Identification of Sphingomyelinase on the Surface of Chlamydia pneumoniae: Possible Role in the Entry into Its Host Cells by Tuula A. Peñate Medina, Juha T. Korhonen, Riitta Lahesmaa, Mirja Puolakkainen, Oula Peñate Medina, Paavo K. J. Kinnunen

“…We have recently suggested a novel mechanism, autoendocytosis, for the entry of certain microbes into their hosts, with a key role played by the sphingomyelinase-catalyzed topical conversion of sphingomyelin to ceramide, the differences in the biophysical properties of these two lipids providing the driving force. The only requirement for such microbes to utilize this mechanism is that they should have a catalytically active SMase on their outer surface while the target cells should expose sphingomyelin in the external leaflet of their plasma membrane. …”
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Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue by Odile Poulain-Godefroy, Olivier Le Bacquer, Pauline Plancq, Cécile Lecœur, François Pattou, Gema Frühbeck, Philippe Froguel

“…It was recently demonstrated that TLR4 activation via dietary lipids triggers inflammatory pathway and alters insulin responsiveness in the fat tissue during obesity. …”
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Gypenoside ameliorates insulin resistance and hyperglycemia via the AMPK-mediated signaling pathways in the liver of type 2 diabetes mellitus mice by Mengxue Song, Dehong Tan, Bin Li, Yanqun Wang, Lin Shi

“…Gps reduced fasting blood glucose and serum lipids, as well as significantly improved T2DM mice glucose tolerance and insulin resistance (IR). …”
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Universal, untargeted detection of bacteria in tissues using metabolomics workflows by Wei Chen, Min Qiu, Petra Paizs, Miriam Sadowski, Toma Ramonaite, Lieby Zborovsky, Raquel Mejias-Luque, Klaus-Peter Janßen, James Kinross, Robert D. Goldin, Monica Rebec, Manuel Liebeke, Zoltan Takats, James S. McKenzie, Nicole Strittmatter

“…Here, we describe a biomarker-based strategy that utilises bacterial small molecular metabolites and lipids for direct detection of bacteria in complex samples using mass spectrometry (MS). …”
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Targeting KRAS: from metabolic regulation to cancer treatment by Yanyan Shi, Huiling Zheng, Tianzhen Wang, Shengpu Zhou, Shiqing Zhao, Mo Li, Baoshan Cao

“…Here, we review the metabolic reprogramming of glucose, glutamine, and lipids regulated by oncogenic KRAS, with an emphasis on recent insights into the relationship between changes in metabolic mechanisms driven by KRAS mutant and related advances in targeted therapy. …”
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Proximate Analysis of Poultry-Mix Formed Feed Using Maize Bran as a Base by Solagbade Saheed Afolabi, John Oluwafemi Oyeyode, Wasswa Shafik, Zubair. A. Sunusi, Adegoke Abdullahi Adeyemi

“…The following was revealed in a proximate analysis of the feeds: moisture ranged from 1.18% to 1.54%, unrefined lipids 0.99–3.08%, total carbohydrate 57% to 72%, ash content 38.48% to 38.92%, unrefined protein 18.38% to 22.53% and unrefined fiber 2.0% to 4.65% respectively for broilers and layers. …”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…EVs, nano-scale membrane vesicles, mediate intercellular communication by encapsulating a diverse cargo of proteins, lipids, and nucleic acids. Their therapeutic potential lies in delivering cargos, activating signaling pathways, and efficiently mitigating oxidative stress—an essential aspect of overcoming limitations in stem cell-based tissue repair. …”
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Properties of Edible Films Based on Oxidized Starch and Zein by Elizabeth Argüello-García, Javier Solorza-Feria, J. Rodolfo Rendón-Villalobos, Francisco Rodríguez-González, Alfredo Jiménez-Pérez, Emmanuel Flores-Huicochea

“…The oxidized starch showed differences from native starch due to the oxidation process, showing a decrease in lipids, proteins, and amylose. The increase of the sodium hypochlorite increased the content of carbonyl and carboxyl groups in the ranges 0.015–0.028% and 0.022–0.031%, respectively. …”
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Characterization of Serum Phospholipase A2 Activity in Three Diverse Species of West African Crocodiles by Mark Merchant, Kate Juneau, Jared Gemillion, Rodolfo Falconi, Aaron Doucet, Matthew H. Shirley

