Activation of the Peroxisome Proliferator-Activated Receptors (PPAR-α/γ) and the Fatty Acid Metabolizing Enzyme Protein CPT1A by Camel Milk Treatment Counteracts the High-Fat Diet-... by Haifa M. AlNafea, Aida A. Korish

“…Camel milk treatment to the NAFLD animals remarkably upregulated PPARs (α, γ) and the downstream enzyme CPT1A in the metabolically active tissues involved in cellular uptake and beta-oxidation of fatty acids. The enhanced lipid metabolism in the CM-treated animals was linked with decreased expression of FABP1 and suppression of IL-6, TNF-α, and leptin release with augmented adiponectin production. …”
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Metabolomic profiling reveals systemic metabolic disruptions induced by combined exposure to particulate matter and ozone by Yue Ge, Maliha S. Nash, Aimen K. Farraj

“…Using targeted metabolomics, we identified significant alterations in metabolites involved in lipid metabolism (phosphatidylcholines), energy metabolism (acylcarnitine C3), and oxidative stress (glutamine). …”
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In Silico Analysis of the Gene Expression Patterns between Aldosterone-Producing Adenoma and Nonfunctional Adrenocortical Adenoma by Yongfa Dai, Jing Li, Hong Wen, Jie Liu, Jianling Li

“…WISP2, S100A10, SSTR5-AS1, SLC29A1, APOC1, and SLITRK4 are six real hub genes with the same gene expression pattern between the combined and validation datasets, three of which indirectly or directly participate in lipid metabolism including WISP2, S100A10, and APOC1. According to the gene expression pattern of DEGs, we speculated five candidate drugs with potential therapeutic value for APA, one of which is cycloheximide, an inhibitor for phospholipid biosynthesis. …”
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Cardiometabolic index and mortality risks: elevated cancer and reduced cardiovascular mortality risk in a large cohort by Junjie Wang, Li Xiao, Zhou Li

“…This novel index, which combines lipid metabolism and body composition, is the focus of this study, aimed at exploring its association with all-cause and specific mortality in an all-age adult population. …”
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Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

“…Metabolomic analysis revealed 82 distinct metabolites in adult zebrafish exposed to TCS. Lipid metabolism, especially glycerophospholipid metabolism, and amino acid regulation pathways were co-enriched by multi-omics combinatorial analysis. …”
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Target miRNA identification for the LPL gene in large yellow croaker (Larimichthys crocea) by Kalim Ullah, Aslam Hossain, Mingyue Cao, Liangyi Xue, Yajun Wang

“…The investigation culminated in the identification of miR-84a and miR-1231-5p as key miRNAs that modulate fat hydrolysis, highlighting their potential roles in lipid metabolism. Subsequent in-depth analysis further implicated these miRNAs, along with miR-891a, as prospective targets of LPL, suggesting their integral involvement in the regulation of this critical enzyme. …”
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Beneficial Effects of Poplar Buds on Hyperglycemia, Dyslipidemia, Oxidative Stress, and Inflammation in Streptozotocin-Induced Type-2 Diabetes by Shiqin Peng, Ping Wei, Qun Lu, Rui Liu, Yue Ding, Jiuliang Zhang

“…Moreover, 50% fraction could significantly decrease total cholesterol (TC), alleviate abnormal lipid metabolism, and enhance antioxidant capacity in the serum. …”
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Exploring the mechanism of berberine treatment for atherosclerosis combined with non-alcoholic fatty liver disease based on bioinformatic and experimental study. by Shushu Wang, Kachun Lu, Liwen Lin, Gaijie Li, Yuxin Han, Zhichao Lin, Qingmin Chu, Kunsheng Wu, Peijian Liu, Guiting Zhou, Rui Peng, Chuanjin Luo

“…Both conditions share common pathophysiological pathways including abnormal lipid metabolism and inflammation. Berberine (BBR), an isoquinoline alkaloid, is known for its beneficial effects on various metabolic and cardiovascular disorders. …”
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Sex differences in the expression of lipid oxidation and glucose uptake genes in muscles of fasted mice by N. A. Feofanova, T. V. Yakovleva, E. N. Makarova, N. M. Bazhan

“…Our aim was to find out whether there were sex differences in hormonal regulation and the expression of genes controlling glucose and lipid metabolism in skeletal muscles in response to fasting. …”
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Physiological and pathological roles of PGAM5: An update and future trend by Weibin He, Wenlong He, Zhongchan Sun, Pengcheng He

“…Additionally, we summarize some novel roles of PGAM5 in cellular senescence, lipid metabolism, and immune response modulation in recent studies. …”
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Protective role of Pannexin1 in lymphatic endothelial cells in the progression of atherosclerosis in female mice. by Avigail Ehrlich, Graziano Pelli, Bernard Foglia, Filippo Molica, Brenda R Kwak

