S³DR-Det: A Rotating Target Detection Model for High Aspect Ratio Shipwreck Targets in Side-Scan Sonar Images by Quanhong Ma, Shaohua Jin, Gang Bian, Yang Cui, Guoqing Liu, Yihan Wang

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On Bridge Graphs with Local Antimagic Chromatic Number 3 by Wai-Chee Shiu, Gee-Choon Lau, Ruixue Zhang

Subjects: “…local antimagic labeling…”
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Density functional theory calculation for understanding the roles of biochar in immobilizing exchangeable Al3 + and enhancing soil quality in acidic soils by Debo He, Xinyi Liu, Dongni Hu, Ping Lei, Jinbo Zhang, Zhixin Dong, Bo Zhu

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A Stitch in Time by Brigid O’Farrell

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SaliencyMix+: Noise-Minimized Image Mixing Method With Saliency Map in Data Augmentation by Hajeong Lee, Zhixiong Jin, Jiyoung Woo, Byeongjoon Noh

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New dynamic load balancing method based on roulette wheel selection and its implementation by ZOU Yuan-ping1, LIU Hong-lin2

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Research on extended access control mechanism in online social network by Rongna XIE, Xiaonan FAN, Lin YUAN, Zichen GUO, Jiayu ZHU, Guozhen SHI

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A practice of user profile in big data by Xiaoxia WANG, Jingsha LIU, Dandan XU

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A discovery strategy for APT anomaly based on homologous behavior analysis by Yihan YU, Yu FU, Xiaoping WU, Hongcheng LI

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Semi-Supervised Change Detection with Data Augmentation and Adaptive Thresholding for High-Resolution Remote Sensing Images by Wuxia Zhang, Xinlong Shu, Siyuan Wu, Songtao Ding

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Promoting Shared Metacognition in Online Learning: The Practices of Distributed Teaching Presence and the Relationships to Cognitive Presence by Ye Chen, Lixuan Chen

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Preoperative Physical Activity Improvement with the Use of Activity Trackers in Patients Undergoing Radical Cystectomy—A Bicentric, Open-label, Randomised Controlled Trial: A Clinical Study Protocol of the PreAct Trial by Johannes Hermann Kilz, Marie Angela Sidoti Abate, Victoria Luise Simone Wieland, Luisa Egen, Caelan Max Haney, Aleksander Antoniewicz, Alexander Studier-Fischer, Thomas Stefan Worst, Maurice Stephan Michel, Patrick Honeck, Niklas Westhoff, Maximilian Christian Kriegmair, Karl-Friedrich Kowalewski

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Anti-LAG-3 antibody LBL-007 plus anti-PD-1 antibody toripalimab in advanced nasopharyngeal carcinoma and other solid tumors: an open-label, multicenter, phase Ib/II trial by Gang Chen, Dong-Chen Sun, Yi Ba, Ya-Xiong Zhang, Ting Zhou, Yuan-Yuan Zhao, Hong-Yun Zhao, Wen-Feng Fang, Yan Huang, Zhen Wang, Chao Deng, De-Sheng Hu, Wei Wang, Jin-Guan Lin, Gui-Ling Li, Su-Xia Luo, Zhi-Chao Fu, Hai-Sheng Zhu, Hui-Li Wang, Sheng-Li Cai, Xiao-Qiang Kang, Li Zhang, Yun-Peng Yang

“…Abstract Purpose Open-label phase Ib/II study to investigate the safety and efficacy of LBL-007, an anti-LAG-3 antibody, plus toripalimab, an anti-PD-1 antibody, in patients with previously treated advanced nasopharyngeal carcinoma (NPC) and other solid tumors. …”
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Micro–Positron Emission Tomography/Contrast-Enhanced Computed Tomography Imaging of Orthotopic Pancreatic Tumor–Bearing Mice Using the αβ Integrin Tracer Cu-Labeled Cyclam-RAFT-c(-RGDfK-) by Winn Aung, Zhao-Hui Jin, Takako Furukawa, Michael Claron, Didier Boturyn, Chizuru Sogawa, Atsushi B. Tsuji, Hidekatsu Wakizaka, Toshimitsu Fukumura, Yasuhisa Fujibayashi, Pascal Dumy, Tsuneo Saga

“…The purpose of this study was to develop a clinically relevant orthotopic xenotransplantation model of pancreatic cancer and to perform a preclinical evaluation of a new positron emission tomography (PET) imaging probe, 64 Cu-labeled cyclam-RAFT-c(-RGDfK-) 4 peptide ( 64 Cu-RAFT-RGD), using this model. …”
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Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors by Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

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AOZORA: long-term safety and joint health in paediatric persons with haemophilia A without factor VIII inhibitors receiving emicizumab – protocol for a multicentre, open-label, phase IV clinical study by Seitaro Yoshida, Masashi Taki, Hideyuki Takedani, Midori Shima, Keiji Nogami, Azusa Nagao, Haruko Yamaguchi-Suita, Yui Kyogoku, Akira Ishiguro, Kaoru Kitsukawa

“…The AOZORA study will evaluate the long-term safety and joint health of paediatric PwHA without factor (F)VIII inhibitors taking emicizumab; here, we report the details of the study protocol and baseline data.Methods and analysis AOZORA is a multicentre, open-label, phase IV clinical study in Japan that aims to enrol approximately 30 PwHA aged <12 years without FVIII inhibitors. …”
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Effect of Imeglimin, a Novel Anti-Diabetic Agent, on Insulin Secretion and Glycemic Variability in Type 2 Diabetes Treated with DPP-4 Inhibitor: A 16-Week, Open Label, Pilot Study by Itsukaichi A, Yoshikawa F, Fuchigami A, Iwata Y, Sato G, Miyagi M, Hirose T, Uchino H

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Open-label randomised clinical trial investigating whether robot-assisted kidney transplantation can reduce surgical complications compared to open kidney transplantation (ORAKTx): study protocol for a randomised clinical trial by Milla Ortved, Julia Dagnæs-Hansen, Hein V. Stroomberg, Thomas Kistorp, Malene Rohrsted, Søren Schwartz Sørensen, Andreas Røder

“…Methods This is a single-site, open-label, randomised clinical trial comparing RAKT to OKT. …”
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Semiautomatic Landmark-Based Two-Dimensional—Three-Dimensional Image Fusion in Living Mice: Correlation of Near-Infrared Fluorescence Imaging of Cy5.5-Labeled Antibodies with Flat-Panel Volume Computed Tomography by Christian Dullin, Marta Zientkowska, Joanna Napp, Jeannine Missbach-Guentner, Hans-Willi Krell, Friedemann Muller, Eckhardt Grabbe, Lutz-F. Tietze, Frauke Alves

“…Binding of Cy5.5-labeled matriptase-specific antibody to pancreatic tumors and Cy5.5-labeled uPAR-specific antibody to mammary carcinomas was assessed by time-domain NIRF imaging measuring the location of fluorescence intensity and its lifetime. …”
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A single-center, single-arm, prospective, open-label, and comparative trial to evaluate the safety and tolerability profile of a 90-day oral L-arginine hydrochloride intervention for patients with amyotrophic lateral sclerosis by Hiroyuki Naito, Masahiro Nakamori, Megumi Toko, Yuki Hayashi, Taku Tazuma, Tomoaki Watanabe, Keito Ishihara, Keisuke Tachiyama, Yu Yamazaki, Hirofumi Maruyama

“…We conducted a single-center, single-arm, prospective, open-label, and comparative trial to assess the safety and tolerability of L-arginine hydrochloride in ALS patients. …”
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