The impact of solute carrier proteins on disrupting substance regulation in metabolic disorders: insights and clinical applications by Jiangxia Du, Minhui Shen, Jiajia Chen, Hao Yan, Zhifei Xu, Xiaochun Yang, Bo Yang, Bo Yang, Peihua Luo, Peihua Luo, Kefeng Ding, Yuhuai Hu, Qiaojun He, Qiaojun He, Qiaojun He, Qiaojun He

“…Dysregulation in the processes of absorption, transport, metabolism, and excretion of these metabolites can lead to the onset of severe metabolic disorders, such as type 2 diabetes, non-alcoholic fatty liver disease, gout and hyperbilirubinemia. As the second largest membrane receptor supergroup, several major families in the solute carrier (SLC) supergroup have been found to play key roles in the transport of substances such as carbohydrates, lipids, urate, bile acids, monocarboxylates and zinc ions. …”
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Sex differences in the relationship between body composition and MASLD progression in a murine model of metabolic syndrome by Laura Manjarrés, Aline Xavier, Leticia González, Camila Garrido, Flavia C. Zacconi, Katherine Rivera, Laura Parra, Alkystis Phinikaridou, Cecilia Besa, Marcelo E. Andia

“…Summary: Metabolic dysfunction-associated steatotic liver disease (MASLD) progression exhibits significant sex differences, with males generally developing more severe disease. …”
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Selecting Candidates for Liver Transplantation: A Medical Ethics Perspective on the Microallocation of a Scarce and Rationed Resource by Eric M Yoshida

“…Following the success and acceptance of transplantation in the treatment of end-stage liver disease, there has been a progressive increase in the number of patients seeking a limited supply of donor organs. …”
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Emerging nanomedicine strategies for hepatocellular carcinoma therapy by Chen Guo, Jiayu Zhang, Xiaomeng Cai, Rui Dou, Jiaruo Tang, Zhengyuan Huang, Xueting Wang, Yan Guo, Hanqing Chen, Jun Chen

“…Abstract Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with a range of risk factors, including viral infections, alcoholic liver disease, exposure to fungal toxins, obesity, and type 2 diabetes. …”
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Latent Inflammation and Insulin Resistance in Adipose Tissue by I. S. Stafeev, A. V. Vorotnikov, E. I. Ratner, M. Y. Menshikov, Ye. V. Parfyonova

“…It closely associates with metabolic disorders such as type 2 diabetes mellitus (T2DM) and hepatic and cardiovascular diseases such as nonalcoholic fatty liver disease, atherosclerosis, myocarditis, and hypertension. …”
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Hepatoprotective effects of propolis ethanol extract on D-galactose-induced aging mice: A metabolomics and transcriptomics analysis focusing on insulin resistance pathways by Jinjia Liu, Songhao Tian, Jixiang Wang, Qing Sang, Wenting Su, Jinqiang Wu, Fenglei Zai

“…These findings provide a scientific foundation for the therapeutic potential of PEE in anti-aging and liver disease.…”
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis by Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

“…Reengaging LXR signaling by treatment with synthetic agonist reverses MASH in LXRα mutant mice suggesting that LXRα normally functions to impede the development of liver disease.…”
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Morbidity and Mortality Rates from Digestive Diseases in the RF Northwestern Federal District (NWFD) and Measures to Reduce Them by Andrey Yu. Baranovsky, Alexey M. Belyaev, Elina A. Kondrashina

“…The main non-oncological reasons for the development of these disorders include alcoholic liver disease, chronic alcoholic pancreatitis, peptic ulcer complications and NSAID-associated gastropathies. …”
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Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics by T. Kumanan, V. Sujanitha, S. Balakumar, N. Sreeharan

“…The contributory role of alcohol-induced increase in hepatic iron stores and lipid content is discussed. Late-stage liver disease with fibrosis seems to be protective for the development of ALA. …”
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Markers of Inflammation and Fibrosis in Alcoholic Hepatitis and Viral Hepatitis C by Manuela G. Neuman, Hemda Schmilovitz-Weiss, Nir Hilzenrat, Marc Bourliere, Patrick Marcellin, Cristhian Trepo, Tony Mazulli, George Moussa, Ankit Patel, Asad A. Baig, Lawrence Cohen

