Gastric Cancer Mesenchymal Stem Cells Inhibit NK Cell Function through mTOR Signalling to Promote Tumour Growth by Shuwei Guo, Chao Huang, Fengfeng Han, Bin Chen, Ying Ding, Yuanyuan Zhao, Zhihong Chen, Shaodi Wen, Mei Wang, Bo Shen, Wei Zhu

“…Mechanistically, mammalian target of rapamycin (mTOR) signalling, a critical regulator of cellular metabolism that mediates the function of immune cells, was inhibited in NK cells treated with GCMSCs. …”
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FOSL2 activates TGF‐β1‐mediated GLUT1/mTOR signaling to promote diabetic kidney disease by Xuelin He, Min Xia, Guanghui Ying, Qien He, Zhaogui Chen, Li Liu, Qiao Zhang, Jianxin Cai

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Rapamycin Attenuates Endothelial Apoptosis Induced by Low Shear Stress via mTOR and Sestrin1 Related Redox Regulation by Junxia Zhang, Zhimei Wang, Junjie Zhang, Guangfeng Zuo, Bing Li, Wenxing Mao, Shaoliang Chen

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Role of PI3K/AKT/mTOR signaling pathway and sirtuin genes in chronic obstructive pulmonary disease development by G. F. Korytina, L. Z. Akhmadishina, V. A. Markelov, Y. G. Aznabaeva, O. V. Kochetova, T. R. Nasibullin, A. P. Larkina, N. N. Khusnutdinova, N. Sh. Zagidullin, T. V. Victorova

“…We aimed to assess the combined effect of the PI3K/AKT/mTOR signaling pathway (PIK3R1, AKT1, MTOR, PTEN) and sirtuin (SIRT1, SIRT3, SIRT6) genes to COPD risk. …”
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Hydroxyurea mitigates diabetic kidney disease through mTOR-S6K signaling pathway in STZ-induced diabetic mice by Wanying Cheng, Cenzhu Wang, Meican Ma, Yu Zhou

“…Moreover, HU treatment significantly inhibited the mTOR signaling pathway in both in both in vivo and in vitro experiments.ConclusionThis study unveils a new role of HU in alleviating diabetic kidney disease by modulating inflammation and apoptosis through the mTOR-S6K pathway. …”
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Rapamycin inhibits tamoxifen-induced endometrial proliferation in vitro as a pilot approach for endometrial protection in breast cancer by Akiko Nakamura, Yuji Tanaka, Tsukuru Amano, Akie Takebayashi, Akimasa Takahashi, Tetsuro Hanada, Yutaka Yoneoka, Shunichiro Tsuji, Takashi Murakami

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α-methyltryptophan-mediated protection against diabetic nephropathy in db/db mice as studied with a metabolomics approach by Aimin Cai, Dingchao Shen, Qiushuang Xiong, Jie Ding, Yang Ding, Xinlu Lin, Lijia Chen, Qing Yao, Qing Yao, Guangyong Lin, Ruijie Chen, Vadivel Ganapathy, Vadivel Ganapathy, Longfa Kou

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Sulforaphane acutely activates multiple starvation response pathways by Kendra S. Plafker, Constantin Georgescu, Nathan Pezant, Atul Pranay, Scott M. Plafker

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Lingguizhugan decoction enhances autophagy of Alzheimer’s disease via regulating the mTOR/ p70s6K pathway in vivo and in vitro by Xiaojing Chen, Qingrong Tian, Min Gao, Xibin Zhou, Chunxiang Zhou

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Assessing Metabolic Changes in Response to mTOR Inhibition in a Mantle Cell Lymphoma Xenograft Model Using AcidoCEST MRI by Paul J. Akhenblit PhD, Neale T. Hanke PhD, Alexander Gill BS, Daniel O. Persky MD, Christine M. Howison MS, Mark D. Pagel PhD, Amanda F. Baker PharmD, PhD

“…To perform this study, we used the Granta 519 human mantle cell lymphoma cell line, which is an aggressive B-cell malignancy that demonstrates activation of the phosphatidylinositol-3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway. We performed in vitro and in vivo studies using the Granta 519 cell line to investigate the efficacy and associated changes induced by the mTOR inhibitor, everolimus (RAD001). …”
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The Petri Dish-N2B27 Culture Condition Maintains RPE Phenotype by Inhibiting Cell Proliferation and mTOR Activation by Hui Lou, Chunpin Lian, Fanjun Shi, Liqun Chen, Sicheng Qian, Hui Wang, Xiaoyun Zhao, Xiaoyan Ji, Jingfa Zhang, Guoxu Xu

