Involvement of Mechanistic Target of Rapamycin (mTOR) in Valine Orexigenic Effects in Rainbow Trout by Sara Comesaña, Mauro Chivite, Ayelén M. Blanco, María Alborja-Valado, Jessica Calo, Marta Conde-Sieira, José L. Soengas

“…However, it is not clear which precise mechanisms link the activation of mTOR and the alteration in feed intake levels since we did not observe changes in mRNA levels of appetite-regulatory neuropeptides as well as in the phosphorylation status and levels of integrative proteins.…”
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Epithelial mesenchymal transition and cancer stem cell markers in oral epithelial dysplasia and oral squamous cell carcinoma by Burcu Tokozlu, Özlem Özer Yücel, Sibel E. Gültekin, Leyla Arslan Bozdağ

“…OSCC cases showed significantly higher CD133 immunoreactivity and inflammation scores and significantly decreased E-cadherin expression compared to OED and OEH groups. Snail mRNA up-regulation was seen in 100% of the OSCC cases followed by 85% for OED cases and 82.5% OEH cases among those that displayed positive mRNA expression by RT-qPCR. …”
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D-stem mutation in an essential tRNA increases translation speed at the cost of fidelity. by Madison N Schrock, Krishna Parsawar, Kelly T Hughes, Fabienne F V Chevance

“…Our results support a model in which the tRNA bending component of the accommodation step in mRNA translation allows EF Tu time to enhance its ability to differentiate tRNA interactions between cognate and near-cognate mRNA codons.…”
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High Levels of 17β-Estradiol Are Associated with Increased Matrix Metalloproteinase-2 and Metalloproteinase-9 Activity in Tears of Postmenopausal Women with Dry Eye by Guanglin Shen, Xiaoping Ma

“…Tear MMP-2 and MMP-9 concentrations (P<0.001), as well as the MMP-9 mRNA expression in conjunctival samples (P=0.02), were significantly higher in dry eye subjects than in controls. …”
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Functions of METTL1/WDR4 and QKI as m7G modification - related enzymes in digestive diseases by Wenyan Zhou, Yan Yi, Wenyu Cao, Xiaolin Zhong, Ling Chen

“…Methyl-transferation of m7G modification is catalyzed by the enzyme complex of methyltransferase-like 1 (METTL1) and WD repeat domain 4 (WDR4), and Quaking (QKI) recognizes internal m7G methylated mRNA and regulates mRNA translation and stabilization. …”
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Association of Low Expression of NUMB in Peripheral Blood with Acute Myocardial Infarction by Heyu Meng, Lihong Li, Jianjun Ruan, Yanqiu Chen, Zhaohan Yan, Jinsha Liu, Xiangdong Li, Cuiying Mao, Ping Yang

“…However, the AMI group had 0.885 times lower NUMB mRNA expression than the SCAD group P<0.05. Conclusion. …”
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Matrix metalloproteinase-12 by M2 macrophages induced epithelial to mesenchymal transition in chronic rhinosinusitis with nasal polyps. by Joo-Hoo Park, Jae-Min Shin, Hyun-Woo Yang, Tae Hoon Kim, Seung Hoon Lee, Ok Sarah Shin, Il-Ho Park

“…MMP-12 decreased E-cadherin but induced fibronectin, vimentin, and α-SMA mRNA and protein expression in primary nasal epithelial cells and air-liquid interface culture. …”
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Spatiotemporal Pattern of Neuroinflammation After Impact-Acceleration Closed Head Injury in the Rat

“…We found an early upregulation of IL-1<mml:math alttext="$eta$"> <mml:mi>&#x03B2;</mml:mi> </mml:math>, IL-6, and TNF-<mml:math alttext="$alpha$"> <mml:mi>&#x03B1;</mml:mi> </mml:math> mRNA between 1h and 7h after injury; the expression of iNOS mRNA only revealed a significant increase at 4h. …”
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Cloning, Characterization and Expression Pattern of the Ovarian Cytochrome P450 Cyp19a1aGene in Gonadal Developmental Period of Cobaltcap Silverside Hypoatherina tsurugae by Dilip Kumar Bej

“…The upregulation of the cyp19a1a transcription factor is required for granulosa cell differentiation and ovarian maintenance. 1630 bp of cyp19a1 mRNA transcript of Hypoatherina tsurugae was cloned and sequenced. …”
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Altered ERK1/2 Signaling in the Brain of Learned Helpless Rats: Relevance in Vulnerability to Developing Stress-Induced Depression by Yogesh Dwivedi, Hui Zhang

“…In frontal cortex and hippocampus of LH rats, we found that mRNA and protein expressions of ERK1 and ERK2 were significantly reduced, which was associated with their reduced activation and phosphorylation in cytosolic and nuclear fractions, where ERK1 and ERK2 target their substrates. …”
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Glycyrrhizin Attenuates Toll Like Receptor-2, -4 and Experimental Vasospasm in a Rat Model by Chih-Zen Chang, Shu-Chuan Wu, Aij-Lie Kwan