“…Atherosclerosis is a progressive arterial disease arising from imbalanced lipid metabolism and a maladaptive immune response. The lymphatic system ensures tissue fluid homeostasis, absorption of dietary fats and trafficking of immune cells to draining lymph nodes, thereby potentially affecting atherogenesis. …”
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Impact of sex on the adaptation of adult mice to long consumption of sweet-fat diet by N. M. Bazhan, T. V. Iakovleva, A. D. Dubinina, E. N. Makarova

“…The aim of this work was to determine the sex-associated effect of SFD on the expression of genes related to carbohydrate-lipid metabolism in adult mice. For 10 weeks, male and female С57Bl mice were fed a standard laboratory chow (Control group) or a diet, which consisted of laboratory chow supplemented with sweet cookies, sunflower seeds and lard (SFD group). …”
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Liquid Chromatography-Mass Spectrometry-Based Metabolomic Analysis of Metabolites and Metabolic Pathways of Selenium-Enriched Auricularia auricula by YUE Shibo, CUI Hang, SHEN Qin, CAO Dongmei

“…These results showed that lipid metabolism, amino acid metabolism and the biosynthesis of other secondary metabolites in A. auricula changed significantly after selenization, which had a significant effect on lipids, amino acids and other metabolites in A. auricula. …”
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Changes in Adipokines following Laparoscopic Roux-en-Y Gastric Bypass Surgery in Chinese Individuals with Type 2 Diabetes Mellitus and BMI of 22–30 kg·m−2 by Chandrama Shrestha, Honghui He, Yiqun Liu, Shaihong Zhu, Jing Xiong, Zhaohui Mo

“…Significant reductions in anthropometric measurements and indicators of glucose and lipid metabolism and moderate reductions in insulin resistance and fasting insulin were observed at three months after LRYGB. …”
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A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis by Elbio Leiguez, Karina Cristina Giannotti, Mariana do Nascimento Viana, Márcio Hideki Matsubara, Cristina Maria Fernandes, José Maria Gutiérrez, Bruno Lomonte, Catarina Teixeira

“…MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. Macrophages (MΦs) loaded with LDs, termed foam cells, characterize early blood vessel fatty-streak lesions during atherosclerosis. …”
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Ficus carica and Sizigium cumini Regulate Glucose and Lipid Parameters in High-Fat Diet and Streptozocin-Induced Rats by El-Shaimaa A. Arafa, Waseem Hassan, Ghulam Murtaza, Manal Ali Buabeid

“…Body weights, blood glucose level, complete blood count (CBC), cholesterol, triglycerides (TG), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) were recorded to analyze their effects on glucose and lipid metabolism. Further, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured to examine their effects on lipid peroxidation and ant oxidative enzyme. …”
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The PI4K2A gene positively regulates lipid synthesis in bovine mammary epithelial cells and attenuates the inhibitory effect of t10,c12-CLA on lipid synthesis by Tong Mu, Honghong Hu, Xiaofang Feng, Chuanchuan Wang, Juan Zhang, Zhihong Sun, Yaling Gu

“…In this study, we used primary bovine mammary epithelial cells(BMECs)as a model and utilized overexpression and knockdown techniques for the PI4K2A gene to investigate the specific mechanisms by which it regulates lipid metabolism in BMECs. We studied whether PI4K2A regulates the inhibition of trans-10, cis-12 conjugated linoleic acid (t10,c12-CLA) on lipid synthesis in BMECs. …”
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Vitamin D Supplementation Ameliorates Metabolic Dysfunction in Patients with PCOS: A SystematicReview of RCTs and Insight into the Underlying Mechanism by Shan Guo, Reshef Tal, Haoyu Jiang, Tao Yuan, Ying Liu

“…The findings of the present meta-analysis indicate that vitamin D supplementation exerted favorable effects among women with PCOS on glucose metabolism and lipid metabolism, especially in vitamin D deficient women, but had no significant effect on the androgenic profile or inflammation status.…”
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Lipid profile alterations in non-infectious uveitis: correlation with quantitative optical coherence tomography angiography parameters by Lei Feng, Guangming Qin, Junhui Shen

“…The impact of uveitis on lipid metabolism remains unclear.Methods This is a cross-sectional study included 416 patients with non-infectious uveitis (NIU) and 416 healthy subjects. …”
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The effects of chicken hydrolyzed proteins in extruded diets on plasma and fecal metabolic profiles in adult dogs by Clare Hsu, Fabio Marx, Ryan Guldenpfennig, Maria R. C. de Godoy

“…The main difference in lipid metabolism between CHd and CONd was the bile acid metabolism, showing lower circulating bile acid, lower unconjugated bile acid excretion and higher taurine-conjugated bile acid excretion in the CHd group (q < 0.05). …”
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