A Proinflammatory Effect of the β-Glucan from Pleurotus cornucopiae Mushroom on Macrophage Action by Ken-ichiro Minato, Akihiro Ohara, Masashi Mizuno

“…However, the PCPS did not induce to express both IL-12 and IL-10 mRNA in the macrophages. Next, the P. cornucopiae extract (containing mainly PCPS) treatment against mice showed significant increases in TNF and IL-1β mRNA expressions in the peritoneal macrophages of them. …”
Get full text

Vaccination ARN messager (ARNm), modèle de transition de la biologie fondamentale à la médecine by Sansonetti, Philippe J.

“…Sixty years elapsed between the discovery of messenger RNA (mRNA) and the use of this molecule in an unprecedented global vaccination campaign that brought the Covid-19 pandemic under control. …”
Get full text

Messenger RNA Turnover Processes in Escherichia coli, Bacillus subtilis, and Emerging Studies in Staphylococcus aureus by Kelsi L. Anderson, Paul M. Dunman

“…The regulation of mRNA turnover is a recently appreciated phenomenon by which bacteria modulate gene expression. …”
Get full text

Exploration of Some Nutrient Absorption–Related Genes and Intestinal Histology in Japanese Quails (Coturnix japonica) Throughout Their Productive Lifespan by Hamid Reza Rafieian‐Naeini, Mahdi Zhandi, Maryam Taghipour‐Shahbandi, Amir Reza Sabzian, Ali Reza Yousefi, Mahboubeh Khajehnabi, Woo Kyun Kim

“…The mRNA abundance of the CALB1, SGLT1, SGLT5, EAAT3 and NaPi‐IIb genes were compared among groups. …”
Get full text

Forskolin Inhibits Lipopolysaccharide-Induced Modulation of MCP-1 and GPR120 in 3T3-L1 Adipocytes through an Inhibition of NFκB by Jeanne Durendale Chiadak, Tatjana Arsenijevic, Kevin Verstrepen, Françoise Gregoire, Nargis Bolaky, Valérie Delforge, Véronique Flamand, Jason Perret, Christine Delporte

“…In DC, LPS increased MCP-1, TLR-4, and nuclear factor-κB1 (NFκB1) mRNA levels, whereas it decreased GPR120 mRNA levels. …”
Get full text

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…The various brain areas of the control animals showed an appreciable amount of Anx-1 at mRNA or protein level; on the other hand, the animals which had been pretreated with either steroid, showed a more intense Anx-1 mRNA signal than the controls in many areas. …”
Get full text

CRP and TNF-α  Induce PAPP-A Expression in Human Peripheral Blood Mononuclear Cells by Weiping Li, Hongwei Li, Fusheng Gu

“…Actinomycin D treatment completely prevented CRP and TNF-α induction of PAPP-A mRNA and protein expression. Additionally, nuclear factor- (NF-) κB inhibitor (BAY11-7082) potently inhibited both CRP and TNF-α stimulated PAPP-A mRNA and protein expression. …”
Get full text

不同原发病的肝移植患者围术期调节性Ｔ细胞的变化

“…ＨＳＮＳ组术后Ｔｒｅｇ％和Ｆｏｘｐ３ ｍＲＮＡ表达较术前逐渐下降，并在术后第１４天与术前比较有显著性差异（Ｐ ＝ ０．００４）；ＴＨＣ组术后Ｔｒｅｇ％和Ｆｏｘｐ３ ｍＲＮＡ表达也有下降趋势，其中Ｆｏｘｐ３ ｍＲＮＡ表达在第１４ 天与术前比较有显著性差异（Ｐ ＝ ０．０１９）；ＮＴＨＣ组术后Ｔｒｅｇ％和Ｆｏｘｐ３ ｍＲＮＡ在各时间点与术前比较无明显变化（Ｐ ＞ ０．０５）。…”
Get full text

