Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study by Umberto Vespasiani-Gentilucci, Chiara Dell’Unto, Antonio De Vincentis, Andrea Baiocchini, Marco Delle Monache, Roberto Cecere, Adriano Maria Pellicelli, Valerio Giannelli, Simone Carotti, Giovanni Galati, Paolo Gallo, Francesco Valentini, Franca Del Nonno, Davide Rosati, Sergio Morini, Raffaele Antonelli-Incalzi, Antonio Picardi

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Alström’s Syndrome, Leber’s Hereditary Optic Neuropathy, or Retinitis Pigmentosa? A Case of Misdiagnosis by Palaiologos Alexopoulos, Chrysanthos Symeonidis, Tryfon Rotsos

“…AS affects metabolism, and symptomatology includes type 2 diabetes mellitus (T2DM), obesity, hypogonadism and gynecomastia in males, progressive bilateral sensorineural hearing loss, cardiomyopathy, nonalcoholic fatty liver disease (NAFLD), cirrhosis, and chronic progressive kidney disease. …”
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Autoimmune Hepatitis: Clinical Manifestations and Diagnostic Criteria by Ian G Mcfarlane

“…This review (published in 1999) noted that the original descriptive criteria appeared to be quite robust and required only relatively minor modifications to bring them up to date with developments and experience in diagnostic modalities for liver disease in general. Analysis of published data on the application of the original criteria in nearly 1000 patients revealed that the diagnostic scoring system had an overall diagnostic accuracy of 89.8%, with a sensitivity of 98.0%. …”
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Modeling challenges of hepatitis D virus kinetics during bulevirtide-based therapy by Adquate Mhlanga, Ori Wasserman, Pietro Lampertico, Scott J. Cotler, Harel Dahari

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Algorithm of management of patients with acute cholestatic hepatitis (Clinical case presentation) by T. A. Deyeva, Ye. N. German, M. V. Mayevskaya, V. T. Ivashkin

“…In the submitted case a main role in recognition of an etiology of liver disease have played by careful taking of past history and analysis of all possible causes of disease, that can be the key point in diagnostic search and choice of patient management tactics.…”
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Model for hepatitis C virus transmissions by Elamin H. Elbasha

“…Hepatitis C virus (HCV) is a leading cause of chronic liver disease. Thispaper presents a deterministic model for HCV infection transmission and usesthe model to assess the potential impact of antiviral therapy. …”
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Update on a Pharmacokinetic-Centric Alternative Tier II Program for MMT—Part II: Physiologically Based Pharmacokinetic Modeling and Manganese Risk Assessment by Michael D. Taylor, Harvey J. Clewell, Melvin E. Andersen, Jeffry D. Schroeter, Miyoung Yoon, Athena M. Keene, David C. Dorman

“…We also present novel PBPK simulations to predict manganese tissue concentrations in fetal, neonatal, pregnant, or aged individuals, as well as individuals with liver disease or chronic manganese inhalation. The results of these simulations could help guide risk assessors in the application of uncertainty factors as they establish exposure guidelines for the general public or workers.…”
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Characterization of liver, adipose, and fecal microbiome in obese patients with MASLD: links with disease severity and metabolic dysfunction parameters by Katherine J. P. Schwenger, Julia K. Copeland, Yasaman Ghorbani, Lina Chen, Elena M. Comelli, David S. Guttman, Sandra E. Fischer, Timothy D. Jackson, Allan Okrainec, Johane P. Allard

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a range of histological findings from the generally benign simple steatosis to steatohepatitis (MASH) which can progress to fibrosis and cirrhosis. …”
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Imaging the Abdominal Manifestations of Cystic Fibrosis by C. D. Gillespie, M. K. O’Reilly, G. N. Allen, S. McDermott, V. O. Chan, C. A. Ridge

“…Liver cirrhosis is the most important extrapulmonary cause of death in CF, yet significant challenges remain in the diagnosis of CF related liver disease. The capacity to predict those patients at risk of developing cirrhosis remains a significant challenge. …”
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Polymorphism of genes and drug-induced liver injury by P. Ye. Tkachenko, M. V. Mayevskaya, V. T. Ivashkin

“…Data of investigations allow to expand the concept of pathogenetic mechanisms of drug-induced liver disease, that, in turn, promotes development of the test systems providing diagnostics at molecular genetic level.…”
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Intestinal Permeability Assays: a Review by A. A. Iakupova, S. R. Abdulkhakov, R. K. Zalyalov, A. G. Safin, R. A. Abdulkhakov

