Short-term abstinence from alcohol and changes in cardiovascular risk factors, liver function tests and cancer-related growth factors: a prospective observational study by Gautam Mehta, Rajiv Jalan, Matteo Rosselli, James Maurice, Stewart Macdonald, Alexandra Cronberg, Tanya Khera-Butler, Colin Sumpter, Safa Al-Khatib, Anjly Jain, Christos Charalambous, Amir Gander, Cynthia Ju, Talay Hakan, Roy Sherwood, Devaki Nair, Kevin P Moore

“…Exclusion criteria were known liver disease or alcohol dependence.Primary and secondary outcome measures The primary outcome was change in insulin resistance (homeostatic model assessment (HOMA) score). …”
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Direct targeting of risk factors significantly increases the detection of liver cirrhosis in primary care: a cross-sectional diagnostic study utilising transient elastography by Guruprasad P Aithal, Indra Neil Guha, Stephen D Ryder, Emilie A Wilkes, David J Harman, Martin W James, Matthew Jelpke, Dominic S Ottey, Timothy R Card

“…Objectives To assess the feasibility of a novel diagnostic algorithm targeting patients with risk factors for chronic liver disease in a community setting.Design Prospective cross-sectional study.Setting Two primary care practices (adult patient population 10 479) in Nottingham, UK.Participants Adult patients (aged 18 years or over) fulfilling one or more selected risk factors for developing chronic liver disease: (1) hazardous alcohol use, (2) type 2 diabetes or (3) persistently elevated alanine aminotransferase (ALT) liver function enzyme with negative serology.Interventions A serial biomarker algorithm, using a simple blood-based marker (aspartate aminotransferase:ALT ratio for hazardous alcohol users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE).Main outcome measures Diagnosis of clinically significant liver disease (defined as liver stiffness ≥8 kPa); definitive diagnosis of liver cirrhosis.Results We identified 920 patients with the defined risk factors of whom 504 patients agreed to undergo investigation. …”
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Primary sclerosing cholangitis by Marina G Silveira, Keith D Lindor

“…Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy. …”
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Management of Coagulopathy in Patients with Decompensated Liver Cirrhosis by Pooja D. Amarapurkar, Deepak N. Amarapurkar

“…As there is reduction in both anti and procoagulant factors, global tests of coagulation are normal in patients with acute and chronic liver disease indicating that coagulopathy in liver disease is more of a myth than a reality. …”
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Characteristic features of ulcerative colitis with concomitant primary sclerosing cholangitis by Artur W. Uździcki, Marta Wawrzynowicz-Syczewska

“…It is often complicated by the presence of primary sclerosing cholangitis, a chronic, cholestatic liver disease, characterised by the inflammation and fibrosis of bile ducts. …”
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Highlights of the Fourth Canadian Symposium on Hepatitis C: Moving towards a National Action Plan by Selena M. Sagan, Benoit Dupont, Jason Grebely, Mel Krajden, Sonya A. MacParland, Jennifer F. Raven, Sahar Saeed, Jordan J. Feld, D. Lorne Tyrrell, Joyce A. Wilson

“…The Canadian Institutes of Health Research (CIHR) and the Public Health Agency of Canada (PHAC) have identified HCV-related liver disease as a priority. In 2015, the release of well-tolerated, short course treatments (~12 weeks) able to cure the majority of treated HCV patients revolutionized HCV therapy. …”
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CALLY index, but not HALP score, is associated with mortality in cirrhosis patients by Yıldız Günay, Bedel Cihan, Zortuk Ökkeş, Selvi Fatih, Karanci Yusuf

“…Cirrhosis is a chronic liver disease that is characterized by inflammation and fibrosis, as well as liver dysfunction. …”
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Exploring the association between herbal medicine usage and drug-induced liver injury: insights from a nationwide population-based cohort study using SCCS in South Korea by Taehyun Yang, Juhee Ahn, Juhee Ahn, Sungho Won, Sungho Won, Sungho Won, Sanghun Lee

“…Patients with pre-existing liver disease exhibit increased susceptibility to DILI. …”
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Prediction of MASLD using different screening indexes in Chinese type 2 diabetes mellitus by Mengmeng Hu, Jingyu Yang, Beibei Gao, Zhoulu Wu, Ying Wu, Dandan Hu, Qiong Shen, Lei Chen

“…Abstract Background Formerly known as non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) has now become the most widespread chronic liver disease worldwide. …”
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Severe metabolic accumulation of VV116 in kidney transplant patients with impaired renal function: a case series report by Jiaying Zhang, Yuan Gao, Xiaoyun Miao, Wei Wang, Zhongkai Zhou, Yunyi Gao, Liwei Liu, Menghua Wu, Ke Ma, Ling Zhou, Yan Yang, Sha Meng, Yingmei Feng, Zhuorui Zhao, Wei Liu, Danlei Mou, Zixin Kang, Lianchun Liang, Zhongjie Hu

