Management of Diabetes Mellitus in Patients with Chronic Liver Diseases by Yingying Zhao, Huichun Xing, Xiaomei Wang, Weini Ou, Hong Zhao, Ben Li, Yue Li, Ying Duan, Liwei Zhuang, Wei Li, Danying Cheng, Min Quan, Yu Zhang, Shibo Ji

“…The liver is regarded as an important link in the management and control of DM, including the alleviation of glucose metabolism and lipid metabolism and others via glucose storage and endogenous glucose generation from glycogen stored in the liver. …”
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Hubungan Kadar FT4 dan TSH Serum dengan Profil Lipid Darah pada Pasien Hipertiroid yang Dirawat Inap di RSUP Dr. M. Djamil Padang Tahun 2009 - 2013 by Aga Pratama, Eti Yerizel, Rudy Afriant

“…It has spesific effects on cell metabolism, including lipid metabolism.L ipid metabolism disorder in hyperthyroid will inflict clinical manifestation; such as mood disorders, depression, and increased aggressive behavior. …”
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Multi-omics dissection of metabolic dysregulation associated with immune recovery in people living with HIV-1 by Lin-Yu Wan, Sin Man Lam, Hui-Huang Huang, Wen-Jing Cao, Xiang-Yi Cao, Xue-Meng Li, Li-Ping Zhang, Jia-Min Gao, Chao Zhang, Xing Fan, Yan-Mei Jiao, Guanghou Shui, Fu-Sheng Wang, Jin-Wen Song

“…Pathway enrichment and differential correlation analyses underscore perturbed systemic lipid metabolism in treatment response to ART, possibly mediated by host-commensal metabolic interactions. …”
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Effects of excessive body fat on colostrum lipid patterns: overweight/obese vs. normal weight mothers by Qian Liu, Yan Liu, Di Yang, Yanpin Liu, Yan Liu, Weicang Qiao, Juncai Hou, Yaling Wang, Minghui Zhang, Kai Yang, Xiaofei Fan, Ziqi Li, Junying Zhao, Lijun Chen

“…Prenatal overweight/ obesity (OW/ OB) can alter colostrum lipid patterns, thereby affecting the lipid metabolism and even the cognitive and healthy development of infants. …”
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Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis by Phuong T.T. Nguyen, Mia Shiue, Nina Kuprasertkul, Pedro Costa-Pinheiro, Luke T. Izzo, Laura V. Pinheiro, Hayley A. Affronti, Gabriel Gugiu, Shivani Ghaisas, Joyce Y. Liu, Jordan C. Harris, Charles W. Bradley, John T. Seykora, Xiaolu Yang, Taku Kambayashi, Clementina Mesaros, Brian C. Capell, Kathryn E. Wellen

“…Summary: ATP-citrate lyase (ACLY) generates cytosolic acetyl-coenzyme A (acetyl-CoA) for lipid synthesis and is a promising therapeutic target in diseases with altered lipid metabolism. Here, we developed inducible whole-body Acly-knockout mice to determine the requirement for ACLY in normal tissue functions, uncovering its crucial role in skin homeostasis. …”
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Modified neuroimmune processes and emotional behaviour in weaned and late adolescent male and female mice born via caesarean section by Mathieu Di Miceli, Moïra Rossitto, Maud Martinat, Flore Marchaland, Sarah Kharbouche, Marion Graland, Farah Younes, Alexandra Séré, Agnès Aubert, Lydia Rabbaa Khabbaz, Charlotte Madore, Jean-Christophe Delpech, Rebeca Martín, Sophie Layé

“…At weaning, animals born by CSD presented altered microglia, inflammatory and lipid metabolism signatures, with increased expression of Cd36, Csf1r and Tnfα in different brain regions of males, but not in females. …”
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity by Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López

“…In the hypothalamus, AMPK plays a crucial role in regulating energy balance, including feeding, energy expenditure, peripheral glucose and lipid metabolism. However, most research on hypothalamic AMPK has concentrated on the catalytic subunits AMPKα1 and AMPKα2, with little focus on the regulatory subunits. …”
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Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypan... by Peylhard, Moana, Berthier, David, Dayo, Guiguigbaza-Kossigan, Chantal, Isabelle, Sylla, Souleymane, Nidelet, Sabine, Dubois, Emeric, Martin, Guillaume, Sempéré, Guilhem, Flori, Laurence, Thévenon, Sophie