“…The assay and result standardisation will facilitate practice in functional and organic intestinal diseases, as well as allergies, diabetes mellitus, non-alcoholic fatty liver disease and some other illnesses.…”
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Targeting ion homeostasis in metabolic diseases: Molecular mechanisms and targeted therapies by Yanjiao Zhang, Kaile Ma, Xinyi Fang, Yuxin Zhang, Runyu Miao, Huifang Guan, Jiaxing Tian

“…The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing annually, imposing a significant burden on both human health and the social economy. …”
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Use of Idarucizumab to Revert the Anticoagulant Effect of Dabigatran in Heart Transplant Surgery: An Institutional Experience by Álvaro Herrera-Escandón, Orlando Castaño-Cifuentes, Carlos A. Plata-Mosquera

“…Heart transplant is a surgical procedure with a high risk of perioperative bleeding in patients with a previous history of sternotomy, congestive liver disease, and/or use of oral anticoagulants. Anticoagulation is usually done with coumarin agents (warfarin, acenocoumarol), while on the waiting list, vitamin K is available allowing for partial reversal of the anticoagulant effect, although with variable INR and risk of uncontrolled bleeding. …”
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Efficacy of nucleoside analogues for hepatitis B virus-related liver failure: A network meta-analysis by Wu Jian, Yin Fang, Zhou Xinmin

“…The highest two- and three-month survival rate was recorded for patients using tenofovir. The end-stage liver disease (MELD) score and mortality in patients undergoing tenofovir treatment were the lowest. …”
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Differential Impacts of Soybean and Fish Oils on Hepatocyte Lipid Droplet Accumulation and Endoplasmic Reticulum Stress in Primary Rabbit Hepatocytes by Xueping Zhu, Zhihui Xiao, Yumin Xu, Xingli Zhao, Ping Cheng, Ningxun Cui, Mingling Cui, Jie Li, Xiaoli Zhu

“…Parenteral nutrition-associated liver disease (PNALD) is a severe ailment associated with long-term parenteral nutrition. …”
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Liver Injury with Features Mimicking Autoimmune Hepatitis following the Use of Black Cohosh by Grace Guzman, Eric R. Kallwitz, Christina Wojewoda, Rohini Chennuri, Jamie Berkes, Thomas J. Layden, Scott J. Cotler

“…Both patients reported black cohosh use for at least six months and had no evidence of another cause of liver disease. Their liver biopsies showed a component of centrilobular necrosis consistent with severe drug-induced liver injury. …”
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Relationship Between N-AFLD and Serum Uric Acid Levels in Non-Diabetic and Non- Obese Adults by Gültekin Pekcan, Hüseyin Demirci, Fahri Yakaryılmaz

“…Objective: Many studies are interested in the association between non-alcoholic fatty liver disease (N-AFLD) and other parameters. Our study evaluated the association between serum uric acid (SrUA) levels and N-AFLD in non-diabetic non-obese adults. …”
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Incidence of Severe Hepatotoxicity Related to Antiretroviral Therapy in HIV/HCV Coinfected Patients by Emily L. Heil, Mary L. Townsend, Kenneth Shipp, Amy Clarke, Melissa D. Johnson

“…Hepatotoxicity is a concern in HIV/hepatitis C virus (HCV) coinfected patients due to their underlying liver disease. This study assessed the incidence of hepatotoxicity in HIV/HCV co-infected patients in two outpatient infectious diseases clinics. …”
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Applicability of Oral Fluid and Dried Blood Spot for Hepatitis B Virus Diagnosis by Livia Melo Villar, Cristianne Sousa Bezerra, Helena Medina Cruz, Moyra Machado Portilho, Geane Lopes Flores

“…Hepatitis B virus (HBV) is one of the major causes of chronic liver disease worldwide; however most of individuals are not aware about the infection. …”
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The 5th Canadian Symposium on Hepatitis C Virus: We Are Not Done Yet—Remaining Challenges in Hepatitis C by Nicholas van Buuren, Lorraine Fradette, Jason Grebely, Alexandra King, Mel Krajden, Sonya A. MacParland, Alison Marshall, Sahar Saeed, Joyce Wilson, Marina B. Klein, Selena M. Sagan

“…Both the Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identified HCV-related liver disease as a priority and supported the establishment of a National Hepatitis C Research Network. …”
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