Comparative metabolomics reveals eggshell translucency formation using LC-MS Analysis by Ying Ma, Zhonghua Ning

“…The results showed that we identified two essential metabolic pathways through differential metabolite pathway analysis, which were glycine, serine, and threonine metabolism related to amino acids metabolism and the PPAR metabolic pathway related to lipid metabolism. Furthermore, this study helps us understand the process of translucency egg production in poultry. …”
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Administration of Traditional Chinese Blood Circulation Activating Drugs for Microvascular Complications in Patients with Type 2 Diabetes Mellitus by Lisha He, Han Wang, Chengjuan Gu, Xinhui He, Linhua Zhao, Xiaolin Tong

“…Furthermore, we summarized the effects and mechanism of TCM on improving blood rheology, inhibiting aggregation of platelet, forming advanced glycation end products (AGEs), regulating oxidative stress, reducing blood fat, and improving lipid metabolism. The paper provides a new theoretical basis for the clinical practice of TCM in the prevention and treatment of DM and its microvascular complications.…”
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Peroxisome Proliferator-Activated Receptor Alpha Target Genes by Maryam Rakhshandehroo, Bianca Knoch, Michael Müller, Sander Kersten

“…Here, we present an overview of the involvement of PPARα in lipid metabolism and other pathways through a detailed analysis of the different known or putative PPARα target genes. …”
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Role of PPARs in Trypanosoma cruzi Infection: Implications for Chagas Disease Therapy by Eugenia Hovsepian, Federico Penas, Gerardo A. Mirkin, Nora B. Goren

“…The nuclear receptors known as peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of lipid metabolism and inflammation. The precise role of PPAR ligands in T. cruzi infection or in Chagas disease is poorly understood. …”
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Exercise as a mean to reverse the detrimental effect of high-fat diet on bone’s fracture characteristics by Ilias Doulamis, Despina N. Perrea, Panagiotis E. Chatzistergos, Athanasios S. Mitousoudis, Stavros K. Kourkoulis

“…The aim of this study is to investigate whether exercise can reverse some of the adverse effects of high-fat-diet-induced obesity on lipid metabolism and bone biomechanical properties. A total of 26 adult male C57bl/6J mice were randomly assigned into three groups: (A) Control group (n=6), (B) High-fat diet group (n=10), (C) High-fat diet and exercise group (n=10). …”
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Severe Hypertriglyceridemia Induced Pancreatitis in Pregnancy by Natasha Gupta, Seema Ahmed, Lemuel Shaffer, Paula Cavens, Josef Blankstein

“…Hypertriglyceridemia may occur in pregnancy due to normal physiological changes leading to abnormalities in lipid metabolism. We report a case of severe gestational hypertriglyceridemia that caused acute pancreatitis at full term and was successfully treated with postpartum therapeutic plasma exchange. …”
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A mutation in LXRα uncovers a role for cholesterol sensing in limiting metabolic dysfunction-associated steatohepatitis by Alexis T. Clark, Lillian Russo-Savage, Luke A. Ashton, Niki Haghshenas, Nicolas A. Amselle, Ira G. Schulman

“…Abstract Liver x receptor alpha (LXRα) functions as an intracellular cholesterol sensor that regulates lipid metabolism at the transcriptional level in response to the direct binding of cholesterol derivatives. …”
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Effects of polyunsaturated fatty acids on mitigation of the side effects of isotretionin treatment for patients with acne vulgaris: a narrative review by Agnieszka Kaźmierska, Izabela Anna Bolesławska, Juliusz Przysławski

“…Long-term use of the drug can also cause liver dysfunction, lipid metabolism and also cause an increase in uric acid levels. …”
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PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases by Yongchun Shen, Lei Chen, Tao Wang, Fuqiang Wen

“…Recent evidence suggests that a key regulator of airway inflammation, hyperresponsiveness, and remodeling is peroxisome proliferator-activated receptor gamma (PPARγ), a ligand-activated transcription factor that regulates adipocyte differentiation and lipid metabolism. PPARγ is expressed in structural, immune, and inflammatory cells in the lung. …”
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Mechanisms of Action of Mesenchymal Stem Cells in Metabolic-Associated Fatty Liver Disease by Sitong Yi, Qingwei Cong, Ying Zhu, Qiumin Xu