“…Susceptible Zebu Fulani breed differed from other breeds by the strongest modification in lipid metabolism regulation. Overall, this study provides a better understanding of the biological mechanisms at work during infection, especially concerning the interplay between immunity and metabolism that seems differentially regulated depending on the cattle breeds. …”
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Leptin decreases Th17/Treg ratio to facilitate neuroblastoma via inhibiting long-chain fatty acid catabolism in tumor cells by Meng Li, Di Li, Hai-Yun Wang, Weixin Zhang, Zhenjian Zhuo, Huiqin Guo, Jiabin Liu, Yue Zhuo, Jue Tang, Jing He, Lei Miao

“…These findings highlight that excess leptin contributes to lipid metabolism dysfunction in NB cells and subsequently misdirects CD4+ T cell differentiation in tumor micro-environment (TME), indicating that targeting leptin could be a therapeutic strategy for retarding NB progression.…”
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Baseline Serum Cholesterol Is Associated with a Response to Pegylated Interferon Alfa-2b and Ribavirin Therapy for Chronic Hepatitis C Genotype 2 by Naota Taura, Tatsuki Ichikawa, Hisamitsu Miyaaki, Yoshiko Kadokawa, Takuya Tsutsumi, Shotaro Tsuruta, Yuji Kato, Osami Inoue, Noboru Kinoshita, Kazuo Ohba, Hiroyuki Kato, Kazuyuki Ohata, Junichi Masuda, Keisuke Hamasaki, Hiroshi Yatsuhashi, Kazuhiko Nakao

“…HCV infection is associated with lipid disorders because this virus utilizes the host lipid metabolism to sustain its life cycle. Several studies have indicated that higher concentrations of serum cholesterol and LDL before treatment are important predictors of higher rates of sustained virological response (SVR). …”
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Effect of prolonged starvation on nutrition utilization and transcriptional responses in Pacific oyster (Crassostrea gigas) by Mingkun Liu, Chenchen Wei, Wenwen Xu, Lintao Tan, Li Li, Guofan Zhang

“…Transcriptomic analysis revealed that the amino acid and lipid metabolism increased over starvation, while carbohydrate metabolism initially rose and then declined, with a notable tipping point on day 10. …”
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Tofogliflozin attenuates renal lipid deposition and inflammation via PPARα upregulation mediated by miR-21a impairment in diet-induced steatohepatitic mice by Sae Nishihara, Masahiro Koseki, Katsunao Tanaka, Takashi Omatsu, Ayami Saga, Hiroshi Sawabe, Hiroyasu Inui, Takeshi Okada, Tohru Ohama, Daisuke Okuzaki, Yoshihiro Kamada, Masafumi Ono, Makoto Nishida, Mikio Watanabe, Yasushi Sakata

“…Therefore, we used this model to evaluate the effects of tofogliflozin on renal lipid metabolism and inflammation. Male 8–10-week-old C57Bl/6 mice were fed a high-fat/high-cholesterol/high-sucrose/bile acid (HF/HC/HS/BA) diet with 0.015% tofogliflozin (Tofo group) or an HF/HC/HS/BA diet alone (SLD group). …”
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Association between exposure to perfluoroalkyl and polyfluoroalkyl substances with estimated glomerular filtration rate: Mediating role of serum albumin by Hua Fang, Huajing Chang, Danjing Chen, Wenxin Qiu, Jiangwang Fang, Yunli Wu, Xian-E. Peng

“…Functional enrichment analysis suggested PFAS impair renal function by affecting lipid metabolism and increasing oxidative stress. Conclusions: PFAS exposure is negatively associated with eGFR and positively associated with the risk of decreased renal function, with albumin playing a partial mediating role.…”
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Transcriptome Analysis Reveals the Molecular Mechanism of PLIN1 in Goose Hierarchical and Pre-Hierarchical Follicle Granulosa Cells by Hua He, Yueyue Lin, Xi Zhang, Hengli Xie, Zhujun Wang, Shenqiang Hu, Liang Li, Hehe Liu, Chunchun Han, Lu Xia, Jiwei Hu, Jiwen Wang, Lin Liao, Xin Yuan

