Bile acids and incretins as modulators of obesity-associated atherosclerosis by Andrijana Kirsch, Juergen Gindlhuber, Diana Zabini, Elena Osto, Elena Osto

“…Obesity is one of the major global health concerns of the 21st century, associated with many comorbidities such as type 2 diabetes mellitus (T2DM), metabolic dysfunction-associated steatotic liver disease, and early and aggressive atherosclerotic cardiovascular disease, which is the leading cause of death worldwide. …”
Get full text

Prognostic factors for transplant-free survival in patients with secondary sclerosing cholangitis associated with critical illness by Christoph Schramm, Hartmut Schmidt, Christian Gerges, Alisan Kahraman, Christian M Lange, Jassin Rashidi-Alavijeh, Katharina Willuweit, Georgios Konstantis, Dorsa Ghaffar Loy Moghadam, Alexandra Frey, Nargiz Nuruzade, Moritz Passenberg

“…The C-index was 0.78 (95% CI 0.65, 0.91), surpassing the model of end-stage liver disease score’s prognostic accuracy (Concordance Index at 3 years: 66.2% vs 74.9%).Conclusion These findings provide valuable insights for establishing standard exception criteria for this rare liver disease, which could lead to improved organ allocation. …”
Get full text

Interplay of PNPLA3 and HSD17B13 Variants in Modulating the Risk of Hepatocellular Carcinoma among Hepatitis C Patients by Carla De Benedittis, Mattia Bellan, Martina Crevola, Elena Boin, Matteo Nazzareno Barbaglia, Venkata Ramana Mallela, Paolo Ravanini, Elisa Ceriani, Stefano Fangazio, Pier Paolo Sainaghi, Michela Emma Burlone, Rosalba Minisini, Mario Pirisi

“…Carriage of PNPLA3 G∗ allele was associated with a trend of progressively more severe liver disease, from mild fibrosis to significant fibrosis, cirrhosis, and HCC (p=0.007). …”
Get full text

Characteristics of Hepatitis C Virus Infection in HIV-Infected People by Curtis L Cooper, Andrew D Badley, Jonathan B Angel

“…Co-infected individuals develop histological and clinical features of HCV liver disease more rapidly than HIV-seronegative patients. …”
Get full text

Liver metastases in gastroenteropancreatic neuroendocrine tumours – treatment methods by Paweł Gut

“…Surgical approaches that allow the safe treatment of multiple, bilateral, large tumours, and that combine extirpative, ablative and interventional therapies, have expanded the population of patients with neuroendocrine tumors (NET) liver metastases (LMs) who can benefit from aggressive treatment of their liver disease. Pre-treatment staging often includes the biochemical assessment of serologic markers such as serotonin, insulin, vasoactive intestinal peptide, and chromogranin, even in patients without clinically apparent hormonal excess. …”
Get full text

Mechanisms of Alcohol-Induced Endoplasmic Reticulum Stress and Organ Injuries by Cheng Ji

Get full text

Cardiac Failure after Liver Transplantation Requiring a Biventricular Assist Device by Rita Jermyn, Eiei Soe, David D’Alessandro, Julia Shin, William Jakobleff, Daniel Schwartz, Milan Kinkhabwala, Paul J. Gaglio

“…This case highlights the importance of preoperatively recognizing extrahepatic iron deposition in patients referred for liver transplantation irrespective of etiology of liver disease as this may prevent postoperative complications.…”
Get full text

Fatal Hepatic Decompensation in a Patient with Hepatitis B Cirrhosis Following Famciclovir Withdrawal by Robert P Myers, Rabindra Chaudhary, Kevin Fonseca, Samuel S Lee

“…Hepatitis B virus (HBV) infection is a major cause of chronic liver disease worldwide. Famciclovir is a nucleoside analogue with potent antiviral activity that appears promising in the management of patients with HBV infection. …”
Get full text

Unusual Infections Complicating the Use of Steroids with Severe Alcoholic Hepatitis: Report of 2 Cases by Vitor Arantes, Pina Michieletti, Ross Cameron, Jenny Heathcote, Morris Sherman

“…The authors report two patients with alcoholic liver disease who developed life-threatening infections after steroid therapy was started. …”
Get full text

Late-Onset Ornithine Carbamoyltransferase Deficiency Accompanying Acute Pancreatitis and Hyperammonemia by Marcel Cerqueira Cesar Machado, Gilton Marques Fonseca, José Jukemura

“…Here, we describe a patient with acute severe pancreatitis who developed hyperammonemia and encephalopathy without liver disease. Urea cycle disorder was suspected and hemodialysis was initiated. …”
Get full text

Relationship between Experimental Diet in Rats and Nonalcoholic Hepatic Disease: Review of Literature by Ayane A. Rodrigues, Raíssa S. B. Andrade, Daniel F. P. Vasconcelos