“…As compared with other culture conditions, RPE cells in the petri dish-N2B27 condition could maintain RPE phenotype with increased expression of RPE-specific genes and decreased expression of EMT-related genes. The AKT/mTOR pathway was also decreased in petri dish-N2B27 condition. …”
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TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer by Cui Chen, Zehong Chen, Jinze Zhao, Xinyun Wen, Hanming Yao, Zijin Weng, Huiping Xiong, Zongheng Zheng, Juekun Wu

“…Subsequent gene set enrichment analysis (GSEA) confirms that TMEM45A activates the AKT/mTOR signaling pathway, which is integral to cell cycle progression and glycolysis. …”
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The Protective Effects of 18β-Glycyrrhetinic Acid on Imiquimod-Induced Psoriasis in Mice via Suppression of mTOR/STAT3 Signaling by Haiming Chen, Huazhen Liu, Bin Tang, Yuchao Chen, Ling Han, Jingjie Yu, Yuhong Yan, Chuanjian Lu

“…Its anti-inflammatory and immunomodulatory activities may be related to its suppression of the STAT3 and mTOR signaling. In conclusion, GA ameliorated the symptoms of psoriasis, at least in part, through inhibition of inflammatory cytokines and STAT3/mTOR signaling and activation of Tregs in both lymph nodes and spleens. …”
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IL-37 attenuated HPV induced inflammation of oral epithelial cells via inhibiting PI3K/AKT/mTOR by Yahong Shi, Ning Liu, Yunfang Bai, Kunshan Li, Chencong Li, Yujiao Hou

“…Additionally, the study uncovered that the mTOR inhibitor, rapamycin, could effectively compromise the effects of IL-37 on HPV-induced inflammation. …”
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Peroxisome Proliferator-Activated Receptor γ Regulates Lipid Metabolism in Sheep Trophoblast Cells through mTOR Pathway-Mediated Autophagy by Kexing Hao, Jing Wang, Hengbin Yu, Lei Chen, Weibin Zeng, Zhengrong Wang, Guangdong Hu

“…We found that PPARγ inhibited the activity of mammalian target of rapamycin (mTOR) pathway in STCs for a certain period of time, promoted the increase of autophagy and lysosome formation, and enhanced the accumulation of lipid droplets and triglycerides. …”
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Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitors by Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, Marta Salido, Nuria Juanpere‐Rodero, Federico Rojo, Aura Muntasell, Joan Albanell, Ana Rovira, Joaquim Bellmunt

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Exosomes Play an Important Role in the Progression of Plasma Cell Mastitis via the PI3K-Akt-mTOR Signaling Pathway by Xiaohong Wang, Yong Han, Jian Liu, Yingzhe Zhang, Kai Cheng, Jiwei Guo, Qingqun Guo, Song Liu, Hongguang Sun, Yitong Hua, Guoqiang Zhang, Shujian Xu, Fengli Guo, Zhenlin Yang

“…The decreased HSP90AA1 and EEF2, excessive production of p-AKT, and p-mTOR were consistent with clinical specimens. Inhibition of exosome secretion significantly inhibited inflammatory cell infiltration, and the mammary duct had maintained a better structure in the PCM mouse model. …”
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GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway by Chenhua Luo, ZhiMing Xiao, WenLong Yang

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Renoprotective Effect of Pitavastatin against TAA-Induced Renal Injury: Involvement of the miR-93/PTEN/AKT/mTOR Pathway by Marawan A. Elbaset, Bassim M. S. A. Mohamed, Passant E. Moustafa, Tuba Esatbeyoglu, Sherif M. Afifi, Alyaa F. Hessin, Sahar S. Abdelrahman, Hany M. Fayed

“…By altering the PTEN/AKT/mTOR pathway, pitavastatin may boost kidney antioxidant capacity and minimize oxidative damage. …”
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miR-149 Alleviates Ox-LDL-Induced Endothelial Cell Injury by Promoting Autophagy through Akt/mTOR Pathway by Zhongsheng Zhu, Jinyu Li, Rui Tong, Xiaorong Zhang, Bo Yu

“…RT-qPCR and western blot were carried out to determine the mRNA and protein expressions of Akt and mTOR. Results. The miR-149 level in HUVECs was reduced by ox-LDL (100 μg/mL) incubation in a time-dependent manner. miR-149-mimic transfection markedly protected HUVECs from ox-LDL-induced injury, with increased cell viability and reduced caspase-3 activity. miR-149 mimics enhanced HUVEC autophagy, which was induced initially by ox-LDL. miR-149 mimics also markedly downregulated the expression of Akt, p-Akt, mTOR, and p-mTOR in ox-LDL-treated HUVECs. …”
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