“…Gene Ontology (GO) analysis revealed that in the four groups (phGC: over_vs_over-NC; hGC: over_vs_over-NC; phGC: si_vs_si-NC; hGC: si_vs_si-NC), most differentially expressed genes (DEGs) were significantly enriched (<i>p</i> < 0.05) in pathways related to biological processes (BPs), particularly those associated with the regulation of cellular lipid metabolism and oxidative stress. KEGG analysis further identified significant enrichment (<i>p</i> < 0.05) in pathways related to cell apoptosis and the cell cycle. …”
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Characterization and Nutritional Intervention Effects of <i>Canna edulis</i> Type 5 Resistant Starch in Hyperlipidemia Mice by Houxier Li, Nan Wang, Jiahui Wu, Shuting Tan, Yan Li, Nan Zhang, Li Yang, Aji Li, Rongting Min, Maochun Xiao, Shiyao Su, Xiang Wang, Xueyong Wang

“…Numerous reports have indicated that the type 3 resistant starch (RS3) derived from <i>Canna edulis</i> can regulate lipid metabolism. However, it remains unclear whether the type 5 resistant starch (RS5) exhibits similar effects. …”
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Genetic interaction between oxidative stress and body mass index in a Spanish population by Francisco Lara-Hernández, Rebeca Melero, María Elena Quiroz-Rodríguez, Celeste Moya-Valera, Mariana de Jesús Gallardo-Espinoza, Luis Álvarez, Ingrid Lizeth Valarezo-Torres, Laisa Briongos-Figuero, Jessica Abadía-Otero, Francisco Javier Mena-Martin, Guillermo Saez, Josep Redon, Juan-Carlos Martín-Escudero, Ana-Bárbara García-García, Guillermo Ayala, Felipe Javier Chaves

“…The genes selected regulate several key biological processes, including obesity, blood pressure, inflammation, lipid metabolism and redox homeostasis. Our findings indicate a robust association between specific genes and both BMI and oxidative stress parameters. …”
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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome by Kira A Cozzolino, Lynn Sanford, Samuel Hunter, Kayla Molison, Benjamin Erickson, Meaghan CS Courvan, Taylor Jones, Deepa Ajit, Matthew D Galbraith, Joaquín M Espinosa, David Bentley, Mary Ann Allen, Robin D Dowell, Dylan J Taatjes

“…A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN signaling in CA-treated cells, revealing mechanistic links between Mediator kinases, lipid metabolism, and nuclear receptor function. Collectively, our results establish CDK8/CDK19 as context-specific metabolic regulators, and reveal that these kinases control gene expression not only via TFs, but also through metabolic changes and splicing. …”
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Dietary Tannic Acid Promotes Growth Performance and Resistance Against <i>Aeromonas hydrophila</i> Infection by Improving the Antioxidative Capacity and Intestinal Health in the Ch... by Liqin Ji, Yisen Shangguan, Chen Chen, Chengqing Wei, Junxian Zhu, Xiaoyou Hong, Xiaoli Liu, Xinping Zhu, Wei Li

“…Integrative analyses of two omics revealed that 2 g/kg of TA mitigated inflammation by activating the PPAR signaling pathway and regulating the lipid metabolism via multiple pathways, such as steroid biosynthesis and α-linolenic acid metabolism. …”
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Intermittent fasting boosts antitumor immunity by restricting CD11b+Ly6Clow Ly6Glow cell viability through glucose metabolism in murine breast tumor model by Chenghao Fu, Zhehao Liang, Zemiao Niu, Ning Chen, Yuemin Li, Zhenhua Liang, Yanwei Huo, Hao Xi, Rong Wang, Yonghuan Yan, Xiaoru Gano, Mengtian Wang, Yun Huang, Yan Zhang, Mingming Gao, Pin Lü

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Pantothenate kinase 4 controls skeletal muscle substrate metabolism by Adriana Miranda-Cervantes, Andreas M. Fritzen, Steffen H. Raun, Ondřej Hodek, Lisbeth L. V. Møller, Kornelia Johann, Luisa Deisen, Paul Gregorevic, Anders Gudiksen, Anna Artati, Jerzy Adamski, Nicoline R. Andersen, Casper M. Sigvardsen, Christian S. Carl, Christian T. Voldstedlund, Rasmus Kjøbsted, Stefanie M. Hauck, Peter Schjerling, Thomas E. Jensen, Alberto Cebrian-Serrano, Markus Jähnert, Pascal Gottmann, Ingo Burtscher, Heiko Lickert, Henriette Pilegaard, Annette Schürmann, Matthias H. Tschöp, Thomas Moritz, Timo D. Müller, Lykke Sylow, Bente Kiens, Erik A. Richter, Maximilian Kleinert

“…Abstract Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. …”
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