“…The pathophysiology of nonalcoholic fatty liver disease (NAFLD) is related to unhealthy lifestyles that combine sedentary lifestyle, hypercaloric diets, excessive saturated fats, refined carbohydrates, and high intake of fructose as a food additive to various processed products. …”
Get full text

Herb-Induced Liver Injury by Cimicifuga racemosa and Thuja occidentalis Herbal Medications for Fertility by Rohan Patel, Fareeha Alavi, Susel Ortega, Ajsza Matela

“…Upon a detailed investigation, the patient did not have evidence of underlying liver disease or any other risk factors to explain her presentation. …”
Get full text

Lack of adipocyte FAM20C improves whole body glucose homeostasis by Liping Deng, Yanshan Huang, Feifei Zhao, Puxin Chen, Xiaohong Huang

“…Our results demonstrate that knockout mice are protected against high fat diet‐induced obesity, adiposity, and fatty liver disease. Additionally, knockout mice exhibited improved metabolic phenotypes, including enhanced glucose tolerance and insulin sensitivity compared with control mice. …”
Get full text

Investigation of Bacteremia due to Aeromonas Species and Comparison with That due to Enterobacteria in Patients with Liver Cirrhosis by Toru Shizuma, Chiharu Tanaka, Hidezo Mori, Naoto Fukuyama

“…However, in the Aeromonas group, the model for end-stage liver disease (MELD) score and Child-Pugh score were significantly higher than in the enterobacteria group. …”
Get full text

Mechanisms and active substances of targeting lipid peroxidation in ferroptosis regulation by Hui Chen, Lingli Chen, Wenjun Wang

“…Ferroptosis is a novel form of cell death driven by iron-dependent lipid peroxidation and it is implicated in various diseases, such as liver disease, acute kidney injury, cardiovascular disease, neurodegenerative disease and cancer. …”
Get full text

Advantages and Disadvantages of Hyperbaric Oxygen Treatment in Mice with Obesity Hyperlipidemia and Steatohepatitis by Koichi Tsuneyama, Yen-Chen Chen, Makoto Fujimoto, Yoshiyuki Sasaki, Wataru Suzuki, Tsutomu Shimada, Seiichi Iizuka, Mitsunobu Nagata, Masaki Aburada, Shao-Yuan Chen

“…The effect of hyperbaric oxygen treatment (HBOT) was examined using MSG mice, which are an animal model of obesity, hyperlipidemia, diabetes, and nonalcoholic fatty liver disease. Nineteen MSG male mice were divided into HBOT treated and control groups at 12 weeks of ages. …”
Get full text

Validation and Refinement of the Baveno VI Criteria for Ruling Out High-Risk Varices by Hong Zhou, Han Hu, Maoyong Tian, Jun Chu, Caiyun Tian, Yanqing Yang, Shide Lin

“…The Baveno VI criteria recommend the use of a simple algorithm based on a liver stiffness measurement<20 kPa through transient elastography and a platelet count>150×109/L for ruling out high-risk varices in patients with compensated advanced chronic liver disease. A large number of studies have validated the clinical usefulness of Baveno VI criteria for excluding high-risk varices. …”
Get full text

Characterization and Detection Strategy Exploration in Cryptogenic Hepatocellular Carcinoma: Insights From a Super‐Aged Region in Japan by Takaaki Sugihara, Takakazu Nagahara, Takuya Kihara, Suguru Ikeda, Yoshiki Hoshino, Yukako Matsuki, Takuki Sakaguchi, Hiroki Kurumi, Takumi Onoyama, Tomoaki Takata, Tomomitsu Matono, Hajime Isomoto

“…Excluding cases associated with hepatitis viral infection, alcoholic liver disease, non‐alcoholic fatty liver disease/steatohepatitis, autoimmune hepatitis, primary biliary cholangitis, and congestive hepatopathy, the study specifically focused on genuine c‐HCC. …”
Get full text

Mesenchymal Stem Cells Ameliorate Hepatic Ischemia/Reperfusion Injury via Inhibition of Neutrophil Recruitment by Shihui Li, Xu Zheng, Hui Li, Jun Zheng, Xiaolong Chen, Wei Liu, Yan Tai, Yingcai Zhang, Genshu Wang, Yang Yang

Get full text

Combination Treatments of Plasma Exchange and Umbilical Cord-Derived Mesenchymal Stem Cell Transplantation for Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failur... by Wen-xiong Xu, Hong-liang He, Shun-wen Pan, Yuan-li Chen, Mei-ling Zhang, Shu Zhu, Zhi-liang Gao, Liang Peng, Jian-guo Li

“…The multivariate logistic regression analysis demonstrated that hemoglobin, prothrombin activity, and MELD (model for end-stage liver disease) score were the independent factors associated with the unfavorable outcome (all P<0.05). …”
Get full text