Physiological and behavioural resistance of malaria vectors in rural West-Africa: a data mining study to address their fine-scale spatiotemporal heterogeneity, drivers, and predict... by Taconet, Paul, Soma, Dieudonné Diloma, Zogo, Barnabas, Mouline, Karine, Simard, Frédéric, Koffi, Alphonsine Amanan, Dabiré, Roch Kounbobr, Pennetier, Cédric, Moiroux, Nicolas

“…The explanatory variables covered a wide range of potential environmental determinants of vector resistance to insecticide or behavioural resistance phenotypes: vector control, human availability and nocturnal behaviour, macro and micro-climatic conditions, landscape, etc. The resulting models revealed many statistically significant associations, although their predictive powers were overall weak. …”
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Out-of-phase relationship of Holocene moisture variations between the northeastern and southeastern Tibetan plateau and its societal impacts by Duo Wu, Minmin Ma, Yongxiu Lu, Shilong Guo, Tao Wang, Xuyi Ma, Guanghui Dong

“…Decreasing moisture in YNP promoted the expansion of an open landscape, which affected the development of agriculture during the period of ∼4600‒2200 BP. …”
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Water resources carrying capacity before and after volcanic eruption by M. Dede, S.B. Wibowo, Y. Prasetyo, I.W. Nurani, P.B. Setyowati, S. Sunardi

“…The eruption of Mount Merapi in 2010 changed the landscape and community livelihoods due to the redistribution of a large volume of volcanic materials. …”
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Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation by Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu

“…‘Cardiovascular outcome’ and ‘diabetic kidney diseases’ were identified as keywords in their burst period over the past three years.Conclusion Our bibliometric analysis illuminates the contours of nephrology and microcirculation research, revealing a landscape ripe for challenges and the seeds of future scientific innovation. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Following 500 ns, MD simulations showed that these mutations caused a significant distortion in the protein conformational, protein-protein interactions (PPIs), and drug binding landscape compared to Bcl-2WT.ConclusionDespite being a predictive study, the findings presented in this report would offer a perspective insight for further experimental investigation, rational drug design, and cancer gene therapy.…”
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CADD-based discovery of novel oligomeric modulators of PKM2 with antitumor activity in aggressive human glioblastoma models by Maia Cabrera, Romina Armando, Ian Czarnowski, Patricio Chinestrad, Ramiro Blanco, Alejandra Zinni, Daniel Gómez, Diego L. Mengual Gómez, Pablo Lorenzano Menna

“…ADMET studies further highlighted their strong potential as lead PKM2 inhibitors for GBM treatment.Molecular dynamics (MD) simulations and post-MD analyses, including Dynamic Cross-Correlation Maps (DCCM), Probability Density Function (PDF), and Free Energy Landscape (FEL), confirmed the stability of the protein-ligand interactions and highlighted critical residues at the dimer-dimer interface. …”
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Unveiling vegetation recovery dynamics in Andean grasslands along a trans-Andean natural gas pipeline by Fiorella Eduardo-Palomino, Héctor Chuquillanqui, Reynaldo Linares-Palomino

“…The study area was divided into 12 large ecological landscape units (ELUs) to facilitate data comparison and interpretation. …”
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Awareness and Attitude Toward Artificial Intelligence Among Medical Students and Pathology Trainees: Survey Study by Anwar Rjoop, Mohammad Al-Qudah, Raja Alkhasawneh, Nesreen Bataineh, Maram Abdaljaleel, Moayad A Rjoub, Mustafa Alkhateeb, Mohammad Abdelraheem, Salem Al-Omari, Omar Bani-Mari, Anas Alkabalan, Saoud Altulaih, Iyad Rjoub, Rula Alshimi

“…ObjectiveThis study aims to assess and compare medical AI-related attitudes among medical students in general medicine and in one of the visually oriented fields (pathology), along with illuminating their anticipated role of AI in the rapidly evolving landscape of AI-enhanced health care. MethodsThis was a cross-sectional study that used a web-based survey composed of a closed-ended questionnaire. …”
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Trends and future predictions of chronic kidney disease due to diabetes mellitus type 2 attributable to dietary risks: insights based on GBD 2021 data by Ming Xu, Ming Xu, Hongxia Wei, Hongxia Wei, Dongqing Lv, Dongqing Lv, Yanhong Wei, Yanhong Wei, Ziang Liu, Ziang Liu, Yi Zhang, Yi Zhang, Yunfeng Liu, Yunfeng Liu, Yunfeng Liu

“…Throughout this period, both mortality and DALY rates associated with dietary risks increased significantly, with the most rapid increase in diet high in sugar-sweetened beverages, highlighting the considerable impact of dietary factors on the global CKD-T2DM landscape. Geographic disparities in T2DM trends are evident, with the most significant increases in age-standardized mortality rates (ASMR) and age-standardized DALY rates (ASDR) observed in regions such as high-income North America and Central Latin America. …”
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Identification and quantification of transposable element transcripts using Long-Read RNA-seq in Drosophila germline tissues by Rebollo, Rita, Gerenton, Pierre, Cumunel, Eric, Mary, Arnaud, Sabot, François, Burlet, Nelly, Gillet, Benjamin, Hughes, Sandrine, S. Oliveira, Daniel, Goubert, Clément, Fablet, Marie, Vieira, Cristina, Lacroix, Vincent

