SUPPRESSION OF SUBGENOMIC HEPATITIS C VIRUS RNA REPLICON REPLICATION IN Huh-7 CELLS BY THE NS3 PROTEASE INHIBITOR SCH5030334: A STOCHASTIC MATHEMATICAL MODEL by E. L. Mishchenko, N. V. Ivanisenko, I. R. Akberdin, P. S. Demenkov, V. A. Likhoshvai, N. A. Kolchanov, V. A. Ivanisenko

“…Hepatitis C virus (HCV) causes a severe liver disease frequentlyassociatedwith cirrhosis andhepatocellular carcinoma. …”
Get full text

Progression of Hepatic Adenoma to Carcinoma in the Setting of Hepatoportal Sclerosis in HIV Patient: Case Report and Review of the Literature by M. I. Montenovo, F. G. Jalikis, M. Yeh, J. D. Reyes

“…This case also highlights the broad differential diagnosis that should always be included in the study of any liver disease in this patient population, including the performance of invasive and aggressive tests to arrive at the final diagnosis.…”
Get full text

MORIX: Machine learning-aided framework for lethality detection and MORtality inference with eXplainable artificial intelligence in MAFLD subjects by Domenico Lofù, Paolo Sorino, Tommaso Colafiglio, Caterina Bonfiglio, Rossella Donghia, Gianluigi Giannelli, Angela Lombardi, Tommaso Di Noia, Eugenio Di Sciascio, Fedelucio Narducci

“…Metabolic dysfunction-associated fatty liver disease (MAFLD) introduces new diagnostic criteria for fatty liver disease that are independent of alcohol consumption and viral hepatitis infection. …”
Get full text

Acyl-CoA Thioesterase 1 Contributes to Transition of Steatosis to Metabolic-Associated Steatohepatitis by Elisa Pasini, Cristina Baciu, Marc Angeli, Bianca Arendt, Diogo Pellegrina, Jüri Reimand, Keyur Patel, George Tomlinson, Mohammad T. Mazhab-Jafari, Lakshmi P. Kotra, Sandra Fischer, Johane P. Allard, Atul Humar, Mamatha Bhat

“…Metabolic dysfunction-associated steatohepatitis (MASH) has become the leading cause of chronic liver disease, but there has been no approved pharmacotherapy to date. …”
Get full text

The use of urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin for diagnosis of hepato-renal syndrome in advanced cirrhotic patients by Mohamed Adel Abd Elaziz, Asmaa Mustafa Gouda Elewa, Dina Zaki Mohamed Zaki Abdel Hamid, Nohier Essam Soliman Ahmed Hassan, Éva Csongrádi, Emad Hamdy Hamouda Mohammed, Mohammed Abdel Gawad

“…Background Chronic liver disease is a common and important clinical problem. …”
Get full text

Knowledge, attitudes and practices to hepatitis B among South African primary healthcare staff by Atlegang Mashilo, Itumeleng Mompati, Refilwe Ramakatane, Didintle Sebitloane, Naledi Sibi, Philippa C. Matthews, Cornel Van Rooyen, Dominique Goedhals, Sabeehah Vawda

“…Background: Hepatitis B virus (HBV), a significant cause of liver disease globally, is recognised as a 2030 elimination target by the World Health Organization (WHO). …”
Get full text

Organizing Pneumonia Associated with Pegylated Interferon α and Ribavirin Therapy by Amit Chopra, Creticus Marak, Narendrakumar Alappan, Chang Shim

“…Hepatitis C virus infection is the leading cause of chronic liver disease in the United States of America. Pegylated interferon α and ribavirin combination is the mainstay of treatment. …”
Get full text

Hepatocellular Bile Salt Transport: Lessons from Cholestasis by Michael Trauner, Peter Fickert, Rudolf E Stauber

“…This review summarizes the molecular defects in hepatocellular membrane transporters that are associated with hereditary and acquired forms of cholestatic liver disease.…”
Get full text

Outcomes of Adult Liver Retransplantation: A Canadian National Database Analysis by Peter D. Yoon, Madhukar S. Patel, Carla F. Murillo Perez, Tommy Ivanics, Marco P.A.W. Claasen, Hala Muaddi, David Wallace, Bettina Hansen, Gonzalo Sapisochin

“…Results. 377 (6.5%) patients underwent liver retransplantation. Autoimmune liver disease and hepatitis C virus (HCV) were the most common underlying diagnoses. …”
Get full text