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CIHR Canadian HIV Trials Network Coinfection and Concurrent Diseases Core: Canadian Guidelines for Management and Treatment of HIV/Hepatitis C Coinfection in Adults by Mark Hull, Marina Klein, Stephen Shafran, Alice Tseng, Pierre Giguère, Pierre Côté, Marc Poliquin, Curtis Cooper, on behalf of The CIHR Canadian HIV Trials Network HIV/Hepatitis C Management and Treatment Guidelines Working Group

“…HIV-HCV management is more complex due to the accelerated progression of liver disease, the timing and nature of antiretroviral and HCV therapy, mental health and addictions management, socioeconomic obstacles and drug-drug interactions between new HCV direct-acting antiviral therapies and antiretroviral regimens.…”
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Pretransplant Evaluation and Liver Transplantation Outcome in PBC Patients by Maja Mijic, Ivona Saric, Bozena Delija, Milos Lalovac, Nikola Sobocan, Eva Radetic, Dora Martincevic, Tajana Filipec Kanizaj

“…Primary biliary cholangitis (PBC) is an autoimmune chronic cholestatic liver disease characterized by progressive cholangiocyte and bile duct destruction leading to fibrosis and finally to liver cirrhosis. …”
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Evaluating the Cause of Death in Obese Individuals: A Ten-Year Medical Autopsy Study by Jad Saab, Steven P. Salvatore

“…Increased death rates in the obese due to pulmonary embolism and liver disease should receive special clinical attention. …”
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TFCP2 Genetic Polymorphism Is Associated with Predisposition to and Transplant Prognosis of Hepatocellular Carcinoma by Zhikun Liu, Feng Gao, Zhou Shao, Haiyang Xie, Lin Zhou, Xiao Xu, Shusen Zheng

“…These findings indicate that rs7959378 is associated with the risk of HCC in patient with chronic liver disease and prognosis of HCC patients after liver transplantation.…”
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Liver Transplantation in Alcohol-Associated Hepatitis. Benefits and Limitations of Psychosocial Selection and Support in Alcohol Relapse. The Experience of a Tertiary Center in Ita... by Luca S. Belli, Adelaide Panariello, Giovanni Perricone, Paola Prandoni, Raffaella Viganò, Chiara Mazzarelli, Chiara Becchetti, Sara Giacalone, Giovanna Donvito, Sara Conti, Paolo A. Cortesi, Elena Roselli, Gianpaola Monti, Marco Carbone, Luciano G. De Carlis, Luciano G. De Carlis, Mauro Percudani

“…Thirty (30%) were listed, of whom 25 underwent early liver transplantation (eLT) after a median time of 36 days from the index episode of SAH with a median model for end stage liver disease (MELD) score of 36, whereas 33 (33%) were excluded, with psycho-social issues being the main cause of exclusion in 18 patients (54.5%). …”
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Barriers Preventing Liver Transplantation in Canadians with HIV Infection – Perceptions of HIV Specialists by Curtis L Cooper, Joanne DeForest, John Gill, Richard Lalonde, on behalf of the Canadian HIV Trials Network (CTN) Co-Infection Core Group

“…A median 20% of the nearly 12,700 HIV patients followed at these sites had concurrent liver disease (20% caused by hepatitis C virus, 5% caused by hepatitis B virus and 5% were alcohol-related). …”
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Urinary tract infections in patients with decompensated liver cirrhosis, listed for liver transplantation by P. D. Bessonov, I. V. Borzunov, E. N. Bessonova

“…To study the urinary infection rate in patients with liver cirrhosis (LC) and indications for liver transplantation with assessment of etiologic spectrum and features of the progression of liver disease at development of this complication. Material and methods. …”
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Herbicide Widespread: The Effects of Pethoxamid on Nonalcoholic Fatty Liver Steatosis In Vitro by Anna Virginia Adriana Pirozzi, Antonietta Stellavato, Chiara Schiraldi, Mariateresa Giuliano

“…Due to similarities to glyphosate, we did look at the effect of pethoxamid on impaired liver cells HepG2, using a nonalcoholic fatty liver disease (NAFLD) cell model in vitro. Pethoxamid was cytotoxic starting at 1 ppm. …”
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The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study by Priyanka Parajuli, Lara A.C. Phipps, Roy Sabo, Rasha Alsaadawi, Amanda Robinson, Evan French, Richard K. Sterling, N3C. consortium

“…Results: The severity of SARS-CoV-2 decreased in the omicron-subsequent wave with decreased utilization of mechanical ventilation and decreased 30-day mortality among patients with comorbidities like diabetes mellitus, obesity, and liver disease. Although with each subsequent wave, the sex distribution remained equal and constant, there was an increase in rates of diabetes, liver disease, and respiratory disease amongst patients hospitalized with COVID-19 over the COVID waves despite the decreasing 30-day mortality and mechanical ventilation. …”
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Evaluation of Adrenal Function in Nonhospitalized Patients with Cirrhosis by Maryam Moini, Mitra Yazdani Sarvestani, Mesbah Shams, Masood Nomovi

“…Categorization of liver disease severity was done according to model for end-stage liver disease (MELD) score. …”
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