Spatial identification of regions exposed to multi-hazards at the pan-European level by T.-E. Antofie, T.-E. Antofie, S. Luoni, A. Tilloy, A. Sibilia, S. Salari, G. Eklund, D. Rodomonti, C. Bountzouklis, C. Corbane

“…By employing a meta-analysis approach and aggregating the hotspots of exposure to single hazards, we provide an objective, statistically robust assessment of the European multi-hazard landscape at the finest spatial subdivision level, local administrative units (LAUs). …”
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mHealth-based intervention by community workers to support family caregivers of persons with dementia living at home: study protocol for a cluster randomised controlled trial by Pankaj Bhardwaj, Hanne Konradsen, Manoj Kumar Gupta, Abhik Sinha, Nitin Kumar Joshi, Suresh K Sharma, Naresh Nebhinani, Marie Tyrrell, Åsa G Craftman, Zarina Nahar Kabir

“…Additionally, usability and cost analyses will be conducted to evaluate the practicality and economic feasibility of the intervention.The expected outcomes of this study include the creation of a scalable mHealth platform that facilitates remote support, bridges geographical gaps and enhances the well-being of caregivers in India’s evolving healthcare landscape.Ethics and dissemination Ethical approval has been obtained from the Institutional Ethical Committee of AIIMS Jodhpur (AIIMS/IEC/2022/4245).Trial registration number Clinical Trials Registry: CTRI/2022/12/048320.…”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…This study aims to systematically evaluate the research landscape, identify emerging hotspots, and provide guidance for future investigations.MethodsArticles on glioma chemoradiotherapy resistance published between 2003 and 2023 were retrieved from the Web of Science Core Collection, resulting in 4,528 publications. …”
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Methylprednisolone substituted lipid nanoparticles deliver C3 transferase mRNA for combined treatment of spinal cord injury by Haoru Dong, Zongxing He, Shiyi Cai, Haiqiang Ma, Lili Su, Jianfeng Li, Huiying Yang, Rong Xie

“…Currently, the therapeutic landscape for SCI is notably sparse, with limited effective treatment options available. …”
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The safety and efficacy of immune checkpoint blockade in children, adolescents, and young adults: A systematic review and meta-analysis by Pedro C.A. Reis, João Evangelista Ponte Conrado, Mariana Macambira Noronha, Luís Felipe Leite da Silva, Erick Figueiredo Saldanha, Jonathan Metts

“…Background: Immune checkpoint blockade (ICB) has changed the treatment landscape for many types of adult cancer. However, for children, adolescents, and young adults (CAYAs) clinical experience lags behind that of adults. …”
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Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…Conclusion: MALAT1 stands out as a key player in the complex landscape of OSCC pathogenesis, impacting tumorigenesis, metastasis, and treatment outcomes through multifaceted molecular mechanisms. …”
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Emerging malaria in Indonesia: An overview of Plasmodium knowlesi infections by Nisa Fauziah, Karomahul Malaya Jati, Fedri Ruluwedrata Rinawan, Naufal Fakhri Nugraha, Bachti Alisjahbana, Jontari Hutagalung

“…Background: Plasmodium knowlesi, the fifth malaria-causing parasite species, is currently changing the landscape of the most dominant malaria-causing species in the Southeast Asia by becoming the emerging significant cause of malaria in the region, including in Indonesia. …”
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Pastoral livestock farming constraints and adaptation strategies in response to institutional reforms in the Sudano-Sahelian zone of West Africa by Basnewindé Ilboudo, Alhassane Zaré, Alhassane Zaré, Innocent Charles Emmanuel Traoré, Innocent Charles Emmanuel Traoré, Loyapin Bondé, Reginald Tang Guuroh, Reginald Tang Guuroh, Reginald Tang Guuroh, Oumarou Ouédraogo

“…The main information collected included pastoral landscape and the current state of the livestock production system. …”
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Oocyte transcriptomes and follicular fluid proteomics of ovine atretic follicles reveal the underlying mechanisms of oocyte degeneration by Yukun Song, Erhan Hai, Nan Zhang, Yu Zhang, Junlan Wang, Xitong Han, Jiaxin Zhang

“…Meanwhile, we also characterized unique features of the oocyte transcriptional landscape in the atretic follicle stage that displayed cell death-related transcriptional changes and mechanisms, such as autophagy (TBK1 and IRS4), necroptosis (PKR), and apoptosis (MARCKS). …”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Thus, a variety of infrastructure and measures to accommodate the diversity of wildlife moving across forest patches in a fragmented landscape is recommended.…”
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University Leadership: Transparency in Communication with External Stakeholders by Nadiia Artyukhova, Olena Churikanova, Kseniia Bliumska-Danko

