Overexpression of MiR-183/96/182 Triggers Retina-Like Fate in Human Bone Marrow-Derived Mesenchymal Stem Cells (hBMSCs) in Culture by Mohammad-Reza Mahmoudian-Sani, Fatemeh Forouzanfar, Samira Asgharzade, Nilufar Ghorbani

“…Retinal degeneration is considered as a condition ensued by different blinding disorders such as retinitis pigmentosa, age-related macular degeneration, and diabetic retinopathy, which can cause loss of photoreceptor cells and also lead to significant vision deficiencies. …”
Get full text

Global, regional, and national burden of blindness and vision loss attributable to smoking from 1990 to 2021, and forecasts to 2030: findings from the Global Burden of Disease Stud... by Yi Zeng, Yixian Liu, Xingyi Chen, Jennifer Kenny, Rong Rong, Xiaobo Xia

“…Methods We extracted data on years lived with disability (YLDs) and age-standardized YLDs rate (ASYR) related to blindness and vision loss (BVL) caused by smoking, including cataracts and age-related macular degeneration (AMD), from the Global Burden of Disease (GBD) database for the years 1990 to 2021. …”
Get full text

Optical Coherence Tomography Angiography in Retinal Vascular Diseases and Choroidal Neovascularization by Rodolfo Mastropasqua, Luca Di Antonio, Silvio Di Staso, Luca Agnifili, Angela Di Gregorio, Marco Ciancaglini, Leonardo Mastropasqua

“…Patients were affected with myopic CNV (2 eyes), age-related macular degeneration related (2), branch retinal vein occlusion (BRVO) (2), and branch retinal artery occlusion (BRAO) (1). …”
Get full text

Effect of In Vitro Exposure of Corticosteroid Drugs, Conventionally Used in AMD Treatment, on Mesenchymal Stem Cells by Raffaele Nuzzi, Monica Gunetti, Deborah Rustichelli, Barbara Roagna, Francesca Fronticelli Bardelli, Franca Fagioli, Ivana Ferrero

“…Age-related macular degeneration (AMD) is a leading cause of legal blindness in individuals over 60 years of age, characterized by the dysfunction of retinal pigmented epithelium cells, specifically in the macular area. …”
Get full text

Comparison of different decellularization methods for human anterior lens capsules by Jianfeng Yu, Pengfei Li, Kai Fan, Jiawei Luo, Huaijin Guan

“…Abstract Background Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. …”
Get full text

Association of arterial stiffness and eye disease: a systematic review and meta-analysis by Robert Scragg, Angela L Beros, John D Sluyter

“…Background This systematic review and meta-analysis assesses the association of arterial stiffness with age-related macular degeneration (AMD), glaucoma, retinal vein occlusion (RVO) and retinopathy (diabetic and hypertensive).Methods Medline and Embase were systematically searched for observational studies of arterial stiffness and eye disease. …”
Get full text

Detection Rate and Diagnostic Value of Optical Coherence Tomography Angiography in the Diagnosis of Polypoidal Choroidal Vasculopathy: A Systematic Review and Meta-Analysis by Yuelin Wang, Jingyuan Yang, Bing Li, Mingzhen Yuan, Youxin Chen

“…This study aimed to evaluate the detection rate of polyps and branching vascular networks (BVNs) in polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA) and assess the sensitivity and specificity of OCTA in differentiating PCV from wet age-related macular degeneration (wAMD). Materials and Methods. We searched PubMed, EMBASE, Cochrane Library, and other sources. …”
Get full text

Therapeutic Effect of Oral Bisphosphonates on Choroidal Neovascularization in the Human Eye by Shigeru Honda, Takayuki Nagai, Naoshi Kondo, Masahide Fukuda, Sentaro Kusuhara, Yasutomo Tsukahara, Akira Negi

“…Choroidal neovascularization (CNV) is often associated with age-related macular degeneration (AMD) and pathological myopia (PM). …”
Get full text

Early OCT Angiography Changes of Macular Neovascularization in Patients with Exudative AMD Treated with Brolucizumab in a Real-World Setting by Anne Rübsam, Saskia Rau, Daniel Pilger, Oliver Zeitz, Antonia M. Joussen

“…To report on the short-term outcome of intravitreal brolucizumab in patients with neovascular age-related macular degeneration (nAMD). Methods. This is a prospective, interventional, monocentric study on 10 eyes of 10 patients with a treatment-naïve neovascular AMD. …”
Get full text

Essential Role of Thioredoxin 2 in Mitigating Oxidative Stress in Retinal Epithelial Cells by Eriko Sugano, Namie Murayama, Maki Takahashi, Kitako Tabata, Makoto Tamai, Hiroshi Tomita

“…Disruption of these systems leads to the development of age-related macular degeneration. Thioredoxin 2 (Trx2) is a potent antioxidant, which acts directly on mitochondria. …”
Get full text

Correlation of Macular Focal Electroretinogram with Ellipsoid Zone Extension in Stargardt Disease by Edoardo Abed, Giorgio Placidi, Luigi Calandriello, Marco Piccardi, Francesca Campagna, Matteo Bertelli, Angelo Maria Minnella, Maria Cristina Savastano, Benedetto Falsini

