Diabetic macular degeneration (DM) is often characterized by the early accumulation of lipid deposits on the retina, referred to as hard exudates (HEs), which originate from damaged retinal blood vessels. …”
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174
Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies?
Published 2015-01-01“…The effects of lutein and zeaxanthin on the prevention and treatment of various eye diseases, including age-related macular degeneration, diabetic retinopathy and cataract, ischemic/hypoxia induced retinopathy, light damage of the retina, retinitis pigmentosa, retinal detachment, and uveitis, have been studied in different experimental animal models. …”
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175
Predictive Factors in OCT Analysis for Visual Outcome in Exudative AMD
Published 2012-01-01“…This is a retrospective analysis of 87 patients with exudative age-related macular degeneration who received three monthly intravitreal ranibizumab injections. …”
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176
Inflammatory Mediators and Angiogenic Factors in Choroidal Neovascularization: Pathogenetic Interactions and Therapeutic Implications
Published 2010-01-01“…Choroidal neovascularization (CNV) is a common and severe complication in heterogeneous diseases affecting the posterior segment of the eye, the most frequent being represented by age-related macular degeneration. Although the term may suggest just a vascular pathological condition, CNV is more properly definable as an aberrant tissue invasion of endothelial and inflammatory cells, in which both angiogenesis and inflammation are involved. …”
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177
Targeting Inflammation in Emerging Therapies for Genetic Retinal Disease
Published 2013-01-01“…Genetic retinal diseases such as age-related macular degeneration and monogenic diseases such as retinitis pigmentosa account for some of the commonest causes of blindness in the developed world. …”
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178
A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina
Published 2025-01-01“…Abstract The lack of effective therapies for visual restoration in Retinitis pigmentosa and macular degeneration has led to the development of new strategies, such as optogenetics and retinal prostheses. …”
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179
Reference dietary patterns in Portugal: Mediterranean diet vs Atlantic diet
Published 2025-01-01“…Most of the studies were conducted with younger people (children or adolescents) or older people, and some were made with patients suffering from a specific pathology, like heart disease, AIDS, or macular degeneration. Both diets emphasize natural, local, and seasonal foods prepared using traditional methods. …”
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180
Role of topological indices in predictive modeling and ranking of drugs treating eye disorders
Published 2025-01-01“…Here, we considered certain drugs treating eye-related disorders, including cataract, glaucoma, diabetic retinopathy, and macular degeneration. By combining modeling and decision-makings approaches, this study presents a cost-effective way to comprehend the behavior of molecules. …”
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