Integrated analysis of transcriptome, sRNAome, and degradome involved in the drought-response of maize Zhengdan958 by Yang Shuqiong, Liu Jiafei, Cao Lingling, Chen Jibao, Duan Pengfei

“…Moreover, 6,340 target genes of 445 miRNAs were validated using degradome sequencing, forming 281 miRNA–mRNA pairs in control (CK) and drought-stressed (DS) library. …”
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曲伏前列腺素对培养人眼睫状肌细胞基质金属蛋白酶-2表达的影响 by 蓝育青, 肖剑晖, 彭蔚, 张弛, 郭慧, 宋欣

“…Zymography技术分别检测4组细胞MMP-2的活性,重复4次。【结果】设定对照组mRNA相对表达量为1做作标准,6 h、12 h、24 h组MMP-2 mRNA相对表达量为0.58±0.04、1.20±0.05、1.95±0.11,MMP-2 mRNA表达呈逐渐升高趋势（P=0.000）;ELISA检测MMP-2的A值分别为0.0503±0.0021、0.0627±0.0017、0.0673±0.0025、0.0783±0.0039,MMP-2的表达随travoprost作用时间延长逐渐升高（P=0.000）。…”
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Genistein Attenuates Lipopolysaccharide-Induced Hepatic Oxidative Stress and Inflammatory Responses in Turbot (Scophthalmus maximus L.) Juveniles by Xiao-qian Zhou, Zi-yan Shi, Hai-hong Chen, Xin Xiao, Dan Xu, Zhi-jie Dan

“…Results exhibited that hepatic proinflammatory factors, oxidative stress-related factors, and apoptotic factors mRNA expression were significantly upregulated after intraperitoneal injection of LPS in turbot, compared with the Control group (p<0.05). …”
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Resveratrol Induces Differentiation of Human Umbilical Cord Mesenchymal Stem Cells into Neuron-Like Cells by Li Guo, Liang Wang, Li Wang, Shi Yun-peng, Jing-jing Zhou, Zongmao Zhao, De-Pei Li

“…Nestin, GFAP, and NSE protein and mRNA were measured at posttreatment time points of 2 h, 4 h, 6 h, 12 h, and 24 h. …”
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Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy by Shan He, Jian Ye, Yu Wang, Lu yang Xie, Si Yi Liu, Qin kai Chen

“…Subsequent analyses included Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment, Gene Set Enrichment Analysis (GSEA), and Protein-Protein Interaction (PPI) network analysis. Additionally, mRNA-miRNA, mRNA-drug, and mRNA-transcription factor (TF) interaction networks were constructed. …”
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Effects of Cranberry Extract (Vaccinium macrocarpon) Supplementation on Lipid Peroxidation and Inflammation in Patients with Chronic Kidney Disease (Stages 3-4): A Randomized Contr... by Laís de Souza Gouveia Moreira, Karla Thaís Resende Teixeira, Ludmila F. M. F. Cardozo, Livia Alvarenga, Bruna Regis, Jessyca Sousa de Brito, Viviane de Oliveira Leal, Natalia Alvarenga Borges, Isabela de Souza da Costa Brum, José Carlos Carraro-Eduardo, Giovanna B. Borini, Andresa A. Berretta, Marcelo Ribeiro-Alves, Denise Mafra

“…There were no differences in NF-kB or Nrf2 mRNA expressions (p=0.99 and p=0.89) or TBARS, CRP, and IL-6 plasma levels after cranberry supplementation. …”
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Shared Genes and Pathways in Ulcerative Colitis and Ankylosing Spondylitis: Functional Validation and Implications for Diagnosis by Li L, An G, Li F, Zhang D, Zhu X, Liang C, Zhao Y, Xie K, Zhou P, Zhu H, Jin X, Du L

“…Subsequent functional experiments revealed significant increases in the mRNA expressions of S100A12 and VAMP5 in patients with AS and UC. …”
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Transcriptional activity of repair, apoptosis and cell cycle genes (TP53, MDM2, ATM, BAX, BCL-2, CDKN1A, OGG1, XPC, PADI4, MAPK8, NF-KB1, STAT3, GATA3) in chronically exposed perso... by V. S. Nikiforov, E. A. Blinova, A. I. Kotikova, A. V. Akleyev