“…Incubation of different volumes of crocodile serum with bacteria labeled with a fluorescent fatty acid in the sn-2 position of membrane lipids resulted in a volume-dependent liberation of fluorescent probe. …”
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A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents by Harningsih Karim, Arief Azis, Ananda Ramadani, Anita Anita, Ahyar Ahmad, Hasnah Natsir, Paulina Taba, Suriati Eka Putri, Sarlan Sarlan, Siti Halimah Larekeng, Rizal Irfandi

“…A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. …”
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Biosynthesis of Xanthan Gum from Fermenting Shrimp Shell: Yield and Apparent Viscosity by Larissa Alves de Sousa Costa, Márcio Inomata Campos, Janice Izabel Druzian, Ana Maria de Oliveira, Enio Nazaré de Oliveira Junior

“…It was found that the SSAE contained 89.75% moisture, 0.054% ash, 8.069% protein, 0.787 lipids, and 1.337% carbohydrates. Media containing different concentrations of SSAE and supplemented with urea (0.01%) and phosphate (0.1%) were fermented in a shaker, and the results obtained were compared with those obtained from sucrose (control) with the same supplementation and fermentation conditions. …”
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Application of Metabolomics to Study Effects of Bariatric Surgery by Paulina Samczuk, Michal Ciborowski, Adam Kretowski

“…Detected changes pertain to amino acid, lipids, carbohydrates, or gut microbiota alterations. …”
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Eicosanoid and cytokine levels in plasma of patients during mesenteric infarction by N. Nathan, Y. Denizot, P. Feiss

“…Activation of phospholipase A2 is suggested by the increase in the stable metabolite of PGI2 and might be by itself or through lipidic metabolites, a major systemic stimulus of IL-6 and IL-8 production.…”
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Potential Mechanisms of Exercise in Gestational Diabetes by Saeid Golbidi, Ismail Laher

“…Increased intramyocellular lipids also increase cellular oxidative stress with subsequent generation of reactive oxygen species. …”
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On the Reaction of 2-Alkanoylnaphthohydroquinones with Hydroxylamine: Access to Cytotoxic 2-(Hydroxyamino)-1,4-naphthoquinone and Their 3-(Hydroxyimino)alkyl Analogous by Jaime A. Valderrama, Andrea Pérez-Herrera, Giulio G. Muccioli, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Pedro Buc Calderon, Julio Benites

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From Prion Diseases to Prion-Like Propagation Mechanisms of Neurodegenerative Diseases by Isabelle Acquatella-Tran Van Ba, Thibaut Imberdis, Véronique Perrier

“…According to the prion hypothesis, PrPSc can trigger the autocatalytic conversion of PrPC into PrPSc, presumably in the presence of cofactors (lipids and small RNAs) that have been recently identified. …”
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Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros by Konstantinos Makrilakis, Stavros Liatis

“…In nearly all asymptomatic PWD, however, the results of screening will generally not change medical therapy, since aggressive preventive measures, such as control of blood pressure and lipids, would have been already indicated, and above all, invasive revascularization procedures (either with percutaneous coronary intervention or coronary artery bypass grafting) have not been shown in randomized clinical trials to confer any benefit on morbidity and mortality. …”
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Advances in Fluorescence Techniques for the Detection of Hydroxyl Radicals near DNA and Within Organelles and Membranes by Eleanor C. Ransdell-Green, Janina Baranowska-Kortylewicz, Dong Wang

“…Hydroxyl radicals (^•OH), the most potent oxidants among reactive oxygen species (ROS), are a major contributor to oxidative damage of biomacromolecules, including DNA, lipids, and proteins. The overproduction of ^•OH is implicated in the pathogenesis of numerous diseases such as cancer, neurodegenerative disorders, and some cardiovascular pathologies. …”
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Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy by Paul A. Dayton, Shukui Zhao, Susannah H. Bloch, Pat Schumann, Kim Penrose, Terry O. Matsunaga, Reena Zutshi, Alexander Doinikov, Katherine W. Ferrara

“…Lipid-coated perfluorocarbon nanodroplets are submicrometer-diameter liquid-filled droplets with proposed applications in molecularly targeted therapeutics and ultrasound (US) imaging. …”
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Disruption of biological membranes by hydrophobic molecules: a way to inhibit bacterial growth by Alejandra Gabriela Valdez-Lara, Ángela M. Jaramillo-Granada, Daniel Ortega-Zambrano, Eristeo García-Marquez, Jorge Alberto García-Fajardo, H. Mercado-Uribe, J. C. Ruiz-Suárez

“…First, we carried out calorimetric measurements to evaluate the effects of these drugs on model membranes formed by lipids from these bacteria. We found that the drugs modify their transition temperature, enthalpy of cohesion, and cooperativity, which indicates a strong alteration of the membranes. …”
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