Fast and sensitive virus detection using a plasmonic sensor that integrates electrokinetically assisted sampling and surface-enhanced Raman scattering by Shamim Azimi, Maryam Moridsadat, Bhavin Shastri, Bruce W. Banfield, Carlos Escobedo, Aristides Docoslis

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Can nebulised heparin reduce acute lung injury in patients with SARS‑CoV‑2 requiring advanced respiratory support in Ireland: the CHARTER‑Ireland phase Ib/IIa, randomised, parallel-group, open-label study by David Cosgrave, Bairbre McNicholas, Ciara Hanley, John Robert Sheehan, Padraig Calpin, Maeve Kernan, Darragh Murphy, Alberto Alvarez‑Iglesias, John Ferguson, Camilla Giacomini, Christine Greene, Catriona Cody, Shane McGeary, Marion Murphy, Marianne Fitzgerald, Gerard Curley, Barry Dixon, Roger J. Smith, Claire Masterson, Daniel O’Toole, Frank van Haren, John G. Laffey

“…Methods This was a phase Ib/IIa open-label multi-centre, randomised controlled trial. …”
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Efficacy and safety of perioperative sintilimab plus platinum-based chemotherapy for potentially resectable stage IIIB non-small cell lung cancer (periSCOPE): an open-label, single-arm, phase II trialResearch in context by Xiangyang Yu, Chujian Huang, Longde Du, Chunguang Wang, Yikun Yang, Xin Yu, Shengcheng Lin, Chenglin Yang, Hongbo Zhao, Songhua Cai, Zhe Wang, Lixu Wang, Xiaotong Guo, Baihua Zhang, Zhentao Yu, Jie He, Kai Ma

“…Methods: Patients diagnosed with stage IIIB NSCLC through invasive staging approaches and/or PET/CT scans and evaluated as having a high probability of radical resection of the primary lesion and metastatic lymph nodes with clear pathological margins by a multidisciplinary team were enrolled in this open-label, single-arm, phase II trial at a single centre in China. …”
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Assessing the safety and feasibility of neoadjuvant hormone and radiation therapy followed by robot-assisted radical prostatectomy for treating locally advanced prostate cancer: protocol for an open-label, dose-escalation, single-centre, phase I clinical trial by Yu-Tian Xiao, Xianzhi Zhao, Yifan Chang, Xiaojun Lu, Ye Wang, Huojun Zhang, Shancheng Ren

“…We have designed this trial to investigate whether this combination, which theoretically maximises local control, is a safe and feasible approach for treating locally advanced prostate cancer.Methods and analysis This study is a phase I, open-label study to investigate the safety and feasibility of neoadjuvant hormone and radiation therapy followed by robot-assisted radical prostatectomy by a traditional 3+3 dose-escalation design with four planned radiation dose levels (39.6 Gy/22F, 45 Gy/25F, 50.4 Gy/28F and 54 Gy/30F). …”
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Multimodal Imaging of Integrin Receptor-Positive Tumors by Bioluminescence, Fluorescence, Gamma Scintigraphy, and Single-Photon Emission Computed Tomography Using a Cyclic RGD Peptide Labeled with a Near-Infrared Fluorescent Dye and a Radionuclide by W. Barry Edwards, Walter J. Akers, Yunpeng Ye, Philip P. Cheney, Sharon Bloch, Baogang Xu, Richard Laforest, Samuel Achilefu

“…The in vivo distribution of 111 In-labeled LS308 in a 4t1 luc tumor-bearing mouse model was studied by fluorescence, bioluminescence, planar gamma, and single-photon emission computed tomography (SPECT). …”
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Imaging the Met Receptor Tyrosine Kinase (Met) and Assessing Tumor Responses to a Met Tyrosine Kinase Inhibitor in Human Xenograft Mouse Models with a [Tc] (AH-113018) or CY 5** (AH-112543) Labeled Peptide by Elaine M. Jagoda, Sibaprasad Bhattacharyya, Joseph Kalen, Lisa Riffle, Avrum Leeder, Stephanie Histed, Mark Williams, Karen J. Wong, Biying Xu, Lawrence P. Szajek, Osama Elbuluk, Fabiola Cecchi, Kristen Raffensperger, Meghana Golla, Donald P. Bottaro, Peter Choyke