“…They can also reduce liver tissue injury and reverse the development of MAFLD by regulating immune response, antifibrotic activities, and lipid metabolism. Moreover, several advantages are attributed to MSC-derived exosomes (MSC-exosomes), such as targeted delivery, reliable reparability, and poor immunogenicity. …”
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Untargeted metabolomics reveal the corrective effects of scorpion on epileptic mice by Lele Li, Shengyu Ge, Yang Wang, Heyun Zhu, Bo Feng

“…Differential metabolites related to epilepsy were then used to pinpoint relevant pathways in epileptic mice, such as linoleic acid metabolism, biosynthesis of unsaturated fatty acids, glycerophospholipid metabolism, and ether lipid metabolism. In conclusion, this study highlights the corrective effects of Scorpion on epileptic mice and provides insight into the underlying metabolic pathways involved in its efficacy.…”
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The Roles of PPARs in the Fetal Origins of Metabolic Health and Disease by William D. Rees, Christopher J. McNeil, Christopher A. Maloney

“…These findings suggest that two separate PPAR-dependent mechanisms may be involved in the fetal adaptations to the maternal diet, one, mediated by PPAR-γ and PPAR-β/δ, regulating cell growth and differentiation; and another adapting long-term lipid metabolism via epigenetic changes in PPAR-α to optimise postnatal survival.…”
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All roads lead to Rome: the plasticity of gut microbiome drives the extensive adaptation of the Yarkand toad-headed agama (Phrynocephalus axillaris) to different altitudes by Jianghao Du, Peng Zheng, Weizhen Gao, Qianru Liang, Lin Leng, Lei Shi

“…Metabolites involved in amino acid and lipid metabolism differed significantly at different altitudes. …”
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Blood and bile lipid composition and the risk of gallstones at diabetes mellitus of the 1st and 2nd type by V. V. Tsukanov, Yu. L. Tonkikh, A. V. Vasyutin

“…Type II DM is followed by more pronounced lipidemia and increase in bile cholesterol saturation, type I DM, but the latter is also associated with lipid metabolism disorders and the risk of gallstone disease development.…”
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Expression of protein phosphatase 4 in different tissues under hypoxia by Yanyan Ma, Jing Hou, Dengliang Huang, Yaogang Zhang, Zhe Liu, Meiyuan Tian

“…Protein phosphatase 4 (PP4) has been found as a new factor in the regulation of sugar and lipid metabolism. Here, we investigate the differential expression of PP4 at a simulated altitude of 4,500 m in the heart, lung, and brain tissues of rats. …”
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Evidence and Potential Mechanisms of Traditional Chinese Medicine for the Adjuvant Treatment of Coronary Heart Disease in Patients with Diabetes Mellitus: A Systematic Review and M... by Yu Wei, Qi-You Ding, Chak Yeung, Yi-shan Huang, Bo-xun Zhang, Li-li Zhang, Run-Yu Miao, Sha Di, Lin-Hua Zhao, Xiao-Lin Tong

“…Although there is high-quality evidence that TCM is effective in regulating glucose and lipid metabolism, the cardiovascular protective effect of TCM in the treatment of diabetes mellitus has not been fully elucidated, especially in patients with both diabetes mellitus and coronary heart disease (CHD). …”
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Psychobiotic effects of probiotics and prebiotics by V. T. Ivashkin, K. V. Ivashkin

“…Intestinal microbiome is a factor of hypothalamic-pituitary-adrenal axis formation that is involved in regulation of immunomodulation, lipid metabolism, energy balance and electrophysiologic activity of enteric nervous system. …”
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The Current Knowledge of the Role of PPAR in Hepatic Ischemia-Reperfusion Injury by M. Elias-Miró, M. B. Jiménez-Castro, M. Mendes-Braz, A. Casillas-Ramírez, C. Peralta

“…Peroxisome proliferator-activated receptors (PPARs) are major regulators of lipid metabolism and inflammation. In this paper, we review the PPAR signaling pathways and present some of their lesser-known functions in liver regeneration. …”
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The role of lipids in promoting hair growth through HIF-1 signaling pathway by Jieun Seo, Kotone Matsumoto, Ayaka Nanmo, Shan Tu, Do-Won Jeong, Yang-Sook Chun, Lei Yan, Tatsuto Kageyama, Junji Fukuda

“…In the present study, we found that lipid metabolism was attenuated in the scalp tissues of patients with androgenetic alopecia. …”
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The Lipid Parameters and Lipoprotein(a) Excess in Hashimoto Thyroiditis by D. O. Yetkin, B. Dogantekin

“…Thyroid autoimmunity may have some effect on Lp(a) and lipid metabolism.…”
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