“…Stargardt disease (STGD1) is the most common cause of inherited juvenile macular degeneration. This disease is characterized by a progressive accumulation of lipofuscin in the outer retina and subsequent loss of photoreceptors and retinal pigment epithelium. …”
Get full text

From botany to bedside: a review of the health benefits of Lycium barbarum as a functional food by Alois Berisha, Elena-Alexandra Alexa, Robbie Kelleher, Tao Zhang

“…Furthermore, its role in addressing age-related macular degeneration and chronic conditions such as cancer and metabolic syndrome is highlighted. …”
Get full text

Automated Detection of Macular Diseases by Optical Coherence Tomography and Artificial Intelligence Machine Learning of Optical Coherence Tomography Images by Soichiro Kuwayama, Yuji Ayatsuka, Daisuke Yanagisono, Takaki Uta, Hideaki Usui, Aki Kato, Noriaki Takase, Yuichiro Ogura, Tsutomu Yasukawa

“…The diagnoses involved normal eyes (n=570) and those with wet age-related macular degeneration (AMD) (n=136), diabetic retinopathy (DR) (n=104), epiretinal membranes (ERMs) (n=90), and another 19 diseases. …”
Get full text

Drug Screening of Flavonoids as Potential VEGF Inhibitors Through Computational Docking and Cell Models by Shengying Lin, Roy Wai-Lun Tang, Yutong Ye, Chenxi Xia, Jiahui Wu, Ran Duan, Ka-Wing Leung, Tina Ting-Xia Dong, Karl Wah-Keung Tsim

“…Vascular endothelial growth factor (VEGF), also known as VEGF-A, has been linked to various diseases, such as wet age-related macular degeneration (wAMD) and cancer. Even though there are VEGF inhibitors that are currently commercially available in clinical applications, severe adverse effects have been associated with these treatments. …”
Get full text

Acute-Onset Vitreous Hemorrhage of Unknown Origin before Vitrectomy: Causes and Prognosis by Dong Yoon Kim, Soo Geun Joe, Seunghee Baek, June-Gone Kim, Young Hee Yoon, Joo Yong Lee

“…Among these, retinal vein occlusion (RVO), retinal break, and age-related macular degeneration (AMD) were identified in 74 (43.8%), 50 (29.6%), and 21 (12.4%) patients, respectively. …”
Get full text

iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study by Peter D. Westenskow, Felicitas Bucher, Stephen Bravo, Toshihide Kurihara, Daniel Feitelberg, Liliana P. Paris, Edith Aguilar, Jonathan H. Lin, Martin Friedlander

“…Photoreceptors rely heavily on the RPE, and death or dysfunction of RPE is characteristic of age-related macular degeneration (AMD), a very common neurodegenerative disease for which no cure exists. …”
Get full text

Association of dietary inflammatory index with ocular diseases: a population-based cross-sectional study by Xue Wang, Can Zhang, Haitao Jiang

“…Abstract Background Our research was designed to investigate the relationship between dietary inflammatory index (DII) and risk of ocular diseases, including glaucoma, cataract, age-related macular degeneration (ARMD), and diabetic retinopathy. Methods We used the National Health and Nutrition Examination Survey (NHANES) data from 2005 to 2008 to conduct this study. …”
Get full text

Repeated exposure to low doses of light induces retinal damage in vivo in a wavelength-dependent manner by Anaïs Françon, Laurent Jonet, Francine Behar-Cohen, Alicia Torriglia

“…However, meta-analyses pointed out the role of lifelong light exposure in the onset of age-related macular degeneration, suggesting a cumulative effect of light exposure. …”
Get full text

Promiscuous Chemokine Antagonist (BKT130) Suppresses Laser-Induced Choroidal Neovascularization by Inhibition of Monocyte Recruitment by Shira Hagbi-Levi, Michal Abraham, Liran Tiosano, Batya Rinsky, Michelle Grunin, Orly Eizenberg, Amnon Peled, Itay Chowers

“…Background. Age-related macular degeneration (AMD), the most common cause of blindness in the developed world, usually affects individuals older than 60 years of age. …”
Get full text

Resveratrol Supplementation in Wet AMD: Association With Fewer Intravitreal Injections and Reduced Macular Fibrosis by Datseris I, Rouvas A, Tzanidaki ME, Kardara M, Geros V, Gouliopoulos N

“…Ioannis Datseris,1 Alexandros Rouvas,2 Malvina-Efthymia Tzanidaki,1 Marina Kardara,1 Vasileios Geros,2 Nikolaos Gouliopoulos2 1Ophthalmology Department, Ophthalmological Institute “OMMA”, Athens, Greece; 2 2nd Department of Ophthalmology, Medical School of University of Athens, “attikon” University Hospital, Athens, GreeceCorrespondence: Ioannis Datseris, Ophthalmological Institute OMMA, Katehaki 74, Athens, 11525, Greece, Tel +302106755850, Fax +302106755851, Email jodats13@me.comPurpose: To evaluate the 2-year outcomes of resveratrol oral supplement given as an adjunctive treatment in patients with wet age-related macular degeneration (AMD) that were treated with intravitreal injections of aflibercept.Patients and Methods: In our retrospective study, 50 treatment-naïve patients suffering from wet-AMD were included. …”
Get full text