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  1. 5641

    Antimicrobial resistance, virulence gene profiles, and molecular epidemiology of enterococcal isolates from patients with urinary tract infections in Shanghai, China by Weiyi Wu, Shuzhen Xiao, Lizhong Han, Qiong Wu

    Published 2025-01-01
    “…The prevalence of E. faecalis CC16 and E. faecium CC17 further complicates the treatment landscape for Enterococcal UTIs.IMPORTANCEThis study highlighted the critical need to understand Enterococcal strains causing UTIs in Shanghai, given their high prevalence. …”
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  2. 5642

    Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury by Dandan Mao, Qi Chen, Shuolan Tong, Zixia Xu, Guofeng Yu, Chuan Chang, Yao Lv

    Published 2025-01-01
    “…Additionally, relying on the immune infiltration landscape associated with cuproptosis, we carried out immune cell correlation analysis on hub genes. …”
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  3. 5643

    Digital interactive experience- and game-based fall interventions for community-dwelling healthy older adults: a cross-disciplinary systematic review by Celina Ciemer, Celina Ciemer, Lisa Kröper, Thomas Jürgen Klotzbier, Sabiha Ghellal, Nadja Schott

    Published 2025-01-01
    “…Digital, interactive interventions, incorporating experience-, and game-related aspects, offer a promising solution, making this topic inherently cross-disciplinary.ObjectiveThis review aims to assess the current landscape of digital interactive experience and game-based fall interventions for community-dwelling, healthy older adults. …”
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  4. 5644

    Direct and indirect effects of land use on microbiomes of trap-nesting solitary bee larvae and nests by Birte Peters, Birte Peters, Birte Peters, Sara Diana Leonhardt, Michael Schloter, Alexander Keller

    Published 2025-01-01
    “…However, the drivers and dynamics of healthy microbiome in solitary bees are still poorly understood, especially regarding the direct and indirect effects of land use on the diversity and composition of these microbial communities.MethodsWe examined bacterial communities in the offspring and nest materials of the Megachilid trap-nesting solitary bee, Osmia bicornis, along a gradient of land use intensification by 16S rRNA gene metabarcoding. Given that landscape composition, climatic conditions, and food resources are known to influence microbial compositions in solitary bee species, we hypothesized that land use changes would alter resources available for food and nest material collection and thereby affecting the microbiomes in offspring and their nest environments. …”
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  5. 5645
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  7. 5647

    Predictive Policing and Enhancing Security Performance through Artificial Intelligence Applications by Bensalem Kheira

    Published 2024-12-01
    “… The digital transformation era has revolutionized the global landscape, urging countries to modernize their infrastructures to integrate artificial intelligence (AI) applications effectively. …”
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  8. 5648

    Comprehensive computational analysis of differentially expressed miRNAs and their influence on transcriptomic signatures in prostate cancer by Fahad M. Aldakheel, Hadeel Alnajran, Ayesha Mateen, Shatha A. Alduraywish, Mohammed S. Alqahtani, Rabbani Syed

    Published 2025-01-01
    “…These findings both reinforce our current understanding of prostate cancer’s molecular landscape and point to unexplored pathways that could lead to novel therapeutic strategies. …”
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  9. 5649

    The Association Between COVID-19 Vaccination Uptake and Information-Seeking Behaviors Using the Internet: Nationwide Cross-Sectional Study by Kazuya Taira, Misa Shiomi, Takayo Nakabe, Yuichi Imanaka

    Published 2025-01-01
    “…This research sheds light on how the digital information landscape influences health behaviors, stressing the importance of accurate and trustworthy health information amidst global health emergencies.…”
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  10. 5650

    Mitigation of environmental impacts in ornamental rock and limestone aggregate quarries in arid and semi-arid areas by M.A. Peñaranda Barba, V. Alarcón Martínez, I. Gómez Lucas, J. Navarro Pedreño