“…The clustering method provided essential insights into which institutions lead in transparency and where improvements are necessary, reinforcing that transparency is key to ensuring competitiveness within the higher education landscape. This research broadens the understanding of transparency in higher education, offering practical recommendations for universities seeking to enhance their external communication practices. …”
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Preclinical evaluation of avutometinib and defactinib in high‐grade endometrioid endometrial cancer by Tobias Max Philipp Hartwich, Miranda Mansolf, Cem Demirkiran, Michelle Greenman, Stefania Bellone, Blair McNamara, Shuvro P. Nandi, Ludmil B. Alexandrov, Yang Yang‐Hartwich, Silvia Coma, Jonathan Pachter, Alessandro D. Santin

“…Methods Whole‐exome sequencing (WES) was used to evaluate the genetic landscape of five primary EAC cell lines. The in vitro activity of avutometinib and defactinib as single agents and in combination was evaluated using cell viability, cell cycle, and cytotoxicity assays. …”
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Hospital antimicrobial stewardship funding and resourcing impact on broad-spectrum antibiotic use: a cross-sectional study by Megan Tu, Zong Heng Shi, Valerie Leung, Kevin A Brown, Kevin L Schwartz, Nick Daneman, Bradley J Langford

“…Methods: We conducted a cross-sectional study of antimicrobial use (AMU) across 63 Ontario hospitals from April 2020 to March 2023. The Ontario ASP Landscape Survey provided data on ASP resourcing and antibiotic utilization. …”
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Optimal irrigation and nitrogen fertilization for growth and yield of perennial ryegrass (Lolium perenne) by DUAN Kelong, NIU Zuirong, ZHANG Zhenrong, SONG Shuzhen, LI Miaoqi, GUO Sheng

“…[Objective] Ryegrass (Lolium perenne) is extensively cultivated in Northwestern China for various purposes ranging from forage to landscaping. This paper presents the results of an experimental study on optimal irrigation and nitrogen fertilization for growth and yield of perennial ryegrass in managed grasslands in Yongdeng County in Gansu province, China. …”
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Social Structure Analysis in Management of South Sumatra Inland Waters by Fevi Rahma Dwi Putri, Arif Satria, Rilus A. Kinseng, Taryono Taryono

“…The participants in this social landscape strived to accumulate capital to enhance their competitiveness within the L3S domain. …”
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Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications by Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono

“…This bibliometric analysis provides valuable insights into the global research landscape, guiding future studies in the management of spinal TB.…”
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Immune-related gene SOX10 affects ferroptosis in pancreatic cancer and facilitates tumor progression by targeting CMTM7-mediated Wnt/β-catenin signaling pathway by Guixing Jiang, Bicheng Wu, Kaikai Wang, Xiaofan Pu, Senhao Zhou, Xin Zhong, Xiaolong Liu, Suihan Wang, Tianyu Lin

“…Methods Relationships between SOX10 and immune landscape were estimated using bioinformatic approaches. …”
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Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024 by Yuxin Hu, Yuxin Hu, Yuxin Hu, Jingyi Tang, Jingyi Tang, Jingyi Tang, Hanzhang Hong, Hanzhang Hong, Yexin Chen, Yexin Chen, Beibei Ye, Ziheng Gao, Ziheng Gao, Gegongming Zhu, Lin Wang, Lin Wang, Lin Wang, Weijing Liu, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang

“…In recent years, however, there has been a shift towards biomarkers, inflammation and necrosis, which indicate current and future research directions in this area.ConclusionThe global landscape of the ferroptosis research in kidney disease from 2012 to 2024 was presented. …”
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Bug off or bug out: mapping flight secrets of Triatoma garciabesi (Hemiptera: Reduviidae) through climate, geography, and greenery by Thaiane Verly, Thaiane Verly, Federico G. Fiad, Ana Laura Carbajal-de-la-Fuente, Ana Laura Carbajal-de-la-Fuente, Sebastián Pita, Romina V. Piccinali, Romina V. Piccinali, Patricia A. Lobbia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Paz Sánchez-Casaccia, Antonieta Rojas de Arias, María José Cavallo, Gisel V. Gigena, Claudia S. Rodríguez, María C. Vega-Gómez, Miriam Rolón, Julieta Nattero, Julieta Nattero, Julieta Nattero

“…The size and shape components and the geographic, climatic, and/or vegetation indexes explained covariation in all flight-related traits.DiscussionT. garciabesi appears to be a species sensitive to vegetation cover and landscape features. This study provides evidence for this by showing clear variation in flight-related traits across the species and lineage distribution range, as well as indications of isolation by distance and variation in flight-related traits according to climate, geography, and vegetation cover.…”
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Assessing Four Decades of Land Use and Land Cover Change: Policy Impacts and Environmental Dynamics in the Min River Basin, Fujian, China by Weixuan Huang, Anil Shrestha, Yifan Xie, Jianwu Yan, Jingxin Wang, Futao Guo, Yuee Cao, Guangyu Wang

“…First, we mapped and quantified changes (i.e., LULCC and landscape indices) in forests, croplands, urban areas, and water bodies from 1980 to 2020 using the China National Land Use/Cover Change (CNLUCC) and ArcGIS Pro 2.3. …”
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