TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility by Elijah Edmondson, Takahito Kimura, Eunmi Hwang, Minjun Kim, Andrew Warner, Yuelin Zhu, Li Zhao, Yanlin Yu, Xuguang Zhu, Maria Hernandez, Noemi Kedei, Sheue-yann Cheng

“…Our studies provide new insights to understand uterine epithelial morphogenesis and how thyroid dysfunction could lead to female infertility.…”
Get full text

Potential Azo-8-hydroxyquinoline derivatives as multi-target lead candidates for Alzheimer's disease: An in-depth in silico study of monoamine oxidase and cholinesterase inhibitors. by Fatima Zahra Guerguer, Bouchra Rossafi, Oussama Abchir, Yasir S Raouf, Dhabya Bakhit Albalushi, Abdelouahid Samadi, Samir Chtita

“…This study proposes and designs a series of novel molecules derived from 8-hydroxyquinoline (Azo-8HQ) as potential multi-target lead candidates for treating AD. An exhaustive in silico analysis was conducted, encompassing docking studies, ADMET analysis, density functional theory (DFT) studies, molecular dynamics simulations, and subsequent MM-GBSA calculations to examine the pharmacological potential of these molecules with the specific targets of interest. …”
Get full text

Study Comparison between Alcoholic Extract of Broccoli, Folic Acid and Ferrous Sulfate Against Damage of the Cardiovascular System Induced by Lead-acetate in Rabbits by Dina S Dheyab, Jawad K Arrak, Majida A J Al-Qayim

“…The present study aimed to investigate the role of broccoli, folic acid, and ferrous sulfate in treating cardiovascular damage induced by lead acetate. Twenty-five female local rabbits 5 months in age with a verge of  weighing 1500 Kg were divided into 5 randomized groups: 1st as a control group (C) and the other four groups 2nd(lead acetate ),3rd(T1F),4th(T2FS),5th(T3B) were exposed to lead acetate 10 mg/kg/Bw/daily for 4 weeks , the second group continued to receive a lead for 8 weeks, while 3rd,4th, and 5th treated with alcoholic extract of the broccoli, folic acid and ferrous sulfate respectively. …”
Get full text

The use of ethanol as contrast enhancer in synchrotron X-ray phase-contrast imaging leads to heterogeneous myocardial tissue shrinkage: a case report by Gabriel Bernardino, Àngels Calvet-Mirabent, Hector Dejea, Eduard Guasch, Anne Bonnin, Patricia Garcia-Canadilla

Get full text

Can Primary Cardiac Myxofibrosarcoma Grow Quickly from Zero to a Size Leading to Left-Sided Heart Failure within 9 Months? by Levan Karazanishvili, Eduard Limonjiani

Get full text

Single Charge Current in a Normal Mesoscopic Region Attached to Superconductor Leads via a Coupled Poisson Nonequilibrium Green Function Formalism by David Verrilli, F. P. Marin, Rafael Rangel

“…We study the I-V characteristic of mesoscopic systems or quantum dot (QD) attached to a pair of superconducting leads. Interaction effects in the QD are considered through the charging energy of the QD; that is, the treatment of current transport under a voltage bias is performed within a coupled Poisson nonequilibrium Green function (PNEGF) formalism. …”
Get full text

All roads lead to Rome: the plasticity of gut microbiome drives the extensive adaptation of the Yarkand toad-headed agama (Phrynocephalus axillaris) to different altitudes by Jianghao Du, Peng Zheng, Weizhen Gao, Qianru Liang, Lin Leng, Lei Shi

Get full text

Civil Nationalism through Criminal Legislation in Iran (Study of the Process of Activities Leading to the Legislation of Criminal Laws Supporting Ethnic-Religious Identities in Iran) by Hossein Mirmohammad Sadeghi, Alireza Gharaghani

Get full text

Can a theory-based intervention lead primiparous women to decide to have a normal vaginal delivery? A randomized controlled trial by Rashin Pourashraf, Masoumeh Abbasi-Shavazi, Mahboubeh Valiani, Sara Jambarsang, Hossein Ali Sadeghian