“…A peptide targeting Met labeled with [ 99m Tc] had high affinity in vitro (K d = 3.3 nM) and detected relative changes in Met in human cancer cell lines. …”
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Optimized chemical labeling method for isolation of 8-oxoG-modified RNA, ChLoRox-Seq, identifies mRNAs enriched in oxidation and transcriptome-wide distribution biases of oxidation events post environmental stress by Matthew R. Burroughs, Philip J. Sweet, Lydia M. Contreras

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Safety of Abemaciclib in Indian Patients with Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced and/or Metastatic Breast Cancer: A Multicenter, Nonrandomized, Open-Label, Single-Arm, Phase 4 Study by Dinesh Chandra Doval, Tanveer Maksud, Rajnish Nagarkar, Satheesh Chiradoni Thunagappa, Rakesh Taran, Saurabh Prasad, Anoop T. Manoharan, Minish Jain, Dhruv Mehta, Prabrajya Narayan Mohapatra, Sachin Gupta, Kritarth Naman Singh, Aarohan Pruthi, Rohit Arora

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Pharmacokinetics of PP353, a formulation of linezolid for intervertebral disc administration, in patients with chronic low back pain and Modic change Type 1: A first‐in‐human, Phase 1b, open‐label, single‐dose study by Shiva S. Tripathi, Robert Sneath, Aprajay Golash, Parag Desai, Duncan McHale, Sarah Guest, Charlie Brindley, Paul Cummings, Shane Smith, Conrad Stroud, Graham Scott, Steve Ruston, Lloyd Czaplewski

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Platform Randomised trial of INterventions against COVID-19 In older peoPLE (PRINCIPLE): protocol for a randomised, controlled, open-label, adaptive platform, trial of community treatment of COVID-19 syndromic illness in people at higher risk by Sarah Tonkin-Crine, Simon de Lusignan, Jienchi Dorward, Susan Hopkins, Gail Hayward, F D Richard Hobbs, Ly-Mee Yu, Oliver van Hecke, Julie Allen, Emma Ogburn, Christopher C Butler, Heather Rutter, Oghenekome Gbinigie, Sharon Tonner, Emily Bongard, Aleksandra Borek, Philip H Evans, Martin Llewelyn, Benjamin R Saville, Nicholas Berry, Hannah Swayze, David Judge, Jenna Grabey, Nicholas P B Thomas, Monique I Andersson, Mahendra Patel

“…Introduction There is an urgent need to idenfy treatments for COVID-19 that reduce illness duration and hospital admission in those at higher risk of a longer illness course and complications.Methods and analysis The Platform Randomised trial of INterventions against COVID-19 In older peoPLE trial is an open-label, multiarm, prospective, adaptive platform, randomised clinical trial to evaluate potential treatments for COVID-19 in the community. …”
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A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive heavily pretreated solid tumors: results from a phase Ia/Ib first-in-human, open-label, single center study by Na Song, Na Song, Yuee Teng, Yuee Teng, Jing Shi, Jing Shi, Zan Teng, Zan Teng, Bo Jin, Bo Jin, Jinglei Qu, Jinglei Qu, Lingyun Zhang, Lingyun Zhang, Ping Yu, Ping Yu, Lei Zhao, Lei Zhao, Jin Wang, Jin Wang, Aodi Li, Aodi Li, Linlin Tong, Linlin Tong, Shujie Jiang, Shujie Jiang, Yang Liu, Yang Liu, Liusong Yin, Xiaoling Jiang, Tie Xu, Jian Cui, Xiujuan Qu, Xiujuan Qu, Yunpeng Liu, Yunpeng Liu

