Safety and immunogenicity of an optimized self-replicating RNA platform for low dose or single dose vaccine applications: a randomized, open label Phase I study in healthy volunteers by Christian J. Maine, Shigeki J. Miyake-Stoner, Darina S. Spasova, Gaelle Picarda, Annie C. Chou, Emily D. Brand, Melanie D. Olesiuk, Christine C. Domingo, Hunter J. Little, Thomas T. Goodman, Jacqueline L. Posy, Jasmin Gonzalez, Terrina L. Bayone, Jessica Sparks, Ebony N. Gary, Zhi Xiang, Nicholas J. Tursi, Casey E. Hojecki, Hildegund C. J. Ertl, David B. Weiner, Irafasha C. Casmil, Anna K. Blakney, Brandon Essink, Guillermo Somodevilla, Nathaniel S. Wang, Andrew J. Geall, Zelanna Goldberg, Parinaz Aliahmad

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Clinical efficacy of 0.1% cyclosporine A in dry eye patients with inadequate responses to 0.05% cyclosporine A: a switching, prospective, open-label, multicenter study by Sook Hyun Yoon, Eun Chul Kim, In-Cheon You, Chul Young Choi, Jae Yong Kim, Jong Suk Song, Joon Young Hyon, Hong Kyun Kim, Kyoung Yul Seo

“…Design This study was designed as a switching, prospective, multicenter, 12-week, open-label study. Methods Patients with dry eye disease (DED), who experienced inadequate responses to at least 3 months of treatment with 0.05% cyclosporine, were enrolled in this study. …”
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Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in patients with advanced solid tumors by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

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Efficacy and Safety of Risankizumab in Patients with Psoriasis Showing Suboptimal Response to Secukinumab or Ixekizumab: Results from a Phase 3b, Open-Label, Single-Arm (aIMM) Study by Richard B. Warren, Lev Pavlovsky, Antonio Costanzo, Michael Bukhalo, Neil J. Korman, Yu-Huei Huang, Georgios Kokolakis, Andreas Pinter, Nadia Ibrahim, Yanbing Zheng, Leonidas Drogaris, Vassilis Stakias, Ahmed M. Soliman, Simone Rubant, Diamant Thaçi

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Off-label transcatheter aortic valve-in-valve implantation in severe bioprosthetic aortic valve dysfunction after bioprosthetic Bentall operation: a scoping review, case study and proposed approach by Nicholas Wen-Sheng Chew, Rodney Yu-Hang Soh, Gwyneth Kong, Yinghao Lim, Ivandito Kuntjoro

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In vivo scanning laser fundus and high-resolution OCT imaging of retinal ganglion cell injury in a non-human primate model with an activatable fluorescent-labeled TAT peptide probe. by Xudong Qiu, Seth T Gammon, Carol Rasmussen, Federica Pisaneschi, Charlene B Y Kim, James Ver Hoeve, Steven W Millward, Edward M Barnett, T Michael Nork, Paul L Kaufman, David Piwnica-Worms

“…In the present study, we investigated TcapQ488 in non-human primates (NHPs) to identify labeling efficacy and early signals of injured RGC, to determine species-dependent changes in RGC probe uptake and clearance, and to determine dose-limiting toxicities. …”
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An Open-Label Comparative Study of the Impact of Two Types of Electrical Stimulation (Direct Current Neuromuscular Electrical Stimulation and Transcutaneous Electrical Stimulation) on Physical Therapy Treatment of Diabetic Peripheral Neuropathy by Dimitrios Kostopoulos, Konstantine Rizopoulos, Joe McGilvrey, Jennifer Hauskey, Jeff Courcier, Kay Connor-Israel, Harry Koster, Ramona von Leden

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Randomized, Open-Label Phase 2 Study of Apalutamide plus Androgen Deprivation Therapy versus Apalutamide Monotherapy versus Androgen Deprivation Monotherapy in Patients with Biochemically Recurrent Prostate Cancer by Rahul Aggarwal, Joshi J. Alumkal, Russell Z. Szmulewitz, Celestia S. Higano, Alan H. Bryce, Angela Lopez-Gitlitz, Sharon A. McCarthy, Branko Miladinovic, Kelly McQuarrie, Shibu Thomas, Ke Zhang, Eric J. Small

