A Prospective, Observational Study on Adverse Drug Reactions in Hospitalized Pediatric Cancer Patients in a Tertiary Care Teaching Hospital by Nancy Khajuria, Nikhil Menia, Seema Gupta

“…Conclusion: this study highlights the prevalence of adverse drug reactions (ADRs) in children undergoing chemotherapy, particularly in those receiving treatment for acute lymphoblastic leukaemia. The findings emphasise the significant impact of ADRs on these patients. …”
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Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia by Youssef Al-Tonbary, Mohammad Al-Haggar, Rasha EL-Ashry, Sahar EL-Dakroory, Hanan Azzam, Ashraf Fouda

“…This study aimed to evaluate the antioxidant role of vitamin E and N-acetyl cysteine (NAC) in overcoming treatment-induced toxicity in acute lymphoblastic leukaemia (ALL) during the intensive period of chemo-/radiotherapy, almost the first two months of treatment. …”
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Aetiology of haemorrhagic cystitis: BK Polyomavirus and Adenovirus detection by Yoliswa Z. Chili, Menzi B. Nkosi, Nicky-Louise Byrne, Moepeng J. Maseko, Stephen N.J. Korsman, Gert U. Van Zyl

“…This case report details haemorrhagic cystitis in a 49-year-old female with chronic lymphocytic leukaemia (CLL), recurrent haematuria and detected BK polyomavirus (BKPyV) and adenovirus (HAdV) in urine. …”
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Retrospective analysis of enzootic bovine leucosis spread in Republic of Dagestan considering natural and climatic conditions by A. R. Mustafayev, M. O. Baratov

“…From 1988 to 2022, the Republican veterinary laboratories serologically tested3,205,118 animal sera for the antibodies to bovine leukaemia virus (BLV) antigen, and 76,133 (2.4%) of them were positive. …”
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Enhanced Engraftment of a Very Low-Dose Cord Blood Unit in an Adult Haemopoietic Transplant by Addition of Six Mismatched Viable Cord Units by Stephen J. Proctor, Catherine E. Chapman, Rachel Sharples, Helen L. Lucraft, Jennifer Wilkinson, Jane Conn, Peter G. Middleton

“…An ablative stem cell transplant was performed in an adult with relapsed acute lymphoblastic leukaemia (ALL), using a single HLA-matched cord blood unit (mononuclear cell dose 0.8×107 ), supported by six mismatched cord blood units (one unit per 10 kg recipient weight). …”
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The use of premature chromosome condensation to study in interphase cells the influence of environmental factors on human genetic material by Vasiliki I. Hatzi, Georgia I. Terzoudi, Christina Paraskevopoulou, Vasilios Makropoulos, Demetrios P. Matthopoulos, Gabriel E. Pantelias

“…The PCC has been successfully used in problems involving cell cycle analysis, diagnosis and prognosis of human leukaemia, assessment of interphase chromosome malformations resulting from exposure to radiation or chemicals, as well as elucidation of the mechanisms underlying the conversion of DNA damage into chromosomal damage. …”
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In Vitro Evaluation of a Stable Monomeric Gold(II) Complex with Hematoporphyrin IX: Cytotoxicity against Tumor and Kidney Cells, Cellular Accumulation, and Induction of Apoptosis by Georgi Momekov, Dilyan Ferdinandov, Spiro Konstantinov, Sonja Arpadjan, Daniela Tsekova, Galina Gencheva, Panayot R. Bontchev, Margarita Karaivanova

“…The complex exhibits strong cytotoxicity, whereby the leukaemia- and lymphoma-derived cell lines are more sensitive, with IC50 values comparable to those of the reference anticancer drug cisplatin. …”
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Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands by Virtudes Moreno, Julia Lorenzo, Francesc X. Aviles, M. Helena Garcia, João P. Ribeiro, Tânia S. Morais, Pedro Florindo, M. Paula Robalo

“…Compounds 1, 2, and 3 showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).…”
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Synthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoates by Jan Tengler, Iva Kapustíková, Matúš Peško, Rodney Govender, Stanislava Keltošová, Petr Mokrý, Peter Kollár, Jim O'Mahony, Aidan Coffey, Katarína Král'ová, Josef Jampílek

“…Cytotoxicity assay of effective compounds was performed using the human monocytic leukaemia THP-1 cell line. Compounds with predicted amphiphilic properties were also tested for their effects on the rate of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. …”
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Expression Levels of Some Antioxidant and Epidermal Growth Factor Receptor Genes in Patients with Early-Stage Non-Small Cell Lung Cancer by Giuseppe De Palma, Paola Mozzoni, Olga Acampa, Eveline Internullo, Paolo Carbognani, Michele Rusca, Matteo Goldoni, Massimo Corradi, Marcello Tiseo, Pietro Apostoli, Antonio Mutti

“…Antioxidant genes included heme oxygenase 1 (HO-1), superoxide dismutase-1 (SOD-1), and -2 (SOD-2), whereas epidermal growth factor receptor genes consisted of epidermal growth factor receptor (EGFR) and v-erb-b2 erythroblastic leukaemia viral oncogene homolog 2 (HER-2). Twenty-eight couples of lung biopsies were obtained and gene transcripts were quantified by Real Time RT-PCR. …”
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Screening for monoclonal B-lymphocyte expansion in a hospital-based Chinese population with lymphocytosis: an observational cohort study by Yue Wang, Jing Li, Peng Liu, Jiadai Xu, Zheng Wei