    Published 2021-10-01
    “…All of this has given rise to numerous active and abandoned mines, where no restoration process has been carried out, generating strong impacts on the environment.METHODS: In this study, 8 environmental impact assessments studies of ornamental rock and aggregate quarries in the Region of Murcia were analysed to identify the negative impacts on the abiotic and biotic environment, landscape, socio-economic and socio-cultural environment, and infrastructures and analysing preventive and control measures. …”
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  11. 5651

    Pathological variants in HPV-independent vulvar tumours by Sanja A. Farkas, Alvida Qvick, Gisela Helenius, Gabriella Lillsunde-Larsson

    Published 2025-01-01
    “…The mutational frequencies and landscape for HPV-associated and HPV-independent vulvar tumor development are supposedly two distinctly different pathways and more detailed knowledge on target biological mechanisms for individualized future treatments is needed. …”
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  12. 5652

    The Mediating Role of Cognitive Reappraisal on Bedtime Procrastination and Sleep Quality in Higher Educational Context: A Three-Wave Longitudinal Study by Zhang Y, Rehman S, Addas A, Ahmad M, Khan A

    Published 2025-01-01
    “…Yuan Zhang,1 Shazia Rehman,2 Abdullah Addas,3,4 Mehmood Ahmad,5 Ayesha Khan6 1College of Art, Nanyang Vocational College of Agriculture, Nan Yang, Henan, 47300, People’s Republic of China; 2Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China; 3Department of Civil Engineering, College of Engineering, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia; 4Landscape Architecture Department, Faculty of Architecture and Planning, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; 5Department of Pharmacology and Toxicology, Faculty of Veterinary and Animal Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan; 6Department of Applied Psychology, Faculty of Social Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, PakistanCorrespondence: Shazia Rehman, Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, People’s Republic of China, Tel +86-13308429613, Email rehmanshazia.malik@gmail.comBackground: While bedtime procrastination is commonly associated with adverse outcomes such as poor sleep quality, the mechanisms mediating these effects remain underexplored. …”
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  13. 5653
  14. 5654

    Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation by Jinru Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Yingying Li, Minglan Yao, Hao Li, Xiaoping Luo, Yan Hao

    Published 2025-01-01
    “…HIF1A is a key participant in brain hypoxia, but its contribution to the pathophysiological landscape of ASD remains unclear. Methods: ASD-related datasets were obtained from GEO database, and HIF1A-related genes from GeneCards. …”
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  15. 5655
  16. 5656

    Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

    Published 2025-01-01
    “…Conclusions This study provided a microecological landscape of the lower respiratory tract with advanced NSCLC to ICI interventions and presented a multidimensional perspective with favoured outcomes that may improve the predictive capacity of the localized microbiome in clinical practices. …”
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  17. 5657

    Blockchain-assisted improved interval type-2 fuzzy deep learning-based attack detection on internet of things driven consumer electronics by Rana Alabdan, Bayan Alabduallah, Nuha Alruwais, Munya A. Arasi, Somia A. Asklany, Omar Alghushairy, Fouad Shoie Alallah, Abdulrhman Alshareef

    Published 2025-01-01
    “…The Internet of Things (IoTs) revolutionizes the consumer electronics landscape by presenting a degree of personalization and interactivity that was previously unimaginable. …”
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  18. 5658
  19. 5659

    Systematic multiomics analysis and in vitro experiments suggest that ITGA5 could serve as a promising therapeutic target for ccRCC by Xiangxian Che, Xi Tian, Zhenda Wang, Shuxuan Zhu, Shiqi Ye, Yue Wang, Yihan Chen, Yiyun Huang, Aihetaimujiang Anwaier, Peifeng Yao, Yijia Chen, Keting Wu, Yifei Liu, Wenhao Xu, Hailiang Zhang, Dingwei Ye

    Published 2024-11-01
    “…The localization of ITGA5 primarily in endothelia and macrophages further verified its magnitude in angiogenesis and aroused our excavation in ITGA5 regulation of immune infiltration landscape. Generally, ITGA5-high ccRCC presented an immunosuppressive TME by inducing a lower level of CD8 + T cell infiltration. …”
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  20. 5660