Mechanism of Inflammation Regulation of α7nAChR in Spleen and Spinal Dorsal Horn of Mice with Paclitaxel-induced Neuropathic Pain by Electroacupuncture on Zusanli Acupoint by PANG Lina, LAN Yanyan, WANG Zhifu, CHEN Xiaomei, YU Xiangmei

“…Compared with the model group, the mRNA level and protein expression of TNF-α in spleen and spinal dorsal horn of the electroacupuncture group significantly decreased (<italic>P</italic>&lt;0.05). …”
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锌离子抑制动脉粥样硬化进程中的巨噬细胞泡沫化 by 田甜, 周芳敏, 汤勇波

“…oxLDL处理组与对照组相比，锌调控-铁调控相关蛋白基因（ZIP）中，ZIP10、ZIP12、ZIP14的mRNA表达量升高（P<0.05），ZIP4、ZIP7、ZIP8的mRNA表达量降低（P<0.05）；而锌转运蛋白（ZnT）基因中，ZnT4的mRNA表达量上调（P<0.01），ZnT1的mRNA表达量下调至（P<0.05）。…”
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FDFT1 inhibits macrophage M1 polarization and promotes colorectal cancer progression by GAO Yuan, HUANG Yulan, ZHAO Kun

“…RT-qPCR was used to detect the mRNA levels of corresponding targets in MC38 cells after transfection. …”
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Effect of Xingbi Gel Nasal Drops on Rats with Allergic Rhinitis Based on the Nasal Mucosa-Hippocampus Neuroimmune Mechanism by FAN Xueqi, QIU Caixia, YAN Shuiping, ZHUANG Xiangli, AI Si, GUO Lihua, ZHENG Jian

“…Compared with the normal group, the nasal mucosal EOS counts all significantly increased in the model group, the traditional Chinese medicine group and the western medicine group after treatment (<italic>P</italic>&lt;0.05); compared with the model group, the nasal mucosa EOS counts decreased significantly in the traditional Chinese medicine group and the western medicine group after treatment (<italic>P</italic>&lt;0.05). (5) mRNA transcription levels and protein expression levels of Fyn, SP, VIP and NPY in hippocampus: compared with the normal group, mRNA transcription levels of Fyn, SP and VIP and average OD values of Fyn, SP and VIP increased significantly in the hippocampus in the model group (<italic>P</italic>&lt;0.05), while mRNA transcription levels of NPY and average OD values of NPY decreased significantly (<italic>P</italic>&lt;0.05). …”
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Curdlan sulphate modulates protein synthesis and enhances NF-κB and C/EBP binding activity in HepG2 cells by A. Guzdek, H. Rokita

“…Curdlan sulphate may, at least in part, affect protein synthesis at a pretranslational level, as the expression of ACT mRNA was found to be increased, whereas intracellular enzyme, manganese superoxide dismutase mRNA level was decreased in the cell culture treated with curdlan sulphate. …”
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Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD by Pritha Majumder, Biswanath Chatterjee, Khadiza Akter, Asmar Ahsan, Su Jie Tan, Chi-Chen Huang, Jen-Fei Chu, Che-Kun James Shen

“…Abstract Background Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning/memory development. …”
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Deciphering the pseudouridine nucleobase modification in human diseases: From molecular mechanisms to clinical perspectives by Shiheng Jia, Xue Yu, Na Deng, Chen Zheng, Mingguang Ju, Fanglin Wang, Yixiao Zhang, Ziming Gao, Yanshu Li, Heng Zhou, Kai Li

“…Abstract RNA pseudouridylation, a dynamic and reversible post‐transcriptional modification found in diverse RNA species, is crucial for various biological processes, including tRNA homeostasis, tRNA transport, translation initiation regulation, pre‐mRNA splicing, enhancement of mRNA translation, and translational fidelity. …”
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The Liposuction-Induced Effects on Adiponectin and Selected Cytokines Are Not Affected by Exercise Training in Women by Marina Yazigi Solis, Guilherme Giannini Artioli, Eduardo Montag, Vitor de Salles Painelli, Fábio Lopes Saito, Fernanda Rodrigues Lima, Hamilton Roschel, Bruno Gualano, Antonio Herbert Lancha Junior, Fabiana Braga Benatti