“…Overall, this first comparison of TEs between testes and ovaries uncovers differences in their transcriptional landscape, at the subclass and insertion level.…”
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Genomic characterization and molecular predictive biomarkers for chemotherapy in patients with metastatic triple-negative breast cancer treated in a real-world setting by Erik Olsson, Henrik Lindman, Evangelos Digkas, Viktoria Thurfjell, Haidar Mir Ali, Ute Krüger, Anna-Karin Wennstig, Marie Sundqvist, Antonios Valachis

“…Further research into the genomic landscape of tumors from patients with rapid progression or exceptional response to different treatment strategies can provide insights into mechanisms of resistance and identify predictive biomarkers.…”
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A spatiotemporal optimization engine for prescribed burning in the Southeast US by Reetam Majumder, Adam J. Terando, J. Kevin Hiers, Jaime A. Collazo, Brian J. Reich

“…Many ecosystems in the Southeast US are dependent upon frequent low-intensity surface fires to sustain native biodiversity, ecosystem services, and endangered species populations. Today, landscape-scale prescribed fire is required to manage these systems for conservation objectives and to mitigate wildland fire risk. …”
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A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma by Dantong Sun, Helei Hou, Feiyue Feng, Weizheng Wu, Jingyu Tan, Tongji Xie, Jiayu Liu, Jinsong Wang, Haili Qian, Junling Li, Puyuan Xing

“…Abstract Background Osimertinib has emerged as a critical element in the treatment landscape following recent clinical trials. Further investigation into the mechanisms driving resistance to Osimertinib is necessary to address the restricted treatment options and survival advantages that are compromised by resistance in patients with EGFR-mutated lung adenocarcinoma (LUAD). …”
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Role of Gender in Shaping Consumer Responses to Doctor Influencer: Insights into Brand Perceptions and Repurchase Intentions in the Indonesian Mineral Water Industry by Endang Dwi Amperawati, Rahmawati Rahmawati, Endang Hariningsih, Wing Wahyu Winarno, Diana Airawaty, Agus Dwianto

“…These insights offer a new perspective on influencer marketing, emphasizing the importance of expertise, success appeal, congruency, and gender considerations, thereby providing marketers with strategic guidance in the digital landscape. …”
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Comparative indicators of morphology and seed productivity in rare <i>Iris</i> L. spp. within their natural habitats and under cultivation in the Southern Urals by A. V. Kryukova, A. N. Mustafina, L. M. Abramova

“…., I. pumila is recommended for landscaping settlements in the South Urals as the most stable species.…”
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Service delivery and the role of clinical pharmacists in UK primary care for older people, including people with dementia: a scoping review by Alice Burnand, Abi Woodward, Vladimir Kolodin, Jill Manthorpe, Yogini Jani, Mine Orlu, Cini Bhanu, Kritika Samsi, Victoria Vickerstaff, Jane Wilcock, Jane Ward, Greta Rait, Nathan Davies

“…Searches included literature exploring the landscape of clinical pharmacy services for older people in the UK, focusing on roles and services delivered, perceptions, and experiences. …”
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Expert Consensus on the Management of Acute Otitis Media in India: A Delphi Study by Tanu Singhal, Shyam Kukreja, Jaydeep Choudhury, Vijay Yewale, Balasubramanian Sundaram, Jagdish Chinnappa, Suhas Prabhu, Balaji Veeraraghavan, Camilla Rodrigues, Vidya Krishna, Winsley Rose, Samir Bhargava

“…The changing epidemiological landscape in India and growing concerns about antimicrobial resistance underscore the need for evidence-based, updated guidance on management. …”
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MORKO: A Multi-objective Runge–Kutta Optimizer for Multi-domain Optimization Problems by Kanak Kalita, Pradeep Jangir, Sundaram B. Pandya, Ahmed Ibrahim Alzahrani, Fahad Alblehai, Laith Abualigah, Absalom E. Ezugwu

“…Abstract In the current landscape, there is a rapid increase in the creation of new algorithms designed for specialized problem scenarios. …”
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Deep proteomics and network pharmacology reveal sex- and age-shared neuropathic pain signatures in mouse dorsal root ganglia by Sabrina Grundtner, Julia R. Sondermann, Feng Xian, Daniel Malzl, Daniel Segelcke, Esther M. Pogatzki-Zahn, Jörg Menche, David Gómez-Varela, Manuela Schmidt

“…Consequently, we provide an innovative resource of the molecular landscape of neuropathic pain, enabling novel opportunities for translational pain research and network-based drug discovery.…”
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Comprehensive Chloroplast Genome Analysis of Four <i>Callitriche</i> (Plantaginaceae) Species for Phylogenetic and Conservation Insights by Zirui Zhang, Wenbo Shi, Siqi Hu, Lanruo Mou, Chao Shi, Bingyue Zhu, Jing Yang

“…Moreover, they can be utilized as horticultural plants for landscape greening. However, due to the threats of climate change and environmental degradation, some species within this genus have been listed as endangered. …”
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