Get full text

Maternal asthma imprints fetal lung ILC2s via glucocorticoid signaling leading to worsened allergic airway inflammation in murine adult offspring by Tomoaki Takao, Ako Matsui, Chie Kikutake, Keiko Kan-o, Azusa Inoue, Mikita Suyama, Isamu Okamoto, Minako Ito

Get full text

Complications of Mesenteric Vein Thrombosis: Heterozygous Factor V Leiden Mutation Leads to Pulmonary Embolism in a Patient With Post–Bowel Resection Surgery by Hafiz Muhammad Hamza, Muhammad Muiz Malik, Ayaz Ahmed Awan, Muhammad Daoud Tariq, Mohamed Daoud, Aman Goyal

Get full text

Preoperative halo-pelvic traction leading to near-complete airway obstruction in a child with severe thoracic lordosis and scoliosis: a case report by Ruoxi Wang, Jinqian Liang, Lulu Ma

“…However, there are potential risks of mechanical compression of bronchial structures, especially in patients with severe thoracic lordosis and scoliosis, which can lead to life-threatening airway obstruction. Case presentation A 11-year-old boy diagnosed with neurofibromatosis received preoperative halo-pelvic traction for forty days with a Cobb angle reduced from 99° to 51°. …”
Get full text

Effect of blindfolding the lead resuscitator on frequency of closed-loop communication during veterinary cardio-pulmonary resuscitation training: a randomized, controlled pilot study by Olivia X. Walesby, Giacomo Stanzani, Lindsay Kellett-Gregory, Mayank Seth, Emily K. Thomas

“…Each group was randomized as either control (CG) or blindfolded (BG) with the lead resuscitator always a veterinarian. The intervention involved the lead resuscitator wearing a blindfold during the third of four CPR simulation scenarios for the BG groups only.Measurements and main resultsVideo footage of Scenarios 2 (before) and 4 (after) the intervention was reviewed to quantify complete CLCs. …”
Get full text

Park7 deletion leads to sex-specific transcriptome changes involving NRF2-CYP1B1 axis in mouse midbrain astrocytes by Sergio Helgueta, Tony Heurtaux, Alessia Sciortino, Yujuan Gui, Jochen Ohnmacht, Pauline Mencke, Ibrahim Boussaad, Rashi Halder, Pierre Garcia, Rejko Krüger, Michel Mittelbronn, Manuel Buttini, Thomas Sauter, Lasse Sinkkonen

“…Abstract Loss-of-function mutations in PARK7, encoding for DJ-1, can lead to early onset Parkinson’s disease (PD). In mice, Park7 deletion leads to dopaminergic deficits during aging, and increased sensitivity to oxidative stress. …”
Get full text

Evaluating attachment-based family therapy in residential treatment in the United States: does adolescents’ increased attachment security to caregivers lead to decreases in depressive symptoms? by Guy Diamond, Alannah Shelby Rivers, Payne Winston-Lindeboom, Jody Russon, Michael Roeske

Get full text

Synchronous Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and Metastatic Squamous Cell Carcinoma of the Cervix Involving the Coronary Arteries Leading to Acute Myocardial Infarction by Michelle Bernshteyn, Alexandria Smith-Hannah, Amit S. Dhamoon

Get full text

Contamination Features and Source Apportionment of Heavy Metals in the River Sediments around a Lead-Zinc Mine: A Case Study in Danzhai, Guizhou, China by Rongguo Sun, Yue Gao, Jing Xu, Yang Yang, Yutao Zhang

“…The spatial patterns, ecological risks, and sources of heavy metals (HMs), including Pb, Zn, Mn, Cu, Cd, Hg, and As in river sediments, were identified around a lead-zinc mine of Danzhai, Guizhou, China. The concentrations of selected HMs and their coefficient variations indicated that the river sediments around this typical lead-zinc mine were obviously contaminated with HMs. …”
Get full text

miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

Get full text

Hyperglycemia in Streptozotocin-Induced Diabetes Leads to Persistent Inflammation and Tissue Damage Following Uveitis Due to Reduced Levels of Ciliary Body Heme Oxygenase-1 by Settimio Rossi, Michele D'Amico, Annalisa Capuano, Mary Romano, Pasquale Petronella, Clara Di Filippo

Get full text