Surgery for chronic pyothorax after failed amplatzer closure of bronchopleural fistula by Yohann Vincent, Alessandra Lenzini, Amir Hanna, Nicolas Leymarie, Brendan Le Picault, Elie Fadel

Get full text

A Roadmap to the Brittle Bones of Cystic Fibrosis by Ashwini P. Gore, Soon Ho Kwon, Antine E. Stenbit

“…The maintenance of bone health is essential for the CF population during their lives to prevent pain and fractures but also as they approach lung transplantation since severe bone disease can lead to exclusion from lung transplantation. …”
Get full text

Pulmonary Vein Thrombosis Associated with Metastatic Follicular Thyroid Carcinoma: A Case Report and Review by Maria Mavromati, Annick Gerber, Gregor John

“…Pulmonary vein thrombosis (PVT) mainly occurs following lung transplantation but cases associated with thoracic malignancy have also been described. …”
Get full text

How to Recondition Ex Vivo Initially Rejected Donor Lungs for Clinical Transplantation: Clinical Experience from Lund University Hospital by Sandra Lindstedt, Atli Eyjolfsson, Bansi Koul, Per Wierup, Leif Pierre, Ronny Gustafsson, Richard Ingemansson

“…A major problem in clinical lung transplantation is the shortage of donor lungs. Only about 20% of donor lungs are accepted for transplantation. …”
Get full text

Pleuroparenchymal Fibroelastosis as a Late-Onset Pulmonary Toxicity after Treatment with Anticancer Chemotherapy for High-Risk Neuroblastoma by Satoshi Yokoyama, Risa Kanai, Daisuke Fukao, Keigo Hamahata

“…Survival is poor, and the only therapy is lung transplantation. Here, we report a patient who developed PPFE as a late-onset pulmonary toxicity after treatment with anticancer chemotherapy for high-risk neuroblastoma (NB).…”
Get full text

Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey by Emil Vilstrup Moen, Thomas Skovhus Prior, Michael Kreuter, Wim A. Wuyts, Maria Molina-Molina, Marlies Wijsenbeek, Antonió Morais, Argyrios Tzouvelekis, Christopher J. Ryerson, Fabian Caro, Ivette Buendia-Roldan, Jesper M. Magnusson, Joyce S. Lee, Julie Morisett, Justin M. Oldham, Lauren K. Troy, Manuela Funke-Chambour, Maria Laura Alberti, Raphael Borie, Simon L. F. Walsh, Sujeet Rajan, Yasuhiro Kondoh, Yet H Khor, Elisabeth Bendstrup

“…The survey consisted of 74 questions divided into eight topics: characteristics of respondents, diagnosis, screening of first-degree relatives, screening tools, genetic testing methods, lung transplantation, ethical concerns, and future needs. …”
Get full text

Suppurative Mediastinitis Secondary to Burkholderia Cepacia in a Patient with Cystic Fibrosis by Ronald B George, Yannick Cartier, Alan G Casson, Paul Hernandez

“…Burkholderia cepacia is an important opportunistic pathogen among patients with cystic fibrosis (CF); it is associated with deterioration of lung function, poor outcome following lung transplantation and increased mortality. Fever, an elevated white blood cell count, weight loss and an often fatal deterioration in pulmonary function characterize a particular clinical course, termed ‘Cepacia syndrome’. …”
Get full text

Combined Kidney-Liver, Heart-Liver, and Kidney-Pancreas Transplantations from a Single Deceased Donor by Matteo Ravaioli, Matteo Serenari, Matteo Cescon, Sofia Martin Suarez, Alessandro Cucchetti, Giorgio Ercolani, Massimo Del Gaudio, Fausto Catena, Cristina Morelli, Giorgio Arpesella, Antonio Daniele Pinna

Get full text

A Brief Review of Chronic Obstructive Pulmonary Disease by James C Hogg

“…A recent study, based on a combination of multidetector computed tomography scanning of an intact specimen with microcomputed tomography and histological analysis of lung tissue samples, reported that the number of terminal bronchioles were reduced from approximately 44,500/lung pair in control (donor) lungs to approximately 4800/lung pair in lungs donated by individuals with very severe (Global initiative for chronic Obstructive Lung Disease stage 4) chronic obstructive pulmonary disease (COPD) treated by lung transplantation. The present short review discusses the hypothesis that a rapid rate of terminal bronchiolar destruction causes the rapid decline in lung function leading to advanced COPD. …”
Get full text

Catamenial Hemoptysis and Pneumothoraces in a Patient with Cystic Fibrosis by Chris M Parker, Robert Nolan, M Diane Lougheed

“…The patient was treated empirically with danazol and subsequently underwent a successful double-lung transplantation. Danazol was discontinued postoperatively, and she was started on an oral contraceptive. …”
Get full text

Advancements in lung regeneration: from bench to bedside by Danial Khayatan, Peyman Esmaeili Fard Barzegar, Arooj Fatima, Tayyaba Sattar, Ambreen Zahid, Syeda Aiman Batool, Mehreen Jabbar, Maryam Mureed, Fatima Haider, Aymun Javed Butt, Sana Hanif, Alexander Seifalian, Hamid Tebyaniyan

