Transient Pneumonitis as a Possible Adverse Reaction to the BNT162b2 COVID-19 mRNA Vaccine in a Patient with Rheumatoid Arthritis: A Case Report and Review of the Literature by Yusuke Ohkubo, Shin-ichiro Ohmura, Ryuhei Ishihara, Toshiaki Miyamoto

“…Herein, we describe a case of pneumonitis following COVID-19 mRNA vaccination in a patient with rheumatoid arthritis, which resolved spontaneously.…”
Get full text

Regulatory networks of mRNAs and miRNAs involved in the immune response of diamondback moth, Plutella xylostella to fungal infection by Mei-Qiong Xie, Long-Jiang Wang, Hua-Mei Xiao, Shu-Jun Wei

Subjects: Get full text

Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour modelResearch in context by Carole Fournier, Marion Mercey-Ressejac, Valentin Derangère, Amal Al Kadi, David Rageot, Christine Charrat, Alexis Leroy, Julien Vollaire, Véronique Josserand, Marie Escudé, Séverine Escaich, François Ghiringhelli, Thomas Decaens, Fabrice P. Navarro, Evelyne Jouvin-Marche, Patrice N. Marche

Subjects: “…mRNA vaccine…”
Get full text

Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vaccine by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

Subjects: Get full text

UTR-Insight: integrating deep learning for efficient 5′ UTR discovery and design by Saichao Pan, Hanyu Wang, Hang Zhang, Zan Tang, Lianqiang Xu, Zhixiang Yan, Yong Hu

Subjects: Get full text

Relationship between Sustained Reductions in Plasma Lipid and Lipoprotein Concentrations with Apheresis and Plasma Levels and mRNA Expression of PTX3 and Plasma Levels of hsCRP in Patients with HyperLp(a)lipoproteinemia by Claudia Stefanutti, Fabio Mazza, Michael Steiner, Gerald F. Watts, Joel De Nève, Daniela Pasqualetti, Juergen Paal

“…PTX3 soluble protein levels in plasma were unchanged by 2 sessions of LA; however, a downregulation of mRNA expression for PTX3 was observed, starting with the first session of LA (p<0.001). …”
Get full text

Comparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprouting resistance in wheat by Longqing Sun, Ting Zhao, Dandan Qin, Jing Dong, Daorong Zhang, Xifeng Ren

“…Combined with degradome data, the miRNA-mRNA networks analysis was performed after genome-wide screening of target genes, and then KEGG enrichment highlighted that the starch and sucrose metabolism pathway related to PHS was specifically enriched in an especial target-gene dataset derived from R12R18-HE miRNAs. …”
Get full text

福莫特罗对哮喘小鼠气道杯状细胞增生及 粘蛋白MUC5ac mRNA表达的影响

Subjects: Get full text

伊贝沙坦对糖尿病大鼠肾氧化应激65380;NF-κB活性和 ICAM-1 mRNA表达的影响

“…【目的】 探讨伊贝沙坦对糖尿病大鼠肾脏氧化应激65380;NF-κB活性和ICAM-1 mRNA表达水平的影响65377; 【方法】 将33 只SD大鼠随机分为3 组:正常对照组(C)65380;糖尿病组(D)和伊贝沙坦组(I)65377;糖尿病大鼠模型用链脲佐菌素诱导65377;大鼠饲养12周后,观察24h尿微量白蛋白排泄率(UAER),取出肾脏作肾组织病理检查,测定肾组织中丙二醛(MDA)含量与超氧化物歧化酶(SOD)65380;过氧化氢酶(CAT)65380;谷胱苷肽过氧化物酶(GSH-PX)活性变化65377;逆转录-聚合酶链反应(RT-PCR)法检测肾组织中细胞间粘附因子-1(ICAM-1)mRNA的表达65377;凝胶电泳迁移率变动分析(EMSA)检测核因子(NF)-κB的活性65377; 【结果】 UAER在D组(378 ± 100)及I组(149 ± 58)均显著高于C组(30 ± 13),P < 0.01;I组UAER较D组显著降低,P < 0.0165377;与C组大鼠比较,D组大鼠肾组织MDA含量显著增高(5.8 ± 0.9 vs 3.5 ± 0.2), P < 0.01;SOD65380;CAT及GSH-PX活性均显著降低(22.3 ± 3.1,11.7 ± 0.7,11.3 ± 1.7 vs 39.2 ± 2.0,18.2 ± 0.5,23.2±3.9),P < 0.01;Ⅰ组肾组织MDA含量(4.3 ±0.6)明显低于D组,P < 0.01;SOD65380;CAT及GSH-PX活性(30.7 ± 1.6,13.3 ± 0.4,15.8 ± 2.8)明显高于D组,均P < 0.0165377;NF-κB活性在D组大鼠肾组织(44.3 ± 0.4)明显高于C组(14.6 ± 0.8),P < 0.01;Ⅰ组(37.7±0.3)明显低于D组,P < 0.0165377;D组肾组织ICAM-1 mRNA表达(2.14 ± 0.2)明显高于C组(0.36±0.1),P < 0.01;Ⅰ组肾组织ICAM-1 mRNA(1.37±0.1)表达明显低于D组,P < 0.0165377;【结论】 伊贝沙坦可能部分通过减轻氧化应激反应以及下调糖尿病大鼠肾组织中NF-κB的活性,降低ICAM-1 mRNA的表达水平实现对糖尿病大鼠肾脏的保护作用65377;…”
Get full text

