Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival by Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk

“…Abstract One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. …”
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Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications by Min Li, Lu Ding, Lu Ding, Liyan Cao, Zepeng Zhang, Xueyan Li, Zirui Li, Qinjing Xia, Kai Yin, Siyu Song, Zihan Wang, Haijian Du, Daqing Zhao, Xiangyan Li, Zeyu Wang, Zeyu Wang

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Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides by Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki

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Receptor-Mediated Endocytosis and Brain Delivery of Therapeutic Biologics by Guangqing Xiao, Liang-Shang Gan

“…Transport of macromolecules across the blood-brain-barrier (BBB) requires both specific and nonspecific interactions between macromolecules and proteins/receptors expressed on the luminal and/or the abluminal surfaces of the brain capillary endothelial cells. …”
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Effect of Graphite Nanosheets on Properties of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Larissa Stieven Montagna, Thaís Larissa do Amaral Montanheiro, João Paulo Barros Machado, Fábio Roberto Passador, Ana Paula Lemes, Mirabel Cerqueira Rezende

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A Phenomenological Interpretation of Two-Step Adsorption Kinetics of Humic Acids on Zeolitic Tuff by Luigi Ambrosone, Silvana Canzano, Pasquale Iovino, Stefano Salvestrini, Sante Capasso, Carmine Colella

“…Experiments reveal two distinct stages: the first corresponds to the macromolecules being driven towards the substrate, while the second is the result of arrangement of macromolecules. …”
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Polymethacrylic Acid Adsorption and the Aggregation Stability of Titanium Dioxide Suspensions by M.M. Soltys, Z.M. Yaremko, D.M. Nykypanchuk, L.B. Fedushynska, V.D. Havryliv

“…The results obtained have been discussed in conjunction with the properties of aqueous solutions of partially neutralized polymethacrylic acid and changes in the conformations of the macromolecules.…”
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Structural basis of SIRT7 nucleosome engagement and substrate specificity by Carlos Moreno-Yruela, Babatunde E. Ekundayo, Polina N. Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

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Communication between DNA polymerases and Replication Protein A within the archaeal replisome by Markel Martínez-Carranza, Léa Vialle, Clément Madru, Florence Cordier, Ayten Dizkirici Tekpinar, Ahmed Haouz, Pierre Legrand, Rémy A. Le Meur, Patrick England, Rémi Dulermo, J. Iñaki Guijarro, Ghislaine Henneke, Ludovic Sauguet

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Intracellular dry mass density increases under growth-induced pressure [version 2; peer review: 1 approved, 2 approved with reservations] by Baptiste Alric, Hyojun Kim, Julien Roul, Nolan Chan, Morgan Delarue

“…Our results indicate that the observed decrease in diffusivity could be attributed to the intracellular accumulation of macromolecules. Furthermore, the linear scaling between cell content and growth-induced pressure suggests that the concentrations of macromolecules and osmolytes are maintained proportionally under such pressure in S. cerevisiae.…”
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Exploring anti-cancer activities of epidermal growth factor-immobilized polymeric nanoparticles by Shota Yamamoto, Chia-Jung Chang, Masao Kamimura, Jun Nakanishi

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Nano theranostics involved in bladder cancer treatment by Kunpeng Liu, Qixi Mo, Zhenshan Ding, Shicong Lai, Jian Ren, Qingsong Yu

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Chondrogenic Potential of Human Dental Pulp Stem Cells Cultured as Microtissues by Rubén Salvador-Clavell, José Javier Martín de Llano, Lara Milián, María Oliver, Manuel Mata, Carmen Carda, María Sancho-Tello

“…Cell-cell proximity promotes the chondrogenic differentiation of DPSCs and important synthesis of hyaline chondral macromolecules.…”
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Advancing macromolecular structure determination with microsecond X-ray pulses at a 4th generation synchrotron by Julien Orlans, Samuel L. Rose, Gavin Ferguson, Marcus Oscarsson, Alejandro Homs Puron, Antonia Beteva, Samuel Debionne, Pascal Theveneau, Nicolas Coquelle, Jerome Kieffer, Paolo Busca, Jeremy Sinoir, Victor Armijo, Marcos Lopez Marrero, Franck Felisaz, Gergely Papp, Herve Gonzalez, Hugo Caserotto, Fabien Dobias, Jonathan Gigmes, Guillaume Lebon, Shibom Basu, Daniele de Sanctis

“…Abstract Serial macromolecular crystallography has become a powerful method to reveal room temperature structures of biological macromolecules and perform time-resolved studies. ID29, a flagship beamline of the ESRF 4th generation synchrotron, is the first synchrotron beamline in the world capable of delivering high brilliance microsecond X-ray pulses at high repetition rate for the structure determination of biological macromolecules at room temperature. …”
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Synthesis of Novel Peptide Dendrimers PDL-GB2 and PDL-G2 by Lin Yunzhu, Weng Lingling, Qi Qingrong

“…Peptide dendrimers are a novel type of macromolecules with precise structure, which can be used as drug target vector and controlled-release carrier. …”
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The Role of Non-Genomic Information in Maintaining Thermodynamic Stability in Living Systems by Robert A. Gatenby, B. Roy Frieden

“…Information storage in DNAand translation of that information into proteins is central tomaintenance thermodynamic stability, through increased order thatresults from synthesis of specific macromolecules from monomericprecursors while heat and other reaction products are exportedinto the environment. …”
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From the Search for a Molecular Code of Memory to the Role of Neurotransmitters: A Historical Perspective by Georges Chapouthier

“…Therefore, the chemical bases for memory were investigated in the macromolecules of the brain. Such attempts were relatively unsuccessful, which led to a second period (starting in 1978) with the research emphasizing, in a less ambitious way, the role of the molecular correlates of mnesic processes, in particular in the main transmitter systems of the brain.…”
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Free-standing microcrystals of a fluorescent organic dye: Preparation and spectroscopic study by Mouhammad Abyan, Liliana Bîrlă, Franck Bertorelle, Fernanda Rodrigues, Suzanne Fery-Forgues

“…Suspensions of microcrystals were obtained from an organic fluorescent dye, 4-n-octylamino-7-nitrobenz-2-oxa-1,3-diazole, by reprecipitation in water in the presence of various macromolecules: anionic or cationic PAMAM dendrimer, poly(acrylic acid, sodium salt), poly(acrylamide), and calf thymus DNA. …”
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Phytochemical composition and antimicrobial activity of essential oil from the leaves of Peganum harmala L.  in southern Algeria. by Abderrahmane Ghillace, Ourida Chouitah, Fatima Zohra Kiari, Zineb Fergoug, Zineeddine Daikh

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Small Bowel Review - Part I by ABR Thomson, G Wild

“…Part I of this two-part review of the small bowel examines carbohydrates, including brush border membrane hydrolysis and sugar transport; amino acids, dipeptides, proteins and food allergy, with a focus on glutamine, peptides and macromolecules, and nucleosides, nucleotides and polyamines; salt and water absorption, and diarrhea, including antidiarrheal therapy and oral rehydration treatment; lipids (digestion and absorption, fatty acid binding proteins, intracellular metabolism, lipoproteins and bile acids); and metals (eg, iron) and vitamins.…”
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