“…The underlying limited regenerative capacity of the lung makes this an unmet clinical need, often necessitating lung transplantation for patients with severe lung disease. …”
Get full text

Pleuroparenchymal Fibroelastosis: A New Entity within the Spectrum of Rare Idiopathic Interstitial Pneumonias by Karina Portillo, Ignasi Guasch, Caroline Becker, Felipe Andreo, Maria Teresa Fernández-Figueras, José Ramirez Ruz, Carlos Martinez-Barenys, Samuel García-Reina, Pedro Lopez de Castro, Irene Sansano, Ana Villar, Juan Ruiz-Manzano

“…The etiology of the disease is unclear, although some cases have been associated as a complication after bone marrow transplantation, lung transplantation (LT), chemotherapy, and recurrent respiratory infections. …”
Get full text

Iatrogenic Pulmonary Nodule in a Heart Transplant Recipient by Atul C. Mehta, Juan Wang, Jarmanjeet Singh, Joseph Cicenia

“…Formation of a peripheral pulmonary nodule (PPN) following a TBBx is occasionally encountered among the recipients of the lung transplantation. To our knowledge, this is the first case of TBBx producing a pulmonary nodule in a heart transplant recipient. …”
Get full text

Comparative Study of Angiotensin Convertase Enzyme (ACE2) Gene Expression in Patients with Covid-19 By Molecular Method by Behrooz Farzanegan, Naghmeh Bahrami, Mohammad Fathi, Saba Tahmasebi, Mehdi Kazem Pour Dizaji, Shadi Shafaghi, Farnaz Ahmadi, Farnoush Mohammadi, Seyedeh Zahra Fotook Kiaei, Mona Mohajeri Tehrani, Masoume Farhangiyan, Abdolreza Mohamadnia

Get full text

A Case of Chronic Granulomatous Disease with a Necrotic Mass in the Bronchus: A Case Report and a Review of Literature by Ali Cheraghvandi, Majid Marjani, Saeid Fallah Tafti, Logman Cheraghvandi, Davoud Mansouri

Get full text

Anticoagulation in venous thromboembolism in Behçet’s syndrome: friend or foe? by Rosaria Talarico, Marta Mosca, Raffaele De Caterina, Alessandro Celi, Marco De Carlo, Laura Carrozzi, Federica Di Cianni, Elisabetta Casto, Rosalinda Madonna, Andrea Maria D'Armini, Roberta Pancani

Get full text

Airway basal stem cell therapy for lung diseases: an emerging regenerative medicine strategy by Xingren Liu, Xin Wang, Xue Wu, Shuhua Zhan, Yan Yang, Caiyu Jiang

“…Abstract Chronic pulmonary diseases pose a prominent health threat globally owing to their intricate pathogenesis and lack of effective reversal therapies. Nowadays, lung transplantation stands out as a feasible treatment option for patients with end-stage lung disease. …”
Get full text

Bone Marrow-Derived Multipotent Stromal Cells Attenuate Inflammation in Obliterative Airway Disease in Mouse Tracheal Allografts by Alicia Casey, Fabian Dirks, Olin D. Liang, Hakima Harrach, Katharina Schuette-Nuetgen, Kristen Leeman, Carla F. Kim, Craig Gerard, Meera Subramaniam

“…Obliterative bronchiolitis (OB) remains the most significant cause of death in long-term survival of lung transplantation. Using an established murine heterotopic tracheal allograft model, the effects of different routes of administration of bone marrow-derived multipotent stromal cells (MSCs) on the development of OB were evaluated. …”
Get full text

Integrating pharmacogenetics, multi‐omics and machine learning in the novel therapeutic view of pulmonary hypertension by Chenxi Li, Jipeng Xue, Dongchen Zhou, Xiaomeng Qi, Ting Chen, Zhoubin Li

Get full text

Brazilian Thoracic Association recommendations for the management of lymphangioleiomyomatosis by Bruno Guedes Baldi, Paulo Henrique Ramos Feitosa, Adalberto Sperb Rubin, Alexandre Franco Amaral, Carolina Salim Gonçalves Freitas, Cláudia Henrique da Costa, Eliane Viana Mancuzo, Ellen Caroline Toledo do Nascimento, Mariana Sponholz Araujo, Marcelo Jorge Jacó Rocha, Martina Rodrigues de Oliveira, Tatiana Senna Galvão, Pedro Paulo Teixeira e Silva Torres, Carlos Roberto Ribeiro Carvalho

“…In recent decades, a number of advances have been made in the understanding of the pathophysiology and management of LAM, leading to improvements in its prognosis: identification of the main genetic aspects and the role of the mechanistic target of rapamycin (mTOR) pathway; relationship with hormonal factors, mainly estrogen; characterization of pulmonary and extrapulmonary manifestations in imaging studies; identification and importance in the diagnosis of VEGF-D; a systematic diagnostic approach, often without the need for lung biopsy; use of and indications for the use of mTOR inhibitors, mainly sirolimus, for pulmonary and extrapulmonary manifestations; pulmonary rehabilitation and the management of complications such as pneumothorax and chylothorax; and the role of and indications for lung transplantation. To date, no Brazilian recommendations for a comprehensive approach to the disease have been published. …”
Get full text