高脂血症肾移植患者外周血MCP-1及其受体CCR2 mRNA表达及辛伐他汀治疗的影响 by 王玉新

“…【目的】探讨肾移植术后高脂血症患者外周血单核细胞趋化蛋白-1(MCP-1)及其受体CCR2 mRNA的表达及辛伐他汀治疗影响。【方法】根据患者肾移植术后6个月的血脂水平，从167例肾移植受者中选择60例作为研究对象，其中30例为血脂正常组(A组)，30例为血脂增高组(B组)，健康体检者30例作为对照组，逆转录聚合酶链反应检测各组外周血MCP-1及CCR2 mRNA表达水平。…”
Get full text

ApoM maintains cellular homeostasis between mitophagy and apoptosis by affecting the stability of Nnt mRNA through the Zic3-ApoM-Elavl2-Nnt axis during neural tube closure by Qing Liu, Dan Liu, Yuejiao Wang, Xiaowei Wei, Wei Ma, Hui Gu, Shanshan Jia, Yiwen He, Wenting Luo, Songying Cao, Zhonghua Yang, Anhua Wu, Zhengwei Yuan

“…Specifically, lack of ApoM resulted in reduced cytosolic localization of Elavl2 and caused Nnt mRNA degradation, which further led to impaired cell homeostasis by suppressing PINK1-PRKN-mediated mitophagy and promoting apoptosis and subsequent NTDs formation. …”
Get full text

mRNA Expression of EgCHI1, EgCHI2, and EgCHI3 in Oil Palm Leaves (Elaeis guineesis Jacq.) after Treatment with Ganoderma boninense Pat. and Trichoderma harzianum Rifai by Laila Naher, Soon Guan Tan, Chai Ling Ho, Umi Kalsom Yusuf, Siti Hazar Ahmad, Faridah Abdullah

Get full text

Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diabetes Mellitus by Yongliang Liu, Xinmei Wang, Yan Zhao, Peiqing Zhao, Lianqing Wang, Qiaoli Zhai, Xiaowei Zhang, Wenxiu Tian, Xinxin Xiang, Tao Li

Get full text

<i>Lin28b-let-7</i> Modulates mRNA Expression of <i>GnRH1</i> Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells by Yujing Xie, Xin Li, Meng Wang, Mingxing Chu, Guiling Cao

“…Bioinformatics analysis and mRNA expression of the target genes of DEMIs revealed that the MAPK and PI3K-AKT-mTOR signaling pathways were key pathways that involved the regulatory effect of <i>Lin28b</i> on GnRH. …”
Get full text

One Year Duration of Immune Response Following a 3rd Booster Dose of mRNA Vaccine Against COVID‐19 in 292 Patients With Hematological Malignancies in University Hospital Ostrava, Czech Republic by Ondrej Šušol, Barbora Šušolová, Ondřej Klempíř, Milan Navrátil, Jaromír Gumulec, Zdeněk Kořístek, Juraj Ďuraš, Michal Kaščák, Jana Mihályová, Lukáš Stejskal, Tomáš Jelínek, Petra Richterová, Lenka Szeligová, Hana Plonková, Jana Zuchnická, Barbora Dluhošová, Ivo Demel, David Buffa, Katarína Hradská, Tereza Popková, Ludmila Muroňová, Martin Lachnit, Klára Lančová, Roman Hájek

“…ABSTRACT Aims To evaluate antibody response to mRNA vaccine, identify subgroups with poor response and to determine long‐term antibody durability in hematological patients. …”
Get full text

Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves’ Ophthalmopathy by Przemyslaw Pawlowski, Natalia Wawrusiewicz-Kurylonek, Anja Eckstein, Joanna Reszec, Wlodzimierz Luczynski, Kristian Johnson, Adam Kretowski, Alina Bakunowicz-Lazarczyk, Maria Gorska, Jacek Szamatowicz, Lech Chyczewski, Janusz Mysliwiec

“…To evaluate the relationship between the expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 and the severity of Graves’ orbitopathy (GO). …”
Get full text

CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance by Xuemeng Xu, Qiu Peng, Zongyao Ren, Yaqian Han, Xianjie Jiang, Zhu Wu, Shiming Tan, Wenjuan Yang, Linda Oyang, Xia Luo, Jinguan Lin, Longzheng Xia, Mingjing Peng, Nayiyuan Wu, Yanyan Tang, Hao Tian, Yujuan Zhou, Qianjin Liao

“…Subsequently, circRNF13 augments the stability of ITGB1 mRNA via IGF2BP1 in a manner dependent on m6A modification. …”
Get full text

Longitudinal immunogenicity cohort study of SARS-CoV-2 mRNA vaccines across individuals with different immunocompromising conditions: heterogeneity in the immune response and crucial role of Omicron-adapted booster dosesResearch in context by Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Jacopo Polvere, Simone Lucchesi, Chiara Coppola, Simone Costagli, Gabiria Pastore, Anna Sicuranza, Monica Tozzi, Arianna Lippi, Francesca Panza, Monica Bocchia, Alessandro Bucalossi, Guido Garosi, David Bennett, Sonia Bernazzali, Massimiliano Fabbiani, Francesca Montagnani, Donata Medaglini

Subjects: Get full text

RNA diagnostics and therapeutics: a comprehensive review by Adeela Fathima Saju, Aditi Mukundan, Divyashree MS, Raghu Chandrashekhar, Archana Mahadev Rao

Subjects: Get full text

Development of nucleic acid-based vaccines against dengue and other mosquito-borne flaviviruses: the past, present, and future by Muhammad Bashir Bello, Ahlam Alsaadi, Asif Naeem, Sarah A. Almahboub, Mohammad Bosaeed, Mohammad Bosaeed, Safia S. Aljedani

Subjects: Get full text