“…In contrast, TNF-α, IL-6, and IL-10 mRNA levels in scAT were increased, whereas adiponectin scAT mRNA and serum levels were decreased at POST6 (P<0.05, main effect for time). …”
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阿魏酸通过胰岛素/IGF信号通路和DAF-16促进秀丽隐杆线虫寿命和应激抵抗力 by 况琪斐, 陈巧超, 张玲, 何文, 裴中

“…用50 mmol/L阿魏酸组喂养线虫后，<italic>daf-2</italic>、<italic>akt-2</italic>和<italic>age-1</italic>基因的mRNA表达水平下调（<italic>P</italic>＜0.05），<italic>daf-16</italic>基因的mRNA表达水平上调（<italic>P</italic>＜0.05），并上调其下游靶基因<italic>sod-3</italic>、<italic>clk-2</italic>的mRNA表达，以及下调<italic>ctl-1</italic>、<italic>dod-17</italic>的mRNA表达（<italic>P</italic>＜0.05）。…”
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Ｒ８４８对胸腺基质淋巴细胞生成素调控Ｎａｉｖｅ Ｔ细胞分化的影响 by 陈壮桂

“…（２）Ｂ、Ｃ、Ｄ三组Ｔ细胞表达细胞因子ＩＬ－４和ＩＬ－１３水平均高于Ａ组；Ｂ组ＩＬ－４和ＩＬ－１３均较Ｃ组和Ｄ组高，而Ｄ组高于Ｃ组（均Ｐ＜０．０５）；Ｃ组表达ＩＦＮ－γ水平明显高于其余三组（均Ｐ＜０．０５）；Ａ、Ｂ、Ｄ三组之间ＩＦＮ－γ无明显差异（Ｐ＞０．０５）。（３）Ｃ组和Ｄ组ＧＡＴＡ－３ ｍＲＮＡ水平均低于Ｂ组，但高于空白对照Ａ组，其中Ｄ组ＧＡＴＡ－３ ｍＲＮＡ水平高于Ｃ组；Ｃ组表达Ｔ－ｂｅｔ ｍＲＮＡ水平高于其余三组（均Ｐ＜０．０５）；Ａ、Ｂ、Ｄ三组之间Ｔ－ｂｅｔ水平无明显差异（Ｐ＞０．０５）。…”
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Increased Duodenal Iron Absorption through Upregulation of Ferroportin 1 due to the Decrement in Serum Hepcidin in Patients with Chronic Hepatitis C by Masanori Sato, Koji Miyanishi, Shingo Tanaka, Akira Sakurada, Hiroki Sakamoto, Yutaka Kawano, Kohichi Takada, Masayoshi Kobune, Junji Kato

“…Compared with control participants, duodenal FPN mRNA expression in CHC patients was significantly upregulated. …”
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α７ｎＡＣｈＲ激动剂对血管紧张素Ⅱ诱导的心肌成纤维细胞增殖和胶原合成的影响及其分子机制

“…干预２４ ｈ后，应用ＣＣＫ－８试剂盒检测ＣＦ的增殖能力，ｗｅｓｔｅｒｎ ｂｌｏｔ检测胶原蛋白Ι、α－ＳＭＡ、α７烟碱乙酰胆碱受体（α７ｎＡＣｈＲ）、核中ｐ６５蛋白表达；Ｒｅａｌ－ｔｉｍｅ ＰＣＲ检测α７ｎＡＣｈＲ 的ｍＲＮＡ表达。【结果】 ＡｎｇⅡ干预２４ｈ，ＣＦ增殖显著提高，胶原蛋白Ι、α－ＳＭＡ、核中ｐ６５蛋白的表达明显升高，α７ｎＡＣｈＲ的ｍＲＮＡ和蛋白水平均表达降低；Ａｃｈ、α７ｎＡＣｈＲ激动剂预处理后抑制ＣＦ增殖，胶原蛋白Ι、α－ＳＭＡ和核中ｐ６５蛋白的表达降低，α７ｎＡＣｈＲ的ｍＲＮＡ和蛋白水平均表达升高；Ａｃｈ＋ＭＬＡ预处理， ＣＦ增殖再次提高，胶原蛋白Ι、纤维化因子α－ＳＭＡ、核中ｐ６５蛋白的表达再次明显升高，α７ｎＡＣｈＲ的ｍＲＮＡ和蛋白水平均表达降低。…”
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Serotonin-Exacerbated DSS-Induced Colitis Is Associated with Increase in MMP-3 and MMP-9 Expression in the Mouse Colon by Menglu Chen, Lei Gao, Pan Chen, Dandan Feng, Yalin Jiang, Yongchao Chang, Jianjun Jin, Fong-Fong Chu, Qiang Gao