Effects of Bacillus subtilis-fermented soybean meal replacing fish meal on antioxidant activity, immunity, endoplasmic reticulum stress and hepatopancreas histology in Pacific whit... by Songming Chen, Jieyu Dai, Yan Chen, Qiang Chen, Fen Dong, Congcong Wang, Yulong Sun, Jiteng Wang, Tao Han

“…In terms of endoplasmic reticulum stress, FSBM substitution significantly increased the mRNA expression of eif2α in the hepatopancreas. In muscle, FSBM substitution inhibited the mRNA expression of bip. …”
Get full text

Expression of Dual-Specificity Phosphatase 9 in Placenta and Its Relationship with Gestational Diabetes Mellitus by Qiang Wei, Xiaomin Pu, Li Zhang, Yi Xu, Meifan Duan, Yuemei Wang

“…The aim of the present study was to examine placental levels of DUSP9 mRNA and protein and to investigate the potential role of DUSP9 in the development of gestational diabetes mellitus (GDM). …”
Get full text

Diagnosis of hepatocellular carcinoma using liquid biopsy-based biomarkers: a systematic review and network meta-analysis by Yutong Jiang, Yutong Jiang, Shangwen Qi, Shangwen Qi, Rongrong Zhang, Rongrong Zhang, Ruixia Zhao, Yu Fu, Yuxuan Fang, Yuxuan Fang, Mingyi Shao

“…Subsequent analysis of circRNA and mRNA highlighted hsa_circ_000224, hsa_circ_0003998, KIAA0101 mRNA and GPC-3mRNA as the optimal diagnostic biomarkers for distinguishing HCC from healthy populations and liver disease patients, respectively. …”
Get full text

Decreased Expression of Thyroglobulin and Sodium Iodide Symporter Genes in Hashimoto’s Thyroiditis by Anna Popławska-Kita, Beata Telejko, Katarzyna Siewko, Maria Kościuszko-Zdrodowska, Natalia Wawrusewicz-Kurylonek, Adam Krętowski, Justyna Hryniewicka, Janusz Dzięcioł, Witold Bauer, Robert Milewski, Małgorzata Szelachowska, Maria Górska

“…The patients with HT had lower Tg and NIS mRNA (P=0.002 and P=0.001, resp.), as well as higher TNFα mRNA expression (P=0.049) than the controls. …”
Get full text

益肾汤联合强的松与依那普利对IgA肾病小鼠肾 MMP-965380;TIMP-1表达的影响

“…【目的】探讨中药“益肾汤”治疗IgA肾病(IgAN)的机理65377;【方法】用“口服牛血清白蛋白联合尾静脉注射葡萄球菌肠毒素B”法复制小鼠IgAN模型65377;设正常组65380;模型组65380;益肾汤低浓度65380;益肾汤高浓度65380;强的松+依那普利65380;强的松+依那普利+益肾汤低浓度65380;强的松+依那普利+益肾汤高浓度7组65377;FQ*9鄄PCR法检测小鼠肾组织MMP*9鄄965380;TIMP*9鄄1mRNA表达65380;免疫组化SABC法检测小鼠肾组织MMP*9鄄965380;TIMP*9鄄1的含量65377;【结果】模型组小鼠肾间质MMP*9鄄9表达(PU值:6.9 ± 2.7 vs 5.8 ± 2.1;mRNA表达:0.297 ± 0.025 vs 0.107 ± 0.004)与正常组比较差异无显著性(P > 0.05),而模型组TIMP*9鄄1表达(PU值:18.0 ± 7.7 vs 5.2 ± 2.2;mRNA表达:0.884 ± 0.247 vs 0.109 ± 0.007)则较正常组明显上调(P < 0.05)65377;益肾汤低浓度组与高浓度组之间肾小管间质MMP*9鄄965380;TIMP*9鄄1表达差异无显著性(P > 0.05),但益肾汤高浓度组与低浓度两组MMP*9鄄9表达均强于模型组(PU值:8.9 ± 3.0 vs 6.9 ± 2.7,8.9 ± 3.3 vs 6.9 ± 2.7;mRNA表达:0.397 ± 0.047 vs 0.297 ± 0.025,0.386 ± 0.027 vs 0.297 ± 0.025;P < 0.05),而TIMP*9鄄1的表达均弱于模型组(PU值:14.92 ± 6.07 vs 18.04 ± 7.70,15.55 ± 6.01 vs 18.04 ± 7.70;mRNA表达:0.665 ± 0.197 vs 0.883 ± 0.247,0.713 ± 0.221 vs 0.883 ± 0.247;P <0.05)65377;5个治疗组中强的松+依那普利+益肾汤高浓度组MMP*9鄄9 mRNA及其蛋白表达最强(PU值:34.3 ± 8.7;mRNA表达:1.265 ± 0.433)65380;而TIMP*9鄄1mRNA及其蛋白表达最弱(PU值:9.2 ± 3.4;mRNA表达: 0.293 ± 0.068)65377;【结论】益肾汤可促进IgAN小鼠肾组织MMP*9鄄9的表达65380;抑制TIMP*9鄄1的表达65377;强的松+依那普利+益肾汤的联合治疗方案较单用强的松+依那普利或单用益肾汤治疗IgAN有更好的疗效65377;…”
Get full text