Case report: Rituximab combined with plasma exchange treatment for systemic lupus erythematosus complicated with thrombotic microangiopathy and non-cirrhotic portal hypertension by Jinmei Huang, Wei Fan, Xuyan Chen, Shufan Wu, Zhigao Dong, Yi Zhang, Yiwan Lin, Pingping Xiao

“…The patient was negative for hepatitis virus, autoimmune liver disease antibodies, ceruloplasmin, and tumor markers. …”
Get full text

Влияние курсового приема L-орнитин- L-аспартата на фиброз и стеатоз печени у больных ассоциированной с нарушениями метаболизма жировой болезнью печени (неалкогольной жировой болезн... by Е. V. Garanina

“…Hyperammonaemia develops both in cirrhosis and earlier fibrotic stages during metabolic-associated fatty liver disease (MAFLD). Besides neurotropic, ammonia exerts the hepatotoxic and profibrotic effects. …”
Get full text

Advances in liver engineering with cell, scaffold, and vascularization by Chunyan Liu, Yulian Wang, Xuqian Zhou, Lei Dong

“…Liver tissue engineering is a promising alternative to organ transplantation for the treatment of end-stage liver disease, acute liver failure, and liver-based metabolic disorders. …”
Get full text

A Case of Granulomatosis with Polyangiitis in Pregnancy by Rashid Naseem Khan, Aliya Naseem, Muhammad Athar Khan, Qurat ul Ain Qurat ul Ain, Mamoona Hashim, Hafiza Laila Hashim Khan

“…A 25-year-old woman with chronic liver disease, vasculitis, protein C and S deficiency, hypothyroidism, and gestational diabetes presented at 24 weeks gestation with shortness of breath, fever, and vomiting. …”
Get full text

Risk Factors for Hepatitis C Virus Transmission Obscure in Nigerian Patients by Olive Obienu, Sylvester Nwokediuko, Abraham Malu, Olufunmilayo A. Lesi

“…This warrants further studies on the epidemiology of this important cause of liver disease.…”
Get full text

Clinical Resolution of Osmotic Demyelination Syndrome following Overcorrection of Severe Hyponatremia by Ruhin Yuridullah, Vinod Kumar, Sushant Nanavati, Monisha Singhal, Chandra Chandran

“…Osmotic Demyelination Syndrome (ODS) occurs after rapid overcorrection of severe chronic hyponatremia usually in those with a predisposition such as chronic alcoholism, malnutrition, or liver disease. Rarely, do patients make a full recovery. …”
Get full text

Exocrine pancreatic insufficiency and causes of abdominal symptoms in diabetes patients by Roland Kadaj-Lipka, Grażyna Rydzewska

“…Gastrointestinal side effects include pancreatopathy, small intestinal bacterial overgrowth, oesophageal dysmotility, gastroesophageal reflux disease, gastroparesis, neuropathy, and nonalcoholic fatty liver disease.…”
Get full text

Effects of Super Nutritional Hepatic Copper Accumulation on Hepatocyte Health and Oxidative Stress in Dairy Cows by Jaimie M. Strickland, Doug Lyman, Lorraine M. Sordillo, Thomas H. Herdt, John P. Buchweitz

“…The objective of this study was to determine the association of hepatic copper concentrations with evidence of liver disease. Blood and liver samples were collected at the time of slaughter in cull dairy cows (n=100). …”
Get full text

Gastrointestinal Bleeding Secondary to Portal Hypertensive Duodenopathy in a Patient with Decompensated Liver Cirrhosis by Rohini Krishna, Samuel O. Igbinedion, Richie Diaz, Nazneen Hussain, Moheb Boktor

“…With alcoholic cirrhosis and nonalcoholic fatty liver disease continuously on the rise in the United States, there is also a corresponding rise in portal hypertension. …”
Get full text

Alleviating batch effects in cell type deconvolution with SCCAF-D by Shuo Feng, Liangfeng Huang, Anna Vathrakokoili Pournara, Ziliang Huang, Xinlu Yang, Yongjian Zhang, Alvis Brazma, Ming Shi, Irene Papatheodorou, Zhichao Miao

“…Applied to non-alcoholic fatty liver disease, SCCAF-D unveils meaningful insights into changes in cell proportions during disease progression.…”
Get full text

Cholestasis in Crohn's Disease: A Diagnostic Challenge by Nir Hilzenrat, Esther Lamoureux, Averell Sherker, Albert Cohen

“…A 24-year-old male with Crohn's disease who developed three independent episodes of cholestatic liver disease over an eight-year period is described. …”
Get full text