Diabetic Macular Edema Pathophysiology: Vasogenic versus Inflammatory by Pedro Romero-Aroca, Marc Baget-Bernaldiz, Alicia Pareja-Rios, Maribel Lopez-Galvez, Raul Navarro-Gil, Raquel Verges

“…DM parameters controls (glycemia, arterial tension, and lipids) are the gold standard for preventing DR and DME. …”
Get full text

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche by Alejandro Luarte, Luis Federico Bátiz, Ursula Wyneken, Carlos Lafourcade

“…Stem cells, as well as most cells, release extracellular vesicles such as exosomes, which are nanovesicles able to target specific cell types and thus to modify their function by delivering proteins, lipids, and nucleic acids. Exosomes have recently been tested in vivo and in vitro as therapeutic conveyors for the treatment of diseases. …”
Get full text

Role of Extracellular Vesicles in Placental Inflammation and Local Immune Balance by Zengfang Wang, Ruizhen Yang, Jiaojiao Zhang, Pingping Wang, Zengyan Wang, Jian Gao, Xue Liu

“…EVs contain tens to thousands of different RNA, proteins, small molecules, DNA fragments, and bioactive lipids. EV-derived microRNAs (miRNAs) and proteins regulate inflammation and trophoblast invasion in the placental microenvironment. …”
Get full text

Advances in lysosomal escape mechanisms for gynecological cancer nano-therapeutics by Heng Wei, Yingying Hao, Jin Zhang, Yue Qi, Chong Feng, Chen Zhang

“…We delve into novel materials and strategies developed to bypass the lysosomal barrier, including pH-sensitive linkers, fusogenic lipids, and nanoparticles (NPs) engineered for endosomal disruption. …”
Get full text

Evaluation of Arbuscular Mycorrhizal Fungi Capacity to Alleviate Abiotic Stress of Olive (Olea europaea L.) Plants at Different Transplant Conditions by María Josefina Bompadre, Mariana Pérgola, Laura Fernández Bidondo, Roxana Paula Colombo, Vanesa Analía Silvani, Alejandro Guillermo Pardo, Juan Antonio Ocampo, Alicia Margarita Godeas

“…These conditions generate reactive oxygen species (ROS) in plant tissues causing oxidation of proteins and lipids among others. Some plants have developed adaptive mechanisms to counteract such adverse conditions such as symbiotic association with arbuscular mycorrhizal fungi (AMF). …”
Get full text

Dietary caloric input and tumor growth accelerate senescence and modulate liver and adipose tissue crosstalk by José Xavier do Nascimento Júnior, Júlia da Conceição Gomes, Ricardo Imbroisi Filho, Helber de Maia Valença, Jéssica Ristow Branco, Amanda Bandeira Araújo, Amanda de Oliveira Esteves Moreira, Letícia Diniz Crepaldi, Larissa Pereira Paixão, Alan C. Ochioni, Thainá M. Demaria, João Gabriel Bernardo Leandro, Livia Marques Casanova, Mauro Sola-Penna, Patricia Zancan

“…Finally, we suggest that tumor growth alters liver-adipose tissue crosstalk that upregulates Fgf21, induces senescence, and negatively modulates lipids and carbohydrates metabolism even in caloric-restricted-fed mice.…”
Get full text

Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis by Mahvash Sadeghi, Jalil Tavakol Afshari, Afsane Fadaee, Mohammadreza Dashti, Fatemeh Kheradmand, Sajad Dehnavi, Mojgan Mohammadi

“…They facilitate communication and signalling between cells by transferring a variety of biological substances, such as proteins, lipids, and nucleic acids like mRNA and miRNA. Exosomal miRNAs were shown to be involved in normal and pathological conditions. …”
Get full text

Untargeted Metabolomics Reveals the Metabolic Characteristics and Biomarkers of Antioxidant Properties of Gardeniae Fructus from Different Geographical Origins in China by Wu Jiang, Lingling Jiang, Xiaoli Yin, Shuhui Zhang, Xiaojing Duan, Jiadong Chen, Yingying Liu, Hong Zheng, Zhengming Tao

“…The key chemical categories were obtained as the primary contributors of the antioxidant activity, including prenol lipids, flavonoids, coumarins and derivatives, as well as steroids and steroid derivatives. …”
Get full text