“…The MMP-2, TIMP-1, and TIMP-2 mRNA levels were increased in the inflamed colon. 5-HT induced MMP-3 and MMP-9 mRNA expression in Caco-2 and human neutrophils, respectively, in vitro. …”
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Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis by Reza Ashrafi, Marianne Yon, Lucy Pickavance, Joseph Yanni Gerges, Gershan Davis, John Wilding, Kun Jian, Henggui Zhang, George Hart, Mark Boyett

“…Obese rats had significant upregulation of Cav1.2, HCN4, Kir2.1, RYR2, NCX1, SERCA2a, and RYR2 mRNA and downregulation of ERG mRNA. In the case of HCN4, it was confirmed that there was a significant increase in protein expression. …”
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大鼠实验性心肌梗死后β2肾上腺素受体动态变化及其拮抗剂对室颤阈值的作用

“…【目的】观察心肌梗死后心室肌β2受体mRNA表达水平的动态变化及其拮抗剂对室颤阈值及心室有效不应期的影响。【方法】制作大鼠心肌梗死模型(n=60),随机分为心肌梗死后2、4、8周组,另行假手术为对照组(n=20)。…”
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Maternal prediabetes as a risk factor of preeclampsia and placental dysfunction in pregnant female Sprague-Dawley rats by Aneliswe Siboto, Asiphaphola Ludidi, Ntethelelo Sibiya, Andile Khathi, Phikelelani Ngubane

“…Maternal PD significantly decreased VEGF, PlGF mRNA expression with a slight increase in sFlt-1 mRNA expression comparison to the normal pregnant control group.Conclusions Maternal PD is associated with placental dysfunction due to impaired glucose handling, endothelial dysfunction and an imbalance in angiogenic and antiangiogenic factors. …”
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The Impact of Vaccination on COVID-19, Influenza, and Respiratory Syncytial Virus-Related Outcomes: A Narrative Review by Roberto Debbag, Deborah Rudin, Francesca Ceddia, John Watkins

“…Coadministration of vaccines and combination vaccines, such as multicomponent mRNA vaccines, offer potential advantages in logistics and delivery, thus improving uptake and reducing barriers to adoption of new vaccines. …”
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Interaction mechanism of egg white- derived ACE inhibitory peptide TNGIIR with ACE and its effect on the expression of ACE and AT1 receptor by Zhipeng Yu, Hui Guo, David Shiuan, Chensi Xia, Wenzhu Zhao, Long Ding, Fuping Zheng, Jingbo Liu

“…The oral administration of TNGIIR (2, 10 and 50 mg/kg) for up to four weeks did not reduce the blood pressure of SHR, in contrast to captopril (10 mg/kg, orally), but attenuated the mRNA expression of ACE and AT1 receptor (as did captopril). …”
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Detection of Complement C1q B Chain Overexpression and Its Latent Molecular Mechanisms in Cervical Cancer Tissues Using Multiple Methods by Si-Tong Lin, Zi-Qian Liang, Xiao-Yu Chen, Xin-Qing Ye, Yu-Yan Pang, Jia-Yuan Luo, Jun-Hong Chen, Yi-Wu Dang, Gang Chen

“…We conducted an integrated analysis of C1QB mRNA expression in cervical cancer using public microarrays and RNA-seq data sets by calculating standard mean differences (SMDs). …”
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Transient ocular hypertension remodels astrocytes through S100B. by Weiran Huang, Kenji Matsushita, Rumi Kawashima, Susumu Hara, Yuichi Yasukura, Kaito Yamaguchi, Shinichi Usui, Koichi Baba, Andrew J Quantock, Kohji Nishida

“…Astrocytes displayed weaker GFAP intensity (p < 0.0001) in the early-stage OHT mouse model, prior to the onset of hypertrophy, which was accompanied by an increase in GFAP mRNA expression (p < 0.0001) and a decrease in S100B mRNA expression (p < 0.001). …”
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