“…Among them, a population of circulating monoclonal B-lymphocytes were detected in 14 patients, with 4 having chronic lymphocytic leukaemia (CLL) and 10 having MBL, indicating an overall prevalence of 5.5% for B-LPD (3.9% for MBL). …”
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Comparative retrospective analysis of cord blood transplantation with ATG-containing conditioning regimens and haploidentical stem cell transplantation: similar survival outcomes w... by Yongjia Liu, Zeyin Liang, Hanyun Ren, Yujun Dong, Wei Liu, Yue Yin, Bingjie Wang, Qingyun Wang, Qingya Wang, Yuan Li

“…The overall survival (OS) rate for the CBT and haplo-HSCT groups showed no significant difference. In patients with leukaemia, the CBT cohort showed better OS, GVHD-free and relapse-free survival (GRFS), as well as a lower incidence of disease relapse, although there was no statistical difference.Conclusion Our single-centre retrospective long-term follow-up investigations indicated that although the implantation rate of CBT is lower than that of haplo-HSCT, patients undergoing CBT with ATG-containing conditioning regimens may have a comparable overall survival with a lower risk of GVHD compared to those undergoing haplo-HSCT.…”
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CALR ins5-mediated clonal hematopoiesis causes severe hemolytic anemia in a female PGK1 Ser320Asn carrier by M. L. Morales, H. Cano, B. de la Morena-Barrio, J. L. Vives-Corrons, E. J. Cuenca-Zamora, P. Garrido-Rodríguez, C. Bento, J. Pereira, J. Martínez Nieto, T. H. Chen-Liang, J. L. Fuster, S. Caracena, M. L. Lozano, R. Teruel-Montoya, J. Corral, F. Ferrer-Marín

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Evaluation of the Diversities in the Inflammatory Responses in Cats With Bacterial and Viral Infections by Songul Erhan, Bengu Bilgic, Ezgi Ergen, Mert Erek, Elif Ergul Ekiz, Mukaddes Ozcan, Mehmet Erman Or, Banu Dokuzeylul, Erdal Matur

“…The evaluations were performed based on three groups: healthy control, bacterial infection group (those with bronchopneumonia and gastrointestinal tract and urinary tract infections) and viral infection group (21 with feline coronavirus [FCoV], 3 with feline leukaemia virus [FeLV] and 1 with feline calicivirus), each containing 25 individuals. …”
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Nanostructured lipid carriers co-encapsulating Apigenin and Melatonin: An innovative strategy against cancer by Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, María Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

“…Cytotoxicity studies showed selective cytotoxicity in tumoral cell lines, especially in the leukaemia cells, where co-encapsulation resulted in an additive pharmacological effect against individually loaded NLC. …”
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Identification of immune-associated genes with altered expression in the spleen of mice enriched with probiotic species using RNA-seq profiling by Anh Duc Truong, Ha Thi Thanh Tran, Nhu Thi Chu, Lanh Phan, Hoai Thi Phan, Thu Huong Dang, Hoang Vu Dang, La Anh Nguyen

“…In addition, the Kyoto encyclopedia of genes and genomes and gene ontology analyses revealed that the DEGs were predominantly enriched in defense responses to pathogens, including inflammatory bowel diseases, malaria, leukaemia virus 1, and herpes virus, as well as immune processes related to immune response and signal transduction. …”
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Prone Positioning and Intravenous Zanamivir may Represent Effective Alternatives for Patients with Severe ARDS Virus A (H1N1) Related Pneumonia in Hospitals with no Access to ECM... by Giuseppe Gristina, Giuseppe Nardi, Daniela Orazi, Francesco Nicola Lauria, Maria Beatrice Valli, Eleonora Lalle, Stefano Menzo, Luigi Riccioni, Maria Pia Camporiondo

“…A bone marrow biopsy allowed the diagnosis of an initial stage of “hairy cells leukaemia.” ARDS related to A/H1N1 influenza was the first sign of the disease in our patient. …”
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A two‐phase epigenome‐wide four‐way gene–smoking interaction study of overall survival for early‐stage non‐small cell lung cancer by Leyi Chen, Xiang Wang, Ning Xie, Zhongwen Zhang, Xiaowen Xu, Maojie Xue, Yuqing Yang, Liya Liu, Li Su, Maria Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Ruyang Zhang

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Genetic disruption of Blimp-1 drastically augments the antitumor efficacy of BCMA-targeting CAR T cells by Anthony M. Battram, Joan Mañé-Pujol, David F. Moreno, Aina Oliver-Caldés, Judit Carpio, Oriol Cardus, Luis Gerardo Rodríguez-Lobato, Álvaro Urbano-Ispizua, Carlos Fernández de Larrea

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Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…However, the associations between BATF expression and prognoses in acute myeloid leukaemia (AML) patients and their immunological effects remain unclear.MethodsGenomic and clinical AML data were got from the TCGA (TCGA-LAML) and GEO (GSE37642) databases for the subsequent analysis. …”
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