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561
QRFP43 modulates the activity of the hypothalamic-pituitary-thyroid axis in female sheep
Published 2025-01-01“…Moreover, the relationship between QRFP34 and mRNA expression of the Dio1, Dio2, and Dio3 genes was explored in selected tissues of the HPT axis. …”
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562
RETRACTED ARTICLE: Combined treatment of glibenclamide and CoCl2 decreases MMP9 expression and inhibits growth in highly metastatic breast cancer
Published 2013-05-01“…Some fresh tissues without necrosis were stored at −80°C for mRNA detection and the other tumor tissue was fixed with 10% formalin for H&E and immunohistochemical staining. …”
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563
大鼠脑缺血/再灌注过程中脑型葡萄糖转运体在缺血半影区的表达
Published 2005-01-01“…MCAO1h/R 组GLUT1、GLUT3 mRNA 缺血后升高, 24 h 到达高峰, 但GLUT1 比GLUT3 提前升高, 且升高的幅度更大。 …”
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564
Inhibitory Effect of Lactobacillus delbrueckii subsp. bulgaricus KSFY07 on Kappa-Carrageenan-Induced Thrombosis in Mice and the Regulation of Oxidative Damage
Published 2022-01-01“…Further, experimental results showed that LDSB-KSFY07 was able to upregulate the mRNA expression of copper/zinc-SOD (Cu/Zn-SOD), manganese-SOD, and GSH-Px in the liver tissue of thrombotic mice. …”
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565
Transcriptional Regulation of Δ6-Desaturase by Peroxisome Proliferative-Activated Receptor δ Agonist in Human Pancreatic Cancer Cells: Role of MEK/ERK1/2 Pathway
Published 2013-01-01“…Furthermore, there may be an inhibitory crosstalk between these two regulatory pathways on the mRNA expression of Δ6D and subsequently on Δ6D protein expression.…”
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566
马鹿<italic>CDK8</italic>基因生物信息学分析与组织表达
Published 2023-08-01“…为探究细胞周期蛋白依赖性蛋白激酶8基因(<italic>CDK8</italic>)在马鹿(<italic>Cervus elaphus</italic>)鹿茸的皮、间充质、前软骨和软骨组织中的mRNA表达水平和该基因编码蛋白的生物学特性,采用PCR方法克隆马鹿<italic>CDK8</italic>基因编码区(CDS)全长序列,并连入pMD-18T载体,测得核苷酸序列,进行相似性比对和系统进化树构建;利用生物信息学方法分析CDK8蛋白的组成、结构和理化性质;利用实时荧光定量PCR技术检测<italic>CDK8</italic>基因mRNA在鹿茸组织中的表达水平。…”
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567
P-glycoprotein and/or Histone Deacetylase 2 Regulates Steroid Responsiveness in Childhood Nephrotic Syndrome
Published 2020-01-01“…Similarly, the expression of HDAC2 mRNA was significantly higher at baseline and at remission following 6-week steroid therapy as compared to their expression in those who were resistant to steroids (P < 0.005). …”
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568
Exploring the prognostic role of microbial and genetic markers in lung squamous cell carcinoma
Published 2025-02-01“…The microbial signature built with these microbial genera, exhibited robust predictive accuracy in both the training and validation datasets. Furthermore, hub mRNA between high- and low-risk groups were selected by XGBOOST and intersect with mRNAs screened by univariate Cox regression analysis, finally identifying four mRNA significantly associated with LUSC prognosis. …”
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569
Influence of Dietary Chromium and Vitamin E Supplementation on Performance, Metabolism, and Physiology of Broilers Subjected to Cyclic Heat Stress
Published 2025-01-01“…ABSTRACT This experiment evaluated the influence of chromium (Cr) and vitamin E (VitE) supplementation on the performance, glucose levels, thyroid hormone levels, immune and oxidative response, and 70 kilodalton heat shock protein (HSP70) mRNA expression of broilers under heat stress (HS). …”
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570
Effects of Placenta-Derived Mesenchymal Stem Cells on the Particulate Matter-Induced Damages in Human Middle Ear Epithelial Cells
Published 2019-01-01“…The mRNA expression levels of PGE2, TGFβ, and VEGF were elevated in cocultured PL-MSCs compared to those of control PL-MSCs. …”
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571
Effects of Maternal Hypoxia during Pregnancy on Bone Development in Offspring: A Guinea Pig Model
Published 2014-01-01“…MH did not change primary spongiosa height but lowered collagen-1 mRNA expression in postnatal offspring. There was increased mRNA expression of adipogenesis-related gene (FABP4) in bone from the MH postnatal offspring. …”
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572
Role of Transforming Growth Factor-β1 and Smads Signaling Pathway in Intrauterine Adhesion
Published 2016-01-01“…This altered ratio recommended that IUA was positively correlated to the mRNA and protein expression levels of Smad3, Smad7, and TGF-β1 in blood and uterine tissue. …”
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573
YBX1 alleviates ferroptosis in osteoporosis via the ATF4/FSP1 axis in an m5C manner
Published 2025-01-01“…RNA pulldown and RNA immunoprecipitation experiments were used to determine the binding between YBX1 and ATF4 mRNA and to test the effect of YBX1 on ATF4 mRNA stability in a 5-methylcytosine (m5C)-dependent manner. …”
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574
eIF3 engages with 3’-UTR termini of highly translated mRNAs
Published 2025-01-01“…The results presented here show that eIF3 engages with 3’-UTR termini of highly translated mRNAs, likely reflecting a general rather than specific regulatory function of eIF3, and supporting a role of mRNA circularization in the mechanisms governing mRNA translation.…”
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575
METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression
Published 2025-01-01“…Mechanistically, METTL3 targeted adenine (+1795) on the SLC7A11 mRNA, and the m6A reader IGF2BP2 promoted SLC7A11 mRNA stability by recognizing and binding to the m6A site. …”
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576
Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma
Published 2020-01-01“…We analyzed 551 patients with EAC using single-protein and multiplex immunohistochemistry as well as mRNA in situ technology for the expression and distribution of IDO on subtypes of TILs (INF-γ mRNA and CD4- and CD8-positive T lymphocytes). …”
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577
Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression
Published 2015-01-01“…In contrast, SD diabetic rats demonstrated decreased GLP-1 mRNA, cellular GLP-1R immunoreactivity, and frequency of GLP-1R immunoreactive cells in the neck area compared with controls. …”
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578
High Intestinal and Systemic Levels of Interleukin-23/T-Helper 17 Pathway in Chinese Patients with Inflammatory Bowel Disease
Published 2013-01-01“…Our results indicated that the mRNA levels of IL-12p40 and TL1A were increased in ulcerative colitis (UC) patients. …”
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579
SPARC Levels Modulate the Capacity of Mitomycin to Inhibit the Proliferation of Human Tenon’s Capsule Fibroblasts
Published 2020-01-01“…Compared to control, the si-SPARC and MMC downregulated the SPARC protein by 91% (P<0.01) and 65% (P<0.01) and mRNA by 96% (P<0.01) and 64% (P<0.01), respectively. …”
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580
The Effect and Mechanism of TLR9/KLF4 in FFA-Induced Adipocyte Inflammation
Published 2018-01-01“…Methods. qRT-PCR and Western blot were used to detect the mRNA and protein expression levels of TLR9, KLF4, and key inflammation-related factors. …”
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