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20221
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20222
HPGCN: A graph convolutional network-based prediction model for herbal heat/cold properties
Published 2025-03-01“…Compared to previous machine learning algorithms, the HPGCN obtained optimal classification prediction results for ACC, Recall, Precision, F1, and AUC indicators by 5-fold cross-validation on the training and test sets. …”
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20223
Decoding the m6A epitranscriptomic landscape for biotechnological applications using a direct RNA sequencing approach
Published 2025-01-01“…Here, we introduce pum6a, an innovative attention-based framework that integrates positive and unlabeled multi-instance learning (MIL) to address the challenges of incomplete labeling and missing read-level annotations. …”
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20224
Lipids as key biomarkers in unravelling the pathophysiology of obesity-related metabolic dysregulation
Published 2025-02-01“…The predictive model underwent evaluation across four machine learning algorithms consistently demonstrated the highest predictive accuracy of 0.821, aligning with the findings from the classical logistic regression statistical model. …”
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20225
Effect of Electroacupuncture on Hippocampal Functional Activity and Molecular Expression Profile in Rats with Vascular Cognitive Impairment
Published 2021-12-01“…Barnes maze test was used to evaluate the spatial learning and memory ability of rats; Y maze test was used to evaluate the spatial working memory ability of rats; small animal 7.0 T magnetic resonance resting brain functional imaging was used to analyze the changes of regional homogeneity (ReHo) of hippocampal functional activity; Agilent mRNA expression microarray was used to analyze the differential gene expression of the whole hippocampus genome.Results① Behavioral analysis results: compared with the sham operation group, the Barnes maze escape latency of the model group increased significantly (<italic>P</italic><0.05), the target quadrant duration percentage decreased significantly (<italic>P</italic><0.05), and the Y maze alternation rate decreased significantly (<italic>P</italic><0.05); compared with the model group, the Barnes maze escape latency of the electroacupuncture group decreased significantly (<italic>P</italic><0.05), the target quadrant duration percentage and the Y maze alternation rate increased significantly (<italic>P</italic><0.05). ② ReHo changes results: compared with the sham operation group, the ReHo of functional activitives of the bilateral prefrontal lobes, hippocampus and other brain regions in the model group decreased significantly (<italic>P</italic><0.005); compared with the model group, the ReHo of functional activities of the bilateral hippocampus, prefrontal lobes and piriform cortex in the model group increased significantly (<italic>P</italic><0.005). ③ Genomics results: a total of 705 genes with 2-fold differential expression of hippocampal mRNA between the model group and the sham operation group (<italic>P</italic><0.05), of which 195 genes (such as Sytl1, Trpv6, Klhl14, Npsr1, Myh3, Galnt3, Nr4a1, Bmp3, Egr2, etc.) were down-regulated, of which 510 genes (such as Insl6, Efcab1, Akr1b1, Tagln, Glrb, Akr1c13, Kcne1L, Ubap1, etc.) were up-regulated. …”
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20226
Effect of Repetitive Transcranial Magnetic Stimulation on Patients with Post-Stroke Cognitive Impairment
Published 2019-10-01“…Before and after treatment, the cognitive function scores of the two groups were compared, the changes of mini-mental state examination (MMSE) and Montreal cognitive function (MoCA) scores were compared, the activities of daily living (ADL) and auditory verbal learning test (AVLT) were observed. ELISA method was used to observe the changes of brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF), interleukin-6(IL-6) and high-sensitivity C-reactive protein (hs-CRP) in the two groups after treatment.Results:There were no significant differences in the scores of MoCA, including orientation (ORT), visual space and executive function (EF), naming (NAM), memory (MEM), attention (ATT), language (LANG) and abstract ability (ABS) before treatment between the two groups (<italic>P</italic>> 0.05). …”
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20227
Risk factors and prediction model of breast cancer-related lymphoedema in a Chinese cancer centre: a prospective cohort study protocol
Published 2024-12-01“…Traditional COX regression analysis and seven common survival analysis machine learning algorithms (COX, CARST, RSF, GBSM, XGBS, SSVM and SANN) will be employed for model construction and validation.Ethics and dissemination The study protocol was approved by the Biomedical Ethics Committee of Peking University (IRB00001052-21124) and the Research Ethics Committee of Tianjin Medical University Cancer Institute and Hospital (bc2023013). …”