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Adoptive transfer of zoledronate-expanded autologous Vγ9Vδ2 T-cells in patients with treatment-refractory non-small-cell lung cancer: a multicenter, open-label, single-arm, phase 2 study by Yukari Kobayashi, Masaaki Sato, Kazuhiro Kakimi, Hirokazu Matsushita, Ryuji Suzuki, Takahiro Karasaki, Keita Masuzawa, Koji Nagaoka, Akihiro Hosoi, Shinnosuke Ikemura, Kentaro Kitano, Ichiro Kawada, Tadashi Manabe, Tomohiro Takehara, Toshiaki Ebisudani, Kazuhiro Nagayama, Yukio Nakamura, Hiroyuki Yasuda, Kenzo Soejima, Jun Nakajima

“…Here, we report the results of a phase 2 clinical trial of adoptive cell therapy using zoledronate-expanded autologous Vγ9Vδ2 T-cells for treatment-refractory NSCLC.Methods NSCLC patients who had undergone at least two regimens of standard chemotherapy for unresectable disease or had had at least one treatment including chemotherapy or radiation for recurrent disease after surgery were enrolled in this open-label, single-arm, multicenter, phase 2 study. After preliminary testing of Vγ9Vδ2 T-cell proliferation, autologous peripheral blood mononuclear cells were cultured with zoledronate and IL-2 to expand the Vγ9Vδ2 T-cells. …”
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Safety and tolerability of a single infusion of autologous ex vivo expanded regulatory T cells in adults with ulcerative colitis (ER-TREG 01): protocol of a phase 1, open-label, fast-track dose-escalation clinical trial by Carola Berking, Raja Atreya, Markus F Neurath, Sebastian Zundler, Britta Siegmund, Gerold Schuler, Francesco Vitali, Caroline J Voskens, Diane Stoica, Susanne Roessner, Marita Rosenberg, Manuel Wiesinger, Jutta Wunder, Beatrice Schuler-Thurner

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The near-optimal adjustment of carbon and nitrogen allocations into different organs in early-season rice cultivars with drastically different yield components under nitrogen appli... by Wen Ning, Wen Ning, Lin Su, Lin Su, Dandan Shi, Dandan Shi, Meina Ji, Meina Ji, Xiang Ouyang, Qingfeng Song, Caihong Shao, Xin-Guang Zhu, Shuoqi Chang, Shuoqi Chang

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Free Electron Density Gradients Enhanced Biosensor for Ultrasensitive and Accurate Affinity Assessment of the Immunotherapy Drugs by Youqian Chen, Hongli Fan, Rui Li, Huazhi Zhang, Rui Zhou, Gang L. Liu, Chunmeng Sun, Liping Huang

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Dobutamine-induced alterations in internal carotid artery blood flow and cerebral blood flow in healthy adults by Fengxia Yu, Dong Liu, Xia Ma, Yawen Liu, Linkun Cai, Erwei Zhao, Zixu Huang, Zhe Zhang, Tingting Zhang, PengGang Qiao, Wei Zheng, Chunyan Guo, Linxue Qian, Pengling Ren, Zhenchang Wang

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CSTN: A cross-region crop mapping method integrating self-training and contrastive domain adaptation by Shuwen Peng, Liqiang Zhang, Rongchang Xie, Ying Qu

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Effect of <i>Opuntia ficus-indica</i> Extract in Pro-Healthy Chicken Patties: Physicochemical Properties and Oxidative Stability by Leticia A. Gonçalves, José M. Lorenzo, Roberto Bermúdez, Mirian Pateiro, Marco Antonio Trindade

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Authenticity Verification of Commercial Poppy Seed Oil Using FT-IR Spectroscopy and Multivariate Classification by Didem P. Aykas

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Transient Slope: A Metric for Assessing Heterogeneity from the Dielectrophoresis Spectrum by Emmanuel Egun, Tia Wilson, Zuri A. Rashad, Rominna Valentine, Tayloria N. G. Adams

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