“…High levels of profibrinogenic cytokine transforming factor beta (TGF-β), metalloprotease (MMP2), and tissue inhibitor of matrix metalloprotease 1 (TIMP1) contribute to fibrogenesis in hepatitis C virus (HCV) infection and in alcohol-induced liver disease (ALD). The aim of our study was to correlate noninvasive serum markers in ALD and HCV patients with various degrees of inflammation and fibrosis in their biopsies. …”
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Intraoperative Cardiac Complications in Liver Transplantation: Preoperative Evaluation – A Narrative Review by Nedim Çekmen, Ahmed Uslu

“…The decisive treatment for end-stage liver disease (ESLD) is liver transplantation (LT). Perioperative management of LT is one of the most challenging issues for anesthesiologists. …”
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Fibrolamellar Carcinoma: 2012 Update by Michael Torbenson

“…Their etiology remains a mystery, as they are not associated with chronic liver disease. Fibrolamellar carcinomas are not indolent tumors, but have an overall better prognosis than typical hepatocellular carcinomas, in part because of the younger age at presentation and the lack of cirrhosis. …”
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Primary biliary cirrhosis: clinical and laboratory criteria of diagnostics and up-to-date treatment by L. Yu. Il’chenko, V. I. Reshetn’yak

“…PBC is organ-specific autoimmune liver disease affecting predominantly women that is characterized by chronic progressing destruction of intrahepatic bile ducts with portal inflammation, resulting in development of liver cirrhosis (LC). …”
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miR-559 Inhibits Proliferation, Autophagy, and Angiogenesis of Hepatocellular Carcinoma Cells by Targeting PARD3 by Chunjing Wang, Chengcheng Li, Rui Hao

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Putative Factors That May Modulate the Effect of Exercise on Liver Fat: Insights from Animal Studies by Faidon Magkos

“…An increase in intrahepatic triglyceride (IHTG) content is the hallmark of nonalcoholic fatty liver disease (NAFLD) and is strongly associated with insulin resistance and dyslipidemia. …”
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Hepatitis C Virus Evasion from RIG-I-Dependent Hepatic Innate Immunity by Helene Minyi Liu, Michael Gale

“…Exposure to hepatitis C virus (HCV) usually results in persistent infection that often develops into chronic liver disease. Interferon-alpha (IFN) treatment comprises the foundation of current approved therapy for chronic HCV infection but is limited in overall efficacy. …”
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Zebrafish as a model for human epithelial pathology by Ahmed Abu-Siniyeh, Moayad Khataibeh, Walid Al-Zyoud, Majed Al Holi

“…Zebrafish possess significant cellular and functional homology with mammals, which facilitates the investigation of various diseases, including inflammatory bowel disease, nonalcoholic fatty liver disease, and polycystic kidney disease. The advantages of using zebrafish as a model organism include rapid external development, ease of genetic manipulation, and advanced imaging capabilities, allowing for the real-time observation of disease processes. …”
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Update on Peripheral Arterial Vasodilation, Ascites and Hepatorenal Syndrome in Cirrhosis by Mladen Knotek, Boris Rogachev, Robert W Schrier

“…Orthotopic liver transplantation has remained the only curative treatment for patients with advanced liver disease; other modalities such as transjugular intrahepatic portosystemic shunt or vasopressin analogues may serve as a bridge to transplantation. …”
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Methimazole-Induced Cholestatic Jaundice: A Rare Case and Literature Review by Ahmed Mohamed Nefzi, Dhouha Cherif, Habiba Dabbebi, Haythem Yacoub, Hajer Hassine, Hela Kchir, Khadija Bellil, Nadia Maamouri

“…Concomitant causes of liver disease were ruled out. The treatment was discontinued, and a switch to corticosteroid therapy with a regimen of radioactive iodine sessions was initiated. …”
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Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells by Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu

“…Abstract The global incidence of metabolic dysfunction‐associated fatty liver disease (MAFLD) has risen sharply. This condition is strongly associated with the risk of cardiovascular disease (CVD), but how MAFLD affects the development and progression of CVD, particularly concerning vascular calcification, remains unclear. …”
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