“…Patients with BCR PC after primary definitive therapy and prostate-specific antigen (PSA) doubling time ≤12 months were randomized to open-label apalutamide (240 mg/d) alone, apalutamide plus ADT, or ADT alone (1 : 1:1 ratio) for 12 months followed by a 12-month observation period (NCT01790126). …”
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Perioperative and mid-term results of trans-graft embolization of the hypogastric artery for treatment of type II endoleaks after endovascular aortic repair with off-label use of re-entry catheters by Filippo Griselli, MD, Alessia D’Andrea, MD, Sandro Lepidi, MD, Beatrice Grando, MD, Giovanni Badalamenti, MD, Mario D’Oria, MD

“…Herein, we present the perioperative and mid-term results of one of our endovascular aortic repair cases with type II endoleak from the hypogastric artery, whose ostium was covered by the prior stent graft limbs and that were successfully treated with a novel technique employing re-entry catheters in an off-label fashion. This technique may represent a valid alternative solution when conventional access between artery and prosthesis is laborious or impossible to achieve.…”
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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…Design: Phase I, single-arm, open-label, uncontrolled, dose escalation study. Methods: The study consisted of four cohorts of patients receiving AUP1602-C as a single dose of 2.5 × 10 5 colony-forming units (CFU)/cm 2 ulcer size or as repeated doses between 2.5 × 10 6 and 2.5 × 10 8  CFU/cm 2 administered 3 times per week for 6 weeks. …”
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Effects of perioperative treatment of resectable adenocarcinoma of esophagogastric junction by immunotherapy (Adebrelimab) combined with chemotherapy (XELOX): protocol for a single-center, open-labeled study (AEGIS trial, neoadjuvant immunochemotherapy) by Yingyi Li, Yuqin Cao, Xipeng Wang, Chengqiang Li, Liqin Zhao, Hecheng Li

“…Methods The AEGIS study is a prospective, open-labeled, single-arm, phase II clinical trial. A total of 26 patients with AEG will be enrolled. …”
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Proteomic analysis of murine norovirus-infected Raw 264.7 cells reveals the induction of Ras GTPases by Sung Ho Yun, Md Arif-Ur Rahman, Soo-Bin Nam, Soo Hyeon Kim, Gyuri Kim, Kun Cho, Jong-Soon Choi

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Aggregation algorithm for MPLS multicast flows based on bidirectional shared tree by LI Ling-zhi1, ZHU Yan-qin1, YANG Zhe1

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Clinical confocal laser endomicroscopy for imaging of autofluorescence signals of human brain tumors and non-tumor brain by Marlen Reichenbach, Sven Richter, Roberta Galli, Matthias Meinhardt, Katrin Kirsche, Achim Temme, Dimitrios Emmanouilidis, Witold Polanski, Insa Prilop, Dietmar Krex, Stephan B. Sobottka, Tareq A. Juratli, Ilker Y. Eyüpoglu, Ortrud Uckermann

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Learning with semantic ambiguity for unbiased scene graph generation by Shanjin Zhong, Yang Cao, Qiaosen Chen, Jie Gong

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Research on Intelligent Optical Fiber Infrastructure Management Technology by Tao Zeng, Chengbin Shen, Ming Jiang

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Alterations in cerebral perfusion and corresponding brain functional networks in systemic lupus erythematosus with cognitive impairment by Huiyang Liu, Hu Liu, Bailing Tian, Pingting Yang, Guoguang Fan

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Comparative color stability assessment of orthodontic clear aligners: an in vitro study by Nancy Ajwa, Fatimah Radhi, Rana Aloraini, Ghadi AlSaydalani

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Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication by Dennis Adusei, Bernard O. Asimeng, Francis D. Krampa, Elvis K. Tiburu

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O artista popular e o contrato: lógicas divergentes nas produções musicais by Mariana Mont\u2019Alverne Barreto Lima

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