“…Evaluation of the relative content of mRNA genes for repair, cell cycle, and apoptosis was carried out using real-time PCR. …”
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Folic Acid Supplementation Mitigates Alzheimer’s Disease by Reducing Inflammation: A Randomized Controlled Trial by Hui Chen, Shuai Liu, Lu Ji, Tianfeng Wu, Yong Ji, Yuying Zhou, Miaoyan Zheng, Meilin Zhang, Weili Xu, Guowei Huang

“…Posttreatment, plasma SAM and SAM/SAH levels were significantly higher (P<0.05), while Aβ40, PS1-mRNA, and TNFα-mRNA levels were lower in the intervention group than in the control group (P<0.05). …”
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miR663 Prevents Epo Inhibition Caused by TNF-Alpha in Normoxia and Hypoxia by Mete Ozkurt, Thomas Hellwig-Bürgel, Reinhard Depping, Selda Kadabere, Rumeysa Ozyurt, Abdullah Karadag, Nilüfer Erkasap

“…Conclusions. miR663 is involved in Epo mRNA production and that is able to prevent or reverse the inhibitory effect of TNF-α. …”
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Dietary Histidine Supplementation Maintained Amino Acid Homeostasis and Reduced Hepatic Lipid Accumulation of Juvenile Largemouth Bass, Micropterus Salmoides by Hualiang Liang, Gangchun Xu, Pao Xu, Jian Zhu, Songlin Li, Mingchun Ren

“…However, increased dietary histidine levels downregulated the mRNA levels of core genes of the PPARγ signaling pathways such as PPARγ, FAS, ACC, SREBP1, and ELOVL2. …”
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Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks by Guihong Chen, Wen Zhang, Chenglin Wang, Muhu Chen, Yingchun Hu, Zheng Wang

“…Finally, combined with base complementary pairing and intergroup correlation analysis, a sepsis-associated circRNA-miRNA-mRNA regulatory network was constructed. Differential expression analysis screened 28 mRNAs and 16 circRNAs. …”
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Pro-inflammatory effects of inhaled Great Salt Lake dust particles by Jacob M. Cowley, Cassandra E. Deering-Rice, John G. Lamb, Erin G. Romero, Marysol Almestica-Roberts, Samantha N. Serna, Lili Sun, Kerry E. Kelly, Ross T. Whitaker, Jenna Cheminant, Alessandro Venosa, Christopher A. Reilly

“…Pro-inflammatory biomarker mRNA induction was replicated in vitro using HBEC3-KT and differentiated monocyte-derived (macrophage-like) THP-1 cells. …”
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Effects of prolonged NaHCO3 exposure on the serum immune function, antioxidant capacity, intestinal tight junctions, microbiota, mitochondria, and autophagy in crucian carp (Carass... by Jia Liu, Faye Zhang, Zihao Yan, Zhengyao Guo, Yuqian Lu, Baolan Yao, Yuehong Li, Wenfa Lv

“…The levels of ATG5, ATG7, and Beclin1 mRNA and protein were significantly increased along with the levels of LC3b mRNA and the ratio of protein LC3 II /LC3 I. …”
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Effects of Tributyrin Supplementation on Growth Performance, Intestinal Digestive Enzyme Activity, Antioxidant Capacity, and Inflammation-Related Gene Expression of Large Yellow Cr... by Xiuneng Wang, Min Wan, Zhen Wang, Haitao Zhang, Si Zhu, Xiufei Cao, Ning Xu, Jichang Zheng, Xianyong Bu, Wei Xu, Kangsen Mai, Qinghui Ai

“…However, the mRNA expression of Kelch-like ECH-associated protein 1 (keap1) was remarkably lower in fish fed the FC diet than that fed diets with tributyrin supplementation (P<0.05). …”
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Effects of Treadmill Exercise on Hippocampal Synaptic Plasticity and Expression of Related Proteins in Aging Mice by WANG Sinuo, CAO Yajun, XIANG Qing, YAN Jiamin, LIN Yanting, ZHUANG Yueyang, GUO Xiaoqin, LIU Weilin