糖皮质激素受体在翼状胬肉中的表达及意义 by 戚朝秀, 王晓黎, 李奇根, 邓娟, 叶辉

“…【结果】翼状胬肉及正常人的球结膜组织中均表达GR-α mRNA,不表达GR-β mRNA。其中翼状胬肉（39例）中的GR-α mRNA（×10^3拷贝/μg）为10±4,明显高于正常人球结膜中的2.2±0.3（P〈0.01）,经统计检验有显著性差异。…”
Get full text

Impact of an extended light regimen imposed during nursery period on the performance and lipid metabolism of weanling pigs by Guangfan Liu, Fen Su, Xingyue Zou, Xingming Yang, Liang Tian

“…Moreover, up-regulated mRNA or protein expression of PPARγ and CEBPα, and lower mRNA or protein expression of MTR1, ATGL, HSL, PPARα, and CPT1α, were observed in back subcutaneous fat of LP group compared with that of SP group. …”
Get full text

The mean and noise of stochastic gene transcription with cell division by Qi Wang, Lifang Huang, Kunwen Wen, Jianshe Yu

“…In this paper, we study the impact of cell division on the mean and noise of mRNA numbers by using a two-state stochastic model of transcription. …”
Get full text

Axon regeneration: an issue of translation by Schaeffer, Julia, Belin, Stephane

“…However, it is now well described that mRNA and protein levels correlate only partially in cells, and that the transcription process (from DNA to mRNA) may not directly reflect protein expression. …”
Get full text

The Mitochondria-Targeted Antioxidant SkQ1 Downregulates Aryl Hydrocarbon Receptor-Dependent Genes in the Retina of OXYS Rats with AMD-Like Retinopathy by M. L. Perepechaeva, A. Yu. Grishanova, E. A. Rudnitskaya, N. G. Kolosova

“…Dietary supplementation with SkQ1 decreased the AhR mRNA level in both OXYS and Wistar rats. At baseline, the retinal Cyp1a1 mRNA level was lower in OXYS rats. …”
Get full text

Omega-3 Polyunsaturated Fatty Acids Enhance Neuronal Differentiation in Cultured Rat Neural Stem Cells by Masanori Katakura, Michio Hashimoto, Toshiyuki Okui, Hossain Md Shahdat, Kentaro Matsuzaki, Osamu Shido

“…Treatment with AA decreased Hes1 mRNA but did not affect NeuroD and Map2 mRNA levels. …”
Get full text

Anti-Adhesive Podocalyxin Expression Is Disrupted in Recurrent Implantation Failure by Mustafa Tas

“…The relative expression of endometrial HOXA10 mRNA was calculated using the 2^−ΔΔCt equation. …”
Get full text