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20228
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20229
Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target
Published 2025-01-01“…We utilized data from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO), applying machine learning algorithms to develop a prognostic model based on ACRRGs’ expression. …”
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20230
Automated Quantification of Retinopathy of Prematurity Stage via Ultrawidefield OCT
Published 2025-03-01“…This study evaluates whether the volume of anomalous NVT (ANVTV), defined as abnormal tissue protruding from the regular contour of the retina, can be measured automatically using deep learning to develop quantitative OCT-based biomarkers in ROP. …”
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20231
Sequence of episodic memory-related behavioral and brain-imaging abnormalities in type 2 diabetes
Published 2025-02-01“…The California Verbal Learning Test, Montreal cognitive assessment, and Stroop color word test was used to assess the episodic memory, general cognitive function, and executive function. …”
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20232
Sexual and reproductive health awareness and practices among adolescents and adults in a rural farming community in Baja California, Mexico: a quantitative and qualitative cross-se...
Published 2024-12-01“…Most believed that children should learn about SRH by age 10–15 years, and 94% felt that parents should deliver such education. …”
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20233
Association between estimated glucose disposal rate and cardiovascular diseases in patients with diabetes or prediabetes: a cross-sectional study
Published 2025-01-01“…Methods 10,690 respondents with diabetes and prediabetes from the NHANES 1999–2016 were enrolled in the study. Three machine learning methods (SVM-RFE, XGBoost, and Boruta algorithms) were employed to select the most critical variables. …”
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20234
Genome-wide identification and expression analysis of phytochrome gene family in Aikang58 wheat (Triticum aestivum L.)
Published 2025-01-01“…Additionally, the least absolute shrinkage and selection operator (LASSO) regression algorithm in machine learning was used to screen transcription factors such as bHLH, WRKY, and MYB that influenced the expression of TaAkPHY genes. …”
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20235
Anticholinergic burden and behavioral and psychological symptoms in older patients with cognitive impairment
Published 2025-02-01“…The cholinergic system plays an important role in learning processes, memory, and emotions regulation. …”
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20236
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility
Published 2024-11-01“…We therefore present ChromaFold, a deep learning model that predicts 3D contact maps, including regulatory interactions, from single-cell ATAC sequencing (scATAC-seq) data alone. …”
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20237
Sequencing Silicates in the Spitzer Infrared Spectrograph Debris Disk Catalog. I. Methodology for Unsupervised Clustering
Published 2025-01-01“…This study introduces CLustering UnsupErvised with Sequencer (CLUES), a novel, nonparametric, fully interpretable machine learning spectral analysis tool designed to analyze and classify the spectral data of debris disks. …”
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20238
Pengukuran Kapabilitas Tata Kelola TI Sistem Informasi Tiras dan Transaksi Bahan Ajar Universitas Terbuka Menggunakan Cobit 5
Published 2021-10-01“…Abstract The Open University (UT) teaching material service implements the Information System for Learning Materials and Transactions (SITTA) which in the process encountered problems related to the operation and optimization of Information Technology. …”
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20239
Timber and carbon sequestration potential of Chinese forests under different forest management scenarios
Published 2024-12-01“…This study utilised the national forest inventory (NFI) data to construct a model of forest growth and consumption using a machine learning algorithm (i.e. random forest), identified suitable areas for future forest expansion by integrating multi-source data, and set up three future forest management scenarios: business as usual (BAU), enhanced policy scenario (EPS) and maximum potential scenario (MPS). …”
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20240
Regional-scale precision mapping of cotton suitability using UAV and satellite data in arid environments
Published 2025-02-01“…Six advanced machine learning methods, including Random Forest (RF), were used alongside the ratio mean method to effectively upscale soil water and salt content models from the field to the regional level. …”
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