“…The results of RT-PCR showed that the expression of Dlgap2, GNG4 and KCNQ2 mRNA in the hippocampus of mice in the aged group was lower than that in the adult group, and the expression of GNG4 and KCNQ2 mRNA significantly decreased (<italic>P</italic>&lt;0.05), while the expression of Dlgap2, GNG4 and KCNQ2 mRNA in the hippocampus of mice in the exercise group increased, and the expression of GNG4 mRNA significantly increased than that of the aged group (<italic>P</italic>&lt;0.05). …”
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Effect of Electroacupuncture Prestimulation with Mental Tri-Needles on the Inflammatory Response of Hippocampus in Aged Rats with Perioperative Neurocognitive Disorders by WANG Xiangfeng, HUANG Jinyan, LIU Wei, LUO Huiqin, WANG Guanhui, LIN Qin, CHEN Bin

“…Compared with the control group and the anesthesia group, the percentages of apoptotic cells in the hippocampus of the operation group and the acupuncture group significantly increased (<italic>P</italic>&lt;0.05); and compared with the operation group, the percentage of apoptotic cells in the hippocampus of the acupuncture group significantly decreased (<italic>P</italic>&lt;0.05). (4) Protein contents and mRNA levels of IL-1β, IL-6 and TNF-α in hippocampus: compared with the control group and the anesthesia group, the protein contents and mRNA levels of IL-1β, IL-6 and TNF-α in the operation group significantly increased (<italic>P</italic>&lt;0.05); compared with the operation group, the protein expression of IL-1β, IL-6 and TNF-α and their mRNA levels in the acupuncture group significantly decreased (<italic>P</italic>&lt;0.05).ConclusionEA prestimulation with mental trineedles can reduce the injury and apoptosis of hippocampal cells in aged rats with PND, and improve cognitive function, which may be related to the inhibition of the overexpression of IL-1β, IL-6 and TNF-α in the hippocampus of aged rats and reducing the inflammatory reaction in brain tissue.…”
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Hypoglycemic effects of black brick tea with fungal growth in hyperglycemic mice model by Wei Xu, Yang Zhou, Ling Lin, Dongyin Yuan, Yingqi Peng, Li Li, Wenjun Xiao, Zhihua Gong

“…These teas can promote blood glucose transport and absorption by upregulating the protein and mRNA expression of insulin receptor substrate-1 and glucose transporter-2 and stimulate glycolysis by upregulating the protein and mRNA expression of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. …”
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Two Novel Compounds Isolated from the Marine Fungal Symbiont of Aspergillus unguis Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells: In vitro Study by Bashari MH, Agung MUK, Ariyanto EF, Al Muqarrabun LMR, Salsabila S, Chahyadi A, Rosandy AR, Afifah E, Afni M, Atmaja HE, Putri T, Utami F, Subhan B, Syafrizayanti, Andriani Y, Elfahmi

“…Unguisol A and Unguisol B induced apoptosis in MDA-MB-231 breast cancer cells via BCL2L1 mRNA downregulation, while both compounds induced cell cycle arrest at the S phase through AKT1 mRNA downregulation. …”
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Phenome-wide association studies between SERINC2 and neuropsychiatric disorders by Ping Liu, Xinqun Luo, Liping Cao, Yong Zhang, Jiawu Ji, Xiaoping Wang, Kesheng Wang, Xinghua Pan, Ruilan Yang, Zewen Tan, Yunlong Tan, Chiang-shan Li, Xiaoyun Guo, Zhiren Wang, Xingguang Luo, Xingguang Luo

“…Furthermore, the disease-risk alleles had highly similar regulatory effects on mRNA expression (8.1×10-7≤p ≤ 0.046), subcortical GMVs (7.0×10-4≤p ≤ 0.048) and cortical TH and SA (1.3×10-3≤p ≤ 0.050) in brains across alcoholism, schizophrenia, OCD and autism. …”
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