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy by Kosuke Yamahara, Mako Yasuda, Shinji Kume, Daisuke Koya, Hiroshi Maegawa, Takashi Uzu

“…The multipronged drug approach targeting blood pressure and serum levels of glucose, insulin, and lipids fails to fully prevent the onset and progression of diabetic nephropathy. …”
Get full text

Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…Oxidative stress results in the damage of critical biomolecules like DNA, proteins, and lipids, contributing to the pathogenesis of various diseases. …”
Get full text

INTEGRATION OF SPENT GRAIN INTO FOOD PRODUCTS by ERŞOVA, Svetlana, SAITAN, Olesea, TARNA, Ruslan, RUMEUS, Iurie, CODINĂ, Georgiana Gabriela, GHENDOV-MOSANU, Aliona

“…It is characterized by a diverse chemical composition, mainly composed of proteins and dietary fibers and, to a lesser extent, lipids, minerals, phenolic compounds, as well as B vitamins and vitamin E. …”
Get full text

Antioxidant Potential Overviews of Secondary Metabolites (Polyphenols) in Fruits by Mohammed Sharif Swallah, He Sun, Raïfatou Affoh, Hongling Fu, Hansong Yu

“…Phenolic compounds are of nutritional interest since they aid in the retardation and inhibition of lipids by acting as scavengers that prevent and protect the proliferation of oxidative chains. …”
Get full text

Skeletal Muscle Mitochondria and Aging: A Review by Courtney M. Peterson, Darcy L. Johannsen, Eric Ravussin

“…Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched. Animal and human studies typically show that skeletal muscle mitochondria are altered with aging, including increased mutations in mitochondrial DNA, decreased activity of some mitochondrial enzymes, altered respiration with reduced maximal capacity at least in sedentary individuals, and reduced total mitochondrial content with increased morphological changes. …”
Get full text

Effect of Tremella fuciformis polysaccharide on the stalling and flavor of tteok during storage by Hongxiu Fan, Hongcheng Liu, Wenyi Li, Wenjing Su, Dawei Wang, Shanshan Zhang, Tingting Liu, Yanrong Zhang

“…The addition of TFP to tteok inhibited the development of unpleasant volatile compounds, probably by delaying the oxidation and decomposition of lipids and preserving the antioxidant phenolic compounds in tteok, thus slowing down the flavor deterioration of tteok and contributing to flavor maintainace. …”
Get full text

Deciphering antioxidant interactions via data mining and RDKit by Lucas B. Ayres, Justin T. Furgala, Carlos D. Garcia

“…Abstract Minimizing the oxidation of lipids remains one of the most important challenges to extend the shelf-life of food products and reduce food waste. …”
Get full text

Bat population dynamics: multilevel model based on individuals' energetics by Paula Federico, Dobromir T. Dimitrov, Gary F. McCracken

“…Our individual component describes the growth of an individual female bat by modeling the dynamics of the main body compartments (lipids, proteins, and carbohydrates). A structured population model based on extended McKendrick-von Foerster partial differential equations integrates those individual dynamics and provides insight into possible regulatory mechanisms of population size as well as conditions of population survival and extinction. …”
Get full text

Molecular Basis for Mucolytic Therapy by Bonnie Dasgupta, Malcolm King

“…It is composed of water, mucous glycoproteins, low molecular weight ions, proteins and lipids. The three-dimensional structure of the mucous gel depends on a number of forms of bonding, such as ionic bonds and disulphide bridges. …”
Get full text

Colesterolemia de riesgo by Carlos Gaimetea Castillo, Marcos D. Iraola Ferrer

“…</p>This article presents the optimal lipids level along with their risk and pathologic ranges. …”
Get full text

Comparison of Electrospray Ionization and Atmospheric Chemical Ionization Coupled with the Liquid Chromatography-Tandem Mass Spectrometry for the Analysis of Cholesteryl Esters by Hae-Rim Lee, Sunil Kochhar, Soon-Mi Shim

Get full text

Biophysical and Structural Studies on the Capsid Protein of the Human Immunodeficiency Virus Type 1: A New Drug Target? by José L. Neira

“…Furthermore, interactions with other proteins and lipids are also described. The whole set of results suggests that much of the surface of CAC does not accommodate binding per se, but rather binding sites in the protein are predefined, i.e., there are “hot” spots for binding in CAC (whatever be the molecule to bind). …”
Get full text