“…Basilar arteries were harvested to examine TLRs mRNA and protein (rt-PCR and western blot) and CSF cytokines (rt-PCR). …”
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DNA-Encoded Chromatin Structural Intron Boundary Signals Identify Conserved Genes with Common Function by Justin A. Fincher, Gary S. Tyson, Jonathan H. Dennis

“…The regulation of metazoan gene expression occurs in part by pre-mRNA splicing into mature RNAs. Signals affecting the efficiency and specificity with which introns are removed have not been completely elucidated. …”
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A Novel Model of Cancer-Induced Peripheral Neuropathy and the Role of TRPA1 in Pain Transduction by Ahmad Maqboul, Bakheet Elsadek

“…Immunoblots exhibited an increase in TRPA1 expression on day 14. TRPA1 mRNA underwent an increase on day 7 (normalized to 18S). …”
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整合素α5β1介导的FAK65380;ERK信号传导通路 对K562细胞增殖的影响

“…【目的】 研究整合素α5β1介导的粘着斑激酶(FAK)和细胞外信号调节激酶(ERK)信号转导通路对K562细胞增殖的影响,并初步探讨其作用机制65377; 【方法】 应用四甲基偶氮唑蓝染色法(MTT)检测抗整合素α5β1单抗(Anti-α5β1)对K562细胞增殖的抑制作用,应用反转录PCR(RT-PCR)和蛋白印迹(western blot)方法检测FAK和ERK的mRNA和蛋白表达水平的改变65377;【结果】 Anti-α5β1明显抑制K562细胞的增殖,下调细胞内总FAK及ERK的mRNA和蛋白表达,并抑制其磷酸化水平65377;【结论】 整合素α5β1介导的FAK-ras-ERK信号转导通路可能参与了K562细胞的增殖调控,阻断此通路可明显抑制K562细胞的增殖…”
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Ribosomal Proteins in Ribosome Assembly by Brigitte Pertschy, Ingrid Zierler

“…Ribosomes are the cellular machinery responsible for translating mRNA into proteins, a process fundamental to all domains of life from bacteria to eukaryotes [...]…”
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壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡改善脑缺血再灌注损伤 by 王成毅, 蔡粤芳, 宁振求, 邓敏贞, 孙景波, Sookja Kim CHUNG, 李岩, 程骁

“…②壮通饮减弱了MCAO/R后小鼠大脑组织的三价铁离子蓄积状态；减少MCAO/R后小鼠大脑中与铁离子转运入细胞内相关载体TfR1和DMT1 mRNA的表达（<italic>P</italic>＜0.001）；下调MCAO/R后小鼠大脑脂质过氧化物4-HNE含量和组织脂质过氧化物酶ACSL4 mRNA表达（<italic>P</italic>＜0.001）；降低MCAO/R后小鼠大脑铁死亡标志物PTGS2 mRNA表达（<italic>P</italic>＜0.001）。…”
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Dietary Se-enrich Cardamine violifolia supplementation decreases lipid deposition and improves antioxidant status in the liver of aging laying hens by Mengke Yan, Xin Cong, Hui Wang, Kun Qin, Yuhui Tang, Xiao Xu, Dan Wang, Shuiyuan Cheng, Yulan Liu, Huiling Zhu

“…Dietary Se supplementation promoted (P < 0.05) mRNA expression of Nrf2 in the liver. In contrast, dietary SEY and SEC supplementation resulted in a decrease (P < 0.05) of hepatic Keap1 mRNA expression compared to CON diet. …”
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Regulation and Roles of Urocortins in the Vascular System by Kazunori Kageyama, Ken Teui, Naoki Tamasawa, Toshihiro Suda

“…Human umbilical vein endothelial cells (HUVECs) express Ucns1-3 mRNAs, and the receptor, CRF2a receptor mRNA. Ucns1-3 mRNA levels are differentially regulated in HUVECs. …”
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A High-Fat, High-Fructose Diet Induces Antioxidant Imbalance and Increases the Risk and Progression of Nonalcoholic Fatty Liver Disease in Mice by Kanokwan Jarukamjorn, Nattharat Jearapong, Charinya Pimson, Waranya Chatuphonprasert

“…In the present study, the effects of a high-fat, high-fructose diet (HFFD) on mRNA levels and activities of the antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), were determined in mouse livers and brains. …”
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Determination of antioxidant and immune responses with bile acids supplementation in geese by Jianwen CAO, Lei YANG, Guangpei XU

“…However, a supplementation with 300 mg/kg BAs significantly increased the expression of IL-10 mRNA in the geese"s spleens. Regarding antioxidant indicators, the addition of 150 mg/kg and 300 mg/kg BAs significantly enhanced the serum levels of Superoxide Dismutase (SOD), Glutathione Peroxidase (GSH-Px), and Total Antioxidant Capacity (T-AOC) (P<0.05), as well as upregulated the expression of liver Nrf2, GPX-1 and SOD1 mRNA. …”
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